Penetration of antimicrobials to pulmonary epithelial lining fluid and muscle and impact of drug physicochemical properties determined by microdialysis

Journal of Pharmacological and Toxicological Methods

Volumn 78, Issue , 2016, Pages 58-65

  Rottbøll, Lisa Amanda Holm ^a,b   Friis, Christian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NONE   (Denmark)

Author keywords

Antimicrobials; Colistin; Drug penetration; Extracellular fluid; Gentamicin; Methods; Microdialysis; Physicochemical characteristics; Pigs; Pulmonary epithelial lining fluid

Indexed keywords

CEFQUINOME; COLISTIN; GENTAMICIN; MINOCYCLINE; SULFADIAZINE; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DIFFUSION; DRUG PENETRATION; DRUG PROTEIN BINDING; EPITHELIAL LINING FLUID; EXTRACELLULAR FLUID; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LOADING DRUG DOSE; MICRODIALYSIS; MOLECULAR WEIGHT; MUSCLE; NONHUMAN; PHYSICAL CHEMISTRY; PIG; STEADY STATE; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; METABOLISM; PERMEABILITY; PHYSIOLOGY; PROCEDURES; RESPIRATORY MUCOSA; SKELETAL MUSCLE; TISSUE DISTRIBUTION;

ANIMALS; ANTI-INFECTIVE AGENTS; CHEMICAL PHENOMENA; EXTRACELLULAR FLUID; FEMALE; MICRODIALYSIS; MUSCLE, SKELETAL; PERMEABILITY; RESPIRATORY MUCOSA; SWINE; TISSUE DISTRIBUTION;

EID: 84949255962     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2015.11.007     Document Type: Article

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