NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling

Immunobiology

Volumn 221, Issue 2, 2016, Pages 341-346

  Zamoshnikova, Alina ^a   Groß, Christina J ^b   Schuster, Steffen ^c   Chen, Kaiwen W ^a   Wilson, Anne ^c   Tacchini Cottier, Fabienne ^c   Schroder, Kate ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Inflammation; Migration; Neutrophils; NLRP12; TLR signalling

Indexed keywords

CD14 ANTIGEN; CRYOPYRIN; CXCL1 CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NLRP12 PROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; UNCLASSIFIED DRUG; CXCL1 PROTEIN, MOUSE; MAPK1 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NLRP12 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE MARROW DERIVED MACROPHAGE; CELL MIGRATION; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; NEUTROPHIL; NONHUMAN; POLYMORPHONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SALMONELLOSIS; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CELL MOTION; DEFICIENCY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; MALE; PARASITOLOGY;

ANIMALS; CELL MOVEMENT; CHEMOKINE CXCL1; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEISHMANIA MAJOR; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEUTROPHILS; NF-KAPPA B; ORGAN SPECIFICITY; SIGNAL TRANSDUCTION;

EID: 84951097504     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2015.10.001     Document Type: Article

References (19)

1. Allen, I.C., Non-inflammasome forming NLRs in inflammation and tumorigenesis. Front. Immunol., 5, 2014, 169, 10.3389/fimmu.2014.00169.
2. Allen, I.C., Wilson, J.E., Schneider, M., Lich, J.D., Roberts, R.A., Arthur, J.C., Woodford, R.-M.T., Davis, B.K., Uronis, J.M., Herfarth, H.H., Jobin, C., Rogers, A.B., Ting, J.P.-Y., NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity 36 (2012), 742–754, 10.1016/j.immuni.2012.03.012.
3. Arthur, J.C., Lich, J.D., Aziz, R.K., Kotb, M., Ting, J.P.-Y., Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase. J. Immunol. 179 (2007), 6291–6296.
4. Arthur, J.C., Lich, J.D., Ye, Z., Allen, I.C., Gris, D., Wilson, J.E., Schneider, M., Roney, K.E., O'Connor, B.P., Moore, C.B., Morrison, A., Sutterwala, F.S., Bertin, J., Koller, B.H., Liu, Z., Ting, J.P.-Y., Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. J. Immunol. 185 (2010), 4515–4519, 10.4049/jimmunol.1002227.
5. Ataide, M.A., Andrade, W.A., Zamboni, D.S., Wang, D., Souza, M. do C., Franklin, B.S., Elian, S., Martins, F.S., Pereira, D., Reed, G., Fitzgerald, K.A., Golenbock, D.T., Gazzinelli, R.T., Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog., 10, 2014, e1003885, 10.1371/journal.ppat.1003885.
6. Borghini, S., Tassi, S., Chiesa, S., Caroli, F., Carta, S., Caorsi, R., Fiore, M., Delfino, L., Lasigliè, D., Ferraris, C., Traggiai, E., Di Duca, M., Santamaria, G., D'Osualdo, A., Tosca, M., Martini, A., Ceccherini, I., Rubartelli, A., Gattorno, M., Clinical presentation and pathogenesis of cold-induced autoinflammatory disease in a family with recurrence of an NLRP12 mutation. Arthritis Rheum. 63 (2011), 830–839, 10.1002/art.30170.
7. Chen, K.W., Groß, C.J., Sotomayor, F.V., Stacey, K.J., Tschopp, J., Sweet, M.J., Schroder, K., The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge. Cell Rep. 8 (2014), 570–582, 10.1016/j.celrep.2014.06.028.
8. Jéru, I., Duquesnoy, P., Fernandes-Alnemri, T., Cochet, E., Yu, J.W., Lackmy-Port-Lis, M., Grimprel, E., Landman-Parker, J., Hentgen, V., Marlin, S., McElreavey, K., Sarkisian, T., Grateau, G., Alnemri, E.S., Amselem, S., Mutations in NALP12 cause hereditary periodic fever syndromes. Proc. Natl. Acad. Sci. U. S. A. 105 (2008), 1614–1619, 10.1073/pnas.0708616105.
9. Lich, J.D., Williams, K.L., Moore, C.B., Arthur, J.C., Davis, B.K., Taxman, D.J., Ting, J.P.-Y., Cutting edge: monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. J. Immunol. 178 (2007), 1256–1260.
10. Lord, C.A., Savitsky, D., Sitcheran, R., Calame, K., Wright, J.R., Ting, J.P.-Y., Williams, K.L., Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. J. Immunol. 182 (2009), 2948–2958, 10.4049/jimmunol.0801692.
11. Schroder, K., Tschopp, J., The inflammasomes. Cell 140 (2010), 821–832, 10.1016/j.cell.2010.01.040.
12. Schroder, K., Sagulenko, V., Zamoshnikova, A., Richards, A.A., Cridland, J.A., Irvine, K.M., Stacey, K.J., Sweet, M.J., Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology 217 (2012), 1325–1329, 10.1016/j.imbio.2012.07.020.
13. Thomas, C.J., Schroder, K., Pattern recognition receptor function in neutrophils. Trends Immunol. 34 (2013), 317–328, 10.1016/j.it.2013.02.008.
14. Vladimer, G.I., Weng, D., Paquette, S.W.M., Vanaja, S.K., Rathinam, V.A.K., Aune, M.H., Conlon, J.E., Burbage, J.J., Proulx, M.K., Liu, Q., Reed, G., Mecsas, J.C., Iwakura, Y., Bertin, J., Goguen, J.D., Fitzgerald, K.A., Lien, E., The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37 (2012), 96–107, 10.1016/j.immuni.2012.07.006.
15. Wang, L., Manji, G.A., Grenier, J.M., Al-Garawi, A., Merriam, S., Lora, J.M., Geddes, B.J., Briskin, M., DiStefano, P.S., Bertin, J., PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. J. Biol. Chem. 277 (2002), 29874–29880, 10.1074/jbc.M203915200.
16. Williams, K.L., Taxman, D.J., Linhoff, M.W., Reed, W., Ting, J.P.-Y., Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes. J. Immunol. 170 (2003), 5354–5358.
17. Williams, K.L., Lich, J.D., Duncan, J.A., Reed, W., Rallabhandi, P., Moore, C., Kurtz, S., Coffield, V.M., Accavitti-Loper, M.A., Su, L., Vogel, S.N., Braunstein, M., Ting, J.P.-Y., The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and mycobacterium tuberculosis-induced pro-inflammatory signals. J. Biol. Chem. 280 (2005), 39914–39924, 10.1074/jbc.M502820200.
18. Zaki, M.H., Vogel, P., Malireddi, R.K.S., Body-Malapel, M., Anand, P.K., Bertin, J., Green, D.R., Lamkanfi, M., Kanneganti, T.-D., The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 20 (2011), 649–660, 10.1016/j.ccr.2011.10.022.
19. Zaki, M.H., Man, S.M., Vogel, P., Lamkanfi, M., Kanneganti, T.-D., Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection. Proc. Natl. Acad. Sci. U. S. A. 111 (2013), 385–390, 10.1073/pnas.1317643111.