Efficacy and safety of rosuvastatin therapy in children and adolescents with familial hypercholesterolemia: Results from the CHARON study

Journal of Clinical Lipidology

Volumn 9, Issue 6, 2015, Pages 741-750

  Braamskamp, Marjet J A M ^a   Langslet, Gisle ^b   McCrindle, Brian W ^c   Cassiman, David ^d   Francis, Gordon A ^e   Gagné, Claude ^f   Gaudet, Daniel ^g   Morrison, Katherine M ^h   Wiegman, Albert ^a   Turner, Traci ⁱ   Kusters, D Meeike ^a   Miller, Elinor ^j   Raichlen, Joel S ^j   Wissmar, Jenny ^k   Martin, Paul D ^j   Stein, Evan A ⁱ   Kastelein, John J P ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f Clinique des Maladies Lipidiques de Quebec Incorporated   (Canada)

^g UNIVERSITÉ DE MONTRÉAL   (Canada)

^h MCMASTER UNIVERSITY   (Canada)

ⁱ Metab and Atherosclerosis Res Ctr   (United States)

^j ASTRAZENECA   (United Kingdom)

^k ASTRAZENECA R AND D   (Sweden)

more..

Author keywords

Children; Heterozygous familial hypercholesterolemia; Low density lipoprotein cholesterol; Rosuvastatin; Safety; Tolerability

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; ROSUVASTATIN;

ADOLESCENT; BLOOD; CHILD; CLINICAL TRIAL; FEMALE; HUMAN; HYPERLIPOPROTEINEMIA TYPE II; MALE; SAFETY; TREATMENT OUTCOME;

ADOLESCENT; CHILD; CHOLESTEROL, LDL; FEMALE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; MALE; ROSUVASTATIN CALCIUM; SAFETY; TREATMENT OUTCOME;

EID: 84949731297     PISSN: 19332874     EISSN: 18764789     Source Type: Journal    
DOI: 10.1016/j.jacl.2015.07.011     Document Type: Article

References (21)

1. J. Goldstein, and M. Brown Familial hypercholesterolaemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol Proc Natl Acad Sci U S A 70 1973 2804 2808
2. B.G. Nordestgaard, M.J. Chapman, S.E. Humphries, et al. European Atherosclerosis Society Consensus Panel Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease. Consensus statement of the European Atherosclerosis Society Eur Heart J 34 2013 3478 3490
3. B. Sjouke, D.M. Kusters, I. Kindt, and et al. Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome Eur Heart J 1 2015 560 565
4. D. Marks, M. Thorogood, H. Neil, and S. Humphries A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia Atherosclerosis 168 2003 1 14
5. A. Neil, J. Cooper, J. Betteridge, and et al. Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study Eur Heart J 29 2008 2625 2633
6. A. Wiegman, B.A. Hutten, E. de Groot, and et al. Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial JAMA 292 2004 331 337
7. M. Kusters, B. Hutten, B. McCrindle, and et al. Design and baseline data of a paediatric study with rosuvastatin in familial hypercholesterolaemia J Clin Lipidol 7 2013 408 413
8. National Heart, Lung and Blood Institute Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: summary report Pediatrics 128 2011 S213 S256
9. A. Wiegman, S.S. Gidding, G.F. Watts, and et al. European Atherosclerosis Society Consensus Panel. Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment Eur Heart J 36 2015 2425 2437
10. Cholesterol Treatment Trialists' (CTT) Collaboration Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials Lancet 376 2010 1670 1681
11. H. Avis, M. Vissers, E. Stein, and et al. A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia Arterioscler Thromb Vasc Biol 27 2007 1803 1810
12. A. Vuorio, J. Kuoppala, P.T. Kovanen, and et al. Statins for children with familial hypercholesterolemia Cochrane Database Syst Rev 7 2014 CD006401
13. H. Avis, B. Hutten, C. Gagné, and et al. Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia J Am Coll Cardiol 55 2010 1121 1126
14. W. Friedewald, R. Levy, and D. Frederickson Estimation of concentration of low-density lipoprotein cholesterol in plasma, without the use of the preparative ultracentrifuge Clin Chem 18 1972 499 502
15. P. Couture, L.D. Brun, F. Szots, and et al. Association of specific LDL receptor gene mutations with differential plasma lipoprotein response to simvastatin in young French Canadians with heterozygous familial hypercholesterolemia Arterioscler Thromb Vasc Biol 18 1998 1007 1012
16. S. Bertrais, B. Balkau, M.A. Charles, and et al. Puberty-associated differences in total cholesterol and triglyceride levels according to sex in French children aged 10-13 years Ann Epidemiol 10 2000 316 323
17. G.S. Berenson, S.R. Srinivasan, J.L. Cresanta, T.A. Foster, and L.S. Webber Dynamic changes of serum lipoproteins in children during adolescence and sexual maturation Am J Epidemiol 113 1981 157 170
18. E. Stein, K. Strutt, H. Southworth, P.J. Diggle, E. Miller for the HeFH Study Group Comparison of rosuvastatin versus atorvastatin in patients with heterozygous familial hypercholesterolemia Am J Cardiol 92 2003 1287 1293
19. B. McCrindle, L. Ose, and D. Marais Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicentre, randomized, placebo-controlled trial J Pediatr 142 2003 74 80
20. S. de Jongh, L. Ose, T. Szamosi, et al. Simvastatin in Children Study Group Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized, double-blind, placebo-controlled trial with simvastatin Circulation 106 2002 2231 2237
21. J. Rodenburg, M.N. Vissers, A. Wiegman, and et al. Statin treatment in children with familial hypercholesterolemia: the younger, the better Circulation 116 2007 664 668