The impact of PNPLA3 rs738409 genetic polymorphism and weight gain ≥10 kg after age 20 on non-alcoholic fatty liver disease in non-obese Japanese individuals

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Nishioji, Kenichi ^a   Mochizuki, Naomi ^a   Kobayashi, Masao ^a   Kamaguchi, Mai ^a   Sumida, Yoshio ^b   Nishimura, Takeshi ^b   Yamaguchi, Kanji ^b   Kadotani, Hiroshi ^c   Itoh, Yoshito ^b  

^a KYOTO SECOND RED CROSS HOSPITAL   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC TRAIT; GENETIC VARIABILITY; HUMAN; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PATHOGENESIS; PNPLA3 GENE; RISK FACTOR; WEIGHT GAIN; ALLELE; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; BODY MASS; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; JAPAN; MIDDLE AGED; OBESITY; ODDS RATIO; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPONUTRIN, HUMAN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; LIPID; MEMBRANE PROTEIN; TRIACYLGLYCEROL LIPASE;

ADULT; AGED; ALANINE TRANSAMINASE; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; ASPARTATE AMINOTRANSFERASES; BODY MASS INDEX; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; JAPAN; LIPASE; LIPIDS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; ODDS RATIO; OVERWEIGHT; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; WEIGHT GAIN;

EID: 84949035031     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0140427     Document Type: Article

References (45)

1. Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of nonalcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011; 34:274-85. doi: 10.1111/j.1365-2036.2011.04724.x PMID: 21623852
2. Pagadala MR, McCullough AJ. Non-alcoholic fatty liver disease and obesity: not all about body mass index. Am J Gastroenterol. 2012; 107:1859-61. doi: 10.1038/ajg.2012.320 PMID: 23211853
3. Liu CJ. Prevalence and risk factors for non-alcoholic fatty liver disease in Asian people who are not obese. J Gastroenterol Hepatol. 2012; 27:1555-60. doi: 10.1111/j.1440-1746.2012.07222.x PMID: 22741595
4. Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, et al. and JSG-NAFLD. Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study. J Gastroenterol. 2012; 47:586-95. doi: 10.1007/s00535-012-0533-z PMID: 22328022
5. Kwon YM, Oh SW, Hwang SS, Lee C, Kwon H, Chung GE. Association of nonalcoholic fatty liver disease with components of metabolic syndrome according to body mass index in Korean adults. Am J Gastroenterol. 2012; 107:1852-58. doi: 10.1038/ajg.2012.314 PMID: 23032980
6. Xu C, Yu C, Ma H, Xu L, Miao M, Li Y. Prevalence and risk factors for the development of nonalcoholic Fatty liver disease in a nonobese chinese population: the Zhejiang Zhenhai study. Am J Gastroenterol. 2013; 108:1299-304. doi: 10.1038/ajg.2013.104 PMID: 23567356
7. Nishioji K, Sumida Y, Kamaguchi M, Mochizuki N, Kobayashi M, Nishimura T, et al. Prevalence of and risk factors for non-alcoholic fatty liver disease in a non-obese Japanese population, 2011-2012. J Gastroenterol. 2015; 50:95-108. doi: 10.1007/s00535-014-0948-9 PMID: 24619537
8. De la Cruz AC, Bugianesi E, George J, Day CP, Liaquat H, Charatcharoenwitthaya P, et al. Characteristics and long-term prognosis of lean patients with nonalcoholic fatty liver disease. Digestive Disease Week 2014; abstract 379.
9. Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008; 40:1461-5. doi: 10. 1038/ng.257 PMID: 18820647
10. Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet. 2011; 7: e1001324. doi: 10.1371/journal.pgen. 1001324 PMID: 21423719
11. Hotta K, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, et al. Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease. BMC Med Genet. 2010; 11:172. doi: 10.1186/1471-2350-11-172 PMID: 21176169
12. Wang CW, Lin HY, Shin SJ, Yu ML, Lin ZY, Dai CY, et al. The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population. Liver Int. 2011; 31:1326-31. doi: 10.1111/j.1478-3231.2011.02526.x PMID: 21745282
13. A standard Health Checkup and Health Guidance Program (10 English version). Health Department of the Ministry of Health, Labor and Welfare, Japan, 2007.
14. Kimura T, Deshpande GA, Urayama KY, Masuda K, Fukui T, Matsuyama Y. Weight gain since age 20 is associated with nonalcoholic fatty liver disease in normal weight individuals. J Gastroenterol Hepatol. 2015; 30:909-17. doi: 10.1111/jgh.12861 PMID: 25469977
15. International Obesity Task Force. The Asian-Pacific Perspective: Redefining Obesity and Its Treatment. Health Communications Australia Pty Limited on behalf of the Steering Comittee: Sydney, Australia, 2000.
16. Shah AG, Lydecker A, Murray K, Tetri BN, Contos MJ, Sanyal AJ. Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2009; 7:1104-12. doi: 10.1016/j.cgh.2009.05.033 PMID: 19523535
17. Okanoue T, Makiyama A, Nakayama M, Sumida Y, Mitsuyoshi H, Nakajima T, et al. A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase. J Hepatol. 2005; 43:599-605. PMID: 16024129
18. Hotta K, Kitamoto A, Kitamoto T, Mizusawa S, Teranishi H, Matsuo T, et al. Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women. J Hum Genet. 2012; 57:46-51. doi: 10.1038/jhg.2011.127 PMID: 22071413
19. Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45, 891 individuals. PLoS Genet. 2012; 8:e1002607. doi: 10.1371/journal.pgen.1002607 PMID: 22479202
20. Kojima S, Watanabe N, Numata M, Ogawa T, Matsuzaki S. Increase in the prevalence of fatty liver in Japan overthe past 12 years: analysis of clinical background. J Gastroenterol. 2003; 38:954-61. PMID: 14614602
21. Palmer ND, Musani SK, Yerges-Armstrong LM, Feitosa MF, Bielak LF, Hernaez R, et al. Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. Hepatology. 2013; 58:966-75. doi: 10.1002/hep.26440 PMID: 23564467
22. Hernaez R, McLean J, Lazo M, Brancati FL, Hirschhorn JN, Borecki IB, et al. Association between variants in or near PNPLA3, GCKR, and PPP1R3B with ultrasound-defined steatosis based on data from the third National Health and Nutrition Examination Survey. Clin Gastroenterol Hepatol. 2013; 11:1183-1190. doi: 10.1016/j.cgh.2013.02.011 PMID: 23416328
23. Li Y, Xing C, Tian Z, Ku HC. Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population. BMC Med Genet. 2012; 13:113. doi: 10.1186/1471-2350-13-113 PMID: 23176674
24. Kawaguchi T, Sumida Y, Umemura A, Matsuo K, Takahashi M, Takamura T, et al. Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese. PLoS One. 2012; 7:e38322. doi: 10.1371/journal.pone.0038322 PMID: 22719876
25. Zhang Y, Cai W, Song J, Miao L, Zhang B, Xu Q, et al. Association between the PNPLA3 I148M polymorphism and non-alcoholic fatty liver disease in the Uygur and Han ethnic groups of northwestern China. PLoS One. 2014; 9:e108381. doi: 10.1371/journal.pone.0108381 PMID: 25290313
26. Lee SS, Byoun YS, Jeong SH, Woo BH, Jang ES, Kim JW, et al. Roleofthe PNPLA3 I148M polymorphism in nonalcoholic fatty liver disease and fibrosis in Korea. Dig Dis Sci. 2014; 59:2967-74. doi: 10. 1007/s10620-014-3279-z PMID: 25069572
27. Hyysalo J, Gopalacharyulu P, Bian H, Hyötyläinen T, Leivonen M, Jaser N, et al. Circulating triacylgly-cerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity. Diabetes. 2014; 63:312-22. doi: 10.2337/db13-0774 PMID: 24009255
28. Ruhanen H, Perttilä J, Hölttä-Vuori M, Zhou Y, Yki-Järvinen H, Ikonen E, et al. PNPLA3 mediates hepa-tocyte triacylglycerol remodeling. J Lipid Res. 2014; 55:739-46. doi: 10.1194/jlr.M046607 PMID: 24511104
29. Pirazzi C, Adiels M, Burza MA, Mancina RM, Levin M, Ståhlman M, et al. Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro. J Hepatol. 2012; 57:1276-82. doi: 10.1016/j.jhep.2012.07.030 PMID: 22878467
30. Pirazzi C, Valenti L, Motta BM, Pingitore P, Hedfalk K, Mancina RM, et al. PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells. Hum Mol Genet. 2014; 23:4077-85. doi: 10.1093/hmg/ddu121 PMID: 24670599
31. Shen J, Wong GL, Chan HL, Chan HY, Yeung DK, Chan RS, et al. PNPLA3 gene polymorphism accounts for fatty liver in community subjects without metabolic syndrome. Aliment Pharmacol Ther. 2014; 39:532-9. doi: 10.1111/apt.12609 PMID: 24417250
32. Sookoian S, Pirola CJ. Meta-analysis ofthe influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology. 2011; 53:1883-94. doi: 10.1002/hep.24283 PMID: 21381068
33. Shen J, Wong GL, Chan HL, Chan RS, Chan HY, Chu WC, et al. PNPLA3 gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2015; 30:139-46. doi: 10.1111/jgh.12656 PMID: 25040896
34. Yang Z, Wen J, Tao X, Lu B, Du Y, Wang M, et al. Genetic variation intheGCKRgene is associated with non-alcoholic fatty liver disease in Chinese people. Mol Biol Rep. 2011; 38:1145-50. doi: 10.1007/s11033-010-0212-1 PMID: 20625834
35. Lin YC, Chang PF, Chang MH, Ni YH. Genetic variants in GCKRand PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. Am J Clin Nutr. 2014; 99:869-74. doi: 10.3945/ajcn.113.079749 PMID: 24477042
36. Kitamoto A, Kitamoto T, Nakamura T, Ogawa Y, Yoneda M, Hyogo H, et al. Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits. Endocr J. 2014; 61:683-9. PMID: 24785259
37. Tan HL, Zain SM, Mohamed R, Rampal S, Chin KF, Basu RC, et al. Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene. J Gastroenterol. 2014; 49:1056-64. doi: 10.1007/s00535-013-0850-x PMID: 23800943
38. Zain SM, Mohamed Z, Mohamed R. A common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: a meta-analysis. J Gastroenterol Hepatol. 2015; 30:21-7. doi: 10.1111/jgh.12714 PMID: 25167786
39. Eguchi Y, Eguchi T, Mizuta T, Ide Y, Yasutake T, Iwakiri R, et al. Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease. J Gastoroenterol. 2006; 41:462-69.
40. Hernaez R, Lazo M, Bonekamp S, Kamel I, Brancati FL, Guallar E, et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology. 2011; 54:1082-90. doi: 10.1002/hep.24452 PMID: 21618575
41. Dasarathy S, Dasarathy J, Khiyami A, Joseph R, Lopez R, McCullough AJ. Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study. J Hepatol. 2009; 51:1061-7. doi: 10. 1016/j.jhep.2009.09.001 PMID: 19846234
42. Friedman GD, Collen MF, Fireman BH. Multiphasic Health Checkup Evaluation: a 16-year follow-up. J Chronic Dis. 1986; 39:453-63. PMID: 3711252
43. Yasutake K, Nakamuta M, Shima Y, Ohyama A, Masuda K, Haruta N, et al. Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol. Scand J Gastroenterol 2009; 44:471-7. doi: 10.1080/00365520802588133 PMID: 19058085
44. McCarthy EM, Rinella ME.The role of diet and nutrient composition in nonalcoholic fatty liver disease. J Acad Nutr Diet 2012; 112:401-9. doi: 10.1016/j.jada.2011.10.007 PMID: 22717200
45. Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology. 2008; 134:1369-75. doi: 10.1053/j.gastro.2008.01.075 PMID: 18355813