Inflammatory asthma phenotype discrimination using an electronic nose breath analyzer

Journal of Investigational Allergology and Clinical Immunology

Volumn 25, Issue 6, 2015, Pages 431-437

  Plaza, V ^a   Crespo, A ^a   Giner, J ^a   Merino, J L ^b   Ramos Barbon D ^a   Mateus, E F ^a   Torrego, A ^a   Cosio, B G ^c   Agusti A ^d   Sibila, O ^a  

^a BIOMEDICAL RESEARCH INSTITUTE SANT PAU IIB SANT PAU   (Spain)

^b EPFL   (Switzerland)

^c HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Asthma; Electronic nose; Inflammation; Volatile organic compounds

Indexed keywords

IMMUNOGLOBULIN E; VOLATILE ORGANIC COMPOUND;

ADULT; ANALYZER; ARTICLE; ASTHMA; BODY MASS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISCRIMINANT ANALYSIS; EOSINOPHIL; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEASUREMENT ACCURACY; NEUTROPHIL; NOSE BREATH ANALYZER; PEAK EXPIRATORY FLOW; PHENOTYPE; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SPIROMETRY; SPUTUM; VALIDATION PROCESS; AGED; ELECTRONIC NOSE; IMMUNOLOGY; INFLAMMATION; MIDDLE AGED;

ADULT; AGED; ASTHMA; CROSS-SECTIONAL STUDIES; ELECTRONIC NOSE; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; PHENOTYPE; VOLATILE ORGANIC COMPOUNDS;

EID: 84950314730     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. GEMA. Spanish guideline on the management of asthma. J Investig Allergol Clin Immunol.2010;20 Suppl 1:1–59
2. British guideline on the management of asthma. British Thoracic Society, Scottish Intercollegiate Guidelines Network. Available from: http://www.sign.ac.uk/pdf/sign101.pdf. 2014
3. Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebocontrolled trial. Lancet. 2012;380(9842):651–9
4. Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F, Wang L, Kirkesseli S, Rocklin R, Bock B, Hamilton J, Ming JE, Radin A, Stahl N, Yancopoulos GD, Graham N, Pirozzi G. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med 2013;368(26):2455–66
5. Petsky HL, Cates CJ, Lasserson TJ, Li AM, Turner C, Kynaston JA, Chang AB. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils). Thorax.; 2012;67(3):199–208
6. Jayaram L, Parameswaran K, Sears MR, Hargreave FE. Induced sputum cell counts: their usefulness in clinical practice. Eur Respir J 2000;16(1):150–8
7. Broza YY, Haick H. Nanomaterial-based sensors for detection of disease by volatile organic compounds. Nanomedicine. 2013;8(5):785–806
8. Dragonieri S, Annema JT, Schot R, van der Schee MP, Spanevello A, Carratu P, Resta O, Rabe KF, Sterk PJ. An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD. Lung Cancer. 2009;64(2):166–70
9. Dragonieri S, van der Schee MP, Massaro T, Schiavulli N, Brinkman P, Pinca A, Carratú P, Spanevello A, Resta O, Musti M, Sterk PJ. An electronic nose distinguishes exhaled breath of patients with Malignant Pleural Mesothelioma from controls. Lung Cancer. 2012;75(3):326–31
10. Fens N, Zwinderman AH, van der Schee MP, de Nijs SB, Dijkers E, Roldaan AC, Cheung D, Bel EH, Sterk PJ. Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med. 2009;180(11):1076–82
11. Peled N, Hakim M, Bunn PA, Miller YE, Kennedy TC, Mattei J, Mitchell JD, Hirsch FR, Haick H. Non-Invasive Breath Analysis of Pulmonary Nodules. J Thorac Oncol. 2012;7(10):1528–33
12. Cohen-Kaminsky S, Nakhleh M, Perros F, Montani D, Girerd B, Garcia G, Simonneau G, Haick H, Humbert M. A proof of concept for the detection and classification of pulmonary arterial hypertension through breath analysis with a sensor array. Am J Respir Crit Care Med. 2013;188(6):756–9
13. GINA. Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma. 2014. Available from: http://www.ginasthma.org/.
14. Picado C, Badiola C, Perulero N, Sastre J, Olaguibel JM, Lopez Vina A, Vega JM; Covalair Investigator Group. Validation of the Spanish version of the Asthma Control Questionnaire. Clin Ther. 2008;30(10):1918–31
15. Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, Sicherer S, Golden DB, Khan DA, Nicklas RA, Portnoy JM, Blessing-Moore J, Cox L, Lang DM, Oppenheimer J, Randolph CC, Schuller DE, Tilles SA, Wallace DV, Levetin E, Weber R. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1–148
16. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am J Respir Crit Care Med. 2005;171(8):912–30
17. Dragonieri S, Schot R, Mertens BJ, Le Cessie S, Gauw SA, Spanevello A, Resta O, Willard NP, Vink TJ, Rabe KF, Bel EH, Sterk PJ. An electronic nose in the discrimination of patients with asthma and controls. J Allergy Clin Immunol. 2007;120(4):856–62
18. Sibila O, Garcia-Bellmunt L, Giner J, Merino JL, Suarez-Cuartin G, Torrego A, Solanes I, Castillo D, Valera JL, Cosio BG, Plaza V, Agusti A. Identification of airway bacterial colonization by an electronic nose in Chronic Obstructive Pulmonary Disease. Respir Med, 2014;108(11):1608-14
19. Belda J, Leigh R, Parameswaran K, O’Byrne PM, Sears MR, Hargreave FE. Induced sputum cell counts in healthy adults. Am J Respir Crit Care Med. 2000;161(2 Pt 1):475–8
20. Pin I, Gibson PG, Kolendowicz R, Girgis-Gabardo A, Denburg JA, Hargreave FE, Dolovich J. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992;47(1):25–9
21. Haldar P, Pavord ID. Noneosinophilic asthma: a distinct clinical and pathologic phenotype. J Allergy Clin Immunol. 2007;119(5):1043–4
22. Sanchis J, Casan P, Castillo J, González N, Palenciano L, Roca J. Normativa para la práctica de la espirometría forzada. Arch Bronconeumol. 1989;25:132
23. Roca J, Sanchis J, Agusti-Vidal A, Segarra F, Navajas D, Rodriguez-Roisin R, Casan P, Sans S. Spirometric reference values from a Mediterranean population. Bull Eur Physiopathol Respir.; 1986;22(3):217–24
24. Fens N, Roldaan AC, van der Schee MP, Boksem RJ, Zwinderman AH, Bel EH, Sterk PJ. External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease. Clin Exp Allergy. 2011;41(10):1371–8
25. Montuschi P, Santonico M, Mondino C, Pennazza G, Mantini G, Martinelli E, Capuano R, Ciabattoni G, Paolesse R, Di Natale C, Barnes PJ, D'Amico A. Diagnostic performance of an electronic nose, fractional exhaled nitric oxide, and lung function testing in asthma. Chest. 2010;137(4):790–6
26. Fens N, van der Schee MP, Brinkman P, Sterk PJ. Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions. Clin Exp Allergy. 2013;43(7):705–15
27. Ibrahim B, Basanta M, Cadden P, Singh D, Douce D, Woodcock A, Fowler SJ. Non-invasive phenotyping using exhaled volatile organic compounds in asthma. Thorax.2011;66(9):804–9
28. Wagener A, Brinkman P, Zwinderman A, D’Amico A, Pennazza G, Santonico M. Exhaled Breath Profiling And Eosinophilic Airway Inflammation In Asthma - Results Of A Pilot Study. Am J Respir Crit Care Med. 2013;A2392
29. Van der Schee MP, Palmay R, Cowan JO, Taylor DR. Predicting steroid responsiveness in patients with asthma using exhaled breath profiling. Clin Exp Allergy 2013;43(11):1217–25
30. Fens N, de Nijs SB, Peters S, Dekker T, Knobel HH, Vink TJ, Willard NP, Zwinderman AH, Krouwels FH, Janssen HG, Lutter R, Sterk PJ. Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD. Eur Respir J ; 2011;38(6):1301–9
31. Basanta M, Ibrahim B, Dockry R, Douce D, Morris M, Singh D, Woodcock A, Fowler SJ. Exhaled volatile organic compounds for phenotyping chronic obstructive pulmonary disease: a cross-sectional study. Respir Res. 2012;13:72
32. Lotvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, Lemanske RF Jr, Wardlaw AJ, Wenzel SE, Greenberger PA. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol. 2011;127(2):355–60
33. Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, Boulet LP, Brightling C, Chanez P, Dahlen SE, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343-73
34. Pardo M, Sberveglieri G. Classification of electronic nose data with support vector machines. Sensors Actuators B Chem. 2005;107(2):730–7
35. Kermani BG, Schiffman SS, Nagle HT. Using neural networks and genetic algorithms to enhance performance in an electronic nose. IEEE Trans Biomed Eng. 1999;46(4):429-39.