IL-10 gene polymorphisms are associated with post-bronchiolitis lung function abnormalities at six years of age

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Lauhkonen, Eero ^a   Koponen, Petri ^a   Teräsjärvi, Johanna ^b,c   Gröndahl Yli Hannuksela, Kirsi ^b,c   Vuononvirta, Juho ^b,c   Nuolivirta, Kirsi ^d   Toikka, Jyri O ^e,f   Helminen, Merja ^a   He, Qiushui ^b,c   Korppi, Matti ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TURKU UNIVERSITY   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d SEINÄJOKI CENTRAL HOSPITAL   (Finland)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

^f TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; IL10 PROTEIN, HUMAN;

ARTICLE; BRONCHIOLITIS; BRONCHUS HYPERREACTIVITY; CHILD; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXERCISE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HUMAN; IL 10 GENE; IMPULSE OSCILLOMETRY; LUNG DISEASE; LUNG FUNCTION DEFICIT; MAJOR CLINICAL STUDY; OSCILLOMETRY; PRESCHOOL CHILD; PROMOTER REGION; PROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; FEMALE; GENETICS; INFANT; LUNG; LUNG FUNCTION TEST; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

BRONCHIOLITIS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INTERLEUKIN-10; LUNG; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RESPIRATORY FUNCTION TESTS;

EID: 84949488971     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0140799     Document Type: Article

References (30)

1. Smyth RL, Openshaw PJ. Bronchiolitis. Lancet. 2006; 368: 312-322.
2. Helminen M, Nuolivirta K, Virta M, Halkosalo A, Korppi M, Vesikari T, et al. IL-10 gene polymorphism at-1082 A/G is associated with severe rhinovirus bronchiolitis in infants. Pediatr Pulmonol. 2008; 43: 391-395. doi: 10.1002/ppul.20793
3. Garcia C, Soriano-Fallas A, Lozano J, Leos N, Gomez AM, Ramilo O, et al. Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis. Pediatr Infect Dis J. 2012; 31: 86-89. doi: 10.1097/INF. 0b013e31822dc8c1
4. Bont L, Heijnen CJ, Kavelaars A, van Aalderen WM, Brus F, Draaisma JT, et al. Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a oneyear follow-up study. Am J Respir Crit Care Med. 2000; 161: 1518-1523.
5. Nuolivirta K, Hurme M, Halkosalo A, Koponen P, Korppi M, Vesikari T, et al. Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis. Pediatr Infect Dis J. 2009; 28: 1121-1123. doi: 10.1097/INF.0b013e3181af37ee
6. Hyun MH, Lee CH, Kang MH, Park BK, Lee YH. Interleukin-10 promoter gene polymorphisms and susceptibility to asthma: A meta-Analysis. PLoS One. 2013; 8: e53758. doi: 10.1371/journal.pone.0053758
7. Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, et al. Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2011; 127: 701-21.e1-70. doi: 10.1016/j.jaci.2010.11.050
8. Borish L, Aarons A, Rumbyrt J, Cvietusa P, Negri J, Wenzel S. Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol. 1996; 97: 1288-1296.
9. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet. 1997; 24: 1-8.
10. Crawley E, Kay R, Sillibourne J, Patel P, Hutchinson I, Woo P. Polymorphic haplotypes of the interleukin-10 5' flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum. 1999; 42: 1101-1108.
11. Lyon H, Lange C, Lake S, Silverman EK, Randolph AG, Kwiatkowski D, et al. IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol. 2004; 26: 155-165.
12. Gibson AW, Edberg JC, Wu J, Westendorp RG, Huizinga TW, Kimberly RP. Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus. J Immunol. 2001; 166: 3915-3922.
13. Koponen P, Nuolivirta K, Virta M, Helminen M, Hurme M, Korppi M. Polymorphism of the rs1800896 IL10 promoter gene protects children from post-bronchiolitis asthma. Pediatr Pulmonol. 2014; 49: 800-806. doi: 10.1002/ppul.22909
14. Dubois AB, Brody AW, Lewis DH, Burgess BF Jr. Oscillation mechanics of lungs and chest in man. J Appl Physiol. 1956; 8: 587-594.
15. Oostveen E, MacLeod D, Lorino H, Farre R, Hantos Z, Desager K, et al. The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J. 2003; 22: 1026-1041.
16. Beydon N, Davis SD, Lombardi E, Allen JL, Arets HG, Aurora P, et al. An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med. 2007; 175: 1304-1345.
17. Lauhkonen E, Koponen P, Nuolivirta K, Paassilta M, Toikka J, Korppi M. Lung function by impulse oscillometry at age 5-7 years after bronchiolitis at age 0-6 months. Pediatr Pulmonol. 2015; 50: 389-395. doi: 10.1002/ppul.23039
18. Koponen P, Helminen M, Paassilta M, Luukkaala T, Korppi M. Preschool asthma after bronchiolitis in infancy. Eur Respir J. 2012; 39: 76-80. doi: 10.1183/09031936.00040211
19. Lauhkonen E, Koponen P, Nuolivirta K, Paassilta M, Toikka J, Saari A, et al. Obesity and bronchial obstruction in impulse oscillometry at age 5-7 years in a prospective post-bronchiolitis cohort. Pediatr Pulmonol. 2015; 50: 908-914. doi: 10.1002/ppul.23085
20. Smith H, Reinhold P, Goldman M. Chapter 5. Forced oscillation technique and impulse oscillometry. European Respiratory Society Monograph. 2005; 31: 75-105.
21. Malmberg LP, Pelkonen A, Poussa T, Pohianpalo A, Haahtela T, Turpeinen M. Determinants of respiratory system input impedance and bronchodilator response in healthy Finnish preschool children. Clin Physiol Funct Imaging. 2002; 22: 64-71.
22. Malmberg LP, Makela MJ, Mattila PS, Hammaren-Malmi S, Pelkonen AS. Exercise-induced changes in respiratory impedance in young wheezy children and nonatopic controls. Pediatr Pulmonol. 2008; 43: 538-544. doi: 10.1002/ppul.20805
23. Vuononvirta J, Toivonen L, Grondahl-Yli-Hannuksela K, Barkoff AM, Lindholm L, Mertsola J, et al. Nasopharyngeal bacterial colonization and gene polymorphisms of mannose-binding lectin and toll-like receptors 2 and 4 in infants. PLoS One. 2011; 6: e26198. doi: 10.1371/journal.pone.0026198
24. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics. 2005; 21: 263-265.
25. 1000 Genomes Project Consortium, Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, et al. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012; 491: 56-65. doi: 10. 1038/nature11632
26. Eskdale J, Keijsers V, Huizinga T, Gallagher G. Microsatellite alleles and single nucleotide polymorphisms (SNP) combine to form four major haplotype families at the human interleukin-10 (IL-10) locus. Genes Immun. 1999; 1: 151-155.
27. Clark AG. Inference of haplotypes from PCR-Amplified samples of diploid populations. Mol Biol Evol. 1990; 7: 111-122.
28. Cunningham F, Amode MR, Barrell D, Beal K, Billis K, Brent S, et al. Ensembl 2015. Nucleic Acids Res. 2015; 43: D662-9. doi: 10.1093/nar/gku1010
29. Makela MJ, Kanehiro A, Borish L, Dakhama A, Loader J, Joetham A, et al. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proc Natl Acad Sci U S A. 2000; 97: 6007-6012.
30. Mok CC, Lanchbury JS, Chan DW, Lau CS. Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus. Arthritis Rheum. 1998; 41: 1090-1095.