Drug repurposing: Sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion

Oncogene

Volumn 34, Issue 49, 2015, Pages 5951-5959

  Sleire, L ^a   Skeie, B S ^a,b   Netland, I A ^a   Forde H E ^a   Dodoo, E ^c   Selheim, F ^a   Leiss, L ^a,b   Heggdal, J I ^b   Pedersen, P H ^a,b   Wang, J ^a   Enger, P O ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CYSTINE; GLUTATHIONE; RADIOSENSITIZING AGENT; REACTIVE OXYGEN METABOLITE; SALAZOSULFAPYRIDINE; AMINO ACID TRANSPORTER; DNA; SLC7A11 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; DRUG REPOSITIONING; ENZYME ACTIVE SITE; GAMMA KNIFE RADIOSURGERY; GLIOBLASTOMA; GLIOMA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR XENOGRAFT; ANIMAL; BRAIN NEOPLASMS; DRUG EFFECTS; DRUG SCREENING; METABOLISM; RADIATION RESPONSE; RADIOSURGERY; TUMOR CELL LINE;

AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; CYSTINE; DNA; DRUG REPOSITIONING; GLIOBLASTOMA; GLUTATHIONE; HUMANS; RADIATION-SENSITIZING AGENTS; RADIOSURGERY; RATS; SULFASALAZINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84949322403     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.60     Document Type: Article

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