Circulating stem cells associate with adiposity and future metabolic deterioration in healthy subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 12, 2015, Pages 4570-4578

  Fadini, Gian Paolo ^a,b   Bonora, Benedetta Maria ^a   Marcuzzo, Giorgio ^a   Marescotti, Maria Cristina ^a   Cappellari, Roberta ^a   Pantano, Giorgia ^a   Sanzari, Maria Colomba ^a   Duran, Xavier ^b,c   Vendrell, Joan ^c,d   Plebani, Mario ^a   Avogaro, Angelo ^a,b  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ANTIGEN EXPRESSION; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CARDIOVASCULAR SYSTEM EXAMINATION; CELL EXPANSION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HEMATOPOIETIC STEM CELL; HUMAN; INSULIN SENSITIVITY; LONGITUDINAL STUDY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; METABOLIC SYNDROME X; OBESITY; PRIORITY JOURNAL; TERTIARY CARE CENTER; WAIST CIRCUMFERENCE; BLOOD; BLOOD CELL COUNT; MIDDLE AGED; PATHOLOGY; RISK FACTOR; STEM CELL;

ADIPOSITY; ADULT; ANTIGENS, CD34; BLOOD CELL COUNT; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; METABOLIC DISEASES; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; RISK FACTORS; STEM CELLS;

EID: 84951202794     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-2867     Document Type: Article

References (31)

1. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415-445.
2. Neels JG, Olefsky JM. Inflamed fat: what starts the fire? J Clin Invest. 2006;116:33-35.
3. Fadini G, Marcuzzo G, Marescotti MC, de Kreutzenberg SV, Avogaro A. Elevated white blood cell count is associated with prevalence and development of the metabolic syndrome and its components in the general population. Acta Diabetol. 2012;49:445-451.
4. Welner RS, Kincade PW. Stem cells on patrol. Cell. 2007;131:842-844.
5. Ballard VL, Edelberg JM. Stem cells and the regeneration of the aging cardiovascular system. Circ Res. 2007;100:1116-1127.
6. Massberg S, Schaerli P, Knezevic-Maramica I, et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell. 2007;131:994-1008.
7. Fukuda J, Kaneko T, Egashira M, Oshimi K. Direct measurement of CD34- blood stem cell absolute counts by flow cytometry. Stem Cells. 1998;16:294-300.
8. Fadini GP. A look at the bone marrow predicts the global outcome. Circ Res. 2015;116:232-234.
9. Fadini GP, Losordo D, Dimmeler S. Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use. Circ Res. 2012;110:624-637.
10. Menegazzo L, Albiero M, Avogaro A, Fadini GP. Endothelial progenitor cells in diabetes mellitus. Biofactors. 2012;38:194-202.
11. Fadini GP, de Kreutzenberg SV, Coracina A, et al. Circulating CD34- cells, metabolic syndrome, and cardiovascular risk. Eur Heart J. 2006;27:2247-2255.
12. Muller-Ehmsen J, Braun D, Schneider T, et al. Decreased number of circulating progenitor cells in obesity: beneficial effects of weight reduction. Eur Heart J. 2008;29:1560-1568.
13. Bellows CF, Zhang Y, Simmons PJ, Khalsa AS, Kolonin MG. Influence of BMI on level of circulating progenitor cells. Obesity (Silver Spring). 2011;19:1722-1726.
14. Graziani F, Leone AM, Basile E, et al. Endothelial progenitor cells in morbid obesity. Circ J. 2014;78:977-985.
15. Lui MM, Tse HF, Mak JC, Lam JC, Lam DC, Tan KC, Ip MS. Altered profile of circulating endothelial progenitor cells in obstructive sleep apnea. Sleep Breath. 2013;17:937-942.
16. Yu G, Wu X, Dietrich MA, et al. Yield and characterization of subcutaneous human adipose-derived stem cells by flow cytometric and adipogenic mRNA analyzes. Cytotherapy. 2010;12:538-546.
17. Han J, Koh YJ, Moon HR, et al. Adipose tissue is an extramedullary reservoir for functional hematopoietic stem and progenitor cells. Blood. 2010;115:957-964.
18. Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85:2402-2410.
19. Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome. An American Heart Association/ National Heart, Lung, and Blood Institute Scientific Statement. Executive summary. Cardiol Rev. 2005;13:322-327.
20. Pachon-Pena G, Yu G, Tucker A, et al. Stromal stem cells from adipose tissue and bone marrow of age-matched female donors display distinct immunophenotypic profiles. J Cell Physiol. 2011;226: 843-851.
21. Bourin P, Bunnell BA, Casteilla L, et al. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy. 2013;15:641-648.
22. Mund JA, Estes ML, Yoder MC, Ingram DA, Jr., Case J. Flow cytometric identification and functional characterization of immature and mature circulating endothelial cells. Arterioscler Thromb Vasc Biol. 2012;32:1045-1053.
23. Vermeulen M, Le Pesteur F, Gagnerault MC, Mary JY, Sainteny F, Lepault F. Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells. Blood. 1998;92:894-900.
24. Fadini GP. A reappraisal of the role of circulating (progenitor) cells in the pathobiology of diabetic complications. Diabetologia. 2014; 57:4-15.
25. Gao M, Zhao D, Schouteden S, et al. Regulation of high-density lipoprotein on hematopoietic stem/progenitor cells in atherosclerosis requires scavenger receptor type BI expression. Arterioscler Thromb Vasc Biol. 2014;34:1900-1909.
26. Westerterp M, Gourion-Arsiquaud S, Murphy AJ, et al. Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell. 2012;11:195-206.
27. Gil-Ortega M, Garidou L, Barreau C, et al. Native adipose stromal cells egress from adipose tissue in vivo: evidence during lymph node activation. Stem Cells. 2013;31:1309-1320.
28. Nagareddy PR, Kraakman M, Masters SL, et al. Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab. 2014;19:821-835.
29. Nahrendorf M, Swirski FK. Lifestyle effects on hematopoiesis and atherosclerosis. Circ Res. 2015;116:884-894.
30. Dutta P, Courties G, Wei Y, et al. Myocardial infarction accelerates atherosclerosis. Nature. 2012;487:325-329.
31. Romero-Corral A, Montori VM, Somers VK, et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet. 2006;368:666-678.