Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer

Annals of Surgery

Volumn 263, Issue 4, 2016, Pages 712-718

  Markar, Sheraz R ^a   Gronnier, Caroline ^b,c,d   Duhamel, Alain ^b,e   Pasquer, Arnaud ^f   Thereaux, Jeremie ^g   Du Rieu, Mael Chalret ^h   Lefevre, Jeremie H ⁱ   Turner, Kathleen ^j   Luc, Guillaume ^k   Mariette, Christophe ^b,c,d,e  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c UNIV LILLE   (France)

^d JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^e SIRIC OncoLille ^*  (France)

^f EDOUARD HERRIOT HOSPITAL   (France)

^g BREST UNIVERSITY HOSPITAL   (France)

^h CHU PURPAN   (France)

ⁱ HÔPITAL SAINT ANTOINE   (France)

^j PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^k HAUT LÉVÊQUE HOSPITAL   (France)

more..

Author keywords

Esophageal cancer; Morbidity; Resection margin; Surgery; Survival

Indexed keywords

ADULT; ARTICLE; CANCER ADJUVANT THERAPY; CANCER GROWTH; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CHEMORADIOTHERAPY; ESOPHAGUS CANCER; ESOPHAGUS RESECTION; FEMALE; HUMAN; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; OVERALL SURVIVAL; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROPENSITY SCORE; ADENOCARCINOMA; AGED; CARCINOMA, SQUAMOUS CELL; CLINICAL TRIAL; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; ETIOLOGY; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; NEOPLASM METASTASIS; PATHOLOGY; PREVENTION AND CONTROL; PROGNOSIS; RETROSPECTIVE STUDY; SURVIVAL ANALYSIS; TREATMENT OUTCOME; TUMOR RECURRENCE; VERY ELDERLY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; ESOPHAGEAL NEOPLASMS; ESOPHAGECTOMY; ESOPHAGUS; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; PROPENSITY SCORE; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84950154362     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0000000000001325     Document Type: Article

References (35)

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90.
2. Siegel R, Naishadham D, Jemal A. Cancer statistics 2012. CA Cancer J Clin. 2012;62:10-29.
3. Blot WJ, Devesa SS, Kneller RW, et al. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA. 1991;265:1287-1289.
4. Markar S, Gronnier C, Duhamel A, et al. Pattern of postoperative mortality after esophageal cancer resection according to center volume: results from a large European Multicenter study. Ann Surg Oncol. 2015 [Epub ahead of print].
5. Wu J, Chen QX, Teng LS, et al. Prognostic significance of positive circumferential resection margin in esophageal cancer: a systematic review and meta-analysis. Ann Thorac Surg. 2014;97:446-453.
6. Ando N, Iizuka T, Ide H, et al. Surgery plus chemotherapy compared with surgery along for localized squamous cell carcinoma of the thoracic esophagus: a Japan Clinical Oncology Group Study-JCOG9204. J Clin Oncol. 2003;21:4592-4596.
7. Lyu X, Huang J, Mao Y, et al. Adjuvant chemotherapy after esophagectomy: is there a role in the treatment of lymph node positive thoracic esophageal squamous cell carcinoma. J Surg Oncol. 2014;1110:864-868.
8. Gilbert S, Martel AB, Seely AJ. Prognostic significance of positive radial margin after esophageal cancer resection. J Thorac Cardiovasc Surg. 2014 [Epub ahead of print].
9. Tilly C, Lefevre JH, Svrcek M, et al. R1 rectal resection: look up and don't look down. Ann Surg. 2014;260:794-799.
10. Kooby DA, Lad NL, Squires MH III, et al. Value of intraoperative neck margin analysis during whipple for pancreatic adenocarcinoma: a multicenter analysis of 1399 patients. Ann Surg. 2014;260:494-501.
11. Deeter M, Dorer R, Kuppusamy MK, et al. Assessment of criteria and clinical significance of circumferential resection margins in esophageal cancer. Arch Surg. 2009;144:618-624.
12. Briez N, Piessen G, Bonnetain F, et al. Open versus laparoscopically-assisted oesophagectomy for cancer: a multicenter randomised controlled phase III trial-the MIRO trial. BMC. 2011;11:310.
13. Dindo D, Demartines N, Clavien PA. Classification of Surgical Complications. A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205-213.
14. Sobin LH, Gospodarowicz MK, Wittekind Ch. TNM Classification of Malignant Tumours. 7th ed. Hoboken, NJ: John Wiley & Sons; 2009.
15. Societe National Francaise de Gastro-Enterologie. Cancer de L'Oesophage. 2013 March 1. Available at: http://www.tncd.org/. Accessed July 15, 2014.
16. Lad NL, Squires MH, Maithel SK, et al. Is it time to stop checking frozen section neck margins during pancreaticoduodenectomy? Ann Surg Oncol. 2013;20:3626-3633.
17. Debove C, Maggiori L, Chau A, et al. What happens after R1 resection in patients undergoing laparoscopic total mesorectal excision for rectal cancer? A study in 333 consecutive patients. Colorectal Dis. 2015;17:197-204.
18. Angelsen JH, Horn A, Eide GE, et al. Surgery for colorectal liver metastases: the impact of resection margins on recurrence and overall survival. World J Surg Oncol. 2014;12:127.
19. Pandanaboyana S, White A, Pathak S, et al. Impact of margin status and neoadjuvant chemotherapy on survival, recurrence after liver resection for colorectal liver metastasis. Ann Surg Oncol. 2015;22:173-179.
20. Sjoquist KM, Burmeister BH, Smithers M, et al. Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. Lancet Oncol. 2011;12:681-692.
21. Markar SR, Bodnar A, Rosales J, et al. The impact of neoadjuvant chemo-radiotherapy on perioperative outcomes tumor pathology, and survival in clinical stage II and III esophageal cancer. Ann Surg Oncol. 2013;20:3935-3941.
22. Samejima R, Kitajima Y, Yunotani S, et al. Cyclin D1 is a possible predictor of sensitivity to chemoradiotherapy for esophageal squamous cell carcinoma. Anticancer Res. 1999;19:5515-5521.
23. Maher SG, McDowell DT, Collins BC, et al. Serum proteomic profiling reveals that pretreatment complement protein levels are predictive of esoph-ageal cancer patient response to neoadjuvant chemoradiation. Ann Surg. 2011;254:809-816.
24. Andreyev HJ, Norman AR, Oates J, et al. Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? Eur J Cancer. 1998;34:503-509.
25. Mariette C, De Botton ML, Piessen G. Surgery in esophageal and gastric cancer patients: what is the role for nutrition support in your daily practice? Ann Surg Oncol. 2012;19:2128-2134.
26. Belinson JL, Jarrell MA, McClure M, et al. Serum albumin: its relationship to marrow and renal toxicity from platinum-based combination chemotherapy. Gynecol Oncol. 1990;37:93-95.
27. Robb WB, Messager M, Gronnier C, et al. High-grade toxicity to neoadjuvant treatment for upper gastrointestinal carcinomas: what is the impact on perioperative and oncologic outcomes? Ann Surg Oncol. 2015 [Epub ahead of print].
28. Truant S, Sequier C, Leteurtre E, et al. Tumour biology of colorectal liver metastasis is a more important factor in survival than surgical margin clearance in the era of modern chemotherapy regimens. HPB (Oxford). 2015;17:176-184.
29. Zafirellis K, Dolan K, Fountoulakis A, et al. Multivariate analysis of clinical, operative and pathologic features of esophageal cancer: who needs adjuvant therapy? Dis Esophagus. 2002;15:155-159.
30. Markar S, Gronnier C, Pasquer A, et al. Salvage surgery following chemoradiotherapy in the management of esophageal cancer: is it a viable therapeutic option? J Clin Oncol. in press, DOI:10.1200/JCO.2014.59.9092.
31. Mariette C, Piessen G, Briez N, et al. Oesophagogastric junction adenocarci-noma: which therapeutic approach? Lancet Oncol. 2011;12:296-305.
32. Harvin JA, Lahat G, Correa AM, et al. Neoadjuvant chemoradiotherapy followed by surgery for esophageal adenocarcinoma: significance of microscopically positive circumferential radial margins. J Thorac Cardiovasc Surg. 2012;143:412-420.
33. Pultrum BB, Honing J, Smit JK, et al. A critical appraisal of circumferential resection margins in esophageal carcinoma. Ann Surg Oncol. 2010;17: 812-820.
34. Barbour AP, Rizk NP, Gonen M, et al. Adenocarcinoma ofthe gastoesophageal junction: influence of esophageal resection margin and operative approach on outcome. Ann Surg. 2007;246:1-8.
35. O'Farrell NJ, Donohoe CL, Muldoon C, et al. Lack of independent significance of a close (<1 mm) circumferential resection margin involvement in esophageal and junctional cancer. Ann Surg Oncol. 2013; 20: 2727-2733.