Arctigenin reduces blood pressure by modulation of nitric oxide synthase and NADPH oxidase expression in spontaneously hypertensive rats

Biochemical and Biophysical Research Communications

Volumn 468, Issue 4, 2015, Pages 837-842

  Liu, Ying ^a   Wang, Guoyuan ^a   Yang, Mingguang ^a   Chen, Haining ^a   Zhao, Yan ^a   Yang, Shucai ^a   Sun, Changhao ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Arctigenin; Endothelial nitric oxide synthase; NADPH oxidase; Spontaneously hypertensive rats

Indexed keywords

ARCTIGENIN; CAVEOLIN 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NIFEDIPINE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; THROMBOXANE B2; ANTIHYPERTENSIVE AGENT; FURAN DERIVATIVE; LIGNAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENZYME PHOSPHORYLATION; ESSENTIAL HYPERTENSION; HEMODYNAMIC MONITORING; LONG TERM CARE; MALE; NONHUMAN; PHYSICAL PARAMETERS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; TARGET ORGAN; THORACIC AORTA; ANIMAL; BLOOD PRESSURE; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; HYPERTENSION; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; FURANS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERTENSION; LIGNANS; MALE; NADPH OXIDASE; NITRIC OXIDE SYNTHASE; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY;

EID: 84949565137     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.11.041     Document Type: Article

References (30)

1. P.M. Kearney, M. Whelton, K. Reynolds, P.K. Whelton, and J. He Global burden of hypertension: analysis of worldwide data Lancet 365 2005 217 223
2. J.J. Guilbert The world health report 2002-reducing risks, promoting healthy life Educ. Health Abingdon 16 2003 230
3. S. Awale, J. Lu, S.K. Kalauni, Y. Kurashima, Y. Tezuka, S. Kadota, and et al. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation Cancer Res. 66 2006 1751 1757
4. V. Swarup, J. Ghosh, M.K. Mishra, and A. Basu Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan J. Antimicrob. Chemother. 61 2008 679 688
5. S. Nishiibe Bioactive phenolic compounds in traditional medicines Pure Appl. Chem. 66 1994 2263 2266
6. M.K. Cho, Y.P. Jang, Y.C. Kim, and S.G. Kim Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition Int. Immunopharmacol. 4 2004 1419 1429
7. H.S. Kang, J.Y. Lee, and C.J. Kim Anti-inflammatory activity of arctigenin from Forsythiae Fructus J. Ethnopharmacol. 116 2008 305 312
8. F. Zhao, L. Wang, and K. Liu In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway J. Ethnopharmacol. 122 2009 457 462
9. S. Iwakami, J.B. Wu, Y. Ebizuka, and U. Sankawa Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes Chem. Pharm. Bull. Tokyo 40 1992 1196 1198
10. 2+ antagonist activity of lignans Chem. Pharm. Bull. Tokyo 34 1986 3514 3517
11. J. Duarte, R. Pérez-Palencia, F. Vargas, M.A. Ocete, F. Pérez-Vizcaino, A. Zarzuelo, and et al. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats Br. J. Pharmacol. 133 2001 117 124
12. B.H. Jin, L.B. Qian, S. Chen, J. Li, H.P. Wang, I.C. Bruce, J. Lin, and Q. Xia Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress Eur. J. Pharmacol. 616 2009 200 205
13. Mitsuhiko Nose, Toru Fujimoto, Sansei Nishibe, and Yukio Ogihara Structural transformation of lignan compounds in rat gastrointestinal tract; II. Serum concentration of lignans and their metabolites Planta Med. 59 1993 131 134
14. A.V. Santhanam, S. Viswanathan, and M. Dikshit Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation Eur. J. Pharmacol. 572 2007 189 196
15. T.F. Luscher, and P.M. Vanhoutte Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat Hypertension 8 1986 344 348
16. S. Taddei, A. Virdis, P. Mattei, and A. Salvetti Vasodilation to acetylcholine in primary and secondary forms of human hypertension Hypertension 21 1993 929 933
17. J.A. Panza, P.R. Casino, C.M. Kilcoyne, and A.A. Quyyumi Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension Circulation 87 1993 1468 1474
18. T. Nagao, S. Illiano, and P.M. Vanhoutte Heterogeneous distribution of endothelium-dependent relaxations resistant to NG-nitro-L-arginine in rats Am. J. Physiol. 263 1992 H1090 H1094
19. A. Lückhoff, U. Pohl, A. Mülsch, and R. Busse Differential role of extra- and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells Br. J. Pharmacol. 95 1988 189 196
20. R. Busse, and A. Mulsch Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin FEBS Lett. 265 1990 133 136
21. J.P. Gratton, P. Bernatchez, and W.C. Sessa Caveolae and caveolins in the cardiovascular system Circ. Res. 94 2004 1408 1417
22. S. Dimmeler, I. Fleming, B. Fisslthaler, C. Hermann, R. Busse, and A.M. Zeiher Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature 399 1999 601 605
23. S. Kerr, M.J. Brosnan, and et al. Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium Hypertension 33 1999 1353 1358
24. T. Chabrashvili, A. Tojo, M.L. Onozato, C. Kitiyakara, M.T. Quinn, T. Fujita, and et al. Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney Hypertension 39 2002 269 274
25. B.M. Babior NADPH oxidase Curr. Opin. Immunol. 16 2004 42 47
26. U. Landmesser, H. Cai, S. Dikalov, L. Mc-Cann, J. Hwang, H. Jo, and et al. Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II Hypertension 40 2002 511 515
27. R.B. Singh, M.A. Niaz, S.S. Rastogi, P.K. Shukla, and A.S. Thakur Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease J. Hum. Hypertens. 13 1999 203 208
28. S. Ulker, P.P. McKeown, and U. Bayraktutan Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities Hypertension 41 2003 534 539
29. C.S. Wilcox Effects of tempol and redox-cycling nitroxides in models of oxidative stress Pharmacol. Ther. 126 2010 119 145
30. D. Yang, M. Félétou, N. Levens, J.N. Zhang, and P.M. Vanhoutte A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR Hypertension 41 2003 143 148