-
1
-
-
84920837701
-
Cancer statistics, 2015
-
PID: 25559415
-
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5–29.
-
(2015)
CA Cancer J Clin
, vol.65
, Issue.1
, pp. 5-29
-
-
Siegel, R.L.1
Miller, K.D.2
Jemal, A.3
-
2
-
-
42449114035
-
Multiple myeloma
-
PID: 18332230
-
Kyle RA, Rajkumar SV. Multiple myeloma. Blood. 2008;111(6):2962–72.
-
(2008)
Blood
, vol.111
, Issue.6
, pp. 2962-2972
-
-
Kyle, R.A.1
Rajkumar, S.V.2
-
3
-
-
41949130070
-
Improved survival in multiple myeloma and the impact of novel therapies
-
PID: 17975015
-
Kumar SK, Rajkumar SV, Dispenzieri A, et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood. 2008;111(5):2516–20.
-
(2008)
Blood
, vol.111
, Issue.5
, pp. 2516-2520
-
-
Kumar, S.K.1
Rajkumar, S.V.2
Dispenzieri, A.3
-
4
-
-
6944235003
-
Multiple myeloma
-
PID: 15509819
-
Kyle RA, Rajkumar SV. Multiple myeloma. N Engl J Med. 2004;351(18):1860–73.
-
(2004)
N Engl J Med
, vol.351
, Issue.18
, pp. 1860-1873
-
-
Kyle, R.A.1
Rajkumar, S.V.2
-
5
-
-
84912574090
-
Treatment of transplant-eligible patients with multiple myeloma in 2014
-
PID: 25212884
-
Landau H, Giralt S. Treatment of transplant-eligible patients with multiple myeloma in 2014. Hematol Oncol Clin North Am. 2014;28(5):815–27.
-
(2014)
Hematol Oncol Clin North Am
, vol.28
, Issue.5
, pp. 815-827
-
-
Landau, H.1
Giralt, S.2
-
6
-
-
22044450480
-
Multiple myeloma: the death of VAD as initial therapy
-
Rajkumar SV. Multiple myeloma: the death of VAD as initial therapy. Blood. 2005;106(1):2–3.
-
(2005)
Blood
, vol.106
, Issue.1
, pp. 2-3
-
-
Rajkumar, S.V.1
-
8
-
-
27744492561
-
Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
-
PID: 16118317
-
Rajkumar SV, Hayman SR, Lacy MQ, et al. Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood. 2005;106(13):4050–3.
-
(2005)
Blood
, vol.106
, Issue.13
, pp. 4050-4053
-
-
Rajkumar, S.V.1
Hayman, S.R.2
Lacy, M.Q.3
-
9
-
-
78650303860
-
Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study
-
PID: 21146205
-
Cavo M, Tacchetti P, Patriarca F, et al. Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study. Lancet. 2010;376(9758):2075–85.
-
(2010)
Lancet
, vol.376
, Issue.9758
, pp. 2075-2085
-
-
Cavo, M.1
Tacchetti, P.2
Patriarca, F.3
-
10
-
-
84865171981
-
Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: results of the randomized phase III hovon-65/ gmmg-Hd4 trial
-
PID: 22802322
-
Sonneveld P, Schmidt-Wolf IG, van der Holt B, et al. Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: results of the randomized phase III hovon-65/ gmmg-Hd4 trial. J Clin Oncol. 2012;30(24):2946–55.
-
(2012)
J Clin Oncol
, vol.30
, Issue.24
, pp. 2946-2955
-
-
Sonneveld, P.1
Schmidt-Wolf, I.G.2
van der Holt, B.3
-
11
-
-
67650882695
-
Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial
-
PID: 19225538
-
Reeder CB, Reece DE, Kukreti V, et al. Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial. Leukemia. 2009;23(7):1337–41.
-
(2009)
Leukemia
, vol.23
, Issue.7
, pp. 1337-1341
-
-
Reeder, C.B.1
Reece, D.E.2
Kukreti, V.3
-
12
-
-
77954618168
-
Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
-
PID: 20385792
-
Richardson PG, Weller E, Lonial S, et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood. 2010;116(5):679–86.
-
(2010)
Blood
, vol.116
, Issue.5
, pp. 679-686
-
-
Richardson, P.G.1
Weller, E.2
Lonial, S.3
-
13
-
-
35148825003
-
Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the apex trial
-
PID: 17690257
-
Richardson PG, Sonneveld P, Schuster M, et al. Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the apex trial. Blood. 2007;110(10):3557–60.
-
(2007)
Blood
, vol.110
, Issue.10
, pp. 3557-3560
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.3
-
14
-
-
50449086728
-
Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
-
PID: 18753647
-
San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med. 2008;359(9):906–17.
-
(2008)
N Engl J Med
, vol.359
, Issue.9
, pp. 906-917
-
-
San Miguel, J.F.1
Schlag, R.2
Khuageva, N.K.3
-
15
-
-
38949216066
-
Bird (biaxin [clarithromycin]/revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma
-
PID: 17989313
-
Niesvizky R, Jayabalan DS, Christos PJ, et al. Bird (biaxin [clarithromycin]/revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma. Blood. 2008;111(3):1101–9.
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1101-1109
-
-
Niesvizky, R.1
Jayabalan, D.S.2
Christos, P.J.3
-
16
-
-
84860744403
-
Continuous lenalidomide treatment for newly diagnosed multiple myeloma
-
PID: 22571200, This is a major large randomized study evaluating the roles of continuous lenalidomide therapy versus melphalan-prednisone treatment in non-transplant candidates
-
Palumbo A, Hajek R, Delforge M, et al. Continuous lenalidomide treatment for newly diagnosed multiple myeloma. N Engl J Med. 2012;366(19):1759–69. This is a major large randomized study evaluating the roles of continuous lenalidomide therapy versus melphalan-prednisone treatment in non-transplant candidates.
-
(2012)
N Engl J Med
, vol.366
, Issue.19
, pp. 1759-1769
-
-
Palumbo, A.1
Hajek, R.2
Delforge, M.3
-
17
-
-
0032748385
-
Antitumor activity of thalidomide in refractory multiple myeloma
-
PID: 10564685
-
Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med. 1999;341(21):1565–71.
-
(1999)
N Engl J Med
, vol.341
, Issue.21
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
-
18
-
-
23444447848
-
Imids: a novel class of immunomodulators
-
PID: 16085014
-
Knight R. Imids: a novel class of immunomodulators. Semin Oncol. 2005;32(4 Suppl 5):S24–30.
-
(2005)
Semin Oncol
, vol.32
, pp. 24-30
-
-
Knight, R.1
-
19
-
-
77949350034
-
Identification of a primary target of thalidomide teratogenicity
-
PID: 20223979
-
Ito T, Ando H, Suzuki T, et al. Identification of a primary target of thalidomide teratogenicity. Science. 2010;327(5971):1345–50.
-
(2010)
Science
, vol.327
, Issue.5971
, pp. 1345-1350
-
-
Ito, T.1
Ando, H.2
Suzuki, T.3
-
20
-
-
80855156719
-
Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
-
PID: 21860026
-
Zhu YX, Braggio E, Shi CX, et al. Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide. Blood. 2011;118(18):4771–9.
-
(2011)
Blood
, vol.118
, Issue.18
, pp. 4771-4779
-
-
Zhu, Y.X.1
Braggio, E.2
Shi, C.X.3
-
21
-
-
84873048466
-
High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance
-
PID: 23233657
-
Broyl A, Kuiper R, van Duin M, et al. High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance. Blood. 2013;121(4):624–7.
-
(2013)
Blood
, vol.121
, Issue.4
, pp. 624-627
-
-
Broyl, A.1
Kuiper, R.2
van Duin, M.3
-
22
-
-
33644831033
-
Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the eastern cooperative oncology group
-
PID: 16365178
-
Rajkumar SV, Blood E, Vesole D, Fonseca R, Greipp PR. Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the eastern cooperative oncology group. J Clin Oncol. 2006;24(3):431–6.
-
(2006)
J Clin Oncol
, vol.24
, Issue.3
, pp. 431-436
-
-
Rajkumar, S.V.1
Blood, E.2
Vesole, D.3
Fonseca, R.4
Greipp, P.R.5
-
23
-
-
22044452126
-
Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma
-
PID: 15761019
-
Cavo M, Zamagni E, Tosi P, et al. Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma. Blood. 2005;106(1):35–9.
-
(2005)
Blood
, vol.106
, Issue.1
, pp. 35-39
-
-
Cavo, M.1
Zamagni, E.2
Tosi, P.3
-
24
-
-
75649114103
-
Short-term thalidomide incorporated into double autologous stem-cell transplantation improves outcomes in comparison with double autotransplantation for multiple myeloma
-
PID: 19720903
-
Cavo M, Di Raimondo F, Zamagni E, et al. Short-term thalidomide incorporated into double autologous stem-cell transplantation improves outcomes in comparison with double autotransplantation for multiple myeloma. J Clin Oncol. 2009;27(30):5001–7.
-
(2009)
J Clin Oncol
, vol.27
, Issue.30
, pp. 5001-5007
-
-
Cavo, M.1
Di Raimondo, F.2
Zamagni, E.3
-
25
-
-
33645090967
-
Immunomodulatory analogues of thalidomide in the treatment of multiple myeloma
-
PID: 16507207
-
Suppiah R, Srkalovic JG, Hussein MA. Immunomodulatory analogues of thalidomide in the treatment of multiple myeloma. Clin Lymphoma Myeloma. 2006;6(4):301–5.
-
(2006)
Clin Lymphoma Myeloma
, vol.6
, Issue.4
, pp. 301-305
-
-
Suppiah, R.1
Srkalovic, J.G.2
Hussein, M.A.3
-
26
-
-
77949890246
-
Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: a comparative analysis of 411 patients
-
PID: 20008302
-
Gay F, Hayman SR, Lacy MQ, et al. Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: a comparative analysis of 411 patients. Blood. 2010;115(7):1343–50.
-
(2010)
Blood
, vol.115
, Issue.7
, pp. 1343-1350
-
-
Gay, F.1
Hayman, S.R.2
Lacy, M.Q.3
-
27
-
-
64849085443
-
Proteasome inhibitors in multiple myeloma
-
PID: 19393832
-
Anderson KC. Proteasome inhibitors in multiple myeloma. Semin Oncol. 2009;36(2 Suppl 1):S20–6.
-
(2009)
Semin Oncol
, vol.36
, pp. 20-26
-
-
Anderson, K.C.1
-
28
-
-
33750953054
-
Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: results of an IFM phase II study
-
PID: 17043025
-
Harousseau JL, Attal M, Leleu X, et al. Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: results of an IFM phase II study. Haematologica. 2006;91(11):1498–505.
-
(2006)
Haematologica
, vol.91
, Issue.11
, pp. 1498-1505
-
-
Harousseau, J.L.1
Attal, M.2
Leleu, X.3
-
29
-
-
84877620340
-
Bird (clarithromycin, lenalidomide, dexamethasone): an update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma
-
PID: 23299315
-
Rossi A, Mark T, Jayabalan D, et al. Bird (clarithromycin, lenalidomide, dexamethasone): an update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma. Blood. 2013;121(11):1982–5.
-
(2013)
Blood
, vol.121
, Issue.11
, pp. 1982-1985
-
-
Rossi, A.1
Mark, T.2
Jayabalan, D.3
-
30
-
-
84860907057
-
Randomized, multicenter, phase 2 study (evolution) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma
-
PID: 22422823, This randomized study establishes that a 4-drug regimen is not necessarily superior to 3-drugs in newly diagnosed transplant-eligible myeloma
-
Kumar S, Flinn I, Richardson PG, et al. Randomized, multicenter, phase 2 study (evolution) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma. Blood. 2012;119(19):4375–82. This randomized study establishes that a 4-drug regimen is not necessarily superior to 3-drugs in newly diagnosed transplant-eligible myeloma.
-
(2012)
Blood
, vol.119
, Issue.19
, pp. 4375-4382
-
-
Kumar, S.1
Flinn, I.2
Richardson, P.G.3
-
31
-
-
70350708810
-
Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
-
PID: 19671918
-
Parlati F, Lee SJ, Aujay M, et al. Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood. 2009;114(16):3439–47.
-
(2009)
Blood
, vol.114
, Issue.16
, pp. 3439-3447
-
-
Parlati, F.1
Lee, S.J.2
Aujay, M.3
-
32
-
-
84865333050
-
A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
-
PID: 22665938, This is the first published study of the activity of carfilzomib in the induction setting in transplant candidates
-
Jakubowiak AJ, Dytfeld D, Griffith KA, et al. A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma. Blood. 2012;120(9):1801–9. This is the first published study of the activity of carfilzomib in the induction setting in transplant candidates.
-
(2012)
Blood
, vol.120
, Issue.9
, pp. 1801-1809
-
-
Jakubowiak, A.J.1
Dytfeld, D.2
Griffith, K.A.3
-
34
-
-
70350091086
-
International myeloma working group (imwg) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100)
-
PID: 19554029
-
Giralt S, Stadtmauer EA, Harousseau JL, et al. International myeloma working group (imwg) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100). Leukemia. 2009;23(10):1904–12.
-
(2009)
Leukemia
, vol.23
, Issue.10
, pp. 1904-1912
-
-
Giralt, S.1
Stadtmauer, E.A.2
Harousseau, J.L.3
-
35
-
-
34548138921
-
Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma
-
PID: 17581613
-
Kumar S, Dispenzieri A, Lacy MQ, et al. Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma. Leukemia. 2007;21(9):2035–42.
-
(2007)
Leukemia
, vol.21
, Issue.9
, pp. 2035-2042
-
-
Kumar, S.1
Dispenzieri, A.2
Lacy, M.Q.3
-
36
-
-
45149129384
-
Effect of lenalidomide therapy on mobilization of peripheral blood stem cells in previously untreated multiple myeloma patients
-
PID: 18033320, author reply 1281-2
-
Mazumder A, Kaufman J, Niesvizky R, et al. Effect of lenalidomide therapy on mobilization of peripheral blood stem cells in previously untreated multiple myeloma patients. Leukemia. 2008;22(6):1280. author reply 1281-2.
-
(2008)
Leukemia
, vol.22
, Issue.6
, pp. 1280
-
-
Mazumder, A.1
Kaufman, J.2
Niesvizky, R.3
-
37
-
-
44649202066
-
Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma
-
Mark T, Stern J, Furst JR, et al. Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma. Bio Blood Marrow Transplant. 2008;14(7):795–8.
-
(2008)
Bio Blood Marrow Transplant
, vol.14
, Issue.7
, pp. 795-798
-
-
Mark, T.1
Stern, J.2
Furst, J.R.3
-
38
-
-
79952536052
-
Plerixafor (mozobil) for stem cell mobilization in patients with multiple myeloma previously treated with lenalidomide
-
PID: 20479709
-
Micallef IN, Ho AD, Klein LM, et al. Plerixafor (mozobil) for stem cell mobilization in patients with multiple myeloma previously treated with lenalidomide. Bone Marrow Transplant. 2011;46(3):350–5.
-
(2011)
Bone Marrow Transplant
, vol.46
, Issue.3
, pp. 350-355
-
-
Micallef, I.N.1
Ho, A.D.2
Klein, L.M.3
-
39
-
-
84896691513
-
Optimizing autologous stem cell mobilization strategies to improve patient outcomes: consensus guidelines and recommendations
-
PID: 24141007, Review of impact of induction chemotherapy on ability to harvest hematopoietic stem cells and recommendations
-
Giralt S, Costa L, Schriber J, et al. Optimizing autologous stem cell mobilization strategies to improve patient outcomes: consensus guidelines and recommendations. Biol Blood Marrow Transplant. 2014;20(3):295–308. Review of impact of induction chemotherapy on ability to harvest hematopoietic stem cells and recommendations.
-
(2014)
Biol Blood Marrow Transplant
, vol.20
, Issue.3
, pp. 295-308
-
-
Giralt, S.1
Costa, L.2
Schriber, J.3
-
40
-
-
84885431851
-
Management of elderly patients with cancer
-
PID: 23704247
-
Hurria A. Management of elderly patients with cancer. J Natl Compr Canc Netw. 2013;11(5 Suppl):698–701.
-
(2013)
J Natl Compr Canc Netw
, vol.11
, pp. 698-701
-
-
Hurria, A.1
-
41
-
-
77953945399
-
Best practices in the management of newly diagnosed multiple myeloma patients who will not undergo transplant
-
Niesvizky R, Coleman M, Mark T. Best practices in the management of newly diagnosed multiple myeloma patients who will not undergo transplant. Oncology (Williston Park). 2010;24(3 Suppl 2):14–21.
-
(2010)
Oncology (Williston Park)
, vol.24
, pp. 14-21
-
-
Niesvizky, R.1
Coleman, M.2
Mark, T.3
-
42
-
-
0014236097
-
Melphalan therapy for plasma cell myeloma
-
PID: 5638562
-
Alexanian R, Bergsagel DE, Migliore PJ, Vaughn WK, Howe CD. Melphalan therapy for plasma cell myeloma. Blood. 1968;31(1):1–10.
-
(1968)
Blood
, vol.31
, Issue.1
, pp. 1-10
-
-
Alexanian, R.1
Bergsagel, D.E.2
Migliore, P.J.3
Vaughn, W.K.4
Howe, C.D.5
-
43
-
-
25844477041
-
Multiple myeloma: diagnosis and treatment
-
PID: 16212152
-
Rajkumar SV, Kyle RA. Multiple myeloma: diagnosis and treatment. Mayo Clin Proc. 2005;80(10):1371–82.
-
(2005)
Mayo Clin Proc
, vol.80
, Issue.10
, pp. 1371-1382
-
-
Rajkumar, S.V.1
Kyle, R.A.2
-
44
-
-
0344076348
-
Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: an overview of 6,633 patients from 27 randomized trials. Myeloma Trialists’ collaborative group
-
Group MTC. Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: an overview of 6,633 patients from 27 randomized trials. Myeloma Trialists’ collaborative group. J Clin Oncol. 1998;16(12):3832–42.
-
(1998)
J Clin Oncol
, vol.16
, Issue.12
, pp. 3832-3842
-
-
Group, M.T.C.1
-
45
-
-
32644438680
-
Dexamethasone-based regimens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy
-
PID: 16174762
-
Facon T, Mary JY, Pegourie B, et al. Dexamethasone-based regimens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy. Blood. 2006;107(4):1292–8.
-
(2006)
Blood
, vol.107
, Issue.4
, pp. 1292-1298
-
-
Facon, T.1
Mary, J.Y.2
Pegourie, B.3
-
46
-
-
70350094381
-
International myeloma working group guidelines for the management of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantation
-
PID: 19494840
-
Palumbo A, Sezer O, Kyle R, et al. International myeloma working group guidelines for the management of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantation. Leukemia. 2009;23(10):1716–30.
-
(2009)
Leukemia
, vol.23
, Issue.10
, pp. 1716-1730
-
-
Palumbo, A.1
Sezer, O.2
Kyle, R.3
-
47
-
-
43749117945
-
Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma
-
PID: 18362366
-
Rajkumar SV, Rosinol L, Hussein M, et al. Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma. J Clin Oncol. 2008;26(13):2171–7.
-
(2008)
J Clin Oncol
, vol.26
, Issue.13
, pp. 2171-2177
-
-
Rajkumar, S.V.1
Rosinol, L.2
Hussein, M.3
-
48
-
-
65349142006
-
Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma
-
PID: 18955563
-
Ludwig H, Hajek R, Tothova E, et al. Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma. Blood. 2009;113(15):3435–42.
-
(2009)
Blood
, vol.113
, Issue.15
, pp. 3435-3442
-
-
Ludwig, H.1
Hajek, R.2
Tothova, E.3
-
49
-
-
54049135250
-
Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial
-
PID: 18505783
-
Palumbo A, Bringhen S, Liberati AM, et al. Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial. Blood. 2008;112(8):3107–14.
-
(2008)
Blood
, vol.112
, Issue.8
, pp. 3107-3114
-
-
Palumbo, A.1
Bringhen, S.2
Liberati, A.M.3
-
50
-
-
34848833957
-
Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99–06): a randomised trial
-
PID: 17920916
-
Facon T, Mary JY, Hulin C, et al. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99–06): a randomised trial. Lancet. 2007;370(9594):1209–18.
-
(2007)
Lancet
, vol.370
, Issue.9594
, pp. 1209-1218
-
-
Facon, T.1
Mary, J.Y.2
Hulin, C.3
-
51
-
-
68949137225
-
Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial
-
PID: 19451428
-
Hulin C, Facon T, Rodon P, et al. Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial. J Clin Oncol. 2009;27(22):3664–70.
-
(2009)
J Clin Oncol
, vol.27
, Issue.22
, pp. 3664-3670
-
-
Hulin, C.1
Facon, T.2
Rodon, P.3
-
52
-
-
84874768399
-
Persistent overall survival benefit and no increased risk of second malignancies with bortezomib-melphalan-prednisone versus melphalan-prednisone in patients with previously untreated multiple myeloma
-
PID: 23233713, Major randomized study evaluating the role of adding bortezomib to melphalan + prednisone for induction therapy in non-transplant candidates
-
San Miguel JF, Schlag R, Khuageva NK, et al. Persistent overall survival benefit and no increased risk of second malignancies with bortezomib-melphalan-prednisone versus melphalan-prednisone in patients with previously untreated multiple myeloma. J Clin Oncol. 2013;31(4):448–55. Major randomized study evaluating the role of adding bortezomib to melphalan + prednisone for induction therapy in non-transplant candidates.
-
(2013)
J Clin Oncol
, vol.31
, Issue.4
, pp. 448-455
-
-
San Miguel, J.F.1
Schlag, R.2
Khuageva, N.K.3
-
54
-
-
84907012637
-
Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma
-
PID: 25184863, This is a major randomized trial establishing the superiority of continuous lenalidomide therapy in the upfront treatment of transplant-ineligible myeloma
-
Benboubker L, Dimopoulos MA, Dispenzieri A, et al. Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. N Engl J Med. 2014;371(10):906–17. This is a major randomized trial establishing the superiority of continuous lenalidomide therapy in the upfront treatment of transplant-ineligible myeloma.
-
(2014)
N Engl J Med
, vol.371
, Issue.10
, pp. 906-917
-
-
Benboubker, L.1
Dimopoulos, M.A.2
Dispenzieri, A.3
-
55
-
-
84862696861
-
Efficacy and safety of three bortezomib-based combinations in elderly, newly diagnosed multiple myeloma patients: results from all randomized patients in the community-based, phase 3b upfront study
-
This study compares a 2 vs 3-drug bortezomib-based regimens as induction therapy for transplant-ineligible myeloma
-
Niesvizky R, Flinn IW, Rifkin R, et al. Efficacy and safety of three bortezomib-based combinations in elderly, newly diagnosed multiple myeloma patients: results from all randomized patients in the community-based, phase 3b upfront study. ASH Annu Meet Abstr. 2011;118(21):478. This study compares a 2 vs 3-drug bortezomib-based regimens as induction therapy for transplant-ineligible myeloma.
-
(2011)
ASH Annu Meet Abstr
, vol.118
, Issue.21
, pp. 478
-
-
Niesvizky, R.1
Flinn, I.W.2
Rifkin, R.3
-
56
-
-
84895784261
-
New drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the international myeloma working group (Imwg)
-
PID: 24253022
-
Ocio EM, Richardson PG, Rajkumar SV, et al. New drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the international myeloma working group (Imwg). Leukemia. 2014;28(3):525–42.
-
(2014)
Leukemia
, vol.28
, Issue.3
, pp. 525-542
-
-
Ocio, E.M.1
Richardson, P.G.2
Rajkumar, S.V.3
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