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Volumn 5, Issue , 2015, Pages

Sustained intraocular VEGF neutralization results in retinal neurodegeneration in the Ins2 Akita diabetic mouse

Author keywords

[No Author keywords available]

Indexed keywords

INS2 PROTEIN, MOUSE; INSULIN; NEUTRALIZING ANTIBODY; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

EID: 84950248415     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18316     Document Type: Article
Times cited : (59)

References (56)
  • 1
    • 0021136256 scopus 로고
    • The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years
    • Klein, R., Klein, B. E., Moss, S. E., Davis, M. D. & DeMets, D. L. The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol 102, 520-526 (1984).
    • (1984) Arch Ophthalmol , vol.102 , pp. 520-526
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Davis, M.D.4    DeMets, D.L.5
  • 2
    • 34848907420 scopus 로고    scopus 로고
    • Overview of epidemiologic studies of diabetic retinopathy
    • Klein, B. E. Overview of epidemiologic studies of diabetic retinopathy. Ophthalmic Epidemiol 14, 179-183 (2007).
    • (2007) Ophthalmic Epidemiol , vol.14 , pp. 179-183
    • Klein, B.E.1
  • 3
    • 0021191759 scopus 로고
    • The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years
    • Klein, R., Klein, B. E., Moss, S. E., Davis, M. D. & DeMets, D. L. The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophthalmol 102, 527-532 (1984).
    • (1984) Arch Ophthalmol , vol.102 , pp. 527-532
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Davis, M.D.4    DeMets, D.L.5
  • 4
    • 67749084303 scopus 로고    scopus 로고
    • Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: The diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience 1983-2005
    • Diabetes, C. et al. Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005). Arch Intern Med 169, 1307-1316 (2009).
    • (2009) Arch Intern Med , vol.169 , pp. 1307-1316
    • Diabetes, C.1
  • 5
    • 79960451624 scopus 로고    scopus 로고
    • Five-year visual outcome following laser photocoagulation of diabetic macular oedema
    • quiz 859
    • Jyothi, S. & Sivaprasad, S. Five-year visual outcome following laser photocoagulation of diabetic macular oedema. Eye (Lond) 25, 851-858; quiz 859 (2011).
    • (2011) Eye (Lond) , vol.25 , pp. 851-858
    • Jyothi, S.1    Sivaprasad, S.2
  • 6
    • 84922218322 scopus 로고    scopus 로고
    • Laser photocoagulation for proliferative diabetic retinopathy
    • Evans, J. R., Michelessi, M. & Virgili, G. Laser photocoagulation for proliferative diabetic retinopathy. Cochrane Database Syst Rev 11, CD011234 (2014).
    • (2014) Cochrane Database Syst Rev , vol.11 , pp. CD011234
    • Evans, J.R.1    Michelessi, M.2    Virgili, G.3
  • 8
    • 65549136079 scopus 로고    scopus 로고
    • Intravitreal bevacizumab for diabetic retinopathy
    • Arevalo, J. F. & Garcia-Amaris, R. A. Intravitreal bevacizumab for diabetic retinopathy. Curr Diabetes Rev 5, 39-46 (2009).
    • (2009) Curr Diabetes Rev , vol.5 , pp. 39-46
    • Arevalo, J.F.1    Garcia-Amaris, R.A.2
  • 9
    • 62549101271 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) for primary treatment of diabetic macular oedema
    • Ozkiris, A. Intravitreal bevacizumab (Avastin) for primary treatment of diabetic macular oedema. Eye (Lond) 23, 616-620 (2009).
    • (2009) Eye (Lond) , vol.23 , pp. 616-620
    • Ozkiris, A.1
  • 10
    • 61549094645 scopus 로고    scopus 로고
    • The effect of unilateral intravitreal bevacizumab (avastin), in the treatment of diffuse bilateral diabetic macular edema: A pilot study
    • Velez-Montoya, R. et al. The effect of unilateral intravitreal bevacizumab (avastin), in the treatment of diffuse bilateral diabetic macular edema: a pilot study. Retina 29, 20-26 (2009).
    • (2009) Retina , vol.29 , pp. 20-26
    • Velez-Montoya, R.1
  • 11
    • 33845745774 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema
    • Haritoglou, C. et al. Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema. Retina 26, 999-1005 (2006).
    • (2006) Retina , vol.26 , pp. 999-1005
    • Haritoglou, C.1
  • 12
    • 77952889192 scopus 로고    scopus 로고
    • A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: Report 2
    • e1072
    • Michaelides, M. et al. A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2. Ophthalmology 117, 1078-1086 e1072 (2010).
    • (2010) Ophthalmology , vol.117 , pp. 1078-1086
    • Michaelides, M.1
  • 13
    • 77952257913 scopus 로고    scopus 로고
    • Dose of intravitreal bevacizumab (Avastin) used as preoperative adjunct therapy for proliferative diabetic retinopathy
    • Hattori, T. et al. Dose of intravitreal bevacizumab (Avastin) used as preoperative adjunct therapy for proliferative diabetic retinopathy. Retina 30, 761-764 (2010).
    • (2010) Retina , vol.30 , pp. 761-764
    • Hattori, T.1
  • 14
    • 33748982649 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy
    • Avery, R. L. et al. Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy. Ophthalmology 113, 1695 e1691-1615 (2006).
    • (2006) Ophthalmology , vol.113 , Issue.1695 , pp. e1691-e1615
    • Avery, R.L.1
  • 15
    • 33748985366 scopus 로고    scopus 로고
    • Intravitreal injection of bevacizumab (Avastin) as adjunctive treatment of proliferative diabetic retinopathy
    • Mason, J. O., 3rd, Nixon, P. A. & White, M. F. Intravitreal injection of bevacizumab (Avastin) as adjunctive treatment of proliferative diabetic retinopathy. Am J Ophthalmol 142, 685-688 (2006).
    • (2006) Am J Ophthalmol , vol.142 , pp. 685-688
    • Mason, J.O.1    Nixon, P.A.2    White, M.F.3
  • 16
    • 42449092862 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas
    • Zhang, X., Bao, S., Lai, D., Rapkins, R. W. & Gillies, M. C. Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas. Diabetes 57, 1026-1033 (2008).
    • (2008) Diabetes , vol.57 , pp. 1026-1033
    • Zhang, X.1    Bao, S.2    Lai, D.3    Rapkins, R.W.4    Gillies, M.C.5
  • 17
    • 84902078367 scopus 로고    scopus 로고
    • Diabetic macular edema: New concepts in patho-physiology and treatment
    • Zhang, X., Zeng, H., Bao, S., Wang, N. & Gillies, M. C. Diabetic macular edema: new concepts in patho-physiology and treatment. Cell Biosci 4, 27 (2014).
    • (2014) Cell Biosci , vol.4 , pp. 27
    • Zhang, X.1    Zeng, H.2    Bao, S.3    Wang, N.4    Gillies, M.C.5
  • 20
    • 84858841220 scopus 로고    scopus 로고
    • Diverse roles for VEGF-A in the nervous system
    • Mackenzie, F. & Ruhrberg, C. Diverse roles for VEGF-A in the nervous system. Development 139, 1371-1380 (2012).
    • (2012) Development , vol.139 , pp. 1371-1380
    • MacKenzie, F.1    Ruhrberg, C.2
  • 21
    • 56149103354 scopus 로고    scopus 로고
    • Endogenous VEGF is required for visual function: Evidence for a survival role on muller cells and photoreceptors
    • Saint-Geniez, M. et al. Endogenous VEGF is required for visual function: evidence for a survival role on muller cells and photoreceptors. PLoS One 3, e3554 (2008).
    • (2008) PLoS One , vol.3 , pp. e3554
    • Saint-Geniez, M.1
  • 23
    • 34547702738 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury
    • Nishijima, K. et al. Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Am J Pathol 171, 53-67 (2007).
    • (2007) Am J Pathol , vol.171 , pp. 53-67
    • Nishijima, K.1
  • 24
    • 84887150456 scopus 로고    scopus 로고
    • Seven-year outcomes in ranibizumab-treated patients in ANCHOR MARINA, and HORIZON: A multicenter cohort study (SEVEN-UP
    • Rofagha, S. et al. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology 120, 2292-2299 (2013).
    • (2013) Ophthalmology , vol.120 , pp. 2292-2299
    • Rofagha, S.1
  • 25
    • 84901020200 scopus 로고    scopus 로고
    • Neuronal cell death in the inner retina and the influence of vascular endothelial growth factor inhibition in a diabetic rat model
    • Park, H. Y., Kim, J. H. & Park, C. K. Neuronal cell death in the inner retina and the influence of vascular endothelial growth factor inhibition in a diabetic rat model. Am J Pathol 184, 1752-1762 (2014).
    • (2014) Am J Pathol , vol.184 , pp. 1752-1762
    • Park, H.Y.1    Kim, J.H.2    Park, C.K.3
  • 26
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    • Yoshioka, M., Kayo, T., Ikeda, T. & Koizumi, A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46, 887-894 (1997).
    • (1997) Diabetes , vol.46 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizumi, A.4
  • 27
    • 12944326259 scopus 로고    scopus 로고
    • Why cotton wool spots should not be regarded as retinal nerve fibre layer infarcts
    • McLeod, D. Why cotton wool spots should not be regarded as retinal nerve fibre layer infarcts. Br J Ophthalmol 89, 229-237 (2005).
    • (2005) Br J Ophthalmol , vol.89 , pp. 229-237
    • McLeod, D.1
  • 28
    • 47349111275 scopus 로고    scopus 로고
    • The mystery of cotton-wool spots-a review of recent and historical descriptions
    • Schmidt, D. The mystery of cotton-wool spots-a review of recent and historical descriptions. Eur J Med Res 13, 231-266 (2008).
    • (2008) Eur J Med Res , vol.13 , pp. 231-266
    • Schmidt, D.1
  • 29
    • 0022189519 scopus 로고
    • Cotton-wool spots
    • Brown, G. C. et al. Cotton-wool spots. Retina 5, 206-214 (1985).
    • (1985) Retina , vol.5 , pp. 206-214
    • Brown, G.C.1
  • 30
    • 39049127031 scopus 로고    scopus 로고
    • Microglial activation in human diabetic retinopathy
    • Zeng, H. Y., Green, W. R. & Tso, M. O. Microglial activation in human diabetic retinopathy. Arch Ophthalmol 126, 227-232 (2008).
    • (2008) Arch Ophthalmol , vol.126 , pp. 227-232
    • Zeng, H.Y.1    Green, W.R.2    Tso, M.O.3
  • 31
    • 84897095899 scopus 로고    scopus 로고
    • The dual role of astrocyte activation and reactive gliosis
    • Pekny, M., Wilhelmsson, U. & Pekna, M. The dual role of astrocyte activation and reactive gliosis. Neurosci Lett 565, 30-38 (2014).
    • (2014) Neurosci Lett , vol.565 , pp. 30-38
    • Pekny, M.1    Wilhelmsson, U.2    Pekna, M.3
  • 32
    • 84866511447 scopus 로고    scopus 로고
    • Effects of bevacizumab on neuronal viability of retinal ganglion cells in rats
    • Romano, M. R. et al. Effects of bevacizumab on neuronal viability of retinal ganglion cells in rats. Brain Res 1478, 55-63 (2012).
    • (2012) Brain Res , vol.1478 , pp. 55-63
    • Romano, M.R.1
  • 33
    • 67749116153 scopus 로고    scopus 로고
    • Bevacizumab is not toxic to retinal ganglion cells after repeated intravitreal injection
    • Cheng, C. K. et al. Bevacizumab is not toxic to retinal ganglion cells after repeated intravitreal injection. Retina 29, 306-312 (2009).
    • (2009) Retina , vol.29 , pp. 306-312
    • Cheng, C.K.1
  • 34
    • 34548331324 scopus 로고    scopus 로고
    • Effect of anti-VEGF antibody on retinal ganglion cells in rats
    • Iriyama, A., Chen, Y. N., Tamaki, Y. & Yanagi, Y. Effect of anti-VEGF antibody on retinal ganglion cells in rats. Br J Ophthalmol 91, 1230-1233 (2007).
    • (2007) Br J Ophthalmol , vol.91 , pp. 1230-1233
    • Iriyama, A.1    Chen, Y.N.2    Tamaki, Y.3    Yanagi, Y.4
  • 35
    • 84901505171 scopus 로고    scopus 로고
    • Retinal neurodegenerative changes in the adult insulin receptor substrate-2 deficient mouse
    • Albert-Fort, M. et al. Retinal neurodegenerative changes in the adult insulin receptor substrate-2 deficient mouse. Exp Eye Res 124, 1-10 (2014).
    • (2014) Exp Eye Res , vol.124 , pp. 1-10
    • Albert-Fort, M.1
  • 36
    • 84876339803 scopus 로고    scopus 로고
    • Age-and light-dependent development of localised retinal atrophy in CCL2(/)CX3CR1(GFP/GFP) mice
    • Chen, M. et al. Age-and light-dependent development of localised retinal atrophy in CCL2(/)CX3CR1(GFP/GFP) mice. PLoS One 8, e61381 (2013).
    • (2013) PLoS One , vol.8 , pp. e61381
    • Chen, M.1
  • 38
    • 39149118884 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin
    • Kim, B. W. et al. Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin. Cell Signal 20, 714-725 (2008).
    • (2008) Cell Signal , vol.20 , pp. 714-725
    • Kim, B.W.1
  • 39
    • 0141594635 scopus 로고    scopus 로고
    • Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina
    • Park, S. H. et al. Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina. Diabetologia 46, 1260-1268 (2003).
    • (2003) Diabetologia , vol.46 , pp. 1260-1268
    • Park, S.H.1
  • 40
    • 84859444917 scopus 로고    scopus 로고
    • Protective effects of the neuropeptide PACAP in diabetic retinopathy
    • Szabadfi, K. et al. Protective effects of the neuropeptide PACAP in diabetic retinopathy. Cell Tissue Res 348, 37-46 (2012).
    • (2012) Cell Tissue Res , vol.348 , pp. 37-46
    • Szabadfi, K.1
  • 41
    • 84901320699 scopus 로고    scopus 로고
    • Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse
    • Hombrebueno, J. R., Chen, M., Penalva, R. G. & Xu, H. Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse. PLoS One 9, e97970 (2014).
    • (2014) PLoS One , vol.9 , pp. e97970
    • Hombrebueno, J.R.1    Chen, M.2    Penalva, R.G.3    Xu, H.4
  • 42
    • 0022580197 scopus 로고
    • Color vision defects in early diabetic retinopathy
    • Roy, M. S., Gunkel, R. D. & Podgor, M. J. Color vision defects in early diabetic retinopathy. Arch Ophthalmol 104, 225-228 (1986).
    • (1986) Arch Ophthalmol , vol.104 , pp. 225-228
    • Roy, M.S.1    Gunkel, R.D.2    Podgor, M.J.3
  • 43
    • 0030823293 scopus 로고    scopus 로고
    • Chromatic-contrast threshold impairment in diabetes
    • Tregear, S. J., Knowles, P. J., Ripley, L. G. & Casswell, A. G. Chromatic-contrast threshold impairment in diabetes. Eye (Lond) 11(Pt 4), 537-546 (1997).
    • (1997) Eye (Lond) , vol.11 , pp. 537-546
    • Tregear, S.J.1    Knowles, P.J.2    Ripley, L.G.3    Casswell, A.G.4
  • 45
    • 34547941252 scopus 로고    scopus 로고
    • Autocrine VEGF signaling is required for vascular homeostasis
    • Lee, S. et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell 130, 691-703 (2007).
    • (2007) Cell , vol.130 , pp. 691-703
    • Lee, S.1
  • 46
    • 80051597186 scopus 로고    scopus 로고
    • Microvascular modifications in diabetic retinopathy
    • Durham, J. T. & Herman, I. M. Microvascular modifications in diabetic retinopathy. Curr Diab Rep 11, 253-264 (2011).
    • (2011) Curr Diab Rep , vol.11 , pp. 253-264
    • Durham, J.T.1    Herman, I.M.2
  • 47
    • 84874697146 scopus 로고    scopus 로고
    • Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy
    • Han, Z., Guo, J., Conley, S. M. & Naash, M. I. Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy. Invest Ophthalmol Vis Sci 54, 574-584 (2013).
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 574-584
    • Han, Z.1    Guo, J.2    Conley, S.M.3    Naash, M.I.4
  • 48
    • 22144457454 scopus 로고    scopus 로고
    • The Ins2Akita mouse as a model of early retinal complications in diabetes
    • Barber, A. J. et al. The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci 46, 2210-2218 (2005).
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 2210-2218
    • Barber, A.J.1
  • 49
    • 84929581853 scopus 로고    scopus 로고
    • Evaluation of the response to ranibizumab therapy following bevacizumab treatment failure in eyes with diabetic macular edema
    • Hanhart, J. & Chowers, I. Evaluation of the Response to Ranibizumab Therapy following Bevacizumab Treatment Failure in Eyes with Diabetic Macular Edema. Case Rep Ophthalmol 6, 44-50 (2015).
    • (2015) Case Rep Ophthalmol , vol.6 , pp. 44-50
    • Hanhart, J.1    Chowers, I.2
  • 50
    • 84893549067 scopus 로고    scopus 로고
    • Differential systemic gene expression profile in patients with diabetic macular edema: Responders versus nonresponders to standard treatment
    • Dabir, S. S. et al. Differential systemic gene expression profile in patients with diabetic macular edema: responders versus nonresponders to standard treatment. Indian J Ophthalmol 62, 66-73 (2014).
    • (2014) Indian J Ophthalmol , vol.62 , pp. 66-73
    • Dabir, S.S.1
  • 51
    • 84901360537 scopus 로고    scopus 로고
    • Intravitreal injection of normal saline induces retinal degeneration in the C57BL/6J Mouse
    • Hombrebueno, J. R., Luo, C., Guo, L., Chen, M. & Xu, H. Intravitreal Injection of Normal Saline Induces Retinal Degeneration in the C57BL/6J Mouse. Transl Vis Sci Technol 3, 3 (2014).
    • (2014) Transl Vis Sci Technol , vol.3 , pp. 3
    • Hombrebueno, J.R.1    Luo, C.2    Guo, L.3    Chen, M.4    Xu, H.5
  • 52
    • 0347377779 scopus 로고    scopus 로고
    • Differential inhibition of fluid accumulation and tumor growth in two mouse ascites tumors by an antivascular endothelial growth factor/permeability factor neutralizing antibody
    • Luo, J. C., Toyoda, M. & Shibuya, M. Differential inhibition of fluid accumulation and tumor growth in two mouse ascites tumors by an antivascular endothelial growth factor/permeability factor neutralizing antibody. Cancer Res 58, 2594-2600 (1998).
    • (1998) Cancer Res , vol.58 , pp. 2594-2600
    • Luo, J.C.1    Toyoda, M.2    Shibuya, M.3
  • 53
    • 34347253227 scopus 로고    scopus 로고
    • Panretinal, high-resolution color photography of the mouse fundus
    • Paques, M. et al. Panretinal, high-resolution color photography of the mouse fundus. Invest Ophthalmol Vis Sci 48, 2769-2774 (2007).
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 2769-2774
    • Paques, M.1
  • 54
    • 52049094091 scopus 로고    scopus 로고
    • A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images
    • Xu, H. et al. A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp Eye Res 87, 319-326 (2008).
    • (2008) Exp Eye Res , vol.87 , pp. 319-326
    • Xu, H.1
  • 55
    • 77549088700 scopus 로고    scopus 로고
    • Morphological changes of short-wavelength cones in the developing S334ter-3 transgenic rat
    • Hombrebueno, J. R. et al. Morphological changes of short-wavelength cones in the developing S334ter-3 transgenic rat. Brain Res 1321, 60-66 (2010).
    • (2010) Brain Res , vol.1321 , pp. 60-66
    • Hombrebueno, J.R.1
  • 56
    • 84899868974 scopus 로고    scopus 로고
    • Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye
    • Michael, I. P. et al. Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO Mol Med 6, 604-623 (2014).
    • (2014) EMBO Mol Med , vol.6 , pp. 604-623
    • Michael, I.P.1


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