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Volumn 6, Issue 38, 2015, Pages 40959-40969

PTTG regulates the metabolic switch of ovarian cancer cells via the c-myc pathway

Author keywords

Aerobic glycolysis; Human pituitary tumor transforming gene (PTTG); Metabolic switch; Ovarian cancer; Oxidative phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE TRANSPORTER 1; LACTATE DEHYDROGENASE A; LACTIC ACID; MYC PROTEIN; OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; MYC PROTEIN, HUMAN; PITUITARY TUMOR-TRANSFORMING PROTEIN 1, HUMAN; SECURIN;

EID: 84951186742     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5726     Document Type: Article
Times cited : (26)

References (28)
  • 3
    • 84874889081 scopus 로고    scopus 로고
    • PKM2, a Central Point of Regulation in Cancer Metabolism
    • Wong N, De Melo J, Tang D. PKM2, a Central Point of Regulation in Cancer Metabolism. Int J Cell Biol. 2013; 2013:242513.
    • (2013) Int J Cell Biol , vol.2013
    • Wong, N.1    De Melo, J.2    Tang, D.3
  • 4
    • 79953705886 scopus 로고    scopus 로고
    • Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma
    • Jose C, Bellance N, Rossignol R. Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma. Biochim Biophys Acta. 2011; 1807:552-61.
    • (2011) Biochim Biophys Acta , vol.1807 , pp. 552-561
    • Jose, C.1    Bellance, N.2    Rossignol, R.3
  • 5
    • 26944452745 scopus 로고    scopus 로고
    • Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines
    • Griguer CE, Oliva CR, Gillespie GY. Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines. J Neurooncol. 2005; 74:123-33.
    • (2005) J Neurooncol , vol.74 , pp. 123-133
    • Griguer, C.E.1    Oliva, C.R.2    Gillespie, G.Y.3
  • 6
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • (80-)
    • Levine AJ, Puzio-Kuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science (80-). 2010; 330:1340-4.
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 7
    • 84864040884 scopus 로고    scopus 로고
    • Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells
    • Chen JQ, Russo J. Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells. Biochim Biophys Acta. 2012; 1826:370-84.
    • (2012) Biochim Biophys Acta , vol.1826 , pp. 370-384
    • Chen, J.Q.1    Russo, J.2
  • 8
    • 77955327559 scopus 로고    scopus 로고
    • Pituitary senescence: the evolving role of Pttg
    • Chesnokova V, Melmed S. Pituitary senescence: the evolving role of Pttg. Mol Cell Endocrinol. 2010; 326:55-9.
    • (2010) Mol Cell Endocrinol , vol.326 , pp. 55-59
    • Chesnokova, V.1    Melmed, S.2
  • 9
    • 34249668278 scopus 로고    scopus 로고
    • Pituitary tumor-transforming gene: physiology and implications for tumorigenesis
    • Vlotides G, Eigler T, Melmed S. Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. Endocr Rev. 2007; 28:165-86.
    • (2007) Endocr Rev , vol.28 , pp. 165-186
    • Vlotides, G.1    Eigler, T.2    Melmed, S.3
  • 10
    • 36549058660 scopus 로고    scopus 로고
    • The emerging role of pituitary tumour transforming gene (PTTG) in endocrine tumourigenesis
    • Kim DS, Fong J, Read ML, McCabe CJ. The emerging role of pituitary tumour transforming gene (PTTG) in endocrine tumourigenesis. Mol Cell Endocrinol. 2007; 278:1-6.
    • (2007) Mol Cell Endocrinol , vol.278 , pp. 1-6
    • Kim, D.S.1    Fong, J.2    Read, M.L.3    McCabe, C.J.4
  • 11
    • 84869179174 scopus 로고    scopus 로고
    • Tumorigenic potential of pituitary tumor transforming gene (PTTG) in vivo investigated using a transgenic mouse model, and effects of cross breeding with p53 (+/-) transgenic mice
    • Fong MY, Farghaly H, Kakar SS. Tumorigenic potential of pituitary tumor transforming gene (PTTG) in vivo investigated using a transgenic mouse model, and effects of cross breeding with p53 (+/-) transgenic mice. BMC Cancer. 2012; 12:532.
    • (2012) BMC Cancer , vol.12 , pp. 532
    • Fong, M.Y.1    Farghaly, H.2    Kakar, S.S.3
  • 12
    • 34548596630 scopus 로고    scopus 로고
    • Small interfering RNA against PTTG: a novel therapy for ovarian cancer
    • El-Naggar SM, Malik MT, Kakar SS. Small interfering RNA against PTTG: a novel therapy for ovarian cancer. Int J Oncol. 2007; 31:137-43.
    • (2007) Int J Oncol , vol.31 , pp. 137-143
    • El-Naggar, S.M.1    Malik, M.T.2    Kakar, S.S.3
  • 13
    • 84897528797 scopus 로고    scopus 로고
    • Relationship of PTTG expression with tumor invasiveness and microvessel density of pituitary adenomas: a meta-analysis
    • Li Y, Zhou LP, Ma P, Sui CG, Meng FD, Tian X, Fu LY, Jiang YH. Relationship of PTTG expression with tumor invasiveness and microvessel density of pituitary adenomas: a meta-analysis. Genet Test Mol Biomarkers. 2014; 18:279-85.
    • (2014) Genet Test Mol Biomarkers , vol.18 , pp. 279-285
    • Li, Y.1    Zhou, L.P.2    Ma, P.3    Sui, C.G.4    Meng, F.D.5    Tian, X.6    Fu, L.Y.7    Jiang, Y.H.8
  • 14
    • 84894072403 scopus 로고    scopus 로고
    • PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility
    • Zhou C, Tong Y, Wawrowsky K, Melmed S. PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility. Oncogene. 2014; 33:851-61.
    • (2014) Oncogene , vol.33 , pp. 851-861
    • Zhou, C.1    Tong, Y.2    Wawrowsky, K.3    Melmed, S.4
  • 16
    • 33751536478 scopus 로고    scopus 로고
    • Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells
    • Vlotides G, Cruz-Soto M, Rubinek T, Eigler T, Auernhammer CJ, Melmed S. Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells. Mol Endocrinol. 2006; 20:3321-35.
    • (2006) Mol Endocrinol , vol.20 , pp. 3321-3335
    • Vlotides, G.1    Cruz-Soto, M.2    Rubinek, T.3    Eigler, T.4    Auernhammer, C.J.5    Melmed, S.6
  • 17
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • (80-)
    • Vander HMG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (80-). 2009; 324:1029-33.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander, H.M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 19
    • 84899925866 scopus 로고    scopus 로고
    • Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis
    • Slavov N, Budnik BA, Schwab D, Airoldi EM, van Oudenaarden A. Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis. Cell Rep. 2014; 7:705-14.
    • (2014) Cell Rep , vol.7 , pp. 705-714
    • Slavov, N.1    Budnik, B.A.2    Schwab, D.3    Airoldi, E.M.4    van Oudenaarden, A.5
  • 20
    • 84867249149 scopus 로고    scopus 로고
    • Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)
    • Zheng J. Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). Oncol Lett. 2012; 4:1151-7.
    • (2012) Oncol Lett , vol.4 , pp. 1151-1157
    • Zheng, J.1
  • 21
    • 84897110724 scopus 로고    scopus 로고
    • Cancer therapy: Altering mitochondrial properties
    • Pinton P, Kroemer G. Cancer therapy: Altering mitochondrial properties. Nat Chem Biol. 2014; 10:89-90.
    • (2014) Nat Chem Biol , vol.10 , pp. 89-90
    • Pinton, P.1    Kroemer, G.2
  • 22
    • 0030910680 scopus 로고    scopus 로고
    • Isolation and characterization of a pituitary tumor-transforming gene (PTTG)
    • Pei L, Melmed S. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol. 1997; 11:433-41.
    • (1997) Mol Endocrinol , vol.11 , pp. 433-441
    • Pei, L.1    Melmed, S.2
  • 24
    • 79952279243 scopus 로고    scopus 로고
    • Pituitary tumor-transforming gene and its binding factor in endocrine cancer
    • Smith VE, Franklyn JA, McCabe CJ. Pituitary tumor-transforming gene and its binding factor in endocrine cancer. Expert Rev Mol Med. 2010; 12:e38.
    • (2010) Expert Rev Mol Med , vol.12
    • Smith, V.E.1    Franklyn, J.A.2    McCabe, C.J.3
  • 26
    • 69549124825 scopus 로고    scopus 로고
    • PTTG: an important target gene for ovarian cancer therapy
    • Panguluri SK, Yeakel C, Kakar SS. PTTG: an important target gene for ovarian cancer therapy. J Ovarian Res. 2008; 1:6.
    • (2008) J Ovarian Res , vol.1 , pp. 6
    • Panguluri, S.K.1    Yeakel, C.2    Kakar, S.S.3
  • 27
    • 20444363142 scopus 로고    scopus 로고
    • Insulin and IGF-1 regulate the expression of the pituitary tumor transforming gene (PTTG) in breast tumor cells
    • Thompson AD 3rd, Kakar SS. Insulin and IGF-1 regulate the expression of the pituitary tumor transforming gene (PTTG) in breast tumor cells. FEBS Lett. 2005; 579:3195-200.
    • (2005) FEBS Lett , vol.579 , pp. 3195-3200
    • Thompson, A.D.1    Kakar, S.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.