Controversy in myocardial regeneration

Regenerative Medicine

Volumn 10, Issue 8, 2015, Pages 921-924

  Moccetti, Tiziano ^a   Leri, Annarosa ^b   Anversa, Piero ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

c Kit; cardiac hypertrophy; cardiomyocytes; cell death; cell dedifferentiation; cell proliferation; lineage tracing; stem cells; telomere length

Indexed keywords

PROTEIN P53; REPETITIVE DNA; STEM CELL FACTOR; TROPONIN;

APOPTOSIS; CARDIAC STEM CELL; CARDIOVASCULAR SYSTEM; CELL AGING; CELL DEATH; CELL DIFFERENTIATION; CELL FUNCTION; CELL LOSS; CELL POPULATION; CELL PROLIFERATION; CELL REGENERATION; CELL RENEWAL; CELL VIABILITY; DNA DAMAGE; HEART DEATH; HEART FAILURE; HEART MUSCLE CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGENERATIVE MEDICINE; REVIEW; TISSUE REGENERATION; UPREGULATION; ANIMAL; CARDIAC MUSCLE; CARDIOMEGALY; REGENERATION; TELOMERE HOMEOSTASIS;

ANIMALS; CARDIOMEGALY; HUMANS; MYOCARDIUM; REGENERATION; TELOMERE HOMEOSTASIS;

EID: 84951268652     PISSN: 17460751     EISSN: 1746076X     Source Type: Journal    
DOI: 10.2217/rme.15.61     Document Type: Review

References (23)

1. Suram A, Herbig U. The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses. Aging Cell 13(5), 780-786 (2014).
2. Siddiqi S, Sussman MA. The heart: mostly postmitotic or mostly premitotic? Myocyte cell cycle, senescence, and quiescence. Can. J. Cardiol. 30(11), 1270-1278 (2014).
3. Bernardes de Jesus B, Blasco MA. Telomerase at the intersection of cancer and aging. Trends Genet. 29(9), 513-520 (2013).
4. Sanada F, Kim J, Czarna A et al. c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy. Circ. Res. 114(1), 41-55 (2014).
5. Leri A, Rota M, Pasqualini FS, Goichberg P, Anversa P. Origin of cardiomyocytes in the adult heart. Circ. Res. 116(1), 150-166 (2015).
6. Mohsin S, Siddiqi S, Collins B, Sussman MA. Empowering adult stem cells for myocardial regeneration. Circ. Res. 109(12), 1415-1428 (2011).
7. van Berlo JH, Molkentin JD. An emerging consensus on cardiac regeneration. Nat. Med. 20(12), 1386-1393 (2014).
8. Chugh AR, Beache GM, Loughran JH et al. Administration of cardiac stem cells in patients with ischemic cardiomyopathy: The SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation 126(11 Suppl. 1), S54-S64 (2012).
9. Olivetti G, Abbi R, Quaini F et al. Apoptosis in the failing human heart. N. Engl. J. Med. 336(16), 1131-1141 (1997).
10. Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell. Biol. 9(3), 231-241 (2008).
11. Mani K. Programmed cell death in cardiac myocytes: strategies to maximize post-ischemic salvage. Heart Fail. Rev. 13(2), 193-209 (2008).
12. de Lemos JA, deFilippi CR. Prevalence and significance of detectable troponins as measured by highly sensitive assays in the general population. Coron. Artery Dis. 24(8), 705-709 (2013).
13. Glick D, DeFilippi CR, Christenson R, Gottdiener JS, Seliger SL. Long-term trajectory of two unique cardiac biomarkers and subsequent left ventricular structural pathology and risk of incident heart failure in communitydwelling older adults at low baseline risk. JACC Heart Fail. 1(4), 353-360 (2013).
14. Senyo SE, Steinhauser ML, Pizzimenti CL et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature 493(7432), 433-436 (2013).
15. Bergmann O, Zdunek S, Felker A et al. Dynamics of cell generation and turnover in the human heart. Cell 161(7), 1566-1575 (2015).
16. Potten C, Wilson J. Apoptosis: The Life and Death of Cells. Cambridge University Press, Cambridge, MA, USA (2004).
17. Rota M, Goichberg P, Anversa P, Leri A. Aging effects on cardiac progenitor cell physiology. Compr. Physiol. Rev. 5(4), 1705-1750 (2015).
18. Beltrami AP, Barlucchi L, Torella D et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114(6), 763-776 (2003).
19. Ellison GM, Vicinanza C, Smith AJ et al. Adult c-Kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. Cell 154(4), 827-842 (2013).
20. van Berlo JH, Kanisicak O, Maillet M et al. c-Kit+ cells minimally contribute cardiomyocytes to the heart. Nature 509(7500), 337-341 (2014).
21. Ye L, Zhang EY, Xiong Q et al. Aging Kit mutant mice develop cardiomyopathy. PLoS ONE 7(3), e33407 (2012).
22. Fazel S, Cimini M, Chen L et al. Cardioprotective c-Kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J. Clin. Invest. 116(7), 1865-1877 (2006).
23. Kubin T, Pöling J, Kostin S et al. Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell Stem Cell 9(5), 420-432 (2011).