Association of serum anti-periodontal pathogen antibody with ischemic stroke

Cerebrovascular Diseases

Volumn 34, Issue 5-6, 2012, Pages 385-392

  Hosomi, Naohisa ^a,b   Aoki, Shiro ^a   Matsuo, Katsuhiko ^e   Deguchi, Kazushi ^b   Masugata, Hisashi ^b   Murao, Koji ^b   Ichihara, Noriko ^c   Ohyama, Hideo ^d   Dobashi, Hiroaki ^b   Nezu, Tomohisa ^a   Ohtsuki, Toshiho ^a   Yasuda, Osamu ^f   Soejima, Hirofumi ^g   Ogawa, Hisao ^g   Izumi, Yuichi ^h   Kohno, Masakazu ^b   Tanaka, Junko ^a   Matsumoto, Masayasu ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

^c National Hospital Organization Takamatsu Medical Center   (Japan)

^d Osaka Neurosurgical Hospital   (Japan)

^e Base Technology Center   (Japan)

^f KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

^g KUMAMOTO UNIVERSITY   (Japan)

^h TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Atherosclerosis; Atrial fibrillation; Cerebral infarction; Infectious disease; Periodontitis

Indexed keywords

BACTERIUM ANTIBODY; C REACTIVE PROTEIN;

AGED; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ANTIBODY BLOOD LEVEL; ARTICLE; BRAIN ISCHEMIA; CAROTID ATHEROSCLEROSIS; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; NEPHELOMETRY; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ANTIBODIES, BACTERIAL; ATHEROSCLEROSIS; BACTEROIDACEAE INFECTIONS; BRAIN ISCHEMIA; C-REACTIVE PROTEIN; CAROTID ARTERIES; CAROTID ARTERY DISEASES; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA; RISK FACTORS;

EID: 84870294055     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000343659     Document Type: Article

References (25)

1. Janket SJ, Baird AE, Chuang SK, Jones JA: Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 95: 559-569. (Pubitemid 36886703)
2. Grau AJ, Becher H, Ziegler CM, Lichy C, Buggle F, Kaiser C, Lutz R, Bultmann S, Preusch M, Dorfer CE: Periodontal disease as a risk factor for ischemic stroke. Stroke 2004; 35: 496-501. (Pubitemid 38174436)
3. Pussinen PJ, Alfthan G, Rissanen H, Reunanen A, Asikainen S, Knekt P: Antibodies to periodontal pathogens and stroke risk. Stroke 2004; 35: 2020-2023. (Pubitemid 39136233)
4. Pussinen PJ, Alfthan G, Jousilahti P, Paju S, Tuomilehto J: Systemic exposure to Porphyromonas gingivalis predicts incident stroke. Atherosclerosis 2007; 193: 222-228. (Pubitemid 46776703)
5. Chiang CH, Huang CC, Chan WL, Huang PH, Chen YC, Chen TJ, Lin SJ, Chen JW, Leu HB: Herpes simplex virus infection and risk of atrial fibrillation: A nationwide study. Int J Cardiol 2011, E-pub ahead of print.
6. Aviles RJ, Martin DO, Apperson-Hansen C, Houghtaling PL, Rautaharju P, Kronmal RA, Tracy RP, Van Wagoner DR, Psaty BM, Lauer MS, Chung MK: Inflammation as a risk factor for atrial fibrillation. Circulation 2003; 108: 3006-3010. (Pubitemid 37553570)
7. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd: Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35-41. (Pubitemid 23014379)
8. Hosomi N, Mizushige K, Ohyama H, Takahashi T, Kitadai M, Hatanaka Y, Matsuo H, Kohno M, Koziol JA: Angiotensin-converting enzyme inhibition with enalapril slows progressive intima-media thickening of the common carotid artery in patients with noninsulin-dependent diabetes mellitus. Stroke 2001; 32: 1539-1545. (Pubitemid 32631902)
9. Hosomi N, Ohyama H, Takahashi T, Shinomiya K, Naya T, Ban CR, Osaka K, Kohno M, Koziol JA: Plasma adrenomedullin and carotid atherosclerosis in atherothrombotic ischemic stroke. J Hypertens 2004; 22: 1945-1951. (Pubitemid 39336677)
10. Handa N, Matsumoto M, Maeda H, Hougaku H, Ogawa S, Fukunaga R, Yoneda S, Kimura K, Kamada T: Ultrasonic evaluation of early carotid atherosclerosis. Stroke 1990; 21: 1567-1572.
11. Soejima H, Oe Y, Nakayama H, Matsuo K, Fukunaga T, Sugamura K, Kawano H, Sugiyama S, Shinohara M, Izumi Y, Ogawa H: Periodontal status and Prevotella intermedia antibody in acute coronary syndrome. Int J Cardiol 2009; 137: 304-306.
12. Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E: Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol 2001; 72: 1221-1227. (Pubitemid 33607184)
13. Buhlin K, Gustafsson A, Pockley AG, Frostegard J, Klinge B: Risk factors for cardiovascular disease in patients with periodontitis. Eur Heart J 2003; 24: 2099-2107. (Pubitemid 37486529)
14. Schnabel RB, Sullivan LM, Levy D, Pencina MJ, Massaro JM, D'Agostino RB Sr, Newton-Cheh C, Yamamoto JF, Magnani JW, Tadros TM, Kannel WB, Wang TJ, Ellinor PT, Wolf PA, Vasan RS, Benjamin EJ: Development of a risk score for atrial fibrillation (Framingham Heart Study): A community-based cohort study. Lancet 2009; 373: 739-745.
15. Haissaguerre M, Jais P, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrigue S, Le Mouroux A, Le Metayer P, Clementy J: Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 1998; 339: 659-666. (Pubitemid 28402090)
16. Grayston JT: Chlamydia in atherosclerosis. Circulation 1993; 87: 1408-1409. (Pubitemid 23110413)
17. Mendall MA, Goggin PM, Molineaux N, Levy J, Toosy T, Strachan D, Camm AJ, Northfield TC: Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J 1994; 71: 437-439. (Pubitemid 2068912)
18. Nieto FJ, Adam E, Sorlie P, Farzadegan H, Melnick JL, Comstock GW, Szklo M: Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis. Circulation 1996; 94: 922-927. (Pubitemid 26292841)
19. Haraszthy VI, Zambon JJ, Trevisan M, Zeid M, Genco RJ: Identification of periodontal pathogens in atheromatous plaques. J Periodontol 2000; 71: 1554-1560.
20. Desvarieux M, Demmer RT, Rundek T, Boden-Albala B, Jacobs DR Jr, Papapanou PN, Sacco RL: Relationship between periodontal disease, tooth loss, and carotid artery plaque: The Oral Infections and Vascular Disease Epidemiology Study (INVEST). Stroke 2003; 34: 2120-2125. (Pubitemid 37099823)
21. Desvarieux M, Demmer RT, Rundek T, Boden-Albala B, Jacobs DR Jr, Sacco RL, Papapanou PN: Periodontal microbiota and carotid intima-media thickness: The Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation 2005; 111: 576-582. (Pubitemid 40216484)
22. Pussinen PJ, Nyyssonen K, Alfthan G, Salonen R, Laukkanen JA, Salonen JT: Serum antibody levels to Actinobacillus actinomycetemcomitans predict the risk for coronary heart disease. Arterioscler Thromb Vasc Biol 2005; 25: 833-838. (Pubitemid 40463878)
23. Johansson A, Johansson I, Eriksson M, Ahren AM, Hallmans G, Stegmayr B: Systemic antibodies to the leukotoxin of the oral pathogen Actinobacillus actinomycetemcomitans correlate negatively with stroke in women. Cerebrovasc Dis 2005; 20: 226-232. (Pubitemid 41318199)
24. Roquer J, Cuadrado-Godia E, Giralt-Steinthauer E, Jimena S, Jimenez-Conde J, Martinez-Rodriguez JE, Ois A, Rodriguez-Campello A: Previous infection and stroke: A prospective study. Cerebrovasc Dis 2012; 33: 310-315.
25. Dorfer CE, Becher H, Ziegler CM, Kaiser C, Lutz R, Jorss D, Lichy C, Buggle F, Bultmann S, Preusch M, Grau AJ: The association of gingivitis and periodontitis with ischemic stroke. J Clin Periodontol 2004; 31: 396-401. (Pubitemid 38624033)