Compound stimulus extinction reduces spontaneous recovery in humans

Learning and Memory

Volumn 22, Issue 12, 2015, Pages 589-593

  Coelho, Cesar A O ^a,b   Dunsmoor, Joseph E ^a   Phelps, Elizabeth A ^a,c  

^a NEW YORK UNIVERSITY   (United States)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ASSOCIATION; AUDITORY STIMULATION; COMPOUND EXTINCTION; CONDITIONED REFLEX; CONDITIONING; CONTROLLED STUDY; DEEPENED EXTINCTION; ELECTRODERMAL RESPONSE; FEAR; FEMALE; GROUP DYNAMICS; HABITUATION; HUMAN; HUMAN EXPERIMENT; LEARNING; MALE; NORMAL HUMAN; ORIENTING RESPONSE; PRIORITY JOURNAL; REINFORCEMENT; STATE DEPENDENT LEARNING; STIMULUS RESPONSE; VISUAL STIMULATION; ADOLESCENT; ELECTRIC SHOCK; HEARING; PHOTOSTIMULATION; PHYSIOLOGY; PSYCHOLOGIC TEST; RANDOMIZATION; VISION; YOUNG ADULT;

ACOUSTIC STIMULATION; ADOLESCENT; ADULT; AUDITORY PERCEPTION; CONDITIONING (PSYCHOLOGY); ELECTROSHOCK; EXTINCTION, PSYCHOLOGICAL; FEAR; FEMALE; GALVANIC SKIN RESPONSE; HUMANS; MALE; PHOTIC STIMULATION; PSYCHOLOGICAL TESTS; RANDOM ALLOCATION; VISUAL PERCEPTION; YOUNG ADULT;

EID: 84950120309     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.039479.115     Document Type: Article

References (34)

1. Agren T. 2014. Human reconsolidation: a reactivation and update. Brain Res Bull 105: 70-82.
2. Bouton ME. 2002. Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Biol Psychiatry 52: 976-986.
3. Craske MG, Treanor M, Conway CC, Zbozinek T, Vervliet B. 2014. Maximizing exposure therapy: an inhibitory learning approach. Behav Res Ther 58: 10-23.
4. Culver NC, Vervliet B, Craske MG 2014. Compound extinction: using the Rescorla-Wagner model to maximize exposure therapy effects for anxiety disorders. Clin Psychol Sci 3: 335-348.
5. Dawson ME, Schell AM, Filion DL 2007. The electrodermal system. In Handbook of psychophysiology (ed. Cacioppo IT, Tassinary LG, Berntson GG), pp. 159-181. Cambridge University Press, Cambridge, UK.
6. Dunsmoor JE, Ahs F, Zielinski DJ, LaBar KS 2014. Extinction in multiple virtual reality contexts diminishes fear reinstatement in humans. Neurobiol Learn Mem 113: 157-164.
7. Dunsmoor JE, Campese VD, Ceceli AO, LeDoux JE, Phelps EA 2015. Novelty-facilitated extinction: providing a novel outcome in place of an expected threat diminishes recovery of defensive responses. Biol Psychiatry 78: 203-209.
8. Dymond S, Dunsmoor JE, Vervliet B, Roche B, Hermans D. 2014. Fear generalization in humans: systematic review and implications for anxiety disorder research. Behav Ther. doi:10.1016/j.beth.2014.10.001.
9. Fitzgerald PJ, Seemann JR, Maren S. 2014. Can fear extinctionbe enhanced? A review of pharmacological and behavioral findings. Brain Res Bull 105: 46-60.
10. Glenn CR, Lieberman L, Hajcak G. 2012. Comparing electric shock and a fearful screaming face as unconditioned stimuli for fear learning. Int J Psychophysiol 86: 214-219.
11. Green SR, Kragel PA, Fecteau ME, LaBar KS 2014. Development and validation of an unsupervised scoring system (Autonomate) for skin conductance response analysis. Int J Psychophysiol 91: 186-193.
12. Haaker J, Golkar A, Hermans D, Lonsdorf TB 2014. A review on human reinstatement studies: an overview and methodological challenges. Learn Mem 21: 424-440.
13. Hendry J. 1982. Summation of undetected excitation following extinction of the CER. Anim Learn Behav 10: 476-482.
14. Janak PH, Corbit LH 2011. Deepened extinction following compound stimulus presentation: noradrenergic modulation. Learn Mem 18: 1-10.
15. Kearns DN, Weiss SJ 2012. Extinguished cocaine cues increase drug seeking when presented simultaneously with a non-extinguished cocaine cue. Drug Alcohol Depend 121: 140-147.
16. Kearns DN, Tunstall BJ, Weiss SJ 2012. Deepened extinction of cocaine cues. Drug Alcohol Depend 124: 283-287.
17. Kindt M. 2014. A behavioural neuroscience perspective on the aetiology and treatment of anxiety disorders. Behav Res Ther 62: 24-36.
18. Leung HT, Reeks LM, Westbrook RF 2012. Two ways to deepen extinction and the difference between them. J Exp Psychol Anim Behav Process 38: 394-406.
19. Lissek S, Biggs AL, Rabin SJ, Cornwell BR, Alvarez RP, Pine DS, Grillon C. 2008. Generalization of conditioned fear-potentiated startle in humans: experimental validation and clinical relevance. Behav Res Ther 46: 678-687.
20. Lovibond PF, Davis NR, O'Flaherty AS. 2000. Protection from extinction in human fear conditioning. Behav Res Ther 38: 967-983.
21. McConnell BL, Miller RR 2014. Associative accounts of recovery-from-extinction effects. Learn Motiv 46: 1-15.
22. McConnell BL, Miguez G, Miller RR 2013. Extinction with multiple excitors. Learn Behav 41: 119-137.
23. Milad MR, Quirk GJ 2012. Fear extinction as a model for translational neuroscience: ten years of progress. Annu Rev Psychol 63: 129-151.
24. Mineka S, Zinbarg R. 2006. A contemporary learning theory perspective on the etiology of anxiety disorders: it's not what you thought it was. Am Psychol 61: 10-26.
25. Myskiw JC, Izquierdo I, Furini CR 2014. Modulation of the extinction of fear learning. Brain Res Bull 105: 61-69.
26. Pearce JM. 1987. A model for stimulus generalization in Pavlovian conditioning. Psychol Rev 94: 61-73.
27. Reberg D. 1972. Compound tests for excitation in early acquisition and after prolonged extinction of conditioned suppression. Learn Motiv 3: 246-258.
28. Rescorla RA. 2006. Deepened extinction from compound stimulus presentation. J Exp Psychol Anim Behav Process 32: 135-144.
29. Rescorla RA, Wagner AR 1972. A theory of Pavlovian conditioning: variations in the effectiveness of reinforcement and nonreinforcement. In Classical conditioning II: current research and theory (ed. Black AH, Prokasy WF), pp. 64-99. Appleton-Century-Crofts, New York.
30. Schiller D, Monfils MH, Raio CM, Johnson DC, LeDoux JE, Phelps EA 2010. Preventing the return of fear in humans using reconsolidation update mechanisms. Nature 463: 49-53.
31. Shiban Y, Pauli P, Mühlberger A. 2013. Effect of multiple context exposure on renewal in spider phobia. Behav Res Ther 51: 68-74.
32. Steinfurth EC, Kanen JW, Raio CM, Clem RL, Huganir RL, Phelps EA 2014. Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans. Learn Mem 21: 338-341.
33. Vervliet B, Vansteenwegen D, Hermans D, Eelen P. 2007. Concurrent excitors limit the extinction of conditioned fear in humans. Behav Res Ther 45: 375-383.
34. Vervliet B, Craske MG, Hermans D. 2013. Fear extinction and relapse: state of the art. Annu Rev Clin Psychol 9: 215-248.