Supplemental epilactose prevents metabolic disorders through uncoupling protein-1 induction in the skeletal muscle of mice fed high-fat diets

British Journal of Nutrition

Volumn 114, Issue 11, 2015, Pages 1774-1783

  Murakami, Yuki ^a   Ojima Kato, Teruyo ^b   Saburi, Wataru ^c   Mori, Haruhide ^c   Matsui, Hirokazu ^c   Tanabe, Soichi ^a   Suzuki, Takuya ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Epilactose; Obesity; Propionic acid; Skeletal muscle; Uncoupling protein

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; DISACCHARIDE; EPILACTOSE; FATTY ACID SYNTHASE; GLUCOSE; INSULIN; LIPOPROTEIN LIPASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (PYROPHOSPHATE); TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; ANTIOBESITY AGENT; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PREBIOTIC AGENT; PROPIONIC ACID; PROPIONIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; CONTROLLED STUDY; DENSITOMETRY; ELECTROSPRAY; ENERGY EXPENDITURE; ENERGY METABOLISM; EPIDIDYMIS FAT; FATTY ACID SYNTHESIS; GASTROCNEMIUS MUSCLE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID DIET; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INDUCTION; SKELETAL MUSCLE; SUPPLEMENTATION; TRIACYLGLYCEROL BLOOD LEVEL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ADVERSE EFFECTS; AGONISTS; ANIMAL; C57BL MOUSE; CELL LINE; FERMENTATION; GENETICS; IMMUNOLOGY; INTESTINE FLORA; MACROPHAGE ACTIVATION; METABOLISM; MICROBIOLOGY; PATHOLOGY; RANDOMIZATION; UPREGULATION; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-OBESITY AGENTS; CELL LINE; DIET, HIGH-FAT; DISACCHARIDES; ENERGY METABOLISM; FERMENTATION; GASTROINTESTINAL MICROBIOME; ION CHANNELS; MACROPHAGE ACTIVATION; MALE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; OBESITY; PREBIOTICS; PROPIONATES; RANDOM ALLOCATION; UP-REGULATION;

EID: 84949312923     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114515003505     Document Type: Article

References (30)

1. Cataldi TR, Angelotti M & Bufo SA (1999) Method development for the quantitative determination of lactulose in heat-treated milks by HPAEC with pulsed amperometric detection. Anal Chem 71, 4919-4925.
2. Ito S, Taguchi H, Hamada S, et al. (2008) Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme. Appl Microbiol Biotechnol 79, 433-441.
3. Suzuki T, Nishimukai M, Shinoki A, et al. (2010) Ingestion of epilactose, a non-digestible disaccharide, improves postgastrectomy osteopenia and anemia in rats through the promotion of intestinal calcium and iron absorption. J Agric Food Chem 58, 10787-10792.
4. Kahn SE, Hull RL & Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444, 840-846.
5. Johns DJ, Lindroos AK, Jebb SA, et al. (2015) Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity. Obesity (Silver Spring) 23, 1063-1070.
6. Parillo M & Riccardi G (2004) Diet composition and the risk of type 2 diabetes: epidemiological and clinical evidence. Br J Nutr 92, 7-19.
7. Roberfroid M, Gibson GR, Hoyles L, et al. (2010) Prebiotic effects: metabolic and health benefits. Br J Nutr 104, S1-63.
8. Cani PD & Delzenne NM (2009) The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des 15, 1546-1558.
9. Delzenne NM, Daubioul C, Neyrinck A, et al. (2002) Inulin and oligofructose modulate lipid metabolism in animals: review of biochemical events and future prospects. Br J Nutr 87, S255-S259.
10. Hara T, Kashihara D, Ichimura A, et al. (2014) Role of free fatty acid receptors in the regulation of energy metabolism. Biochim Biophys Acta 1841, 1292-1300.
11. Kimura I, Ozawa K, Inoue D, et al. (2013) The gut microbiota suppresses insulin-mediated fat accumulation via the shortchain fatty acid receptor GPR43. Nat Commun 4, 1829.
12. Ricquier D & Bouillaud F (2000) The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J 345, 161-179.
13. Li B, Nolte LA, Ju JS, et al. (2000) Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat Med 6, 1115-1120.
14. Couplan E, Gelly C, Goubern M, et al. (2002) High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content. J Biol Chem 277, 43079-43088.
15. Reeves PG, Nielsen FH & Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939-1951.
16. Bligh EG & Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37, 911-917.
17. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
18. Okazaki Y, Ohshima N, Yoshizawa I, et al. (2010) A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism. J Biol Chem 285, 27652-27663.
19. Jakobsdottir G, Jadert C, Holm L, et al. (2013) Propionic and butyric acids, formed in the caecum of rats fed highly fermentable dietary fibre, are reflected in portal and aortic serum. Br J Nutr 110, 1565-1572.
20. Nishimukai M, Watanabe J, Taguchi H, et al. (2008) Effects of epilactose on calcium absorption and serum lipid metabolism in rats. J Agric Food Chem 56, 10340-10345.
21. Cani PD, Possemiers S, Van de Wiele T, et al. (2009) Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58, 1091-1103.
22. Xie S, Zhu J, Zhang Y, et al. (2012) Effects of soya oligosaccharides and soya oligopeptides on lipid metabolism in hyperlipidaemic rats. Br J Nutr 108, 603-610.
23. Cypess AM, Lehman S, Williams G, et al. (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360, 1509-1517.
24. Virtanen KA, Lidell ME, Orava J, et al. (2009) Functional brown adipose tissue in healthy adults. N Engl J Med 360, 1518-1525.
25. Harper ME, Green K & Brand MD (2008) The efficiency of cellular energy transduction and its implications for obesity. Annu Rev Nutr 28, 13-33.
26. Katterle Y, Keipert S, Hof J, et al. (2008) Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1. Physiol Genomics 32, 352-359.
27. Nilsson NE, Kotarsky K, Owman C, et al. (2003) Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun 303, 1047-1052.
28. Suzuki T, Elias BC, Seth A, et al. (2009) PKC eta regulates occludin phosphorylation and epithelial tight junction integrity. Proc Natl Acad Sci USA 106, 61-66.
29. Bai Y & Sun Q (2015) Macrophage recruitment in obese adipose tissue. Obes Rev 16, 127-136.
30. Exley MA, Hand L, O'Shea D, et al. (2014) Interplay between the immune system and adipose tissue in obesity. J Endocrinol 223, R41-R48.