Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53

Structure

Volumn 23, Issue 12, 2015, Pages 2246-2255

  Joerger, Andreas C ^a   Bauer, Matthias R ^a   Wilcken, Rainer ^a   Baud, Matthias G J ^a   Harbrecht, Hannes ^a   Exner, Thomas E ^b   Boeckler, Frank M ^b   Spencer, John ^c   Fersht, Alan R ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

drug design; molecular chaperone; mutant rescue; p53; transient protein states

Indexed keywords

CARBAZOLE DERIVATIVE; MUTANT PROTEIN; PROLINE; PROTEIN P53; ANTINEOPLASTIC AGENT; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; CALORIMETRY; CANCER THERAPY; CRYSTAL STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SURFACE PROPERTY; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CHEMICAL PHENOMENA; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STABILITY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84949224551     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2015.10.016     Document Type: Article

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