Methylomic Aging as a Window onto the Influence of Lifestyle: Tobacco and Alcohol Use Alter the Rate of Biological Aging

Journal of the American Geriatrics Society

Volumn 63, Issue 12, 2015, Pages 2519-2525

  Beach, Steven R H ^a,b   Dogan, Meeshanthini V ^c,d   Lei, Man Kit ^b   Cutrona, Carolyn E ^e   Gerrard, Meg ^f   Gibbons, Frederick X ^f   Simons, Ronald L ^b   Brody, Gene H ^b   Philibert, Robert A ^c,d  

^a University of Georgia ^*  (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c IA United States   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e Department of Statistics Center for Statistics and Applications in Forensic Evidence Iowa State University 2438 Osborn Dr Ames   (United States)

^f UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; DNA; UNCLASSIFIED DRUG;

ACCELERATION; ADOLESCENT; ADULT; AGE; AGED; AGING; ALCOHOL CONSUMPTION; ARTICLE; BLACK PERSON; CAUCASIAN; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; FEMALE; HUMAN; LIFESTYLE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL STRESS; RANDOMIZED CONTROLLED TRIAL; SMOKING; TOBACCO; TOBACCO USE; VERY ELDERLY;

EID: 84951299452     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.13830     Document Type: Article

References (39)

1. United Nations. World Population Ageing: 1950-2050. New York: Department of Economic and Social Affairs, 2014.
2. Hannum G, Guinney J, Zhao L, et al., Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 2013; 49: 359-367.
3. Fraga MF, Esteller M,. Epigenetics and aging: The targets and the marks. Trends Genet 2007; 23: 413-418.
4. Horvath S, Zhang Y, Langfelder P, et al., Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol 2012; 13: R97.
5. Boks MP, Derks EM, Weisenberger DJ, et al., The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS ONE 2009; 4: e6767.
6. Mitteldorf JJ,. How does the body know how old it is? Introducing the epigenetic clock hypothesis. Biochemistry (Mosc) 2013; 78: 1048-1053.
7. Monick MM, Beach SR, Plume J, et al., Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. Am J Med Genet B Neuropsychiatr Genet 2012; 159B: 141-151.
8. Elliott H, Tillin T, McArdle W, et al., Differences in smoking associated DNA methylation patterns in South Asians and Europeans. Clin Epigenetics 2014; 6: 4.
9. Dogan MV, Shields B, Cutrona C, et al., The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women. BMC Genom 2014; 15: 151.
10. Zeilinger S, Kühnel B, Klopp N, et al., Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PLoS ONE 2013; 8: e63812.
11. Philibert R, Beach SR, Li K-M, et al., Changes in DNA methylation at the aryl hydrocarbon receptor repressor may be a new biomarker for smoking. Clin Epigenetics 2013; 5: 19-26.
12. Besingi W, Johansson Å,. Smoke related DNA methylation changes in the etiology of human disease. Hum Mol Genet 2013; 23: 2290-2297.
13. Shenker NS, Polidoro S, van Veldhoven K, et al., Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking. Hum Mol Genet 2013; 22: 843-851.
14. Philibert RA, Beach SR, Brody GH,. Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers. Epigenetics 2012; 7: 1331-1338.
15. Joubert BR, Håberg SE, Nilsen RM, et al., 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect 2012; 120: 1425-1431.
16. Philibert R, Penaluna B, White T, et al., A pilot examination of the genome-wide DNA methylation signatures of subjects entering and exiting short-term alcohol dependence treatment programs. Epigenetics 2014; 9: 1-7.
17. Beach SRH, Gerrard M, Gibbons FX, et al., A role for epigenetics in broadening the scope of pediatric care in the prevention of adolescent smoking. Epigenet Diagn Ther 2015; 1: 1-7. E-Pub Ahead of Print.
18. Mokdad AH, Marks JS, Stroup DF, et al., Actual causes of death in the United States, 2000. JAMA 2004; 291: 1238-1245.
19. Centers for Disease Control and Prevention. Vital signs: Current cigarette smoking among adults aged >/=18 years-United States, 2005-2010. MMWR Morb Mortal Wkly Rep 2011; 60: 1207-1212.
20. Centers for Disease Control and Prevention. Alcohol-attributable deaths and years of potential life lost-United States, 2001. MMWR Morbid Mortal Wkly Rep 2004; 53: 866-870.
21. Gorber SC, Schofield-Hurwitz S, Hardt J, et al., The accuracy of self-reported smoking: A systematic review of the relationship between self-reported and cotinine-assessed smoking status. Nicotine Tob Res 2009; 11: 12-24.
22. Caraballo RS, Giovino GA, Pechacek TF,. Self-reported cigarette smoking vs. serum cotinine among U.S. adolescents. Nicotine Tob Res 2004; 6: 19-25.
23. Fendrich M, Mackesy-Amiti ME, Johnson TP, et al., Tobacco-reporting validity in an epidemiological drug-use survey. Addict Behav 2005; 30: 175-181.
24. Sobell LC, Sobell MB,. Alcohol Consumption Measures. 2003. Assessing Alcohol Problems: A Guide for Clinicians. U.S. Department of Health and Human Services [on-line]. Available at http://pubs.niaaa.nih.gov/publications/AssessingAlcohol/index.pdf Accessed August 24, 2014.
25. Sun Q, Townsend MK, Okereke OI, et al., Alcohol consumption at midlife and successful ageing in women: A prospective cohort analysis in the Nurses' Health Study. PLoS Med 2011; 8: e1001090.
26. Ronksley PE, Brien SE, Turner BJ, et al., Association of alcohol consumption with selected cardiovascular disease outcomes: A systematic review and meta-analysis. BMJ 2011; 342: d671.
27. Kaplan MS, Huguet N, Feeny D, et al., Alcohol use patterns and trajectories of health-related quality of life in middle-aged and older adults: A 14-year population-based study. J Stud Alcohol Drugs 2012; 73: 581-590.
28. Tucker KL, Jugdaohsingh R, Powell JJ, et al., Effects of beer, wine, and liquor intakes on bone mineral density in older men and women. Am J Clin Nutr 2009; 89: 1188-1196.
29. Baur JA, Sinclair DA,. Therapeutic potential of resveratrol: The in vivo evidence. Nat Rev Drug Discov 2006; 5: 493-506.
30. Pacholec M, Bleasdale JE, Chrunyk B, et al., SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 2010; 285: 8340-8351.
31. Semba RD, Ferrucci L, Bartali B, et al., Resveratrol levels and all-cause mortality in older community-dwelling adults. JAMA Intern Med 2014; 174: 1077-1084.
32. Yuan H, Marmorstein R,. Red wine, toast of the town (again). Science 2013; 339: 1156-1157.
33. Hubbard BP, Gomes AP, Dai H, et al., Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 2013; 339: 1216-1219.
34. Kremens K, Powers L, Gerke A, et al., Smoking-induced changes in CpG DNA methylation at gene promoter regions target inflammation pathways. Am J Respir Crit Care Med 2012; 185: A2668.
35. Zozulinska D, Wierusz-Wysocka B,. Type 2 diabetes mellitus as inflammatory disease. Diabetes Res Clin Pract 2006; 74 (2 Suppl): S12-S16.
36. Cook DG, Mendall MA, Whincup PH, et al., C-reactive protein concentration in children: Relationship to adiposity and other cardiovascular risk factors. Atherosclerosis 2000; 149: 139-150.
37. Dandona P, Aljada A, Bandyopadhyay A,. Inflammation: The link between insulin resistance, obesity and diabetes. Trends Immunol 2004; 25: 4-7.
38. Horvath S, Zhang Y, Langfelder P, et al., Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol 2012; 13: 1-18.
39. Weidner C, Lin Q, Koch C, et al., Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol 2014; 15: R24.