Efficacy and safety of statin therapy in children with familial hypercholesterolemia: A randomized, double-blind, placebo-controlled trial with simvastatin

Circulation

Volumn 106, Issue 17, 2002, Pages 2231-2237

  De Jongh, Saskia ^a   Ose, Leiv ^a   Szamosi, Tamás ^a   Gagné, Claude ^a   Lambert, M ^a   Scott, Russell ^a   Perron, P ^a   Dobbelaere, Dries ^a   Saborio, M ^a   Tuohy, Mary B ^a   Stepanavage, Michael ^a   Sapre, Aditi ^a   Gumbiner, Barry ^a   Mercuri, Michele ^a   Van Trotsenburg, A S Paul ^a   Bakker, Henk D ^a   Kastelein, John J P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Cholesterol; Drugs; Hypercholesterolemia; Lipids; Pediatrics

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOPHYSIS HORMONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; PRASTERONE SULFATE; SIMVASTATIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ABDOMINAL PAIN; ADOLESCENT; ARTICLE; CHILD; CHILD GROWTH; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; FLATULENCE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MYALGIA; PRIORITY JOURNAL; PRURITUS; PUBERTY; RANDOMIZED CONTROLLED TRIAL; SLEEP DISORDER; THORAX PAIN; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ADOLESCENT; BODY HEIGHT; BODY MASS INDEX; CHILD; DOUBLE-BLIND METHOD; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERLIPOPROTEINEMIA TYPE II; LIPIDS; LIPOPROTEINS; SEXUAL MATURATION; SIMVASTATIN;

EID: 0037159259     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000035247.42888.82     Document Type: Article

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