Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B

International Journal of Cancer

Volumn 131, Issue 9, 2012, Pages 2034-2043

  Beckham, Thomas H ^a   Lu, Ping ^a   Cheng, Joseph C ^a   Zhao, Dan ^c   Turner, Lorianne S ^d   Zhang, Xiaoyi ^b   Hoffman, Stanley ^a   Armeson, Kent E ^b   Liu, Angen ^b   Marrison, Tucker ^a   Hannun, Yusuf A ^a   Liu, Xiang ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d FRANCIS MARION UNIVERSITY   (United States)

Author keywords

acid ceramidase; cathepsin B; invasion; prostate cancer; tumor metastasis

Indexed keywords

ACID CERAMIDASE; CATHEPSIN B; CATHEPSIN B INHIBITOR; COLLAGEN; SPHINGOSINE 1 PHOSPHATE;

ARTICLE; BINDING SITE; BIOSYNTHESIS; CANCER INVASION; CANCER TISSUE; CARCINOGENESIS; CELL MEMBRANE TRANSPORT; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; UPREGULATION;

ACID CERAMIDASE; CATHEPSIN B; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; HUMANS; LYSOPHOSPHOLIPIDS; MALE; NEOPLASM INVASIVENESS; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEIN C-ETS-1; SPHINGOSINE; UP-REGULATION;

EID: 84865546284     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27480     Document Type: Article

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