메뉴 건너뛰기




Volumn 25, Issue , 2016, Pages 13-23

The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials

Author keywords

Cognition; Dementia; Exercise; Meta analysis; Physical Activity

Indexed keywords

AEROBIC EXERCISE; ALZHEIMER DISEASE; ANAEROBIC EXERCISE; COGNITION; DAILY LIFE ACTIVITY; DEMENTIA; EFFECT SIZE; HUMAN; META ANALYSIS; MINI MENTAL STATE EXAMINATION; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SOCIAL INTERACTION; SYSTEMATIC REVIEW; MOTOR ACTIVITY; PSYCHOLOGY;

EID: 84949818896     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2015.11.005     Document Type: Review
Times cited : (459)

References (80)
  • 2
    • 18244384051 scopus 로고    scopus 로고
    • Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
    • Adlard P.A., Perreau V.M., Pop V., Cotman C.W. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J. Neurosci. 2005, 25:4217-4221. 10.1523/JNEUROSCI.0496-05.2005.
    • (2005) J. Neurosci. , vol.25 , pp. 4217-4221
    • Adlard, P.A.1    Perreau, V.M.2    Pop, V.3    Cotman, C.W.4
  • 5
    • 20444398484 scopus 로고    scopus 로고
    • Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus
    • Berchtold N.C., Chinn G., Chou M., Kesslak J.P., Cotman C.W. Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus. Neuroscience 2005, 133:853-861. 10.1016/j.neuroscience.2005.03.026.
    • (2005) Neuroscience , vol.133 , pp. 853-861
    • Berchtold, N.C.1    Chinn, G.2    Chou, M.3    Kesslak, J.P.4    Cotman, C.W.5
  • 6
    • 0036605368 scopus 로고    scopus 로고
    • Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum
    • Berchtold N.C., Kesslak J.P., Cotman C.W. Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J. Neurosci. Res. 2002, 68:511-521. 10.1002/jnr.10256.
    • (2002) J. Neurosci. Res. , vol.68 , pp. 511-521
    • Berchtold, N.C.1    Kesslak, J.P.2    Cotman, C.W.3
  • 7
  • 9
    • 85101510947 scopus 로고    scopus 로고
    • A basic introduction to fixed-effect and random-effects models for meta-analysis Research Synthesis Methods
    • Borenstein, M., Hedges, L., V, Higgins, J.P.T., Rothstein, H.R., 2010. A basic introduction to fixed-effect and random-effects models for meta-analysis Research Synthesis Methods Volume 1, Issue 2. Res. Synth. Methods.
    • (2010) Res. Synth. Methods. , vol.1 , Issue.2
    • Borenstein, M.1    Hedges, L.V.2    Higgins, J.P.T.3    Rothstein, H.R.4
  • 10
    • 84962274854 scopus 로고    scopus 로고
    • A 9-week aerobic and strength training program improves cognitive and motor function in patients with dementia: a randomized, controlled trial
    • Bossers W.J., van der Woude L.H., Boersma F., Hortobágyi T., Scherder E.J., van Heuvelen M.J. A 9-week aerobic and strength training program improves cognitive and motor function in patients with dementia: a randomized, controlled trial. Am. J. Geriatr. Psychiatry 2015, 10.1016/j.jagp.2014.12.191.
    • (2015) Am. J. Geriatr. Psychiatry
    • Bossers, W.J.1    van der Woude, L.H.2    Boersma, F.3    Hortobágyi, T.4    Scherder, E.J.5    van Heuvelen, M.J.6
  • 11
    • 84860726725 scopus 로고    scopus 로고
    • Total daily physical activity and the risk of AD and cognitive decline in older adults
    • Buchman A.S., Boyle P.A., Yu L., Shah R.C., Wilson R.S., Bennett D.A. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology 2012, 78:1323-1329. 10.1212/wnl.0b013e3182535d35.
    • (2012) Neurology , vol.78 , pp. 1323-1329
    • Buchman, A.S.1    Boyle, P.A.2    Yu, L.3    Shah, R.C.4    Wilson, R.S.5    Bennett, D.A.6
  • 13
    • 84896366369 scopus 로고    scopus 로고
    • Can leisure activities slow dementia progression in nursing home residents? A cluster-randomized controlled trial
    • Cheng S.-T.T., Chow P.K., Song Y.-Q.Q., Yu E.C.S., Lam J.H.M. Can leisure activities slow dementia progression in nursing home residents? A cluster-randomized controlled trial. Int. Psychogeriatr. 2014, 26:637-643. 10.1017/s1041610213002524.
    • (2014) Int. Psychogeriatr. , vol.26 , pp. 637-643
    • Cheng, S.-T.T.1    Chow, P.K.2    Song, Y.-Q.Q.3    Yu, E.C.S.4    Lam, J.H.M.5
  • 14
    • 55249116014 scopus 로고    scopus 로고
    • A controlled clinical trial on the effects of motor intervention on balance and cognition in institutionalized elderly patients with dementia
    • Christofoletti G., Oliani M.M., Gobbi S., Stella F., Bucken Gobbi L.T., Renat Canineu P. A controlled clinical trial on the effects of motor intervention on balance and cognition in institutionalized elderly patients with dementia. Clin. Rehabil. 2008, 22:618-626. 10.1177/0269215507086239.
    • (2008) Clin. Rehabil. , vol.22 , pp. 618-626
    • Christofoletti, G.1    Oliani, M.M.2    Gobbi, S.3    Stella, F.4    Bucken Gobbi, L.T.5    Renat Canineu, P.6
  • 15
    • 0036279885 scopus 로고    scopus 로고
    • The effects of a walking/talking program on communication, ambulation, and functional status in residents with Alzheimer disease
    • Cott C.A., Dawson P., Sidani T., Wells T., Sidani S., Wells D. The effects of a walking/talking program on communication, ambulation, and functional status in residents with Alzheimer disease. Alzheimer Dis. Assoc. Disord. 2002, 16:81-87. 10.1097/01.wad.0000015569.76518.fi.
    • (2002) Alzheimer Dis. Assoc. Disord. , vol.16 , pp. 81-87
    • Cott, C.A.1    Dawson, P.2    Sidani, T.3    Wells, T.4    Sidani, S.5    Wells, D.6
  • 17
    • 84877123756 scopus 로고    scopus 로고
    • A meta-analysis of the efficacy of donepezil, rivastigmine, galantamine, and memantine in relation to severity of Alzheimer's disease
    • DiSanto S.G., Prinelli F., Adorni F., Caltagirone C., Musicco M. A meta-analysis of the efficacy of donepezil, rivastigmine, galantamine, and memantine in relation to severity of Alzheimer's disease. J. Alzheimers Dis. 2013, 35:349-361. 10.3233/JAD-122140.
    • (2013) J. Alzheimers Dis. , vol.35 , pp. 349-361
    • DiSanto, S.G.1    Prinelli, F.2    Adorni, F.3    Caltagirone, C.4    Musicco, M.5
  • 18
    • 23444436632 scopus 로고    scopus 로고
    • Exercise-induced overexpression of angiogenic factors and reduction of ischemia/reperfusion injury in stroke
    • Ding Y.H., Luan X.D., Li J., Rafols J.A., Guthinkonda M., Diaz F.G., Ding Y. Exercise-induced overexpression of angiogenic factors and reduction of ischemia/reperfusion injury in stroke. Curr. Neurovasc. Res. 2004, 1:411-420.
    • (2004) Curr. Neurovasc. Res. , vol.1 , pp. 411-420
    • Ding, Y.H.1    Luan, X.D.2    Li, J.3    Rafols, J.A.4    Guthinkonda, M.5    Diaz, F.G.6    Ding, Y.7
  • 19
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M., Davey Smith G., Schneider M., Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 20
    • 57549098808 scopus 로고    scopus 로고
    • Hand motor activity, cognition, mood, and the rest-activity rhythm in dementia: a clustered RCT
    • Eggermont L.H., Knol D.L., Hol E.M., Swaab D.F., Scherder E.J. Hand motor activity, cognition, mood, and the rest-activity rhythm in dementia: a clustered RCT. Behav. Brain Res. 2009, 196:271-278. 10.1016/j.bbr.2008.09.012.
    • (2009) Behav. Brain Res. , vol.196 , pp. 271-278
    • Eggermont, L.H.1    Knol, D.L.2    Hol, E.M.3    Swaab, D.F.4    Scherder, E.J.5
  • 21
    • 67650470231 scopus 로고    scopus 로고
    • Walking the line: a randomised trial on the effects of a short term walking programme on cognition in dementia
    • Eggermont L.H.P., Swaab D.F., Hol E.M., Scherder E.J.A. Walking the line: a randomised trial on the effects of a short term walking programme on cognition in dementia. J. Neurol. Neurosurg. Psychiatry 2009, 80:802-804. 10.1136/jnnp.2008.158444.
    • (2009) J. Neurol. Neurosurg. Psychiatry , vol.80 , pp. 802-804
    • Eggermont, L.H.P.1    Swaab, D.F.2    Hol, E.M.3    Scherder, E.J.A.4
  • 22
    • 84890089673 scopus 로고    scopus 로고
    • The effect of exercise interventions on cognitive outcome in Alzheimer's disease: a systematic review
    • Farina N., Rusted J., Tabet N. The effect of exercise interventions on cognitive outcome in Alzheimer's disease: a systematic review. Int. Psychogeriatr. 2014, 26:9-18. 10.1017/S1041610213001385.
    • (2014) Int. Psychogeriatr. , vol.26 , pp. 9-18
    • Farina, N.1    Rusted, J.2    Tabet, N.3
  • 23
    • 0016823810 scopus 로고
    • Mini-mental state: a practical method for grading the cognitive state of patients for the clinician
    • Folstein M.F., Folstein S.E., McHugh P.R. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 1975, 12:189-198.
    • (1975) J. Psychiatr. Res. , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 25
    • 77953778864 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease: symptomatic and disease-modifying approaches
    • Galimberti D., Scarpini E. Treatment of Alzheimer's disease: symptomatic and disease-modifying approaches. Curr. Aging Sci. 2010, 3:46-56.
    • (2010) Curr. Aging Sci. , vol.3 , pp. 46-56
    • Galimberti, D.1    Scarpini, E.2
  • 26
    • 34548677266 scopus 로고    scopus 로고
    • BDNF and learning: evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression
    • Gómez-Pinilla F., Huie J.R., Ying Z., Ferguson A.R., Crown E.D., Baumbauer K.M., Edgerton V.R., Grau J.W. BDNF and learning: evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression. Neuroscience 2007, 148:893-906. 10.1016/j.neuroscience.2007.05.051.
    • (2007) Neuroscience , vol.148 , pp. 893-906
    • Gómez-Pinilla, F.1    Huie, J.R.2    Ying, Z.3    Ferguson, A.R.4    Crown, E.D.5    Baumbauer, K.M.6    Edgerton, V.R.7    Grau, J.W.8
  • 27
    • 62249177925 scopus 로고    scopus 로고
    • Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence
    • Hamer M., Chida Y. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol. Med 2009, 39:3-11. 10.1017/S0033291708003681.
    • (2009) Psychol. Med , vol.39 , pp. 3-11
    • Hamer, M.1    Chida, Y.2
  • 28
    • 85015558660 scopus 로고    scopus 로고
    • The effect of exercise intervention on cognitive performance in persons at risk of, or with, dementia: a systematic review and meta-analysis
    • Hess N.C.L., Dieberg G., Mcfarlane J.R., Smart N.A. The effect of exercise intervention on cognitive performance in persons at risk of, or with, dementia: a systematic review and meta-analysis. Healthy Aging Res. 2014, 1-10. 10.12715/har.2014.3.3.
    • (2014) Healthy Aging Res. , pp. 1-10
    • Hess, N.C.L.1    Dieberg, G.2    Mcfarlane, J.R.3    Smart, N.A.4
  • 29
    • 5344237365 scopus 로고    scopus 로고
    • The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis
    • Heyn P., Abreu B.C., Ottenbacher K.J. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch. Phys. Med. Rehabil. 2004, 85:1694-1704. 10.1016/j.apmr.2004.03.019.
    • (2004) Arch. Phys. Med. Rehabil. , vol.85 , pp. 1694-1704
    • Heyn, P.1    Abreu, B.C.2    Ottenbacher, K.J.3
  • 30
    • 84887346660 scopus 로고    scopus 로고
    • Cochrane handbook for systematic reviews of interventions 5.1.0
    • (updated March 2011).
    • Higgins, T.J.P., Green, S., 2011. Cochrane handbook for systematic reviews of interventions 5.1.0 (updated March 2011).
    • (2011)
    • Higgins, T.J.P.1    Green, S.2
  • 31
    • 41549114610 scopus 로고    scopus 로고
    • Dance and movement therapeutic methods in management of dementia: a randomized, controlled study
    • Hokkanen L., Rantala L., Remes A.M., Härkönen B., Viramo P., Winblad I. Dance and movement therapeutic methods in management of dementia: a randomized, controlled study. J. Am. Geriatr. Soc. 2008, 56:771-772. 10.1111/j.1532-5415.2008.01611.x.
    • (2008) J. Am. Geriatr. Soc. , vol.56 , pp. 771-772
    • Hokkanen, L.1    Rantala, L.2    Remes, A.M.3    Härkönen, B.4    Viramo, P.5    Winblad, I.6
  • 32
    • 84928777391 scopus 로고    scopus 로고
    • Effects of physical activity training in patients with Alzheimer's dementia: results of a pilot RCT Study
    • Holthoff V.A., Marschner K., Scharf M., Steding J., Meyer S., Koch R., Donix M. Effects of physical activity training in patients with Alzheimer's dementia: results of a pilot RCT Study. PLoS One 2015, 10:e0121478. 10.1371/journal.pone.0121478.
    • (2015) PLoS One , vol.10 , pp. e0121478
    • Holthoff, V.A.1    Marschner, K.2    Scharf, M.3    Steding, J.4    Meyer, S.5    Koch, R.6    Donix, M.7
  • 34
    • 0026586247 scopus 로고
    • Exercise and the brain: angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning
    • Isaacs K.R., Anderson B.J., Alcantara A.A., Black J.E., Greenough W.T. Exercise and the brain: angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning. J. Cereb. Blood Flow Metab. 1992, 12:110-119. 10.1038/jcbfm.1992.14.
    • (1992) J. Cereb. Blood Flow Metab. , vol.12 , pp. 110-119
    • Isaacs, K.R.1    Anderson, B.J.2    Alcantara, A.A.3    Black, J.E.4    Greenough, W.T.5
  • 37
    • 84890525351 scopus 로고    scopus 로고
    • Physical exercise and cognitive performance in the elderly: current perspectives
    • Kirk-Sanchez N.J., McGough E.L. Physical exercise and cognitive performance in the elderly: current perspectives. Clin. Interv. Aging 2014, 9:51-62. 10.2147/cia.s39506.
    • (2014) Clin. Interv. Aging , vol.9 , pp. 51-62
    • Kirk-Sanchez, N.J.1    McGough, E.L.2
  • 38
    • 0037177439 scopus 로고    scopus 로고
    • Exercise induces angiogenesis but does not alter movement representations within rat motor cortex
    • Kleim J.A., Cooper N.R., VandenBerg P.M. Exercise induces angiogenesis but does not alter movement representations within rat motor cortex. Brain Res. 2002, 934:1-6.
    • (2002) Brain Res. , vol.934 , pp. 1-6
    • Kleim, J.A.1    Cooper, N.R.2    VandenBerg, P.M.3
  • 39
    • 33748188974 scopus 로고    scopus 로고
    • Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
    • Kronenberg G., Bick-Sander A., Bunk E., Wolf C., Ehninger D., Kempermann G. Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus. Neurobiol. Aging 2006, 27:1505-1513. 10.1016/j.neurobiolaging.2005.09.016.
    • (2006) Neurobiol. Aging , vol.27 , pp. 1505-1513
    • Kronenberg, G.1    Bick-Sander, A.2    Bunk, E.3    Wolf, C.4    Ehninger, D.5    Kempermann, G.6
  • 40
    • 44949204595 scopus 로고    scopus 로고
    • Effect of regular exercise on senile dementia patients
    • Kwak Y.S., Um S.Y., Son T.G., Kim D.J. Effect of regular exercise on senile dementia patients. Int. J. Sports Med. 2008, 29:471-474. 10.1055/s-2007-964853.
    • (2008) Int. J. Sports Med. , vol.29 , pp. 471-474
    • Kwak, Y.S.1    Um, S.Y.2    Son, T.G.3    Kim, D.J.4
  • 41
    • 33644800309 scopus 로고    scopus 로고
    • Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older
    • Larson E.B., Wang L., Bowen J.D., McCormick W.C., Teri L., Crane P., Kukull W. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann. Intern. Med. 2006, 144:73-81.
    • (2006) Ann. Intern. Med. , vol.144 , pp. 73-81
    • Larson, E.B.1    Wang, L.2    Bowen, J.D.3    McCormick, W.C.4    Teri, L.5    Crane, P.6    Kukull, W.7
  • 42
    • 0035107265 scopus 로고    scopus 로고
    • Physical activity and risk of cognitive impairment and dementia in elderly persons
    • Laurin D., Verreault R., Lindsay J., MacPherson K., Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch. Neurol. 2001, 58:498-504.
    • (2001) Arch. Neurol. , vol.58 , pp. 498-504
    • Laurin, D.1    Verreault, R.2    Lindsay, J.3    MacPherson, K.4    Rockwood, K.5
  • 43
    • 70349256254 scopus 로고    scopus 로고
    • Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies
    • Leem Y.H., Lim H.J., Shim S.B., Cho J.Y., Kim B.S., Han P.L. Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies. J. Neurosci. Res. 2009, 87:2561-2570. 10.1002/jnr.22075.
    • (2009) J. Neurosci. Res. , vol.87 , pp. 2561-2570
    • Leem, Y.H.1    Lim, H.J.2    Shim, S.B.3    Cho, J.Y.4    Kim, B.S.5    Han, P.L.6
  • 44
    • 79955840459 scopus 로고    scopus 로고
    • Applicability and effects of physical exercise on physical and cognitive functions and activities of daily living among people with dementia: a systematic review
    • Littbrand H., Stenvall M., Rosendahl E. Applicability and effects of physical exercise on physical and cognitive functions and activities of daily living among people with dementia: a systematic review. Am. J. Phys. Med. Rehabil. 2011, 90:495-518. 10.1097/PHM.0b013e318214de26.
    • (2011) Am. J. Phys. Med. Rehabil. , vol.90 , pp. 495-518
    • Littbrand, H.1    Stenvall, M.2    Rosendahl, E.3
  • 45
    • 34247269279 scopus 로고    scopus 로고
    • Locomotor exercise alters expression of pro-brain-derived neurotrophic factor, brain-derived neurotrophic factor and its receptor TrkB in the spinal cord of adult rats
    • Macias M., Dwornik A., Ziemlinska E., Fehr S., Schachner M., Czarkowska-Bauch J., Skup M. Locomotor exercise alters expression of pro-brain-derived neurotrophic factor, brain-derived neurotrophic factor and its receptor TrkB in the spinal cord of adult rats. Eur. J. Neurosci. 2007, 25:2425-2444. 10.1111/j.1460-9568.2007.05498.x.
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 2425-2444
    • Macias, M.1    Dwornik, A.2    Ziemlinska, E.3    Fehr, S.4    Schachner, M.5    Czarkowska-Bauch, J.6    Skup, M.7
  • 46
    • 70450195021 scopus 로고
    • Functional evaluation: the Barthel index
    • Mahoney F.I., Barthel D.W. Functional evaluation: the Barthel index. Md State Med. J. 1965, 14:61-65.
    • (1965) Md State Med. J. , vol.14 , pp. 61-65
    • Mahoney, F.I.1    Barthel, D.W.2
  • 47
    • 84931266099 scopus 로고    scopus 로고
    • Combination therapy with cholinesterase inhibitors and memantine for Alzheimer's disease: a systematic review and meta-analysis
    • Matsunaga S., Kishi T., Iwata N. Combination therapy with cholinesterase inhibitors and memantine for Alzheimer's disease: a systematic review and meta-analysis. Int. J. Neuropsychopharmacol. 2015, 18. 10.1093/ijnp/pyu115.
    • (2015) Int. J. Neuropsychopharmacol. , vol.18
    • Matsunaga, S.1    Kishi, T.2    Iwata, N.3
  • 48
    • 84929460429 scopus 로고    scopus 로고
    • Memantine monotherapy for Alzheimer's disease: a systematic review and meta-analysis
    • Matsunaga S., Kishi T., Iwata N. Memantine monotherapy for Alzheimer's disease: a systematic review and meta-analysis. PLoS One 2015, 10:e0123289. 10.1371/journal.pone.0123289.
    • (2015) PLoS One , vol.10 , pp. e0123289
    • Matsunaga, S.1    Kishi, T.2    Iwata, N.3
  • 49
    • 84859851830 scopus 로고    scopus 로고
    • A randomised controlled trial on the effect of exercise on physical: cognitive and affective function in dementia subjects
    • Miu D., Szeto S.L., Mak Y.F. A randomised controlled trial on the effect of exercise on physical: cognitive and affective function in dementia subjects. Asian J. Gerontol. Geriatr. 2008, 3:8-16.
    • (2008) Asian J. Gerontol. Geriatr. , vol.3 , pp. 8-16
    • Miu, D.1    Szeto, S.L.2    Mak, Y.F.3
  • 50
    • 84906638920 scopus 로고    scopus 로고
    • Effect of physical exercise on cognitive performance in older adults with mild cognitive impairment or dementia: a systematic review
    • Öhman H., Savikko N., Strandberg T.E., Pitkälä K.H. Effect of physical exercise on cognitive performance in older adults with mild cognitive impairment or dementia: a systematic review. Dement. Geriatr. Cogn. Disord. 2014, 38:347-365. 10.1159/000365388.
    • (2014) Dement. Geriatr. Cogn. Disord. , vol.38 , pp. 347-365
    • Öhman, H.1    Savikko, N.2    Strandberg, T.E.3    Pitkälä, K.H.4
  • 51
    • 84887190033 scopus 로고    scopus 로고
    • Mapping the clockworks: what does the Clock Drawing Test assess in normal and pathological aging?
    • Paula J.J., Miranda D.M., Moraes E.N., Malloy-Diniz L.F. Mapping the clockworks: what does the Clock Drawing Test assess in normal and pathological aging?. Arq. Neuropsiquiatr. 2013, 71:763-768. 10.1590/0004-282x20130118.
    • (2013) Arq. Neuropsiquiatr. , vol.71 , pp. 763-768
    • Paula, J.J.1    Miranda, D.M.2    Moraes, E.N.3    Malloy-Diniz, L.F.4
  • 52
    • 15744372044 scopus 로고    scopus 로고
    • Physical activity, APOE genotype, and dementia risk: findings from the cardiovascular health cognition study
    • Podewils L.J., Guallar E., Kuller L.H., Fried L.P., Lopez O.L., Carlson M., Lyketsos C.G. Physical activity, APOE genotype, and dementia risk: findings from the cardiovascular health cognition study. Am. J. Epidemiol. 2005, 161:639-651. 10.1093/aje/kwi092.
    • (2005) Am. J. Epidemiol. , vol.161 , pp. 639-651
    • Podewils, L.J.1    Guallar, E.2    Kuller, L.H.3    Fried, L.P.4    Lopez, O.L.5    Carlson, M.6    Lyketsos, C.G.7
  • 53
    • 84872109456 scopus 로고    scopus 로고
    • The global prevalence of dementia: a systematic review and metaanalysis
    • e2
    • Prince M., Bryce R., Albanese E., Wimo A., Ribeiro W., Ferri C.P. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013, 9:63-75. e2. 10.1016/j.jalz.2012.11.007.
    • (2013) Alzheimers Dement. , vol.9 , pp. 63-75
    • Prince, M.1    Bryce, R.2    Albanese, E.3    Wimo, A.4    Ribeiro, W.5    Ferri, C.P.6
  • 55
    • 79952574501 scopus 로고    scopus 로고
    • Epidemiology of Alzheimer disease
    • Reitz C., Brayne C., Mayeux R. Epidemiology of Alzheimer disease. Nat. Rev.Neurol. 2011, 7:137-152. 10.1038/nrneurol.2011.2.
    • (2011) Nat. Rev.Neurol. , vol.7 , pp. 137-152
    • Reitz, C.1    Brayne, C.2    Mayeux, R.3
  • 59
  • 60
    • 34247204182 scopus 로고    scopus 로고
    • Dementia syndromes: evaluation and treatment
    • Scott K.R., Barrett A.M. Dementia syndromes: evaluation and treatment. Expert Rev. Neurother. 2007, 7:407-422. 10.1586/14737175.7.4.407.
    • (2007) Expert Rev. Neurother. , vol.7 , pp. 407-422
    • Scott, K.R.1    Barrett, A.M.2
  • 61
    • 78650213509 scopus 로고    scopus 로고
    • Physical activity and risk of cognitive decline: a meta-analysis of prospective studies
    • Sofi F., Valecchi D., Bacci D., Abbate R., Gensini G.F., Casini A., Macchi C. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J. Intern. Med. 2011, 269:107-117. 10.1111/j.1365-2796.2010.02281.x.
    • (2011) J. Intern. Med. , vol.269 , pp. 107-117
    • Sofi, F.1    Valecchi, D.2    Bacci, D.3    Abbate, R.4    Gensini, G.F.5    Casini, A.6    Macchi, C.7
  • 62
    • 0025897239 scopus 로고
    • A new behavioral assessment scale for geriatric out- and in-patients: the NOSGER (Nurses' observation scale for geriatric patients)
    • Spiegel R., Brunner C., Ermini-Fünfschilling D., Monsch A., Notter M., Puxty J., Tremmel L. A new behavioral assessment scale for geriatric out- and in-patients: the NOSGER (Nurses' observation scale for geriatric patients). J. Am. Geriatr. Soc. 1991, 39:339-347. 10.1111/j1532-5415.1991.tb02897.x.
    • (1991) J. Am. Geriatr. Soc. , vol.39 , pp. 339-347
    • Spiegel, R.1    Brunner, C.2    Ermini-Fünfschilling, D.3    Monsch, A.4    Notter, M.5    Puxty, J.6    Tremmel, L.7
  • 63
    • 67649344641 scopus 로고    scopus 로고
    • Evaluation of a home-based exercise program in the treatment of Alzheimer's disease: the Maximizing independence in dementia (MIND) study
    • Steinberg M., Leoutsakos J.-M.S.M., Podewils L.J., Lyketsos C.G. Evaluation of a home-based exercise program in the treatment of Alzheimer's disease: the Maximizing independence in dementia (MIND) study. Int. J. Geriatr. Psychiatry 2009, 24:680-685. 10.1002/gps.2175.
    • (2009) Int. J. Geriatr. Psychiatry , vol.24 , pp. 680-685
    • Steinberg, M.1    Leoutsakos, J.-M.S.M.2    Podewils, L.J.3    Lyketsos, C.G.4
  • 65
    • 33646822502 scopus 로고    scopus 로고
    • A randomised controlled trial testing the impact of exercise on cognitive symptoms and disability of residents with dementia
    • Stevens J., Killeen M. A randomised controlled trial testing the impact of exercise on cognitive symptoms and disability of residents with dementia. Contemp. Nurse 2006, 21:32-40. 10.5555/conu.2006.21.1.32.
    • (2006) Contemp. Nurse , vol.21 , pp. 32-40
    • Stevens, J.1    Killeen, M.2
  • 69
    • 2342442488 scopus 로고    scopus 로고
    • Cognitive and behavioural effects of music-based exercises in patients with dementia
    • Van de Winckel A., Feys H., De Weerdt W., Dom R. Cognitive and behavioural effects of music-based exercises in patients with dementia. Clin. Rehabil. 2004, 18:253-260. 10.1191/0269215504cr750oa.
    • (2004) Clin. Rehabil. , vol.18 , pp. 253-260
    • Van de Winckel, A.1    Feys, H.2    De Weerdt, W.3    Dom, R.4
  • 71
    • 0034576650 scopus 로고    scopus 로고
    • Neural consequences of environmental enrichment
    • Van Praag H., Kempermann G., Gage F.H. Neural consequences of environmental enrichment. Nat Rev Neurosci 2000, 1:191-198. 10.1038/35044558.
    • (2000) Nat Rev Neurosci , vol.1 , pp. 191-198
    • Van Praag, H.1    Kempermann, G.2    Gage, F.H.3
  • 72
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • Van Praag H., Shubert T., Zhao C., Gage F.H. Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 2005, 25:8680-8685. 10.1523/JNEUROSCI.1731-05.2005.
    • (2005) J. Neurosci. , vol.25 , pp. 8680-8685
    • Van Praag, H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.4
  • 73
    • 0242653760 scopus 로고    scopus 로고
    • Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity
    • Vaynman S., Ying Z., Gomez-Pinilla F. Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience 2003, 122:647-657.
    • (2003) Neuroscience , vol.122 , pp. 647-657
    • Vaynman, S.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 74
    • 80054905928 scopus 로고    scopus 로고
    • Six-month walking program changes cognitive and ADL performance in patients with Alzheimer
    • Venturelli M., Scarsini R., Schena F. Six-month walking program changes cognitive and ADL performance in patients with Alzheimer. Am. J. Alzheimers Dis. Other Demen. 2011, 26:381-388. 10.1177/1533317511418956.
    • (2011) Am. J. Alzheimers Dis. Other Demen. , vol.26 , pp. 381-388
    • Venturelli, M.1    Scarsini, R.2    Schena, F.3
  • 75
    • 84857051992 scopus 로고    scopus 로고
    • A community-based exercise programme to improve functional ability in people with Alzheimer's disease: a randomized controlled trial
    • Vreugdenhil A., Cannell J., Davies A., Razay G. A community-based exercise programme to improve functional ability in people with Alzheimer's disease: a randomized controlled trial. Scand. J. Caring Sci. 2012, 26:12-19. 10.1111/j 1471-6712.2011.00895.x.
    • (2012) Scand. J. Caring Sci. , vol.26 , pp. 12-19
    • Vreugdenhil, A.1    Cannell, J.2    Davies, A.3    Razay, G.4
  • 77
    • 84866290209 scopus 로고    scopus 로고
    • Dementia: a global health priority-highlights from an ADI and World Health Organization report
    • Wortmann M. Dementia: a global health priority-highlights from an ADI and World Health Organization report. Alzheimers Res. Ther. 2012, 4:40. 10.1186/alzrt143.
    • (2012) Alzheimers Res. Ther. , vol.4 , pp. 40
    • Wortmann, M.1
  • 78
    • 0034922575 scopus 로고    scopus 로고
    • A prospective study of physical activity and cognitive decline in elderly women: women who walk
    • Yaffe K., Barnes D., Nevitt M., Lui L.Y., Covinsky K. A prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch. Intern. Med. 2001, 161:1703-1708.
    • (2001) Arch. Intern. Med. , vol.161 , pp. 1703-1708
    • Yaffe, K.1    Barnes, D.2    Nevitt, M.3    Lui, L.Y.4    Covinsky, K.5
  • 79
    • 78651447848 scopus 로고    scopus 로고
    • The effects on cognitive functions of a movement-based intervention in patients with Alzheimer's type dementia: a pilot study
    • Yágüez L., Shaw K.N., Morris R., Matthews D. The effects on cognitive functions of a movement-based intervention in patients with Alzheimer's type dementia: a pilot study. Int. J. Geriatr. Psychiatry 2011, 26:173-181. 10.1002/gps.2510.
    • (2011) Int. J. Geriatr. Psychiatry , vol.26 , pp. 173-181
    • Yágüez, L.1    Shaw, K.N.2    Morris, R.3    Matthews, D.4
  • 80
    • 68149150846 scopus 로고    scopus 로고
    • Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease
    • Yuede C.M., Zimmerman S.D., Dong H., Kling M.J., Bero A.W., Holtzman D.M., Timson B.F., Csernansky J.G. Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease. Neurobiol. Dis. 2009, 35:426-432. 10.1016/j.nbd.2009.06.002.
    • (2009) Neurobiol. Dis. , vol.35 , pp. 426-432
    • Yuede, C.M.1    Zimmerman, S.D.2    Dong, H.3    Kling, M.J.4    Bero, A.W.5    Holtzman, D.M.6    Timson, B.F.7    Csernansky, J.G.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.