Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells

European Journal of Immunology

Volumn 45, Issue 11, 2015, Pages 3010-3021

  Preite, Silvia ^a   Baumjohann, Dirk ^a,c   Foglierini, Mathilde ^a   Basso, Camilla ^a   Ronchi, Francesca ^a,d   Rodriguez, Blanca M Fernandez ^a   Corti, Davide ^a   Lanzavecchia, Antonio ^a,b   Sallusto, Federica ^a  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Antibodies; Germinal center; Lymphopenia; Somatic hypermutation; Tfh cell

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CHEMOKINE RECEPTOR CXCR5; CD3 ANTIGEN; CD3E PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY AFFINITY; ARTICLE; B LYMPHOCYTE; CELL COUNT; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; GERMINAL CENTER; HELPER CELL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SOMATIC MUTATION; T FOLLICULAR HELPER CELL; ADOPTIVE TRANSFER; ANIMAL; C57BL MOUSE; CYTOLOGY; FLOW CYTOMETRY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; MUTATION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD3; B-LYMPHOCYTES; CELL DIFFERENTIATION; FLOW CYTOMETRY; GERMINAL CENTER; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 84951568637     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201545920     Document Type: Article

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