MiR-103 regulates hepatocellular carcinoma growth by targeting AKAP12

International Journal of Biochemistry and Cell Biology

Volumn 71, Issue , 2016, Pages 1-11

  Xia, Wei ^a   Ni, Jing ^a   Zhuang, Juhua ^a   Qian, Leixing ^a   Wang, Peng ^b   Wang, Jiening ^a  

^a SHANGHAI SEVENTH PEOPLE S HOSPITAL   (China)

^b The Seventh People's Hospital   (China)

Author keywords

AKAP12; Hepatocellular carcinoma; MiR 103; PKC ; Telomerase; TERT

Indexed keywords

A KINASE ANCHOR PROTEIN 12; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; MICRORNA; MICRORNA 103; PROTEIN KINASE C ALPHA; TELOMERASE; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; AKAP12 PROTEIN, HUMAN; CELL CYCLE PROTEIN; MIRN103 MICRORNA, HUMAN; PROTEIN KINASE C;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER TISSUE; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; GENE INTERACTION; GENE OVEREXPRESSION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LUCIFERASE ASSAY; MOUSE; NONHUMAN; ONCOGENE; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; ANIMAL; CARCINOGENESIS; CELL TRANSFORMATION; DISEASE COURSE; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; RAT; TUMOR CELL LINE; UPREGULATION;

3' UNTRANSLATED REGIONS; A KINASE ANCHOR PROTEINS; ANIMALS; BASE SEQUENCE; CARCINOGENESIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MICE; MICRORNAS; PROTEIN KINASE C; RATS; UP-REGULATION;

EID: 84951070864     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2015.11.017     Document Type: Article

References (47)

1. V. Ambros The functions of animal microRNAs Nature 431 2004 350 355
2. D. Annibali, U. Gioia, M. Savino, P. Laneve, E. Caffarelli, and S. Nasi A new module in neural differentiation control: two microRNAs upregulated by retinoic acid, miR-9 and -103, target the differentiation inhibitor ID2 PloS One 7 2012 e40269
3. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
4. D.P. Bartel MicroRNAs: target recognition and regulatory functions Cell 136 2009 215 233
5. R. Blanco, P. Munoz, J.M. Flores, P. Klatt, and M.A. Blasco Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis Genes Dev. 21 2007 206 220
6. C. Chapline, J. Cottom, H. Tobin, J. Hulmes, J. Crabb, and S. Jaken A major, transformation-sensitive PKC-binding protein is also a PKC substrate involved in cytoskeletal remodeling J. Biol. Chem. 273 1998 19482 19489
7. C. Chapline, B. Mousseau, K. Ramsay, S. Duddy, Y. Li, S.C. Kiley, and et al. Identification of a major protein kinase C-binding protein and substrate in rat embryo fibroblasts. Decreased expression in transformed cells J. Biol. Chem. 271 1996 6417 6422
8. X. Chen, X. Guo, H. Zhang, Y. Xiang, J. Chen, Y. Yin, and et al. Role of miR-143 targeting KRAS in colorectal tumorigenesis Oncogene 28 2009 1385 1392
9. H.Y. Chen, Y.M. Lin, H.C. Chung, Y.D. Lang, C.J. Lin, J. Huang, W.C. Wang, F.M. Lin, Z. Chen, H.D. Huang, J.Y. Shyy, J.T. Liang, and R.H. Chen miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4 Cancer Res. 72 2012 3631 3641
10. M.C. Choi, H.S. Jong, T.Y. Kim, S.H. Song, D.S. Lee, J.W. Lee, and et al. AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity Oncogene 23 2004 7095 7103
11. C.M. Counter, H.W. Hirte, S. Bacchetti, and C.B. Harley Telomerase activity in human ovarian carcinoma Proc. Natl. Acad. Sci. U. S. A. 91 1994 2900 2904
12. J. Datta, H. Kutay, M.W. Nasser, G.J. Nuovo, B. Wang, S. Majumder, C.G. Liu, S. Volinia, C.M. Croce, T.D. Schmittgen, K. Ghoshal, and S.T. Jacob Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis Cancer Res. 68 2008 5049 5058
13. S. De Minicis, M. Marzioni, A. Benedetti, and G. Svegliati-Baroni New insights in hepatocellular carcinoma: from bench to bedside Ann. Transl. Med. 1 2013 15
14. J.L. Esseltine, and J.D. Scott AKAP signaling complexes: pointing towards the next generation of therapeutic targets? Trends Pharmacol. Sci. 34 2013 648 655
15. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, and D.M. Parkin Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int. J. Cancer J. Int. Cancer 127 2010 2893 2917
16. J.R. Finnerty, W.X. Wang, S.S. Hebert, B.R. Wilfred, G. Mao, and P.T. Nelson The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases J. Mol. Biol. 402 2010 491 509
17. C. Flotho, A. Paulun, C. Batz, and C.M. Niemeyer AKAP12, a gene with tumour suppressor properties, is a target of promoter DNA methylation in childhood myeloid malignancies Br. J. Haematol. 138 2007 644 650
18. Z.V. Fong, and K.K. Tanabe The clinical management of hepatocellular carcinoma in the United States, Europe, and Asia: a comprehensive and evidence-based comparison and review Cancer 120 2014 2824 2838
19. I.H. Gelman The role of SSeCKS/gravin/AKAP12 scaffolding proteins in the spaciotemporal control of signaling pathways in oncogenesis and development Front. Biosci.: J. Virtual Libr. 7 2002 d1782 d1797
20. I.H. Gelman Emerging roles for SSeCKS/Gravin/AKAP12 in the control of cell proliferation, cancer malignancy, and barriergenesis Genes Cancer 1 2010 1147 1156
21. I.H. Gelman Suppression of tumor and metastasis progression through the scaffolding functions of SSeCKS/Gravin/AKAP12 Cancer Metastasis Rev. 31 2012 493 500
22. B. Goeppert, P. Schmezer, C. Dutruel, C. Oakes, M. Renner, M. Breinig, and et al. Down-regulation of tumor suppressor A kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms Hepatology 52 2010 2023 2033
23. C.W. Greider, and E.H. Blackburn Identification of a specific telomere terminal transferase activity in Tetrahymena extracts Cell 43 1985 405 413
24. L.W. Guo, L. Gao, J. Rothschild, B. Su, and I.H. Gelman Control of protein kinase C activity, phorbol ester-induced cytoskeletal remodeling, and cell survival signals by the scaffolding protein SSeCKS/GRAVIN/AKAP12 J. Biol. Chem. 286 2011 38356 38366
25. M. Hayashi, S. Nomoto, M. Kanda, Y. Okamura, Y. Nishikawa, S. Yamada, and et al. Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma J. Surg. Oncol. 105 2012 381 386
26. N. Hoshi, L.K. Langeberg, C.M. Gould, A.C. Newton, and J.D. Scott Interaction with AKAP79 modifies the cellular pharmacology of PKC Mol. Cell 37 2010 541 550
27. S. Jagadeesh, and P.P. Banerjee Inositol hexaphosphate represses telomerase activity and translocates TERT from the nucleus in mouse and human prostate cancer cells via the deactivation of Akt and PKCalpha Biochem. Biophys. Res. Commun. 349 2006 1361 1367
28. S. Jagadeesh, S. Kyo, and P.P. Banerjee Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells Cancer Res. 66 2006 2107 2115
29. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA: Cancer J. Clin. 61 2011 69 90
30. A. Karakatsanis, I. Papaconstantinou, M. Gazouli, A. Lyberopoulou, G. Polymeneas, and D. Voros Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance Mol. Carcinog. 52 2013 297 303
31. N.W. Kim, M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, P.L. Ho, and et al. Specific association of human telomerase activity with immortal cells and cancer Science 266 1994 2011 2015
32. Y.W. Kim, S.Y. Hur, T.E. Kim, J.M. Lee, S.E. Namkoong, I.K. Ki, and et al. Protein kinase C modulates telomerase activity in human cervical cancer cells Exp. Mol. Med. 33 2001 156 163
33. X. Lin, P. Nelson, and I.H. Gelman SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1) - >S progression by controlling the expression and cellular compartmentalization of cyclin D Mol. Cell. Biol. 20 2000 7259 7272
34. X. Lin, P.J. Nelson, B. Frankfort, E. Tombler, R. Johnson, and I.H. Gelman Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras Mol. Cell. Biol. 15 1995 2754 2762
35. X. Lin, E. Tombler, P.J. Nelson, M. Ross, and I.H. Gelman A novel src- and ras-suppressed protein kinase C substrate associated with cytoskeletal architecture J. Biol. Chem. 271 1996 28430 28438
36. S.W. Lowe, and A.W. Lin Apoptosis in cancer Carcinogenesis 21 2000 485 495
37. J.B. Nauert, T.M. Klauck, L.K. Langeberg, and J.D. Scott Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein Curr. Biol: CB 7 1997 52 62
38. P.J. Nelson, and I.H. Gelman Cell-cycle regulated expression and serine phosphorylation of the myristylated protein kinase C substrate, SSeCKS: correlation with culture confluency, cell cycle phase and serum response Mol. Cell. Biochem. 175 1997 233 241
39. J.F. Perz, G.L. Armstrong, L.A. Farrington, Y.J. Hutin, and B.P. Bell The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide J. Hepatol. 45 2006 529 538
40. J. Piontek, and R. Brandt Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons: evidence that gravin provides a dynamic platform for the localization for kinases during neuronal development J. Biol. Chem. 278 2003 38970 38979
41. L.L. Smith, H.A. Coller, and J.M. Roberts Telomerase modulates expression of growth-controlling genes and enhances cell proliferation Nat. Cell Biol. 5 2003 474 479
42. B. Su, Y. Bu, D. Engelberg, and I.H. Gelman SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway J. Biol. Chem. 285 2010 4578 4586
43. B. Su, Q. Zheng, M.M. Vaughan, Y. Bu, and I.H. Gelman SSeCKS metastasis-suppressing activity in MatLyLu prostate cancer cells correlates with vascular endothelial growth factor inhibition Cancer Res. 66 2006 5599 5607
44. H. van Malenstein, J. van Pelt, and C. Verslype Molecular classification of hepatocellular carcinoma anno 2011 Eur. J. Cancer 47 2011 1789 1797
45. D. Yu, H. Zhou, Q. Xun, X. Xu, J. Ling, and Y. Hu microRNA-103 regulates the growth and invasion of endometrial cancer cells through the downregulation of tissue inhibitor of metalloproteinase 3 Oncol. Lett. 3 2012 1221 1226
46. Z. Zhang, W. Zheng, and J. Hai MicroRNA-148b expression is decreased in hepatocellular carcinoma and associated with prognosis Med. Oncol. 31 2014 984
47. B.H. Zhu, Z.X. Yao, S.J. Luo, L.M. Jiang, J.W. Xiao, S.C. Liu, and et al. Effects of antisense oligonucleotides of PKC-alpha on proliferation and apoptosis of HepG2 in vitro Hepatobiliary Pancreat. Dis. Int.: HBPD INT. 4 2005 75 79