The antihypertension drug doxazosin suppresses JAK/STATs phosphorylation and enhances the effects of IFN-α/γ-induced apoptosis

Genes and Cancer

Volumn 5, Issue 11-12, 2014, Pages 460-479

  Park, Mi Sun ^a   Kim, Boh Ram ^a   Kang, Sokbom ^a   Kim, Dae Yong ^b   Rho, Seung Bae ^a  

^a National Cancer Center   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Apoptotic cell death; Cell cycle progression; Doxazosin; Interferon ; JAK STAT activation

Indexed keywords

ALPHA INTERFERON; CASPASE 3; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; DOXAZOSIN; GAMMA INTERFERON; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 2; MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C DELTA; PROTEIN KINASE TYK2; PROTEIN P21; PROTEIN P27; PROTEIN P53; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOUSE; MTT ASSAY; NONHUMAN; OVARIAN CANCER CELL LINE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; TUMOR VOLUME; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING;

EID: 84949495116     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: None     Document Type: Article

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