Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids

Dermatologic Surgery

Volumn 38, Issue 1, 2012, Pages 104-109

  Sadeghinia, Ali ^a   Sadeghinia, Saeed ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; TRIAMCINOLONE ACETONIDE;

ABSENCE OF SIDE EFFECTS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; HUMAN; KELOID; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TATTOOING; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; ADULT; DOUBLE-BLIND METHOD; FLUOROURACIL; HUMANS; INJECTIONS, INTRALESIONAL; KELOID; MIDDLE AGED; TREATMENT OUTCOME; TRIAMCINOLONE ACETONIDE;

EID: 84855559796     PISSN: 10760512     EISSN: 15244725     Source Type: Journal    
DOI: 10.1111/j.1524-4725.2011.02137.x     Document Type: Article

References (31)

1. Cosman B, Crikelair G, Ju DMC, Gaulin JC, et al. The surgical treatment of keloidal scars. Plast Reconstr Surg 1961; 27: 335-58.
2. English RS, Shenefelt PD. Keloids and hypertrophic scars. Dermatol Surg 1999;25:631-8. (Pubitemid 29383470)
3. Stegman SJ, Tromovitch TA, Glogau RG. Treatment of keloids. In: Stegman SJ, editor. Cosmetic dermatologic surgery (2nd ed). Chicago: Year Book Medical; 1990. pp. 201-6.
4. Stucker FJ, Shaw GY. An approach to management of keloids. Arch Otolaryngol Head Neck Sur 1992;118:63-7.
5. Manuskiatti W, Fitzpatrick RE, Goldman MP. Energy density and numbers of treatment affect response of keloidal and hypertrophic sternotomy scars to the 585-nm flashlamppumped pulsed-dye laser. J Am Acad Dermato 2001;45:557-65. (Pubitemid 32917251)
6. Ragoowansi R, Cornes PGS, Glees JP, et al. Ear-lobe keloids: treatment by a protocol of surgical excision and immediate postoperative adjuvant radiotherapy. Br J Plast Surg 2001;54:504-8. (Pubitemid 32851236)
7. Brent B. The role of pressure therapy in management of earlobe keloids: preliminary report of a controlled study. Ann Plast Sur 1978;1:579-81. (Pubitemid 9084011)
8. Layton AM, Yip J, Cunliffe WJ. A comparison of intralesional triamcinolone and cryosurgery in the treatment of acne keloids. Br J Dermatol 1994;130:498-501. (Pubitemid 24204671)
9. Mustoe TA, Cooter RD, Gold MH, et al. International clinical recommendations on scar management. Plast Reconstr Surg 2002;110:560-71. (Pubitemid 34815962)
10. Conejo-Mir JS, Corbi R, Linares R. Carbon dioxide laser ablation associated with interferon alfa-2b injection reduces the recurrence of keloids. J Am Acad Dermatol 1998, 39:1039-40. (Pubitemid 28547751)
11. Uppal RS, Khan U, Kakar S, et al. The effects of a single dose of 5-fluorouracil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision. Plast Reconstr Surg 2001;108:1218-24. (Pubitemid 32953059)
12. Beranak JT. Silicone gel sheeting for the management of hypertrophic and keloids scars: the mechanism of its action. Dermatol Sur 1997;23:401-5.
13. Alster TS, Tanzi EL. Hypertrophic scars and keloids: etiology and management. Am J Clin Dermatol 2003;4:235-43. (Pubitemid 36506429)
14. Lee Y, Minn KW, Baek RM, Hong JJ. A new surgical treatment of keloid: keloid core excision. Ann Plast Sur 2001;46:135-40. (Pubitemid 32147323)
15. Lawrence WT. Treatment of earlobe keloids with surgery plus adjuvant intralesional verapamil and pressure earrings. Ann Plast Sur 1996;37:167-9. (Pubitemid 126424085)
16. Converse JM, Stallings JO. Eradication of large auricular keloids by excision, skin grafting, and intradermal injection of triamcinolone acetonide solution. Case report. Plast Reconstr Sur 1972;49:461-3.
17. Hatoko M, Kuwahara M, Shiba A, et al. Earlobe reconstruction using a subcutaneous island pedicle flap after resection of "earlobe keloid". Dermatol Surg 1998;24:257-61. (Pubitemid 28134559)
18. Tuan T, Nichter LS. The molecular basis of keloid and hypertrophic scar formation. Mol Med Toda 1998;4:19-24. (Pubitemid 28124795)
19. Manuskiatti W, Fitzpatrick RE. Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 2002;138:1149-55. (Pubitemid 35025686)
20. Apikian M, Goodman G. Intralesional 5-fluorouracil in the treatment of keloid scars. Australas J Dermatol 2004;45:140-3. (Pubitemid 38607932)
21. Gupta S, Kalra A. Efficacy and safety of intralesional 5-fluorouracil in the treatment of keloids. Dermatology 2002;204:130-2. (Pubitemid 34297977)
22. Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, et al. Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study. J Am Acad Dermatol 2005;52:474-9.
23. Nanda S, Reddy BS. Intralesional 5-fluorouracil as a treatment modality of keloids. Dermatol Sur 2004;30:54-7. (Pubitemid 38174030)
24. Reed BR, Clark RA. Cutaneous tissue repair: practical implications of current knowledge, II. J Am Acad Dermato 1985;13:919-41. (Pubitemid 16070102)
25. Asilian A, Darougheh A, Shariati F. New combination of triamcinolone, 5- fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg 2006;32:907-15. (Pubitemid 44034368)
26. Koc E, Arca E, Surucu B, Kurumlu Z. An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids. Dermatol Sur 2008;34:1507-14.
27. Fitzpatrick RE. Treatment of inflamed hypertrophic scars using intralesional 5FU. Dermatol Sur 1999;25:224-32. (Pubitemid 29146991)
28. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Me 1999;341:738-46. (Pubitemid 29407375)
29. Ghoshal K, Jacob ST. An alternative molecular mechanism of action of 5-fluoruracil, a potent anti-cancer drug. Biochem Pharmacol 1997;53:1569-75. (Pubitemid 27356085)
30. Blumenkranz MS, Claflin A, Hajek AS. Selection of the therapeutic agents for intra-ocular proliferative disease: cell culture evaluation. Arch Ophthalmol 1984; 102: 598-604. (Pubitemid 14127857)
31. Davison SP, Dayan JH, Clemens MW, et al. Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids. Aesthet Surg J 2009;29:40-6.