Monocarboxylate transporter-dependent mechanism confers resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures

Neuroscience Letters

Volumn 594, Issue , 2015, Pages 99-104

  Gao, Chen ^a   Zhou, Liya ^b   Zhu, Wenxia ^a   Wang, Hongyun ^a   Wang, Ruijuan ^a   He, Yunfei ^a   Li, Zhiyun ^a  

^a LANZHOU GENERAL HOSPITAL   (China)

^b GANSU PROVINCIAL HOSPITAL   (China)

Author keywords

Astrocyte; Co culture; Glucose deprivation; Monocarboxylate transporters; Oxygen deprivation

Indexed keywords

CELL NUCLEUS ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE; MONOCARBOXYLATE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 2; MONOCARBOXYLATE TRANSPORTER 4; OXYGEN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE CULTURE; BRAIN INJURY; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; HIPPOCAMPUS; IN VITRO STUDY; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; RAT; RNA INTERFERENCE; UPREGULATION;

EID: 84950307135     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.03.062     Document Type: Article

References (27)

1. Grasso S., Bramanti V., Tomassoni D., Bronzi D., Malfa G., Traini E., Napoli M., Renis M., Amenta F., Avola R. Effect of lipoic acid and -glyceryl-phosphoryl-choline on astroglial cell proliferation and differentiation in primary culture. J. Neurosci. Res. 2014, 92:86-94.
2. Bramanti V., Grasso S., Tomassoni D., Traini E., Raciti G., Viola M., Li.Volti G., Campisi A., Amenta F., Avola R. Effect of growth factors and steroid hormones on heme oxygenase and cyclin D1 expression in primary astroglial cell cultures. J. Neurosci. Res. 2015, 93:521-529.
3. Carnevale D., De Simone R., Minghetti L. Microglia-neuron interaction in inflammatory and degenerative diseases: role of cholinergic and noradrenergic systems. CNS Neurol. Disord. Drug Targets 2007, 6:388-397.
4. Bramanti V., Tomassoni D., Grasso S., Bronzi D., Napoli M., Campisi A., Li.Volti G., Ientile R., Amenta F., Avola R. Cholinergic precursors modulate the expression of heme oxigenase-1, p21 during astroglial cell proliferation and differentiation in culture. Neurochem. Res. 2012, 37:2795-2804.
5. Cloix J.F., Ardourel M.Y., Hévor T. Glycogen metabolism and brain pathologies. Cent. Nerv. Syst. Agents Med. Chem. 2008, 8:187-197.
6. Simpson I.A., Carruthers A., Vannucci S.J. Supply and demand in cerebral energy metabolism: the role of nutrient transporters. J. Cereb. Blood Flow Metab. 2007, 27:1766-1791.
7. Halestrap A.P., Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 2004, 447:619-628.
8. Rafiki A., Boulland J.L., Halestrap A.P., Ottersen O.P., Bergersen L. Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Neuroscience 2003, 122:677-688.
9. Rosafio K., Pellerin L. Oxygen tension controls the expression of the monocarboxylate transporter MCT4 in cultured mouse cortical astrocytes via a hypoxia-inducible factor-1α-mediated transcriptional regulation. Glia 2014, 62:477-490.
10. Bramanti V., Tomassoni D., Bronzi D., Grasso S., Currò M., Avitabile M., Li.Volsi G., Renis M., Ientile R., Amenta F., Avola R. Alpha-lipoic acid modulates GFAP, vimentin, nestin, cyclin D1 and MAP-kinase espression in astroglial cell cultures. Neurochem. Res. 2010, 35:2070-2077.
11. Liu B., Hong J.S. Primary rat mesencephalic neuron-glia, neuron-enriched, microglia-enriched and astroglia-enriched cultures. Methods Mol. Med. 2003, 79:387-395.
12. Huang X.J., Zhang W.P., Li C.T., Shi W.Z., Fang S.H., Lu Y.B., Chen Z., Wei E.Q. Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. Glia 2008, 56:27-37.
13. Bouzier-Sore A.K., Voisin P., Canioni P., Magistretti P.J., Pellerin L. Lactate is a preferential oxidative energy substrate over glucose for neurons in culture. J. Cereb. Blood Flow Metab. 2003, 23:1298-1306.
14. Wender R., Brown A.M., Fern R., Swanson R.A., Farrell K., Ransom B.R. Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter. J. Neurosci. 2000, 20:6804-6810.
15. Magistretti P.J. Neuron-glia metabolic coupling and plasticity. J. Exp. Biol. 2006, 209:2304-2311.
16. Pellerin L., Magistretti P.J. Sweet sixteen for ANLS. J. Cereb. Blood Flow Metab. 2012, 32:1152-1166.
17. Cui W., Allen N.D., Skynner M., Gusterson B., Clark A.J. Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain. Glia 2001, 34:272-282.
18. Griffin S., Clark J.B., Canevari L. Astrocyte-neurone communication following oxygen glucose deprivation. J. Neurochem. 2005, 95:1015-1022.
19. Li L., Lundkvist A., Andersson D., Wilhelmsson U., Nagai N., Pardo A.C., Nodin C., Ståhlberg A., Aprico K., Larsson K., Yabe T., Moons L., Fotheringham A., Davies I., Carmeliet P., Schwartz J.P., Pekna M., Kubista M., Blomstrand F., Maragakis N., Nilsson M., Pekny M. Protective role of reactive astrocytes in brain ischemia. J. Cereb. Blood Flow Metab. 2008, 28:468-481.
20. Xu L., Emery J.F., Ouyang Y.B., Voloboueva L.A., Giffard R.G. Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia 2010, 58:1042-1049.
21. Dirnagl U., Meisel A. Endogenous neuroprotection: mito-chondria as gateways to cerebral preconditioning. Neuropharmacology 2008, 55:334-344.
22. Dirnagl U., Simon R.P., Hallenbeck J.M. Ischemic tolerance and endogenous neuroprotection. Trends Neurosci. 2003, 26:248-254.
23. Lauritzen F., de Lanerolle N.C., Lee T.S., Spencer D.D., Kim J.H., Bergersen L.H., Eid T. Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus. Neurobiol. Dis. 2011, 41:577-584.
24. Lauritzen F., Heuser K., de Lanerolle N.C., Lee T.S., Spencer D.D., Kim J.H., Gjedde A., Eid T., Bergersen L.H. Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus. Glia 2012, 60:1172-1181.
25. Hamprecht B., Verleysdonk S., Wiesinger H. Enzymes of carbohydrate and energy metabolism. Neuroglia 2005, Oxford University Press, New York. 2nd ed. H. Kettenmann, B.R. Ransom (Eds.).
26. Ghosh A., Cheung Y.Y., Mansfield B.C., Chou J.Y. Brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production. J. Biol. Chem. 2005, 280:11114-11119.
27. Ullah M.S., Davies A.J., Halestrap A.P. The plasma membrane lactate transporter MCT4 but not MCT1, is up-regulated by hypoxia through a HIF- 1alpha-dependent mechanism. J. Biol. Chem. 2006, 281:9030-9037.