New in vitro insights on a cell death pathway induced by magnolol and honokiol in aristolochic acid tubulotoxicity

Food and Chemical Toxicology

Volumn 87, Issue , 2016, Pages 77-87

  Bunel, Valérian ^a   Antoine, Marie Hélène ^a   Stévigny, Caroline ^a   Nortier, Joëlle ^a   Duez, Pierre ^a,b  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF MONS   (Belgium)

Author keywords

Aristolochic acids; Cell cycle; Cell death; Honokiol; Magnolol; Nephrotoxicity

Indexed keywords

ANNEXIN; ARISTOLOCHIC ACID; DNA; HONOKIOL; KI 67 ANTIGEN; LIGNAN; MAGNOLOL; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TROLOX C; 1,1-DIPHENYL-2-PICRYLHYDRAZYL; ARISTOLOCHIC ACID I; BIPHENYL DERIVATIVE; PICRIC ACID; SCAVENGER;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARISTOLOCHIA; ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL MEMBRANE; CELL PROLIFERATION; CELL PROTECTION; CELL SHAPE; CELL SIZE; CELL SURVIVAL; CELL VACUOLE; CELL VIABILITY; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA DEGRADATION; FLOW CYTOMETRY; HOMEOSTASIS; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MAGNOLIA OFFICINALIS; NEPHROTOXICITY; OXIDATIVE STRESS; SENESCENCE; STRUCTURE ANALYSIS; TUBULOTOXICITY; CELL CYCLE; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; KIDNEY TUBULE;

ARISTOLOCHIC ACIDS; BIPHENYL COMPOUNDS; CELL CYCLE; CELL LINE; FREE RADICAL SCAVENGERS; HUMANS; KIDNEY TUBULES; LIGNANS; MOLECULAR STRUCTURE; OXIDATIVE STRESS; PICRATES;

EID: 84949669909     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2015.11.020     Document Type: Article

References (33)

1. Acosta J.C., Gil J. Senescence: a new weapon for cancer therapy. Trends Cell. Biol. 2012, 22:211-219.
2. Bunel V., Antoine M.H., Nortier J., Duez P., Stevigny C. Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro. J. Appl. Toxicol. 2014, 34:1311-1319.
3. Bunel V., Antoine M.-H., Nortier J., Duez P., Stevigny C. Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro. Toxicol In Vitro 2015, 29:458-467.
4. Bunel V., Ouedraogo M., Nguyen A.T., Stévigny C., Duez P. Methods applied to the in vitro primary toxicology testing of natural products: state of the art, strengths, and limits. Planta Med. 2014, 80:1210-1226.
5. Debacq-Chainiaux F., Erusalimsky J.D., Campisi J., Toussaint O. Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo. Nat. Protoc. 2009, 4:1798-1806.
6. Debelle F.D., Vanherweghem J.L., Nortier J.L. Aristolochic acid nephropathy: a worldwide problem. Kidney Int. 2008, 74:158-169.
7. Edinger A.L., Thompson C.B. Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell. Biol. 2004, 16:663-669.
8. Galluzzi L., Vitale I., Abrams J.M., Alnemri E.S., Baehrecke E.H., Blagosklonny M.V., Dawson T.M., Dawson V.L., El-Deiry W.S., Fulda S., Gottlieb E., Green D.R., Hengartner M.O., Kepp O., Knight R.A., Kumar S., Lipton S.A., Lu X., Madeo F., Malorni W., Mehlen P., Nunez G., Peter M.E., Piacentini M., Rubinsztein D.C., Shi Y., Simon H.U., Vandenabeele P., White E., Yuan J., Zhivotovsky B., Melino G., Kroemer G. Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death 2012. Cell. Death Differ. 2012, 19:107-120.
9. Galluzzi L., Vitale I., Vacchelli E., Kroemer G. Cell death signaling and anticancer therapy. Front. Oncol. 2011, 1:5.
10. Grollman A.P., Shibutani S., Moriya M., Miller F., Wu L., Moll U., Suzuki N., Fernandes A., Rosenquist T., Medverec Z., Jakovina K., Brdar B., Slade N., Turesky R.J., Goodenough A.K., Rieger R., Vukelic M., Jelakovic B. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:12129-12134.
11. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell. Res. 1965, 37:614-636.
12. Heinrich M., Chan J., Wanke S., Neinhuis C., Simmonds M.S. Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2-A global assessment based on bibliographic sources. J. Ethnopharmacol. 2009, 125:108-144.
13. Kaczmarek A., Vandenabeele P., Krysko D.V. Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 2013, 38:209-223.
14. Liu Q., Wang Q., Yang X., Shen X., Zhang B. Differential cytotoxic effects of denitroaristolochic acid II and aristolochic acids on renal epithelial cells. Toxicol. Lett. 2009, 184:5-12.
15. Michl J., Ingrouille M.J., Simmonds M.S., Heinrich M. Naturally occurring aristolochic acid analogues and their toxicities. Nat. Prod. Rep. 2014, 31:676-693.
16. Michl J., Jennings H.M., Kite G.C., Ingrouille M.J., Simmonds M.S.J., Heinrich M. Is aristolochic acid nephropathy a widespread problem in developing countries? A case study of Aristolochia indica L. in Bangladesh using an ethnobotanical-phytochemical approach. J. Ethnopharmacol. 2013, 149:235-244.
17. Moriya M., Slade N., Brdar B., Medverec Z., Tomic K., Jelakovic B., Wu L., Truong S., Fernandes A., Grollman A.P. TP53 mutational signature for aristolochic acid: an environmental carcinogen. Int. J. Cancer 2011, 129:1532-1536.
18. Nortier J.L., Martinez M.C., Schmeiser H.H., Arlt V.M., Bieler C.A., Petein M., Depierreux M.F., De Pauw L., Abramowicz D., Vereerstraeten P., Vanherweghem J.L. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N. Engl. J. Med. 2000, 342:1686-1692.
19. Nunez R. DNA measurement and cell cycle analysis by flow cytometry. Curr. Iss. Mol. Biol. 2001, 3:67-70.
20. Pozdzik A.A., Salmon I.J., Debelle F.D., Decaestecker C., Van den Branden C., Verbeelen D., Deschodt-Lanckman M.M., Vanherweghem J.L., Nortier J.L. Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation. Kidney Int. 2008, 73:595-607.
21. Rodriguez-Rocha H., Garcia-Garcia A., Panayiotidis M.I., Franco R. DNA damage and autophagy. Mutat. Res./Fundam. Mol. Mech. Mutagen. 2011, 711:158-166.
22. Ryan M.J., Johnson G., Kirk J., Fuerstenberg S.M., Zager R.A., Torok-Storb B. HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int. 1994, 45:48-57.
23. Schmitt C.A. Cellular senescence and cancer treatment. Biochim. Biophys. Acta (BBA) - Rev. Cancer 2007, 1775:5-20.
24. Scholzen T., Gerdes J. The Ki-67 protein: from the known and the unknown. J. Cell. Physiol. 2000, 182:311-322.
25. Singh T., Gupta N.A., Xu S., Prasad R., Velu S.E., Katiyar S.K. Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor. Oncotarget 2015, 6:21268-21282.
26. Valcu M., Valcu C.M. Data transformation practices in biomedical sciences. Nat. Methods 2011, 8:104-105.
27. Vanherweghem J.L., Depierreux M., Tielemans C., Abramowicz D., Dratwa M., Jadoul M., Richard C., Vandervelde D., Verbeelen D., Vanhaelen-Fastre R., et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 1993, 341:387-391.
28. Vermes I., Haanen C., Steffens-Nakken H., Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 1995, 184:39-51.
29. Wu K.M., Farrelly J.G., Upton R., Chen J. Complexities of the herbal nomenclature system in traditional Chinese medicine (TCM): lessons learned from the misuse of Aristolochia-related species and the importance of the pharmaceutical name during botanical drug product development. Phytomedicine 2007, 14:273-279.
30. Yamani A., Bunel V., Antoine M.-H., Husson C., Stévigny C., Duez P., Elachouri M., Nortier J. Substitution between aristolochia and Bryonia genus in north-eastern Morocco: toxicological implications. J. Ethnopharmacol. 2015, 26:250-260. [Early online].
31. Yu F.Y., Wu T.S., Chen T.W., Liu B.H. Aristolochic acid I induced oxidative DNA damage associated with glutathione depletion and ERK1/2 activation in human cells. Toxicol Vitro 2011, 25:810-816.
32. Zhao C., Liu Z.Q. Comparison of antioxidant abilities of magnolol and honokiol to scavenge radicals and to protect DNA. Biochimie 2011, 93:1755-1760.
33. Zhou J., Ouedraogo M., Qu F., Duez P. Potential genotoxicity of traditional Chinese medicinal plants and phytochemicals: an overview. Phytother. Res. 2013, 27:1745-1755.