메뉴 건너뛰기




Volumn 50, Issue , 2014, Pages 23-28

Chronic overproduction of ghrelin in the hypothalamus leads to temporal increase in food intake and body weight

Author keywords

Energy homeostasis; Ghrelin; Obesity

Indexed keywords

ADENOVIRUS VECTOR; GHRELIN; MESSENGER RNA; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; ACYLTRANSFERASE; GHRELIN O-ACYLTRANSFERASE, MOUSE; HYBRID PROTEIN;

EID: 84951268079     PISSN: 01434179     EISSN: 15322785     Source Type: Journal    
DOI: 10.1016/j.npep.2015.02.002     Document Type: Article
Times cited : (17)

References (31)
  • 1
    • 49649122302 scopus 로고    scopus 로고
    • UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
    • Andrews, Z.B., Liu, Z.W., Walllingford, N., Erion, D.M., Borok, E., Friedman, J.M., et al., 2008. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454 (7206), 846-851.
    • (2008) Nature , vol.454 , Issue.7206 , pp. 846-851
    • Andrews, Z.B.1    Liu, Z.W.2    Walllingford, N.3    Erion, D.M.4    Borok, E.5    Friedman, J.M.6
  • 2
    • 0027190603 scopus 로고
    • Pancreatic polypeptide infusions reduce food intake in Prader-Willi syndrome
    • Berntson, G.G., Zipf, W.B., O'Dorisio, T.M., Hoffman, J.A., Chance, R.E., 1993. Pancreatic polypeptide infusions reduce food intake in Prader-Willi syndrome. Peptides 14 (3), 497-503.
    • (1993) Peptides , vol.14 , Issue.3 , pp. 497-503
    • Berntson, G.G.1    Zipf, W.B.2    O'Dorisio, T.M.3    Hoffman, J.A.4    Chance, R.E.5
  • 3
    • 0035039474 scopus 로고    scopus 로고
    • Unnatural growth hormone-releasing peptide begets natural ghrelin
    • Bowers, C.Y., 2001. Unnatural growth hormone-releasing peptide begets natural ghrelin. J. Clin. Endocrinol. Metab. 86 (4), 1464-1469.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , Issue.4 , pp. 1464-1469
    • Bowers, C.Y.1
  • 4
    • 2542475178 scopus 로고    scopus 로고
    • Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
    • Chen, H.Y., Trumbauer, M.E., Chen, A.S., Weingarth, D.T., Adams, J.R., Frazier, E.G., et al., 2004. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 145 (6), 2607-2612.
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 2607-2612
    • Chen, H.Y.1    Trumbauer, M.E.2    Chen, A.S.3    Weingarth, D.T.4    Adams, J.R.5    Frazier, E.G.6
  • 5
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley, M.A., Smith, R.G., Diano, S., Tschop, M., Pronchuk, N., Grove, K.L., et al., 2003. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37 (4), 649-661.
    • (2003) Neuron , vol.37 , Issue.4 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3    Tschop, M.4    Pronchuk, N.5    Grove, K.L.6
  • 6
    • 33746739498 scopus 로고    scopus 로고
    • Ghrelin and the short-and long-term regulation of appetite and body weight
    • Cummings, D.E., 2006. Ghrelin and the short-and long-term regulation of appetite and body weight. Physiol. Behav. 89 (1), 71-84.
    • (2006) Physiol. Behav , vol.89 , Issue.1 , pp. 71-84
    • Cummings, D.E.1
  • 8
    • 0036787457 scopus 로고    scopus 로고
    • The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    • Date, Y., Murakami, N., Toshinai, K., Matsukura, S., Niijima, A., Matsuo, H., et al., 2002. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123 (4), 1120-1128.
    • (2002) Gastroenterology , vol.123 , Issue.4 , pp. 1120-1128
    • Date, Y.1    Murakami, N.2    Toshinai, K.3    Matsukura, S.4    Niijima, A.5    Matsuo, H.6
  • 11
    • 0036928761 scopus 로고    scopus 로고
    • High circulating ghrelin: a potential cause for hyperphagia and obesity in Prader-Willi syndrome
    • DelParigi, A., Tschop, M., Heiman, M.L., Salbe, A.D., Vozarova, B., Sell, S.M., et al., 2002. High circulating ghrelin: a potential cause for hyperphagia and obesity in Prader-Willi syndrome. J. Clin. Endocrinol. Metab. 87 (12), 5461-5464.
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , Issue.12 , pp. 5461-5464
    • DelParigi, A.1    Tschop, M.2    Heiman, M.L.3    Salbe, A.D.4    Vozarova, B.5    Sell, S.M.6
  • 12
    • 9444264700 scopus 로고    scopus 로고
    • Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents
    • Dezaki, K., Hosoda, H., Kakei, M., Hashiguchi, S., Watanabe, M., Kangawa, K., et al., 2004. Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes 53 (12), 3142-3151.
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3142-3151
    • Dezaki, K.1    Hosoda, H.2    Kakei, M.3    Hashiguchi, S.4    Watanabe, M.5    Kangawa, K.6
  • 13
    • 45349095977 scopus 로고    scopus 로고
    • Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED)
    • Geliebter, A., Hashim, S.A., Gluck, M.E., 2008. Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED). Physiol. Behav. 94 (5), 696-699.
    • (2008) Physiol. Behav , vol.94 , Issue.5 , pp. 696-699
    • Geliebter, A.1    Hashim, S.A.2    Gluck, M.E.3
  • 14
    • 0842330725 scopus 로고    scopus 로고
    • Synaptic interactions between ghrelin-and neuropeptide Y-containing neurons in the rat arcuate nucleus
    • Guan, J.L., Wang, Q.P., Kageyama, H., Takenoya, F., Kita, T., Matsuoka, T., et al., 2003. Synaptic interactions between ghrelin-and neuropeptide Y-containing neurons in the rat arcuate nucleus. Peptides 24 (12), 1921-1928.
    • (2003) Peptides , vol.24 , Issue.12 , pp. 1921-1928
    • Guan, J.L.1    Wang, Q.P.2    Kageyama, H.3    Takenoya, F.4    Kita, T.5    Matsuoka, T.6
  • 15
    • 37349128328 scopus 로고    scopus 로고
    • Synaptic relationships between proopiomelanocortin-and ghrelin-containing neurons in the rat arcuate nucleus
    • Guan, J.L., Okuda, H., Takenoya, F., Kintaka, Y., Yagi, M., Wang, L., et al., 2008. Synaptic relationships between proopiomelanocortin-and ghrelin-containing neurons in the rat arcuate nucleus. Regul. Pept. 145 (1-3), 128-132.
    • (2008) Regul. Pept , vol.145 , Issue.1-3 , pp. 128-132
    • Guan, J.L.1    Okuda, H.2    Takenoya, F.3    Kintaka, Y.4    Yagi, M.5    Wang, L.6
  • 17
    • 0037382853 scopus 로고    scopus 로고
    • Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin
    • Kohno, D., Gao, H.Z., Muroya, S., Kikuyama, S., Yada, T., 2003. Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52 (4), 948-956.
    • (2003) Diabetes , vol.52 , Issue.4 , pp. 948-956
    • Kohno, D.1    Gao, H.Z.2    Muroya, S.3    Kikuyama, S.4    Yada, T.5
  • 18
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., Kangawa, K., 1999. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (6762), 656-660.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 20
    • 0030830526 scopus 로고    scopus 로고
    • Increased leptin messenger RNA and serum leptin levels in children with Prader-Willi syndrome and nonsyndromal obesity
    • Lindgren, A.C., Marcus, C., Skwirut, C., Elimam, A., Hagenas, L., Schalling, M., et al., 1997. Increased leptin messenger RNA and serum leptin levels in children with Prader-Willi syndrome and nonsyndromal obesity. Pediatr. Res. 42 (5), 593-596.
    • (1997) Pediatr. Res , vol.42 , Issue.5 , pp. 593-596
    • Lindgren, A.C.1    Marcus, C.2    Skwirut, C.3    Elimam, A.4    Hagenas, L.5    Schalling, M.6
  • 21
    • 0037085391 scopus 로고    scopus 로고
    • Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells
    • Murata, M., Okimura, Y., Iida, K., Matsumoto, M., Sowa, H., Kaji, H., et al., 2002. Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells. J. Biol. Chem. 277 (7), 5667-5674.
    • (2002) J. Biol. Chem , vol.277 , Issue.7 , pp. 5667-5674
    • Murata, M.1    Okimura, Y.2    Iida, K.3    Matsumoto, M.4    Sowa, H.5    Kaji, H.6
  • 22
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., et al., 2001. A role for ghrelin in the central regulation of feeding. Nature 409 (6817), 194-198.
    • (2001) Nature , vol.409 , Issue.6817 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3    Kojima, M.4    Matsuo, H.5    Kangawa, K.6
  • 23
    • 13444265857 scopus 로고    scopus 로고
    • Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa
    • Otto, B., Cuntz, U., Fruehauf, E., Wawarta, R., Folwaczny, C., Riepl, R.L., et al., 2001. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur. J. Endocrinol. 145 (5), 669-673.
    • (2001) Eur. J. Endocrinol , vol.145 , Issue.5 , pp. 669-673
    • Otto, B.1    Cuntz, U.2    Fruehauf, E.3    Wawarta, R.4    Folwaczny, C.5    Riepl, R.L.6
  • 25
    • 79960839413 scopus 로고    scopus 로고
    • In adults with Prader-Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels
    • Purtell, L., Sze, L., Loughnan, G., Smith, E., Herzog, H., Sainsbury, A., et al., 2011. In adults with Prader-Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels. Neuropeptides 45 (4), 301-307.
    • (2011) Neuropeptides , vol.45 , Issue.4 , pp. 301-307
    • Purtell, L.1    Sze, L.2    Loughnan, G.3    Smith, E.4    Herzog, H.5    Sainsbury, A.6
  • 26
    • 0037173035 scopus 로고    scopus 로고
    • Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice
    • Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S., Furtinger, S., Jenkins, A., et al., 2002. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc. Natl. Acad. Sci. U.S.A. 99 (13), 8938-8943.
    • (2002) Proc. Natl. Acad. Sci. U.S.A , vol.99 , Issue.13 , pp. 8938-8943
    • Sainsbury, A.1    Schwarzer, C.2    Couzens, M.3    Fetissov, S.4    Furtinger, S.5    Jenkins, A.6
  • 27
    • 38549133092 scopus 로고    scopus 로고
    • Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance
    • Sun, Y., Butte, N.F., Garcia, J.M., Smith, R.G., 2008. Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology 149 (2), 843-850.
    • (2008) Endocrinology , vol.149 , Issue.2 , pp. 843-850
    • Sun, Y.1    Butte, N.F.2    Garcia, J.M.3    Smith, R.G.4
  • 28
    • 4043096513 scopus 로고    scopus 로고
    • Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader-Willi syndrome
    • Tan, T.M., Vanderpump, M., Khoo, B., Patterson, M., Ghatei, M.A., Goldstone, A.P., 2004. Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader-Willi syndrome. J. Clin. Endocrinol. Metab. 89 (8), 4162-4165.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , Issue.8 , pp. 4162-4165
    • Tan, T.M.1    Vanderpump, M.2    Khoo, B.3    Patterson, M.4    Ghatei, M.A.5    Goldstone, A.P.6
  • 29
    • 77956357163 scopus 로고    scopus 로고
    • Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans
    • Tong, J., Prigeon, R.L., Davis, H.W., Bidlingmaier, M., Kahn, S.E., Cummings, D.E., et al., 2010. Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes 59 (9), 2145-2151.
    • (2010) Diabetes , vol.59 , Issue.9 , pp. 2145-2151
    • Tong, J.1    Prigeon, R.L.2    Davis, H.W.3    Bidlingmaier, M.4    Kahn, S.E.5    Cummings, D.E.6
  • 30
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop, M., Smiley, D.L., Heiman, M.L., 2000. Ghrelin induces adiposity in rodents. Nature 407 (6806), 908-913.
    • (2000) Nature , vol.407 , Issue.6806 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 31
    • 0025125869 scopus 로고
    • Short-term infusion of pancreatic polypeptide: effect on children with Prader-Willi syndrome
    • Zipf, W.B., O'Dorisio, T.M., Berntson, G.G., 1990. Short-term infusion of pancreatic polypeptide: effect on children with Prader-Willi syndrome. Am. J. Clin. Nutr. 51 (2), 162-166.
    • (1990) Am. J. Clin. Nutr , vol.51 , Issue.2 , pp. 162-166
    • Zipf, W.B.1    O'Dorisio, T.M.2    Berntson, G.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.