-
1
-
-
24944497744
-
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
-
Eberhard D.A., Johnson B.E., Amler L.C., Goddard A.D., Heldens S.L., Herbst R.S., et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J. Clin. Oncol 2005, 23:5900-5909.
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 5900-5909
-
-
Eberhard, D.A.1
Johnson, B.E.2
Amler, L.C.3
Goddard, A.D.4
Heldens, S.L.5
Herbst, R.S.6
-
2
-
-
79953024710
-
Phosphoinositide-3-kinase catalytic alpha and KRAS mutations are important predictors of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer
-
Ludovini V., Bianconi F., Pistola L., Chiari R., Minotti V., Colella R., et al. Phosphoinositide-3-kinase catalytic alpha and KRAS mutations are important predictors of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer. J. Thorac. Oncol 2011, 6:707-715.
-
(2011)
J. Thorac. Oncol
, vol.6
, pp. 707-715
-
-
Ludovini, V.1
Bianconi, F.2
Pistola, L.3
Chiari, R.4
Minotti, V.5
Colella, R.6
-
3
-
-
36849041454
-
Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer
-
Tsao M.S., Aviel-Ronen S., Ding K., Lau D., Liu N., Sakurada A., et al. Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer. J. Clin. Oncol 2007, 25:5240-5247.
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 5240-5247
-
-
Tsao, M.S.1
Aviel-Ronen, S.2
Ding, K.3
Lau, D.4
Liu, N.5
Sakurada, A.6
-
4
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S., Boggon T.J., Dayaram T., Janne P.A., Kocher O., Meyerson M., et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N. Engl. J. Med 2005, 352:786-792.
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
Janne, P.A.4
Kocher, O.5
Meyerson, M.6
-
5
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman J.A., Zejnullahu K., Mitsudomi T., Song Y., Hyland C., Park J.O., et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007, 316:1039-1043.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
-
6
-
-
84902549992
-
Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics
-
Tan D.S., Camilleri-Broet S., Tan E.H., Alifano M., Lim W.T., Bobbio A., et al. Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics. Int. J. Cancer 2014, 135:1092-1100.
-
(2014)
Int. J. Cancer
, vol.135
, pp. 1092-1100
-
-
Tan, D.S.1
Camilleri-Broet, S.2
Tan, E.H.3
Alifano, M.4
Lim, W.T.5
Bobbio, A.6
-
7
-
-
84901602817
-
Incidence of T790M mutation in (sequential) rebiopsies in EGFR-mutated NSCLC-patients
-
Kuiper J.L., Heideman D.A., Thunnissen E., Paul M.A., van Wijk A.W., Postmus P.E., et al. Incidence of T790M mutation in (sequential) rebiopsies in EGFR-mutated NSCLC-patients. Lung Cancer 2014, 85:19-24.
-
(2014)
Lung Cancer
, vol.85
, pp. 19-24
-
-
Kuiper, J.L.1
Heideman, D.A.2
Thunnissen, E.3
Paul, M.A.4
van Wijk, A.W.5
Postmus, P.E.6
-
8
-
-
84939987245
-
Tumor heterogeneity: evolution through space and time in EGFR mutant non small cell lung cancer patients
-
Majem M., Remon J. Tumor heterogeneity: evolution through space and time in EGFR mutant non small cell lung cancer patients. Transl. Lung Cancer Res 2013, 2:226-237.
-
(2013)
Transl. Lung Cancer Res
, vol.2
, pp. 226-237
-
-
Majem, M.1
Remon, J.2
-
9
-
-
84896371874
-
Detection of circulating tumor DNA in early- and late-stage human malignancies
-
Bettegowda C., Sausen M., Leary R.J., Kinde I., Wang Y., Agrawal N., et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci. Transl. Med 2014, 6:224ra224.
-
(2014)
Sci. Transl. Med
, vol.6
, pp. 224ra224
-
-
Bettegowda, C.1
Sausen, M.2
Leary, R.J.3
Kinde, I.4
Wang, Y.5
Agrawal, N.6
-
10
-
-
0035866393
-
DNA Fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells
-
Jahr S., Hentze H., Englisch S., Hardt D., Fackelmayer F.O., Hesch R.-D., et al. DNA Fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 2001, 61:1659-1665.
-
(2001)
Cancer Res
, vol.61
, pp. 1659-1665
-
-
Jahr, S.1
Hentze, H.2
Englisch, S.3
Hardt, D.4
Fackelmayer, F.O.5
Hesch, R.-D.6
-
11
-
-
0642311916
-
Quantification of free circulating DNA as a diagnostic marker in lung cancer
-
Sozzi G., Conte D., Leon M., Cirincione R., Roz L., Ratcliffe C., et al. Quantification of free circulating DNA as a diagnostic marker in lung cancer. J. Clin. Oncol 2003, 21:3902-3908.
-
(2003)
J. Clin. Oncol
, vol.21
, pp. 3902-3908
-
-
Sozzi, G.1
Conte, D.2
Leon, M.3
Cirincione, R.4
Roz, L.5
Ratcliffe, C.6
-
12
-
-
34548593298
-
Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA)
-
Kimura H., Suminoe M., Kasahara K., Sone T., Araya T., Tamori S., et al. Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA). Br. J. Cancer 2007, 97:778-784.
-
(2007)
Br. J. Cancer
, vol.97
, pp. 778-784
-
-
Kimura, H.1
Suminoe, M.2
Kasahara, K.3
Sone, T.4
Araya, T.5
Tamori, S.6
-
13
-
-
0034020197
-
The origin and mechanism of circulating DNA
-
Stroun M., Maurice P., Vasioukhin V., Lyautey J., Lederrey C., Lefort F., et al. The origin and mechanism of circulating DNA. Ann. N. Y. Acad. Sci 2000, 906:161-168.
-
(2000)
Ann. N. Y. Acad. Sci
, vol.906
, pp. 161-168
-
-
Stroun, M.1
Maurice, P.2
Vasioukhin, V.3
Lyautey, J.4
Lederrey, C.5
Lefort, F.6
-
14
-
-
84877579861
-
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
-
Murtaza M., Dawson S.J., Tsui D.W., Gale D., Forshew T., Piskorz A.M., et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 2013, 497:108-112.
-
(2013)
Nature
, vol.497
, pp. 108-112
-
-
Murtaza, M.1
Dawson, S.J.2
Tsui, D.W.3
Gale, D.4
Forshew, T.5
Piskorz, A.M.6
-
15
-
-
84906245875
-
Changes in mutational status during third-line treatment for metastatic colorectal cancer - results of consecutive measurement of cell free DNA, KRAS and BRAF in the plasma
-
Spindler K.-L.G., Pallisgaard N., Andersen R.F., Jakobsen A. Changes in mutational status during third-line treatment for metastatic colorectal cancer - results of consecutive measurement of cell free DNA, KRAS and BRAF in the plasma. Int. J. Cancer 2014, 135:2215-2222.
-
(2014)
Int. J. Cancer
, vol.135
, pp. 2215-2222
-
-
Spindler, K.-L.G.1
Pallisgaard, N.2
Andersen, R.F.3
Jakobsen, A.4
-
16
-
-
84906250256
-
Gefitinib treatment in EGFR mutated Caucasian NSCLC: circulating-free tumor DNA as a surrogate for determination of EGFR status
-
Douillard J.-Y., Ostoros G., Cobo M., Ciuleanu T., Cole R., McWalter G., et al. Gefitinib treatment in EGFR mutated Caucasian NSCLC: circulating-free tumor DNA as a surrogate for determination of EGFR status. J. Thorac. Oncol 2014, 9:1345-1353.
-
(2014)
J. Thorac. Oncol
, vol.9
, pp. 1345-1353
-
-
Douillard, J.-Y.1
Ostoros, G.2
Cobo, M.3
Ciuleanu, T.4
Cole, R.5
McWalter, G.6
-
17
-
-
81855208762
-
Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas
-
Taniguchi K., Uchida J., Nishino K., Kumagai T., Okuyama T., Okami J., et al. Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas. Clin. Cancer Res 2011, 17:7808-7815.
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 7808-7815
-
-
Taniguchi, K.1
Uchida, J.2
Nishino, K.3
Kumagai, T.4
Okuyama, T.5
Okami, J.6
-
18
-
-
84881137132
-
Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping
-
Kim H.-R., Lee S.Y., Hyun D.-S., Lee M.K., Lee H.-K., Choi C.-M., et al. Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping. J. Exp. Clin. Cancer Res 2013, 32:50.
-
(2013)
J. Exp. Clin. Cancer Res
, vol.32
, pp. 50
-
-
Kim, H.-R.1
Lee, S.Y.2
Hyun, D.-S.3
Lee, M.K.4
Lee, H.-K.5
Choi, C.-M.6
-
19
-
-
84896737232
-
Quantitative identification of mutant alleles derived from lung cancer in plasma cell-free DNA via anomaly detection using deep sequencing data
-
Kukita Y., Uchida J., Oba S., Nishino K., Kumagai T., Taniguchi K., et al. Quantitative identification of mutant alleles derived from lung cancer in plasma cell-free DNA via anomaly detection using deep sequencing data. PLoS ONE 2013, 8:e81468.
-
(2013)
PLoS ONE
, vol.8
, pp. e81468
-
-
Kukita, Y.1
Uchida, J.2
Oba, S.3
Nishino, K.4
Kumagai, T.5
Taniguchi, K.6
-
20
-
-
84863967346
-
Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing
-
Narayan A., Carriero N.J., Gettinger S.N., Kluytenaar J., Kozak K.R., Yock T.I., et al. Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing. Cancer Res 2012, 72:3492-3498.
-
(2012)
Cancer Res
, vol.72
, pp. 3492-3498
-
-
Narayan, A.1
Carriero, N.J.2
Gettinger, S.N.3
Kluytenaar, J.4
Kozak, K.R.5
Yock, T.I.6
-
21
-
-
84903218109
-
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
-
Newman A.M., Bratman S.V., To J., Wynne J.F., Eclov N.C.W., Modlin L.A., et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat. Med 2014, 20:548-554.
-
(2014)
Nat. Med
, vol.20
, pp. 548-554
-
-
Newman, A.M.1
Bratman, S.V.2
To, J.3
Wynne, J.F.4
Eclov, N.C.W.5
Modlin, L.A.6
-
22
-
-
84936132730
-
Noninvasive diagnosis of actionable mutations by deep sequencing of circulating free DNA in lung cancer from never-smokers: a proof-of-concept study from BioCAST/IFCT-1002
-
Couraud S., Vaca-Paniagua F., Villar S., Oliver J., Schuster T., Blanché H., et al. Noninvasive diagnosis of actionable mutations by deep sequencing of circulating free DNA in lung cancer from never-smokers: a proof-of-concept study from BioCAST/IFCT-1002. Clin. Cancer Res 2014, 20:4613-4624.
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 4613-4624
-
-
Couraud, S.1
Vaca-Paniagua, F.2
Villar, S.3
Oliver, J.4
Schuster, T.5
Blanché, H.6
-
23
-
-
84861746437
-
Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
-
Forshew T., Murtaza M., Parkinson C., Gale D., Tsui D.W., Kaper F., et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci. Transl. Med 2012, 4:136ra168.
-
(2012)
Sci. Transl. Med
, vol.4
, pp. 136ra168
-
-
Forshew, T.1
Murtaza, M.2
Parkinson, C.3
Gale, D.4
Tsui, D.W.5
Kaper, F.6
-
24
-
-
84872020299
-
Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing
-
Chan K.C.A., Jiang P., Zheng Y.W.L., Liao G.J.W., Sun H., Wong J., et al. Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clin. Chem 2013, 59:211-224.
-
(2013)
Clin. Chem
, vol.59
, pp. 211-224
-
-
Chan, K.C.A.1
Jiang, P.2
Zheng, Y.W.L.3
Liao, G.J.W.4
Sun, H.5
Wong, J.6
-
25
-
-
84923164411
-
Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients
-
Madic J., Kiialainen A., Bidard F.-C., Birzele F., Ramey G., Leroy Q., et al. Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients. Int. J. Cancer 2015, 136:2158-2165.
-
(2015)
Int. J. Cancer
, vol.136
, pp. 2158-2165
-
-
Madic, J.1
Kiialainen, A.2
Bidard, F.-C.3
Birzele, F.4
Ramey, G.5
Leroy, Q.6
-
26
-
-
84903376343
-
PIK3CA and TP53 gene mutations in human breast cancer tumors frequently detected by ion torrent DNA sequencing
-
Bai X., Zhang E., Ye H., Nandakumar V., Wang Z., Chen L., et al. PIK3CA and TP53 gene mutations in human breast cancer tumors frequently detected by ion torrent DNA sequencing. PLoS ONE 2014, 9:e99306.
-
(2014)
PLoS ONE
, vol.9
, pp. e99306
-
-
Bai, X.1
Zhang, E.2
Ye, H.3
Nandakumar, V.4
Wang, Z.5
Chen, L.6
-
27
-
-
84905457536
-
Frequent KIT mutations in human gastrointestinal stromal tumors
-
Xu Z., Huo X., Tang C., Ye H., Nandakumar V., Lou F., et al. Frequent KIT mutations in human gastrointestinal stromal tumors. Sci. Rep.-UK 2014, 4:5907.
-
(2014)
Sci. Rep.-UK
, vol.4
, pp. 5907
-
-
Xu, Z.1
Huo, X.2
Tang, C.3
Ye, H.4
Nandakumar, V.5
Lou, F.6
-
28
-
-
84899762549
-
Frequent mutations in EGFR, KRAS and TP53 genes in human lung cancer tumors detected by ion torrent DNA sequencing
-
Cai X., Sheng J., Tang C., Nandakumar V., Ye H., Ji H., et al. Frequent mutations in EGFR, KRAS and TP53 genes in human lung cancer tumors detected by ion torrent DNA sequencing. PLoS ONE 2014, 9:e95228.
-
(2014)
PLoS ONE
, vol.9
, pp. e95228
-
-
Cai, X.1
Sheng, J.2
Tang, C.3
Nandakumar, V.4
Ye, H.5
Ji, H.6
-
29
-
-
84875211731
-
Cancer heterogeneity: implications for targeted therapeutics
-
Fisher R., Pusztai L., Swanton C. Cancer heterogeneity: implications for targeted therapeutics. Br. J. Cancer 2013, 108:479-485.
-
(2013)
Br. J. Cancer
, vol.108
, pp. 479-485
-
-
Fisher, R.1
Pusztai, L.2
Swanton, C.3
-
30
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M., Rowan A.J., Horswell S., Larkin J., Endesfelder D., Gronroos E., et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med 2012, 366:883-892.
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
Larkin, J.4
Endesfelder, D.5
Gronroos, E.6
-
31
-
-
84859125350
-
Intratumor heterogeneity: seeing the wood for the trees
-
Yap T.A., Gerlinger M., Futreal P.A., Pusztai L., Swanton C. Intratumor heterogeneity: seeing the wood for the trees. Sci. Transl. Med 2012, 4:127ps110.
-
(2012)
Sci. Transl. Med
, vol.4
-
-
Yap, T.A.1
Gerlinger, M.2
Futreal, P.A.3
Pusztai, L.4
Swanton, C.5
-
32
-
-
79957458567
-
Cell-free nucleic acids as biomarkers in cancer patients
-
Schwarzenbach H., Hoon D.S., Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat. Rev. Cancer 2011, 11:426-437.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 426-437
-
-
Schwarzenbach, H.1
Hoon, D.S.2
Pantel, K.3
-
33
-
-
77956487870
-
Plasma DNA level in predicting therapeutic efficacy in advanced nonsmall cell lung cancer
-
Kumar S., Guleria R., Singh V., Bharti A.C., Mohan A., Das B.C. Plasma DNA level in predicting therapeutic efficacy in advanced nonsmall cell lung cancer. Eur. Respir. J. 2010, 36:885-892.
-
(2010)
Eur. Respir. J.
, vol.36
, pp. 885-892
-
-
Kumar, S.1
Guleria, R.2
Singh, V.3
Bharti, A.C.4
Mohan, A.5
Das, B.C.6
-
34
-
-
68049088934
-
EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases
-
Schmid K., Oehl N., Wrba F., Pirker R., Pirker C., Filipits M. EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases. Clin. Cancer Res 2009, 15:4554-4560.
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 4554-4560
-
-
Schmid, K.1
Oehl, N.2
Wrba, F.3
Pirker, R.4
Pirker, C.5
Filipits, M.6
-
35
-
-
84655167222
-
Epidermal growth factor receptor mutation status in circulating free DNA in serum: from IPASS, a phase III study of gefitinib or carboplatin/paclitaxel in non-small cell lung cancer
-
Goto K., Ichinose Y., Ohe Y., Yamamoto N., Negoro S., Nishio K., et al. Epidermal growth factor receptor mutation status in circulating free DNA in serum: from IPASS, a phase III study of gefitinib or carboplatin/paclitaxel in non-small cell lung cancer. J. Thorac. Oncol 2012, 7:115-121.
-
(2012)
J. Thorac. Oncol
, vol.7
, pp. 115-121
-
-
Goto, K.1
Ichinose, Y.2
Ohe, Y.3
Yamamoto, N.4
Negoro, S.5
Nishio, K.6
-
36
-
-
84865682334
-
Clinical significance of circulating tumor cells and free DNA in non-small cell lung cancer
-
Isobe K., Hata Y., Kobayashi K., Hirota N.A.O., Sato K., Sano G.O., et al. Clinical significance of circulating tumor cells and free DNA in non-small cell lung cancer. Anticancer Res 2012, 32:3339-3344.
-
(2012)
Anticancer Res
, vol.32
, pp. 3339-3344
-
-
Isobe, K.1
Hata, Y.2
Kobayashi, K.3
Hirota, N.A.O.4
Sato, K.5
Sano, G.O.6
-
37
-
-
79952711946
-
Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation
-
Oxnard G.R., Arcila M.E., Sima C.S., Riely G.J., Chmielecki J., Kris M.G., et al. Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation. Clin. Cancer Res 2011, 17:1616-1622.
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 1616-1622
-
-
Oxnard, G.R.1
Arcila, M.E.2
Sima, C.S.3
Riely, G.J.4
Chmielecki, J.5
Kris, M.G.6
-
38
-
-
3242709323
-
Mutant DNA in plasma of lung cancer patients: potential for monitoring response to therapy
-
Kimura T., Holland W.S., Kawaguchi T., Williamson S.K., Chansky K., Crowley J.J., et al. Mutant DNA in plasma of lung cancer patients: potential for monitoring response to therapy. Ann. N. Y. Acad. Sci 2004, 1022:55-60.
-
(2004)
Ann. N. Y. Acad. Sci
, vol.1022
, pp. 55-60
-
-
Kimura, T.1
Holland, W.S.2
Kawaguchi, T.3
Williamson, S.K.4
Chansky, K.5
Crowley, J.J.6
|