Responses of magnocellular neurons to osmotic stimulation involves coactivation of excitatory and inhibitory input: An experimental and theoretical analysis

Journal of Neuroscience

Volumn 21, Issue 17, 2001, Pages 6967-6977

  Leng, Gareth ^a   Brown, Colin H ^a   Bull, Philip M ^a   Brown, David ^b   Scullion, Sinead ^a   Currie, James ^a   Blackburn Munro, Ruth E ^c   Feng, Jianfeng ^d   Onaka, Tatsushi ^e   Verbalis, Joseph G ^c   Russell, John A ^a   Ludwig, Mike ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SUSSEX   (United Kingdom)

^e JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Hyponatremia; Hypothalamus; Microdialysis; Modeling; Oxytocin; Supraoptic nucleus

Indexed keywords

4 AMINOBUTYRIC ACID; BICUCULLINE; OXYTOCIN; SODIUM CHLORIDE; VASOPRESSIN;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DENDRITE; EXPERIMENTAL MODEL; GIANT CELL; MALE; MICRODIALYSIS; NERVE CELL MEMBRANE POTENTIAL; NEUROHYPOPHYSIS; NONHUMAN; OSMOSIS; OXYTOCIN RELEASE; PRIORITY JOURNAL; RAT; SUPRAOPTIC NUCLEUS; SYNAPTIC TRANSMISSION;

EID: 0035449976     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-17-06967.2001     Document Type: Article

References (42)

1. Median preoptic neurones projecting to the supraoptic nucleus are sensitive to haemodynamic changes as well as to rise in plasma osmolality in rats
2. Morphological and electrophysiological classification of hypothalamic supraoptic neurons
3. Differential regulation of oxytocin- and vasopressin-secreting nerve terminals
4. Ionic basis for the intrinsic activation of rat supraoptic neurones by hyperosmotic stimuli
5. Electrophysiology of mammalian magnocellular vasopressin and oxytocin neurosecretory neurons
6. Osmoreceptors, osmoreception, and osmoregulation
7. Characterization of the responses of oxytocin- and vasopressin-secreting neurons in the supraoptic nucleus to osmotic stimulation
8. Influence of oxytocin on renal hemodynamics and electrolyte and water excretion
9. Regulation of the milk ejection reflex in the rat
10. Coefficient of variation of interspike intervals greater than 0.5. How and when?
11. Gene expression in the rat supraoptic nucleus induced by chronic hyperos-molality versus hypoosmolality
12. Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart
13. Detailed analysis of blood oxytocin levels during suckling and parturition in the rat
14. Effect of chronic hyponatremia on central and peripheral oxytocin and vasopressin secretion in rats
15. The periventricular anteroventral third ventricle (AV3V): Its relationship with the subfornical organ and neural systems involved in maintaining body fluid homeostasis
16. The origins and significance of pulsatility in hormone secretion from the pituitary
17. Functional identification of magnocellular neuroendocrine neurones
18. The supraoptic nucleus as an osmoreceptor
19. The role of anterior peri-third ventricular structures in the regulation of supraoptic neuronal activity and neurohypophysial hormone secretion in the rat
20. Identification of oxytocin cells in the rat supraoptic nucleus by their response to cholecystokinin injection
21. Physiological pathways regulating the activity of magnocellular neurosecretory cells
22. Autoinhibition of supraoptic nucleus vasopressin neurons in vivo - A combined retrodialysis/electrophysiological study in rats
23. GABAergic projection from the arcuate nucleus to the supraoptic nucleus in the rat
24. Supraoptic neurones of the rat hypothalamus are osmosensitive
25. Efferent neural pathways of the lamina terminalis subserving osmoregulation
26. GABA receptor mediation of median preoptic nucleus-evoked inhibition of supraoptic neurosecretory neurones in rat
27. Membrane properties of organum vasculosum lamina terminalis neurons recorded in vitro
28. Mechanosensitive channels transduce osmosensitivity in supraoptic neurons
29. Gadolinium uncouples mechanical detection and osmoreceptor potential in supraoptic neurons
30. Characterization of spontaneous and evoked inhibitory postsynaptic potentials in rat supraoptic neurosecretory neurons in vitro
31. Cholecystokinin and gastric distension activate oxytocinergic cells in rat hypothalamus
32. Synaptic control of rat supraoptic neurones during osmotic stimulation of the organum vasculosum lamina terminalis in vitro
33. Effects of naloxone and of intraperitoneal hypertonic saline upon oxytocin release and upon supraoptic neuronal activity
34. Effect of anteroventral third ventricle lesions on vasopressin release by organ-cultured hypothalamo-neurohypophyseal explants
35. Interaction of osmotic and volume stimuli in regulation of neurohypophysial secretion in rats
36. Lesion of the organum vasculosum of the lamina terminalis (OVLT) attenuate osmotically-induced drinking and vasopressin secretion in the dog
37. An experimental model of syndrome of inappropriate antidiuretic hormone secretion in the rat
38. Oxytocin produces natriuresis in rats at physiological plasma concentrations
39. Coincident detection of CSF Na+ and osmotic pressure in osmoregulatory neurons of the supraoptic nucleus
40. Organum vasculosum lamina terminalis-evoked postsynaptic responses in rat supraoptic neurones in vitro
41. Chronic hypoosmolality induces a selective decrease in magnocellular neurone soma and nuclear size in the rat hypothalamic supraoptic nucleus