Salt-induced sympathoexcitation involves vasopressin V1a receptor activation in the paraventricular nucleus of the hypothalamus

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 309, Issue 11, 2015, Pages R1369-R1379

  Ribeiro, Natalia ^a   Panizza, Helena do Nascimento ^a   dos Santos, Karoline Martins ^a   Ferreira Neto, Hildebrando C ^a   Antunes, Vagner Roberto ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Hypertension; Paraventricular nucleus of the hypothalamus; Salt loading; Sympathoexcitation; Vasopressin

Indexed keywords

SODIUM CHLORIDE; VASOPRESSIN; VASOPRESSIN V1A RECEPTOR; ARGIPRESSIN; SALT INTAKE; V1A VASOPRESSIN RECEPTOR, RAT; VASOPRESSIN RECEPTOR; VASOPRESSIN RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPERTENSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MEAN ARTERIAL PRESSURE; NERVE CELL; NERVE EXCITABILITY; NONHUMAN; PLASMA OSMOLALITY; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; SALT LOADING; SYMPATHETIC FUNCTION; SYMPATHETIC NERVE; ADRENERGIC SYSTEM; AGONISTS; ANIMAL; ARTERIAL PRESSURE; DISEASE MODEL; DRUG EFFECTS; MALE; METABOLISM; MICROINJECTION; PATHOPHYSIOLOGY; SALT INTAKE; TIME FACTOR; WISTAR RAT;

ANIMALS; ANTIDIURETIC HORMONE RECEPTOR ANTAGONISTS; ARGININE VASOPRESSIN; ARTERIAL PRESSURE; DISEASE MODELS, ANIMAL; HYPERTENSION; MALE; MICROINJECTIONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS, WISTAR; RECEPTORS, VASOPRESSIN; SODIUM CHLORIDE, DIETARY; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS;

EID: 84949255792     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00312.2015     Document Type: Article

References (35)

1. Antunes VR, Yao ST, Pickering AE, Murphy D, Paton JFR. A spinal vasopressinergic mechanism mediates hyperosmolality-induced sympa-thoexcitation. J Physiol 576: 569–583, 2006.
2. Barberis C, Balestres MN, Jard S, Tribollet E, Arsenijevic Y, Dreifuss JJ, Bankowski K, Manning M, Chan WY, Scholosser SS, Holsboer F, Elands J. Characterization of a novel, linear radioiodinated vasopressin antagonist: an excellent radioligand for vasopressin Vxa receptors. Neuroendocrinology 62: 135–146, 1995.
3. Bergquist F, Ludwig M. Dendritic transmitter release: a comparison of two model systems. J Neuroendocrinol 20: 677–686, 2008.
4. Boudaba C, Linn DM, Halmos KC, Tasker JG. Increased tonic activation of presynaptic metabotropic glutamate receptors in the rat supraoptic nucleus following chronic dehydration. J Physiol 551: 815–823, 2003.
5. Brooks VL, Haywood JR, Johnson AK. Translation of salt retention to central activation of the sympathetic nervous system in hypertension. Clin Exp Pharmacol Physiol 32: 426–432, 2005.
6. Bunag RD, Miyajima E. Sympathetic hyperactivity elevates blood pressure during acute cerebroventricular infusions of hypertonic salt in rats. J Cardiovasc Pharmacol 6: 844–851, 1984.
7. Cechetto F, Saper CB. Neurochemical organization of the hypothalamic projection to the spinal cord in the rat. J Comp Neurol 272: 579–604, 1998.
8. Di S, Tasker JG. Dehydration induced synaptic plasticity in magnocellular neurons of the hypothalamic supraoptic nucleus. Endocrinology 145: 5141–5149, 2004.
9. DiBona GF, Sawin LL. Role of renal nerves in sodium retention of cirrhosis and congestive heart failure. Am J Physiol Regul Integr Comp Physiol 260: R298–R305, 1991.
10. Garcia-Estan J, Carbonell LF, Garcia-Salom M, Salazar F, Quesada T. Hemodynamic effects of hypertonic saline in the conscious rat. Life Sci 44: 1343–1350, 1989.
11. He FJ, Markandu ND, Sagnella GA, de Wardener HE, MacGregor GA. Plasma sodium: ignored and underestimated. Hypertension 45: 98–102, 2005.
12. Kotchen TA, Cowley AW Jr, Frohlich ED. Salt in health and disease-a delicate balance. N Engl J Med 368: 1229–1237, 2013.
13. Landgraf R, Ludwig M. Vasopressin release within the supraoptic and paraventricular nuclei of the rat brain: osmotic stimulation via microdialysis. Brain Res 558: 191–196, 1991.
14. Larsen PJ, Mikkelsen JD. Functional identification of central afferent projections conveying information of acute “stress” to the hypothalamic paraventricular nucleus. J Neurosci 15: 2609–2627, 1995.
15. Leng G, Brown CH, Bull PM, Brown D, Scullion S, Currie J, Blackburn-Munro RE, Feng J, Onaka T, Verbalis JG, Russell JA, Ludwig M. Responses of magnocellular neurons to osmotic stimulation involves coactivation of excitatory and inhibitory input: an experimental and theoretical analysis. J Neurosci 21: 6967–6977, 2001.
16. Ludwig M, Callahan MF, Neumann I, Landgraf R, Morris M. Systemic osmotic stimulation increases vasopressin and oxytocin release within the supraoptic nucleus. J Neuroendocrinol 6: 369–373, 1994.
17. Ludwig M, Leng G. Dendritic peptide release and peptide-dependent behaviours. Nat Rev Neurosci 7: 126–136, 2006.
18. Mens WB, Witter A, van Wimersma Greidanus TB. Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): half-times of disappearance of these neuropeptides from CSF. Brain Res 262: 143–149, 1983.
19. Miselis RR. The efferent projections of the subfornical organ of the rat: a circumventricular organ within a neural network subserving water balance. Brain Res 230: 1–23, 1981.
20. Oliet SH, Bourque CW. Mechanosensitive channels transduce osmosensitivity in supraoptic neurons. Nature 364: 341–343, 1993.
21. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. San Diego, CA: Elsevier Academic, 5th ed., 2005.
22. Perlmutter LS, Tweedle CD, Hatton GI. Neuronal/glial plasticity in the supraoptic dendritic zone in response to acute and chronicde hydration. Brain Res 361: 225–232, 1985.
23. Pow CV, Morris JF. Dendrites of hypothalamic magnocellular neurons release neurohipophysial peptides by exocytosis. Neuroscience 32: 435–439, 1989.
24. Pyner S, Coote JH. Identification of an efferent projection from the paraventricular nucleus of the hypothalamus terminating close to spinally projecting rostral ventrolateral medullary neurons. Neuroscience 88: 949–945, 1999.
25. Rossi NF, Maliszewska-Scislo M. Role of paraventricular nucleus vasopressin V1A receptors in the response to endothelin 1 activation of the subfornical organ in the rat. J Physiol Pharmacol 59 Suppl 8: 47–59, 2008.
26. Scrogin KE, Grygielko ET, Brooks VL. Osmolality: a physiological long-term regulator of lumbar sympathetic nerve activity and arterial pressure. Am J Physiol Regul Integr Comp Physiol 276: R1579–R1586, 1999.
27. Masuki S, Sumiyoshi E, Koshimizu T, Qian J, Higuchi K, Tsujimoto G, Nose H. Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice. J Physiol 591: 3651–3665, 2013.
28. Simerly RB, Sawnson LW. Projections of the medial preoptic nucleus: a Phaseolus vulgaris leucoagglutinin anterograde tract tracing study in the rat. J Comp Neurol 270: 209–242, 1988.
29. Son SJ, Filosa JA, Potapenko ES, Biancardi VC, Zheng H, Patel KP, Tobin VA, Ludwig M, Stern JE. Dendritic peptide release mediates interpopulation crosstalk between neurosecretory and preautonomic networks. Neuron 78: 1036–1049, 2013.
30. Stocker SD, Simmons JR, Stornetta RL, Toney GM, Guyenet PG. Water deprivation increases Fos immunoreactivity in PVN autonomic neurons with projections to the spinal cord and rostral ventrolateral medulla. J Comp Neurol 494: 673–685, 2004.
31. Stocker SD, Hunwick KJ, Toney GM. Hypothalamic paraventricular nucleus differentially supports lumbar and renal sympathetic outflow in water-deprived rats. J Physiol 563: 249–263, 2005.
32. Strazzullo P, D’Elia L, Kandala NB, Cappuccio FP. Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies. BMJ 339: b4567, 2009.
33. Toney GM, Stocker SD. Hyperosmotic activation of CNS sympathetic drive: implications for cardiovascular disease. J Physiol 588: 3375–3384, 2010.
34. Weinberger MH. Salt sensitivity of blood pressure in humans. Hypertension 27: 481–490, 1996.
35. Weiss ML, Classen TH, Kenney MJ. Nonuniform sympathetic nerves responses to intravenous hypertonic saline infusion. J Auton Nerv Syst 57: 109–115, 1996.