The PTK7 and ROR2 protein receptors interact in the vertebrate WNT/Planar cell polarity (PCP) pathway

Journal of Biological Chemistry

Volumn 290, Issue 51, 2015, Pages 30562-30572

  Martinez, Sébastien ^a,b,c   Scerbo, Pierluigi ^d   Giordano, Marilyn ^a,b,c   Daulat, Avais M ^a,b,c   Lhoumeau, Anne Catherine ^a,b,c   Thomé, Virginie ^d   Kodjabachian, Laurent ^d   Borg, Jean Paul ^a,b,c  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSTITUT PAOLI CALMETTES   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYST ACTIVITY; CELLS; CHEMICAL ACTIVATION; ENZYMES; MAMMALS; PROTEINS;

DEFINED FUNCTIONS; HETERODIMERIC COMPLEXES; INTRACELLULAR DOMAIN; MOLECULAR MECHANISM; MORPHOGENETIC PROCESS; PROTEIN TYROSINE KINASE; RECEPTOR TYROSINE KINASE; TYROSINE-KINASE RECEPTORS;

CYTOLOGY;

JANUS KINASE; PTK7 PROTEIN; RECEPTOR PROTEIN; ROR2 PROTEIN; UNCLASSIFIED DRUG; WNT5A PROTEIN; CADHERIN; PAPC PROTEIN, XENOPUS; PROTEIN TYROSINE KINASE; PTK7 PROTEIN, XENOPUS; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR; ROR2 PROTEIN, XENOPUS; WNT PROTEIN; XENOPUS PROTEIN; XWNT-5A PROTEIN, XENOPUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MOTION; CELL POLARITY; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; LIGAND BINDING; MAMMAL CELL; NONHUMAN; PLANAR CELL POLARITY PATHWAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY; XENOPUS; ACTIVE TRANSPORT; ANIMAL; BIOSYNTHESIS; CELL NUCLEUS; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MORPHOGENESIS; NONMAMMALIAN EMBRYO; PHYSIOLOGY; XENOPUS LAEVIS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CADHERINS; CELL NUCLEUS; EMBRYO, NONMAMMALIAN; HEK293 CELLS; HUMANS; MORPHOGENESIS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTORS; WNT PROTEINS; WNT SIGNALING PATHWAY; WNT-5A PROTEIN; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 84950336278     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.697615     Document Type: Article

References (32)

1. Montcouquiol, M., Crenshaw, E. B., 3rd, and Kelley, M. W. (2006) Noncanonical Wnt signaling and neural polarity. Annu. Rev. Neurosci. 29, 363-386
2. Zallen, J. A. (2007) Planar polarity and tissue morphogenesis. Cell 129, 1051-1063
3. Simons, M., and Mlodzik, M. (2008) Planar cell polarity signaling: from fly development to human disease. Annu. Rev. Genet. 42, 517-540
4. Wallingford, J. B. (2012) Planar cell polarity and the developmental control of cell behavior in vertebrate embryos. Annu. Rev. Cell Dev. Biol. 28, 627-653
5. Schlessinger, K., Hall, A., and Tolwinski, N. (2009) Wnt signaling pathways meet Rho GTPases. Genes Dev. 23, 265-277
6. Strutt, D. (2008) The planar polarity pathway. Curr. Biol. 18, R898-902
7. Angers, S., and Moon, R. T. (2009) Proximal events in Wnt signal transduction. Nat. Rev. Mol. Cell Biol. 10, 468-477
8. Sebbagh, M., and Borg, J. P. (2014) Insight into planar cell polarity. Exp. Cell Res. 328, 284-295
9. Puppo, F., Thomé, V., Lhoumeau, A. C., Cibois, M., Gangar, A., Lembo, F., Belotti, E., Marchetto, S., Lécine, P., Prébet, T., Sebbagh, M., Shin, W. S., Lee, S. T., Kodjabachian, L., and Borg, J. P. (2011) Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling. EMBO Rep. 12, 43-49
10. Shnitsar, I., and Borchers, A. (2008) PTK7 recruits dsh to regulate neural crest migration. Development 135, 4015-4024
11. Peradziryi, H., Kaplan, N. A., Podleschny, M., Liu, X., Wehner, P., Borchers, A., and Tolwinski, N. S. (2011) PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. EMBO J. 30, 3729-3740
12. Lu, X., Borchers, A. G., Jolicoeur, C., Rayburn, H., Baker, J. C., and Tessier-Lavigne, M. (2004) PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430, 93-98
13. Hayes, M., Naito, M., Daulat, A., Angers, S., and Ciruna, B. (2013) Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development. Development 140, 1807-1818
14. Paudyal, A., Damrau, C., Patterson, V. L., Ermakov, A., Formstone, C., Lalanne, Z., Wells, S., Lu, X., Norris, D. P., Dean, C. H., Henderson, D. J., and Murdoch, J. N. (2010) The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev. Biol. 10, 87
15. Golubkov, V. S., and Strongin, A. Y. (2012) Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7). J. Biol. Chem. 287, 42009-42018
16. Lhoumeau, A. C., Puppo, F., Prébet, T., Kodjabachian, L., and Borg, J. P. (2011) PTK7: a cell polarity receptor with multiple facets. Cell Cycle 10, 1233-1236
17. Golubkov, V. S., Chekanov, A. V., Cieplak, P., Aleshin, A. E., Chernov, A. V., Zhu, W., Radichev, I. A., Zhang, D., Dong, P. D., and Strongin, A. Y. (2010) The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. J. Biol. Chem. 285, 35740-35749
18. Na, H. W., Shin, W. S., Ludwig, A., and Lee, S. T. (2012) The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells. J. Biol. Chem. 287, 25001-25009
19. Lee, H. K., Chauhan, S. K., Kay, E., and Dana, R. (2011) Flt-1 regulates vascular endothelial cell migration via a protein tyrosine kinase-7-dependent pathway. Blood 117, 5762-5771
20. Winberg, M. L., Tamagnone, L., Bai, J., Comoglio, P. M., Montell, D., and Goodman, C. S. (2001) The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance. Neuron 32, 53-62
21. Bin-Nun, N., Lichtig, H., Malyarova, A., Levy, M., Elias, S., and Frank, D. (2014) PTK7 modulates Wnt signaling activity via LRP6. Development 141, 410-421
22. Linnemannstöns, K., Ripp, C., Honemann-Capito, M., Brechtel-Curth, K., Hedderich, M., and Wodarz, A. (2014) The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility. PLoS Genet. 10, e1004443
23. Boudeau, J., Miranda-Saavedra, D., Barton, G. J., and Alessi, D. R. (2006) Emerging roles of pseudokinases. Trends Cell Biol. 16, 443-452
24. Minami, Y., Oishi, I., Endo, M., and Nishita, M. (2010) Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases. Dev. Dyn. 239, 1-15
25. Schambony, A., and Wedlich, D. (2007) Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Dev. Cell 12, 779-792
26. Unterseher, F., Hefele, J. A., Giehl, K., De Robertis, E. M., Wedlich, D., and Schambony, A. (2004) Paraxial protocadherin coordinates cell po-larity during convergent extension via Rho A and JNK. EMBO J. 23, 3259-3269
27. Luxardi, G., Marchal, L., Thomé, V., and Kodjabachian, L. (2010) Distinct Xenopus nodal ligands sequentially induce mesendoderm and control gastrulation movements in parallel to the Wnt/PCP pathway. Development 137, 417-426
28. Marchal, L., Luxardi, G., Thomé, V., and Kodjabachian, L. (2009) BMP inhibition initiates neural induction via FGF signaling and Zic genes. Proc. Natl. Acad. Sci. U.S.A. 106, 17437-17442
29. Nomachi, A., Nishita, M., Inaba, D., Enomoto, M., Hamasaki, M., and Minami, Y. (2008) Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. J. Biol. Chem. 283, 27973-27981
30. Nishita, M., Yoo, S. K., Nomachi, A., Kani, S., Sougawa, N., Ohta, Y., Takada, S., Kikuchi, A., and Minami, Y. (2006) Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration. J. Cell Biol. 175, 555-562
31. Topol, L., Jiang, X., Choi, H., Garrett-Beal, L., Carolan, P. J., and Yang, Y. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation. J. Cell Biol. 162, 899-908
32. Golubkov, V. S., Aleshin, A. E., and Strongin, A. Y. (2011) Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects. J. Biol. Chem. 286, 20970-20976