Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling

International Journal of Biochemistry and Cell Biology

Volumn 71, Issue , 2016, Pages 35-43

  Tian, Wenfang ^a   Fan, Zhiwen ^a   Li, Jianfei ^a   Hao, Chenzhi ^a   Li, Min ^a   Xu, Huihui ^a   Wu, Xiaoyan ^a   Zhou, Bisheng ^a   Zhang, Liping ^c   Fang, Mingming ^a,b   Xu, Yong ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Jiangsu Jiankang Vocational Institute   (China)

^c Department of Biochemistry   (China)

Author keywords

Epigenetics; Hepatic stellate cell; Histone methylation; Liver fibrosis; MRTF A; TGF

Indexed keywords

MYOCARDIN; THIOACETAMIDE; TRANSFORMING GROWTH FACTOR BETA; HISTONE; LYSINE; MKL1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; EPIGENETICS; GENE EXPRESSION; GENETIC ANALYSIS; HISTONE METHYLATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL; THIOACETAMIDE-INDUCED LIVER FIBROSIS; TRANSACTIVATION; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; HEPATIC STELLATE CELL; LIVER CIRRHOSIS; METABOLISM; METHYLATION; PATHOLOGY; TRANSCRIPTION INITIATION;

ANIMALS; CELL LINE; EPIGENESIS, GENETIC; HEPATIC STELLATE CELLS; HISTONES; LIVER CIRRHOSIS; LYSINE; MALE; METHYLATION; MICE; PROMOTER REGIONS, GENETIC; RATS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84951183338     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2015.12.005     Document Type: Article

References (43)

1. P. Bedossa, and V. Paradis Transforming growth factor-beta (TGF-beta): a key-role in liver fibrogenesis J. Hepatol. 22 1995 37 42
2. D. Chen, F. Fang, Y. Yang, J. Chen, G. Xu, Y. Xu, and et al. Brahma-related gene 1 (Brg1) epigenetically regulates CAM activation during hypoxic pulmonary hypertension Cardiovasc. Res. 100 2013 363 373
3. D. Chen, Y. Yang, X. Cheng, F. Fang, G. Xu, Z. Yuan, and et al. Megakaryocytic leukemia 1 directs a histone H3 lysine 4 methyltransferase complex to regulate hypoxic pulmonary hypertension Hypertension 65 2015 821 833
4. G. Chen, X. Chen, A. Sukumar, B. Gao, J. Curley, H.W. Schnaper, and et al. TGFbeta receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells J. Cell Sci. 126 2013 3697 3712
5. P.J. Chen, C. Huang, X.M. Meng, and J. Li Epigenetic modifications by histone deacetylases: biological implications and therapeutic potential in liver fibrosis Biochimie 116 2015 61 69
6. I.J. Cho, Y.W. Kim, C.Y. Han, E.H. Kim, R.A. Anderson, Y.S. Lee, and et al. E-cadherin antagonizes transforming growth factor beta1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation Hepatology 52 2010 2053 2064
7. B.S. Ding, Z. Cao, R. Lis, D.J. Nolan, P. Guo, M. Simons, and et al. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis Nature 505 2014 97 102
8. B.S. Ding, D.J. Nolan, J.M. Butler, D. James, A.O. Babazadeh, Z. Rosenwaks, and et al. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration Nature 468 2010 310 315
9. F. Fang, D. Chen, L. Yu, X. Dai, Y. Yang, W. Tian, and et al. Proinflammatory stimuli engage brahma related gene 1 and brahma in endothelial injury Circ. Res. 113 2013 986 996
10. F. Fang, Y. Yang, Z. Yuan, Y. Gao, J. Zhou, Q. Chen, and et al. Myocardin-related transcription factor A mediates OxLDL-induced endothelial injury Circ. Res. 108 2011 797 807
11. M. Hanna, H. Liu, J. Amir, Y. Sun, S.W. Morris, M.A. Siddiqui, and et al. Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase J. Biol. Chem. 284 2009 23125 23136
12. B. Hu, Z. Wu, and S.H. Phan Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression Am. J. Respir. Cell Mol. Biol. 29 2003 397 404
13. N. Justin, V. De Marco, R. Aasland, and S.J. Gamblin Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies Curr. Opin. Struct. Biol. 20 2010 730 738
14. X. Kong, M. Fang, P. Li, F. Fang, and Y. Xu HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells J. Mol. Cell. Cardiol. 46 2009 292 299
15. H. Lei, D. Wu, J.Y. Wang, L. Li, C.L. Zhang, H. Feng, and et al. C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation Basic Res. Cardiol. 110 2015 35
16. L.L. Luchsinger, C.A. Patenaude, B.D. Smith, and M.D. Layne Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts J. Biol. Chem. 286 2011 44116 44125
17. T. Miller, N.J. Krogan, J. Dover, H. Erdjument-Bromage, P. Tempst, M. Johnston, and et al. COMPASS: a complex of proteins associated with a trithorax-related SET domain protein Proc. Natl. Acad. Sci. U.S.A. 98 2001 12902 12907
18. T. Morita, T. Mayanagi, and K. Sobue Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling J. Cell Biol. 179 2007 1027 1042
19. E.N. Olson, and A. Nordheim Linking actin dynamics and gene transcription to drive cellular motile functions Nat. Rev. Mol. Cell Biol. 11 2010 353 365
20. J.E. Puche, Y. Saiman, and S.L. Friedman Hepatic stellate cells and liver fibrosis Comprehen. Physiol. 3 2013 1473 1492
21. D.C. Rockey, P.D. Bell, and J.A. Hill Fibrosis - a common pathway to organ injury and failure N. Engl. J. Med. 372 2015 1138 1149
22. R. Samarakoon, S.P. Higgins, C.E. Higgins, and P.J. Higgins TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling J. Mol. Cell. Cardiol. 44 2008 527 538
23. B. Schnabl, Y.O. Kweon, J.P. Frederick, X.F. Wang, R.A. Rippe, and D.A. Brenner The role of Smad3 in mediating mouse hepatic stellate cell activation Hepatology 34 2001 89 100
24. A. Shilatifard The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis Annu. Rev. Biochem. 81 2012 65 95
25. X. Shiwen, R. Stratton, J. Nikitorowicz-Buniak, B. Ahmed-Abdi, M. Ponticos, C. Denton, and et al. A role of myocardin related transcription factor-a (mrtf-a) in scleroderma related fibrosis PloS One 10 2015 e0126015
26. X.Z. Shu, L.N. Zhang, R. Zhang, C.J. Zhang, H.P. He, H. Zhou, and et al. Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cells Gene 563 2015 17 23
27. T.H. Sisson, I.O. Ajayi, N. Subbotina, A.E. Dodi, E.S. Rodansky, L.N. Chibucos, and et al. Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis Am. J. Pathol. 185 2015 969 986
28. E.M. Small, J.E. Thatcher, L.B. Sutherland, H. Kinoshita, R.D. Gerard, J.A. Richardson, and et al. Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction Circ. Res. 107 2010 294 304
29. L. Sun, H. Li, J. Chen, V. Dehennaut, Y. Zhao, Y. Yang, and et al. A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis J. Natl. Cancer Inst. 105 2013 887 898
30. K.C. Thompson, A. Trowern, A. Fowell, M. Marathe, C. Haycock, M.J. Arthur, and et al. Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin-10 during the course of activation in vitro Hepatology 28 1998 1518 1524
31. W. Tian, C. Hao, Z. Fan, X. Weng, H. Qin, X. Wu, and et al. Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells J. Hepatol. 62 2015 165 174
32. W. Tian, H. Xu, F. Fang, Q. Chen, Y. Xu, and A. Shen Brahma-related gene 1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice Hepatology 58 2013 576 588
33. W. Tian, and Y. Xu Decoding liver injury: a regulatory role for histone modifications Int. J. Biochem. Cell Biol. 67 10 2015 188 193
34. D.Z. Wang, S. Li, D. Hockemeyer, L. Sutherland, Z. Wang, G. Schratt, and et al. Potentiation of serum response factor activity by a family of myocardin-related transcription factors Proc. Natl. Acad. Sci. U.S.A. 99 2002 14855 14860
35. X. Weng, L. Yu, P. Liang, D. Chen, X. Cheng, Y. Yang, and et al. Endothelial MRTF-A mediates angiotensin II induced cardiac hypertrophy J. Mol. Cell. Cardiol. 80 2015 23 33
36. X. Weng, L. Yu, P. Liang, L. Li, X. Dai, B. Zhou, and et al. A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy J. Mol. Cell. Cardiol. 82 2015 48 58
37. M. Wu, P.F. Wang, J.S. Lee, S. Martin-Brown, L. Florens, M. Washburn, and et al. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS Mol. Cell. Biol. 28 2008 7337 7344
38. H. Xu, X. Wu, H. Qin, W. Tian, J. Chen, L. Sun, and et al. Myocardin-related transcription factor a epigenetically regulates renal fibrosis in diabetic nephropathy J. Am. Soc. Nephrol. 26 2015 1648 1660
39. Y. Yang, D. Chen, Z. Yuan, F. Fang, X. Cheng, J. Xia, and et al. Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1 Nucleic Acids Res. 41 2013 6005 6017
40. Y. Yang, X. Cheng, W. Tian, B. Zhou, X. Wu, H. Xu, and et al. MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cells Nucleic Acids Res. 42 2014 10460 10472
41. L. Yu, X. Weng, P. Liang, X. Dai, X. Wu, H. Xu, and et al. MRTF-A mediates LPS-induced pro-inflammatory transcription by interacting with the COMPASS complex J. Cell Sci. 127 2014 4645 4657
42. M. Zhang, H. Fang, J. Zhou, and B.P. Herring A novel role of Brg1 in the regulation of SRF/MRTFA-dependent smooth muscle-specific gene expression J. Biol. Chem. 282 2007 25708 25716
43. J. Zhou, M. Zhang, H. Fang, O. El-Mounayri, J.M. Rodenberg, A.N. Imbalzano, and et al. The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression Arterioscler. Thromb. Vasc. Biol. 29 2009 921 928