A look at the bone marrow predicts the global outcome

Circulation Research

Volumn 116, Issue 2, 2015, Pages 232-234

  Fadini, Gian Paolo ^a,b  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

Author keywords

aging; biomarkers; cardiovascular diseases; Editorials; regeneration; stem cells

Indexed keywords

ANGIOGENESIS; BONE MARROW; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; EDITORIAL; ENDOTHELIAL PROGENITOR CELL; HEMATOPOIETIC STEM CELL; HIGH RISK POPULATION; HUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; STEM CELL MOBILIZATION; BLOOD; CORONARY ARTERY DISEASE; FEMALE; HEALTH SURVEY; MALE; METABOLISM; MORTALITY; STEM CELL;

CD34 ANTIGEN;

ANTIGENS, CD34; CORONARY ARTERY DISEASE; FEMALE; HUMANS; MALE; POPULATION SURVEILLANCE; STEM CELLS;

EID: 84921946391     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.114.305501     Document Type: Editorial

References (16)

1. Fadini GP, Losordo D, Dimmeler S. Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use. Circ Res. 2012;110:624-637. doi: 10.1161/CIRCRESAHA.111.243386.
2. Fadini GP, Albiero M, Seeger F, Poncina N, Menegazzo L, Angelini A, Castellani C, Thiene G, Agostini C, Cappellari R, Boscaro E, Zeiher A, Dimmeler S, Avogaro A. Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy. Basic Res Cardiol. 2013;108:313. doi: 10.1007/s00395-012-0313-1.
3. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 2001;105:369-377.
4. Méndez-Ferrer S, Lucas D, Battista M, Frenette PS. Haematopoietic stem cell release is regulated by circadian oscillations. Nature. 2008;452:442-447. doi: 10.1038/nature06685.
5. Patel RS, Li Q, Ghasemzadeh N, et al. Circulating CD34+ progenitor cells and risk of mortality in a population with coronary artery disease. Circ Res. 2015;116:289-297. doi: 10.1161/CIRCRESAHA.116.304187.
6. Fadini GP, de Kreutzenberg S, Agostini C, Boscaro E, Tiengo A, Dimmeler S, Avogaro A. Low CD34+ cell count and metabolic syndrome synergistically increase the risk of adverse outcomes. Atherosclerosis. 2009;207:213-219. doi: 10.1016/j.atherosclerosis.2009.03.040.
7. Maruyama S, Taguchi A, Iwashima S, et al. Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients. Kidney Int. 2008;74:1603-1609. doi: 10.1038/ki.2008.495.
8. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, Böhm M, Nickenig G. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med. 2005;353:999-1007. doi: 10.1056/NEJMoa043814.
9. Schmidt-Lucke C, Rössig L, Fichtlscherer S, Vasa M, Britten M, Kämper U, Dimmeler S, Zeiher AM. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation. 2005;111:2981-2987. doi: 10.1161/CIRCULATIONAHA.104.504340.
10. Fadini GP, Maruyama S, Ozaki T, Taguchi A, Meigs J, Dimmeler S, Zeiher AM, de Kreutzenberg S, Avogaro A, Nickenig G, Schmidt-Lucke C, Werner N. Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis. PLoS One. 2010;5:e11488. doi: 10.1371/journal.pone.0011488.
11. Cogle CR, Wise E, Meacham AM, et al; Cardiovascular Cell Therapy Research Network (CCTRN). Detailed Analysis of bone marrow from patients with ischemic heart disease and left ventricular dysfunction: BM CD34, CD11b, and clonogenic capacity as biomarkers for clinical outcomes. Circ Res. 2014;115:867-874. doi: 10.1161/CIRCRESAHA.115.304353.
12. Schutt RC, Trachtenberg B, Cooke JP, et al. Bone marrow characteristics associated with changes in infarct size after stemi: a biorepository evaluation from the cctrn time trial. Circ Res. 2014.
13. Assmus B, Iwasaki M, Schächinger V, Roexe T, Koyanagi M, Iekushi K, Xu Q, Tonn T, Seifried E, Liebner S, Kranert WT, Grünwald F, Dimmeler S, Zeiher AM. Acute myocardial infarction activates progenitor cells and increases Wnt signalling in the bone marrow. Eur Heart J. 2012;33:1911-1919. doi: 10.1093/eurheartj/ehr388.
14. Leone AM, Rutella S, Bonanno G, Abbate A, Rebuzzi AG, Giovannini S, Lombardi M, Galiuto L, Liuzzo G, Andreotti F, Lanza GA, Contemi AM, Leone G, Crea F. Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J. 2005;26:1196-1204. doi: 10.1093/eurheartj/ehi164.
15. Spinetti G, Cordella D, Fortunato O, Sangalli E, Losa S, Gotti A, Carnelli F, Rosa F, Riboldi S, Sessa F, Avolio E, Beltrami AP, Emanueli C, Madeddu P. Global remodeling of the vascular stem cell niche in bone marrow of diabetic patients: implication of the microRNA-155/FOXO3a signaling pathway. Circ Res. 2013;112:510-522. doi: 10.1161/CIRCRESAHA.112.300598.
16. Townsley DM, Dumitriu B, Young NS. Bone marrow failure and the telomeropathies. Blood. 2014;124:2775-2783. doi: 10.1182/blood-2014-05-526285.