Hydrophilic interaction chromatography combined with tandem mass spectrometry method for the quantification of tobramycin in human plasma and its application in a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 973, Issue , 2014, Pages 39-44

  Chen, Lingyun ^a   Chen, Huashan ^b   Shen, Mei ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGZHOU INSTITUTE OF GEOCHEMISTRY   (China)

Author keywords

HILIC MS MS; Human plasma; Pharmacokinetics; Tandem mass spectrometry; Tobramycin

Indexed keywords

ANTIBIOTICS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN);

ELECTROSPRAY IONIZATION (ESI); HILIC-MS/MS; HUMAN PLASMAS; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LINEAR CALIBRATION CURVE; LOWER LIMIT OF QUANTIFICATIONS; TANDEM MASS SPECTROMETRY; TOBRAMYCIN;

HYDROPHILICITY;

ACETONITRILE; AMMONIUM ACETATE; FORMIC ACID; SISOMICIN; TOBRAMYCIN;

ARTICLE; BLOOD SAMPLING; CALIBRATION; CHEMICAL ANALYSIS; CLINICAL STUDY; DRUG DETERMINATION; ELECTROSPRAY; HUMAN; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIMIT OF QUANTITATION; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT ACCURACY; NORMAL HUMAN; PHASE SEPARATION; PLASMA CONCENTRATION-TIME CURVE; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; STANDARD; TANDEM MASS SPECTROMETRY;

EID: 84949116430     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.10.007     Document Type: Article

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