Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: a pilot study

Cellular Oncology

Volumn 39, Issue 2, 2016, Pages 187-193

  Duz, Mehmet Bugrahan ^a   Karatas, Omer Faruk ^b   Guzel, Esra ^a,e   Turgut, Nesrettin Fatih ^c   Yilmaz, Mehmet ^c   Creighton, Chad J ^d   Ozen, Mustafa ^a,d,e  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ERZURUM TECHNICAL UNIVERSITY   (Turkey)

^c ISTANBUL UNIVERSITY   (Turkey)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e BIRUNI UNIVERSITY   (Turkey)

Author keywords

Biomarker; Microarray; miRNA; Saliva; Tongue squamous cell carcinoma

Indexed keywords

MICRORNA; MICRORNA 139 5P; UNCLASSIFIED DRUG; MIRN139 MICRORNA, HUMAN; TUMOR MARKER;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; CANCER DIAGNOSIS; CANCER GRADING; CANCER PATIENT; CANCER SURGERY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DOWN REGULATION; EARLY DIAGNOSIS; FEMALE; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PILOT STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVA; SENSITIVITY AND SPECIFICITY; SMOKING; TONGUE CARCINOMA; TUMOR LOCALIZATION; UPREGULATION; VERY ELDERLY; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RECEIVER OPERATING CHARACTERISTIC; SQUAMOUS CELL CARCINOMA; TONGUE TUMOR;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PILOT PROJECTS; ROC CURVE; SALIVA; TONGUE NEOPLASMS;

EID: 84949507818     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-015-0259-z     Document Type: Article

References (45)

1. J.N. Myers, T. Elkins, D. Roberts, R.M. Byers, Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes. Otolaryngol. Head Neck Surg. 122, 44–51 (2000)
2. I.P. Ribeiro, F. Marques, F. Caramelo, J. Pereira, M. Patrício, H. Prazeres, J. Ferrão, M.J. Julião, M. Castelo-Branco, J.B. de Melo, I.P. Baptista, I.M. Carreira, Genetic gains and losses in oral squamous cell carcinoma: impact on clinical management. Cell Oncol. 37, 29–39 (2014)
3. T. Nakaoka, A. Ota, T. Ono, S. Karnan, H. Konishi, A. Furuhashi, Y. Ohmura, Y. Yamada, Y. Hosokawa, Y. Kazaoka, Combined arsenic trioxide-cisplatin treatment enhances apoptosis in oral squamous cell carcinoma cells. Cell Oncol. 37, 119–129 (2014)
4. R.S. Patel, J.R. Clark, R. Dirven, R. Wyten, K. Gao, C.J. O'Brien, Prognostic factors in the surgical treatment of patients with oral carcinoma. ANZ J. Surg. 79, 19–22 (2009)
5. S. Müller, Y. Pan, R. Li, A.C. Chi, Changing trends in oral squamous cell carcinoma with particular reference to young patients: 1971–2006. The Emory University experience. Head Neck Pathol. 2, 60–66 (2008)
6. A.R. Fakih, R.S. Rao, A.M. Borges, A.R. Patel, Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. Am. J. Surg. 158, 309–313 (1989)
7. K. Rusthoven, A. Ballonoff, D. Raben, C. Chen, Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma. Cancer 112, 345–351 (2008)
8. D. Sidransky, Nucleic acid-based methods for the detection of cancer. Science 278, 1054–1059 (1997)
9. E. Guzel, O.F. Karatas, A. Semercioz, S. Ekici, S. Aykan, S. Yentur, C.J. Creighton, M. Ittmann, M. Ozen, Identification of microRNAs differentially expressed in prostatic secretions of patients with prostate cancer. Int. J. Cancer 136, 875–879 (2015)
10. J. Hoffmann, A. Munz, M. Krimmel, G. Alfter, Intraoperative and postoperative kinetics of serum tumor markers in patients with oral carcinoma. J. Oral Maxillofac. Surg. 56, 1390–1393 (1998)
11. M. Krimmel, J. Hoffmann, C. Krimmel, C.P. Cornelius, N. Schwenzer, Relevance of SCC-Ag, CEA, CA 19.9 and CA 125 for diagnosis and follow-up in oral cancer. J. Craniomaxillofac. Surg. 26, 243–248 (1998)
12. W.R. Kuo, K.W. Lee, K.Y. Ho, S.M. Tsai, F.Y. Chiang, K.H. Juan, Tissue polypeptide antigen, carcinoembryonic antigen, carbohydrate antigen, and CA125 levels as tumor markers in squamous cell carcinoma of the head and neck. Kaohsiung J. Med. Sci. 15, 152–158 (1999)
13. A. Korostoff, L. Reder, R. Masood, U.K. Sinha, The role of salivary cytokine biomarkers in tongue cancer invasion and mortality. Oral Oncol. 47, 282–287 (2011)
14. Y. Ogawa, Y. Taketomi, M. Murakami, M. Tsujimoto, R. Yanoshita, Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing. Biol. Pharm. Bull. 36, 66–75 (2013)
15. M. Yakob, L. Fuentes, M.B. Wang, E. Abemayor, D.T. Wong, Salivary biomarkers for detection of oral squamous cell carcinoma - current state and recent advances. Curr. Oral Health Rep. 1, 133–141 (2014)
16. C. Salazar, R. Nagadia, P. Pandit, J. Cooper-White, N. Banerjee, N. Dimitrova, W.B. Coman, C. Punyadeera, A novel saliva-based microRNA biomarker panel to detect head and neck cancers. Cell Oncol. 37, 331–338 (2014)
17. S. Hu, J. Wang, J. Meijer, S. Ieong, Y. Xie, T. Yu, H. Zhou, S. Henry, A. Vissink, J. Pijpe, C. Kallenberg, D. Elashoff, J.A. Loo, D.T. Wong, Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome. Arthritis Rheum. 56, 3588–3600 (2007)
18. L. Seugnet, J. Boero, L. Gottschalk, S.P. Duntley, P.J. Shaw, Identification of a biomarker for sleep drive in flies and humans. Proc. Natl. Acad. Sci. U. S. A. 103, 19913–19918 (2006)
19. Y. Güven, I. Satman, N. Dinççağ, S. Alptekin, Salivary peroxidase activity in whole saliva of patients with insulin-dependent (type-1) diabetes mellitus. J. Clin. Periodontol. 23, 879–881 (1996)
20. L.C. Fletcher, K.E. Burke, P.L. Caine, N.L. Rinne, C.A. Braniff, H.R. Davis, K.A. Miles, C. Packer, Diagnosing Alzheimer's disease: are we any nearer to useful biomarker-based, non-invasive tests? GMS Health Technol. Assess. 9, Doc01 (2013)
21. C. Streckfus, L. Bigler, T. Dellinger, X. Dai, A. Kingman, J.T. Thigpen, The presence of soluble c-erbB-2 in saliva and serum among women with breast carcinoma: a preliminary study. Clin. Cancer Res. 6, 2363–2370 (2000)
22. X.F. Jin, N. Wu, L. Wang, J. Li, Circulating microRNAs: a novel class of potential biomarkers for diagnosing and prognosing central nervous system diseases. Cell. Mol. Neurobiol. 33, 601–613 (2013)
23. J.A. Weber, D.H. Baxter, S. Zhang, D.Y. Huang, K.H. Huang, M.J. Lee, D.J. Galas, K. Wang, The microRNA spectrum in 12 body fluids. Clin. Chem. 56, 1733–1741 (2010)
24. P.M. Voorhoeve, R. Agami, Classifying microRNAs in cancer: the good, the bad and the ugly. Biochim. Biophys. Acta 1775, 274–282 (2007)
25. M. Seven, O.F. Karatas, M.B. Duz, M. Ozen, The role of miRNAs in cancer: from pathogenesis to therapeutic implications. Future Oncol. 10, 1027–1048 (2014)
26. E.J. Omelia, M.L. Uchimoto, G. Williams, Quantitative PCR analysis of blood- and saliva-specific microRNA markers following solid-phase DNA extraction. Anal. Biochem. 435, 120–122 (2013)
27. Z. Wang, H. Luo, X. Pan, M. Liao, Y. Hou, A model for data analysis of microRNA expression in forensic body fluid identification. Forensic Sci. Int. Genet. 6, 419–423 (2012)
28. O.F. Karatas, E. Guzel, I. Suer, I.D. Ekici, T. Caskurlu, C.J. Creighton, M. Ittmann, M. Ozen, miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer. PLos ONE 9(6), e98675 (2014)
29. C.J. Liu, S.C. Lin, C.C. Yang, H.W. Cheng, K.W. Chang, Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma. Head Neck 34, 219–224 (2012)
30. K.J. Livak, T.D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods 25, 402–408 (2001)
31. R.M. Nagler, M. Barak, M. Peled, H. Ben-Aryeh, M. Filatov, D. Laufer, Early diagnosis and treatment monitoring roles of tumor markers Cyfra 21–1 and TPS in oral squamous cell carcinoma. Cancer 85, 1018–1025 (1999)
32. R. Nagler, G. Bahar, T. Shpitzer, R. Feinmesser, Concomitant analysis of salivary tumor markers--a new diagnostic tool for oral cancer. Clin. Cancer Res. 12, 3979–3984 (2006)
33. S.S. Yilmaz, E. Guzel, O.F. Karatas, M. Yilmaz, C.J. Creighton, M. Ozen, MiR-221 as a pre- and postoperative plasma biomarker for larynx cancer patients. Laryngoscope (2015). doi:10.1002/lary.25332
34. T. Blondal, S. Jensby Nielsen, A. Baker, D. Andreasen, P. Mouritzen, M. Wrang Teilum, I.K. Dahlsveen, Assessing sample and miRNA profile quality in serum and plasma or other biofluids. Methods 59, S1–S6 (2013)
35. N.J. Park, Y. Li, T. Yu, B.M. Brinkman, D.T. Wong, Characterization of RNA in saliva. Clin. Chem. 52, 988–994 (2006)
36. S. Hu, Y. Xie, P. Ramachandran, R.R. Ogorzalek Loo, Y. Li, J.A. Loo, D.T. Wong, Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics 5, 1714–1728 (2005)
37. Y. Li, X. Zhou, M.A. St John, D.T. Wong, RNA profiling of cell-free saliva using microarray technology. J. Dent. Res. 83, 199–203 (2004)
38. N.J. Park, H. Zhou, D. Elashoff, B.S. Henson, D.A. Kastratovic, E. Abemayor, D.T. Wong, Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection. Clin. Cancer Res. 15, 5473–5477 (2009)
39. T.S. Wong, X.B. Liu, B.Y. Wong, R.W. Ng, A.P. Yuen, W.I. Wei, Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin. Cancer Res. 14, 2588–2592 (2008)
40. X. Liu, Z. Chen, J. Yu, J. Xia, X. Zhou, MicroRNA profiling and head and neck cancer. Comp. Funct. Genomics, 837514 (2009).
41. K. Krishnan, A.L. Steptoe, H.C. Martin, D.R. Pattabiraman, K. Nones, N. Waddell, M. Mariasegaram, P.T. Simpson, S.R. Lakhani, A. Vlassov, S.M. Grimmond, N. Cloonan, miR-139-5p is a regulator of metastatic pathways in breast cancer. RNA 19, 1767–1780 (2013)
42. H.D. Zhang, L.H. Jiang, D.W. Sun, J. Li, J.H. Tang, MiR-139-5p: promising biomarker for cancer. Tumour Biol. 36, 1355–1365 (2015)
43. J.K. Rane, M. Scaravilli, A. Ylipää, D. Pellacani, V.M. Mann, M.S. Simms, M. Nykter, A.T. Collins, T. Visakorpi, N.J. Maitland, MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets. Eur. Urol. 67, 7–10 (2015)
44. E. van Rooij, A.L. Purcell, A.A. Levin, Developing microRNA therapeutics. Circ. Res. 110, 496–507 (2012)
45. L. Boldrup, P.J. Coates, G. Laurell, T. Wilms, R. Fahraeus, K. Nylander, Downregulation of miRNA-424: a sign of field cancerisation in clinically normal tongue adjacent to squamous cell carcinoma. Br. J. Cancer 112, 1760–1765 (2015)