Could 5-Fluorouracil or Triamcinolone Be an Effective Treatment Option for Keloid after Surgical Excision? A Meta-Analysis

Journal of Oral and Maxillofacial Surgery

Volumn 74, Issue 5, 2016, Pages 1055-1060

  Shin, Jin Yong ^a   Kim, Jong Seung ^a  

^a Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; TRIAMCINOLONE; ANTIMETABOLITE; GLUCOCORTICOID;

ADJUVANT THERAPY; ARTICLE; CLINICAL EFFECTIVENESS; DRUG EFFICACY; DRUG TREATMENT FAILURE; EXCISION; HUMAN; KELOID; META ANALYSIS; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENT DISEASE; RISK ASSESSMENT; RISK FACTOR; SYSTEMATIC REVIEW; TREATMENT RESPONSE; TREATMENT OUTCOME;

ANTIMETABOLITES; FLUOROURACIL; GLUCOCORTICOIDS; HUMANS; KELOID; TREATMENT OUTCOME; TRIAMCINOLONE;

EID: 84949669878     PISSN: 02782391     EISSN: 15315053     Source Type: Journal    
DOI: 10.1016/j.joms.2015.10.002     Document Type: Article

References (39)

1. S. Meaume, A. Le Pillouer-Prost, B. Richert, and et al. Management of scars: Updated practical guidelines and use of silicones Eur J Dermatol 24 2014 435
2. B.S. Atiyeh, M. Costagliola, and S.N. Hayek Keloid or hypertrophic scar: The controversy: Review of the literature Ann Plast Surg 54 2005 676
3. G. Szulgit, R. Rudolph, A. Wandel, and et al. Alterations in fibroblast alpha1beta1 integrin collagen receptor expression in keloids and hypertrophic scars J Invest Dermatol 118 2002 409
4. A. Bayat, D.A. McGrouther, and M.W. Ferguson Skin scarring BMJ 326 2003 88
5. J.A. Ledon, J. Savas, K. Franca, and et al. Intralesional treatment for keloids and hypertrophic scars: A review Dermatol Surg 39 2013 1745
6. A.J. Nemeth Keloids and hypertrophic scars J Dermatol Surg Oncol 19 1993 738
7. B. Cosman, and M. Wolff Correlation of keloid recurrence with completeness of local excision. A negative report Plast Reconstr Surg 50 1972 163
8. M. Willett, K. Handfield, and J. Marquart Multimodal keloid therapy with excision, application of mitomycin C, and radiotherapy Dermatol Surg 40 2014 480
9. A.M. Wilson Eradication of keloids: Surgical excision followed by a single injection of intralesional 5-fluorouracil and botulinum toxin Can J Plast Surg 21 2013 87
10. J.C. Flickinger A radiobiological analysis of multicenter data for postoperative keloid radiotherapy Int J Radiat Oncol Biol Phys 79 2011 1164
11. R. Ragoowansi, P.G. Cornes, J.P. Glees, and et al. Ear-lobe keloids: Treatment by a protocol of surgical excision and immediate postoperative adjuvant radiotherapy Br J Plast Surg 54 2001 504
12. D.I. Klumpar, J.C. Murray, and M. Anscher Keloids treated with excision followed by radiation therapy J Am Acad Dermatol 31 1994 225
13. T.H. Park, and C.H. Chang Early postoperative magnet application combined with hydrocolloid dressing for the treatment of earlobe keloids Aesthetic Plast Surg 37 2013 439
14. D.J. Rosen, M.K. Patel, K. Freeman, and et al. A primary protocol for the management of ear keloids: Results of excision combined with intraoperative and postoperative steroid injections Plast Reconstr Surg 120 2007 1395
15. P. Donkor Head and neck keloid: Treatment by core excision and delayed intralesional injection of steroid J Oral Maxillofac Surg 65 2007 1292
16. A.P. Sclafani, L. Gordon, M. Chadha, and et al. Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: A randomized, prospective study and review of the literature Dermatol Surg 22 1996 569
17. A. Liberati, D.G. Altman, J. Tetzlaff, and et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration Ann Intern Med 151 2009 W65
18. N. Khare, and S.B. Patil A novel approach for management of ear keloids: Results of excision combined with 5-fluorouracil injection J Plast Reconstr Aesthet Surg 65 2012 e315
19. B. Berman, and F. Flores Recurrence rates of excised keloids treated with postoperative triamcinolone acetonide injections or interferon alfa-2b injections J Am Acad Dermatol 37 1997 755
20. S.P. Davison, S. Mess, L.C. Kauffman, and et al. Ineffective treatment of keloids with interferon alpha-2b Plast Reconstr Surg 117 2006 247
21. E. Hatamipour, S. Mehrabi, M. Hatamipour, and et al. Effects of combined intralesional 5-fluorouracil and topical silicone in prevention of keloids: A double blind randomized clinical trial study Acta Med Iran 49 2011 127
22. M. Egger, G. Davey Smith, M. Schneider, and et al. Bias in meta-analysis detected by a simple, graphical test BMJ 315 1997 629
23. Y.W. Tang Intra- and postoperative steroid injections for keloids and hypertrophic scars Br J Plast Surg 45 1992 371
24. S.J. Xu, J.Y. Teng, J. Xie, and et al. Comparison of the mechanisms of intralesional steroid, interferon or verapamil injection in the treatment of proliferative scars Chin J Plast Surg 25 2009 37 (in Chinese)
25. T.H. Park, S.W. Seo, J.K. Kim, and et al. Clinical characteristics of facial keloids treated with surgical excision followed by intra- and postoperative intralesional steroid injections Aesthetic Plast Surg 36 2012 169
26. N.A. Chowdri, M. Masarat, A. Mattoo, and et al. Keloids and hypertrophic scars: Results with intraoperative and serial postoperative corticosteroid injection therapy Aust N Z J Surg 69 1999 655
27. A.R. Shons, and B.H. Press The treatment of earlobe keloids by surgical excision and postoperative triamcinolone injection Ann Plast Surg 10 1983 480
28. T.A. Mustoe, R.D. Cooter, M.H. Gold, and et al. International clinical recommendations on scar management Plast Reconstr Surg 110 2002 560
29. F.B. Niessen, P.H. Spauwen, J. Schalkwijk, and et al. On the nature of hypertrophic scars and keloids: A review Plast Reconstr Surg 104 1999 1435
30. T. Hayashi, H. Furukawa, A. Oyama, and et al. A new uniform protocol of combined corticosteroid injections and ointment application reduces recurrence rates after surgical keloid/hypertrophic scar excision Dermatol Surg 38 2012 893
31. J.W. de Waard, B.M. de Man, T. Wobbes, and et al. Inhibition of fibroblast collagen synthesis and proliferation by levamisole and 5-fluorouracil Eur J Cancer 34 1998 162
32. A. Al-Attar, S. Mess, J.M. Thomassen, and et al. Keloid pathogenesis and treatment Plast Reconstr Surg 117 2006 286
33. G. Kontochristopoulos, C. Stefanaki, A. Panagiotopoulos, and et al. Intralesional 5-fluorouracil in the treatment of keloids: An open clinical and histopathologic study J Am Acad Dermatol 52 2005 474
34. A. Sadeghinia, and S. Sadeghinia Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids Dermatol Surg 38 2012 104
35. M. Apikian, and G. Goodman Intralesional 5-fluorouracil in the treatment of keloid scars Australas J Dermatol 45 2004 140
36. S.P. Davison, J.H. Dayan, M.W. Clemens, and et al. Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids Aesthetic Surg J 29 2009 40
37. W. Manuskiatti, and R.E. Fitzpatrick Treatment response of keloidal and hypertrophic sternotomy scars: Comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments Arch Dermatol 138 2002 1149
38. S. Sharma, A. Bhanot, A. Kaur, and et al. Role of liquid nitrogen alone compared with combination of liquid nitrogen and intralesional triamcinolone acetonide in treatment of small keloids J Cosmet Dermatol 6 2007 258
39. M.J. Haurani, K. Foreman, J.J. Yang, and et al. 5-Fluorouracil treatment of problematic scars Plast Reconstr Surg 123 2009 139