메뉴 건너뛰기




Volumn 57, Issue 1, 2012, Pages 46-51

Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women

(35)  Hotta, Kikuko a   Kitamoto, Aya a   Kitamoto, Takuya a   Mizusawa, Seiho a   Teranishi, Hajime a   Matsuo, Tomoaki b   Nakata, Yoshio b   Hyogo, Hideyuki c   Ochi, Hidenori c   Nakamura, Takahiro d   Kamohara, Seika e   Miyatake, Nobuyuki f   Kotani, Kazuaki g   Komatsu, Ryoya h   Itoh, Naoto i   Mineo, Ikuo j   Wada, Jun k   Yoneda, Masato l   Nakajima, Atsushi l   Funahashi, Tohru g   more..


Author keywords

computed tomography; CYP17A1; Japanese subjects; NT5C2; sexual dimorphism; subcutaneous fat area; visceral fat area

Indexed keywords

CYTOCHROME P450 17; CYTOCHROME P450 17 A1; FIBROBLAST GROWTH FACTOR 5; UNCLASSIFIED DRUG;

EID: 84863011270     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2011.127     Document Type: Article
Times cited : (35)

References (33)
  • 1
    • 3242795814 scopus 로고    scopus 로고
    • Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    • DOI 10.2337/diabetes.53.8.2087
    • Carr, D. B., Utzschneider, K. M., Hull, R. L., Kodama, K., Retzlaff, B. M., Brunzell, J. D. et al. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes 53, 2087-2094 (2004). (Pubitemid 38970759)
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 2087-2094
    • Carr, D.B.1    Utzschneider, K.M.2    Hull, R.L.3    Kodama, K.4    Retzlaff, B.M.5    Brunzell, J.D.6    Shofer, J.B.7    Fish, B.E.8    Knopp, R.H.9    Kahn, S.E.10
  • 2
    • 30544439060 scopus 로고    scopus 로고
    • Therapy insight: Adipocytokines in metabolic syndrome and related cardiovascular disease
    • DOI 10.1038/ncpcardio0380, PII N0380
    • Matsuzawa, Y. Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat. Clin. Pract. Cardiovasc. Med. 3, 35-42 (2006). (Pubitemid 43078211)
    • (2006) Nature Clinical Practice Cardiovascular Medicine , vol.3 , Issue.1 , pp. 35-42
    • Matsuzawa, Y.1
  • 3
    • 0035039227 scopus 로고    scopus 로고
    • Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
    • Hotta, K., Funahashi, T., Bodkin, N. L., Ortmeyer, H. K., Arita, Y., Hansen, B. C. et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50, 1126-1133 (2001). (Pubitemid 32374544)
    • (2001) Diabetes , vol.50 , Issue.5 , pp. 1126-1133
    • Hotta, K.1    Funahashi, T.2    Bodkin, N.L.3    Ortmeyer, H.K.4    Arita, Y.5    Hansen, B.C.6    Matsuzawa, Y.7
  • 4
    • 33644849140 scopus 로고    scopus 로고
    • Metabolic syndrome-definition and diagnostic criteria in Japan
    • Mastuzawa, Y. Metabolic syndrome-definition and diagnostic criteria in Japan. J. Atheroscler. Thromb. 12, 301 (2005).
    • (2005) J. Atheroscler. Thromb. , vol.12 , pp. 301
    • Mastuzawa, Y.1
  • 7
    • 0032198565 scopus 로고    scopus 로고
    • Genetic and behavioral determinants of waist-hip ratio and waist circumference in women twins
    • Rose, K. M., Newman, B., Mayer-Davis, E. J. & Selby, J. V. Genetic and behavioral determinants of waist-hip ratio and waist circumference in women twins. Obes. Res. 6, 383-392 (1998). (Pubitemid 128679687)
    • (1998) Obesity Research , vol.6 , Issue.6 , pp. 383-392
    • Rose, K.M.1    Newman, B.2    Mayer-Davis, E.J.3    Selby, J.V.4
  • 9
    • 67651236725 scopus 로고    scopus 로고
    • Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution
    • Lindgren, C. M., Heid, I. M., Randall, J. C., Lamina, C., Steinthorsdottir, V., Qi, L. et al. Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genet. 5, e1000508 (2009).
    • (2009) PLoS Genet. , vol.5
    • Lindgren, C.M.1    Heid, I.M.2    Randall, J.C.3    Lamina, C.4    Steinthorsdottir, V.5    Qi, L.6
  • 10
    • 67651216024 scopus 로고    scopus 로고
    • NRXN3 is a novel locus for waist circumference: A genome-wide association study from the CHARGE Consortium
    • Heard-Costa, N. L., Zillikens, M. C., Monda, K. L., Johansson, A., Harris, T. B., Fu, M. et al. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet. 5, e1000539 (2009).
    • (2009) PLoS Genet. , vol.5
    • Heard-Costa, N.L.1    Zillikens, M.C.2    Monda, K.L.3    Johansson, A.4    Harris, T.B.5    Fu, M.6
  • 11
    • 78649508009 scopus 로고    scopus 로고
    • Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population
    • Hotta, K., Nakamura, M., Nakamura, T., Matsuo, T., Nakata, Y., Kamohara, S. et al. Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. J. Hum. Genet. 55, 738-742 (2010).
    • (2010) J. Hum. Genet. , vol.55 , pp. 738-742
    • Hotta, K.1    Nakamura, M.2    Nakamura, T.3    Matsuo, T.4    Nakata, Y.5    Kamohara, S.6
  • 15
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    • Willer, C. J., Speliotes, E. K., Loos, R. J., Li, S., Lindgren, C. M., Heid, I. M. et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25-34 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 25-34
    • Willer, C.J.1    Speliotes, E.K.2    Loos, R.J.3    Li, S.4    Lindgren, C.M.5    Heid, I.M.6
  • 16
    • 59149097625 scopus 로고    scopus 로고
    • Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
    • Meyre, D., Delplanque, J., Chèvre, J. C., Lecoeur, C., Lobbens, S., Gallina, S. et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat. Genet. 41, 157-159 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 157-159
    • Meyre, D.1    Delplanque, J.2    Chèvre, J.C.3    Lecoeur, C.4    Lobbens, S.5    Gallina, S.6
  • 17
    • 80155133629 scopus 로고    scopus 로고
    • Computed tomography analysis of the association between SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
    • Hotta, K., Kitamoto, T., Kitamoto, A., Mizusawa, S., Matsuo, T., Nakata, Y. et al. Computed tomography analysis of the association between SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area. J. Hum. Genet. 56, 716-719 (2011).
    • (2011) J. Hum. Genet. , vol.56 , pp. 716-719
    • Hotta, K.1    Kitamoto, T.2    Kitamoto, A.3    Mizusawa, S.4    Matsuo, T.5    Nakata, Y.6
  • 18
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S. et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl Acad. Sci. USA 106, 9362-9367 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3    Ramos, E.M.4    Mehta, J.P.5    Collins, F.S.6
  • 19
    • 80053261710 scopus 로고    scopus 로고
    • Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
    • Hotta, K., Kitamoto, T., Kitamoto, A., Mizusawa, S., Matsuo, T., Nakata, Y. et al. Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. J. Hum. Genet. 56, 647-651 (2011).
    • (2011) J. Hum. Genet. , vol.56 , pp. 647-651
    • Hotta, K.1    Kitamoto, T.2    Kitamoto, A.3    Mizusawa, S.4    Matsuo, T.5    Nakata, Y.6
  • 21
    • 67349085063 scopus 로고    scopus 로고
    • Genome-wide association study identifies eight loci associated with blood pressure
    • Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, M. D., Bochud, M., Coin, L. et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat. Genet. 41, 666-676 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 666-676
    • Newton-Cheh, C.1    Johnson, T.2    Gateva, V.3    Tobin, M.D.4    Bochud, M.5    Coin, L.6
  • 23
    • 0034885541 scopus 로고    scopus 로고
    • A high-throughput SNP typing system for genome-wide association studies
    • DOI 10.1007/s100380170047
    • Ohnishi, Y., Tanaka, T., Ozaki, K., Yamada, R., Suzuki, H. & Nakamura, Y. A highthroughput SNP typing system for genome-wide association studies. J. Hum. Genet. 46, 471-477 (2001). (Pubitemid 32744120)
    • (2001) Journal of Human Genetics , vol.46 , Issue.8 , pp. 471-477
    • Ohnishi, Y.1    Tanaka, T.2    Ozaki, K.3    Yamada, R.4    Suzuki, H.5    Nakamura, Y.6
  • 24
    • 0032231375 scopus 로고    scopus 로고
    • Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus
    • DOI 10.1086/302114
    • Nielsen, D. M., Ehm, M. G. & Weir, B. S. Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus. Am. J. Hum. Genet. 63, 1531-1540 (1998). (Pubitemid 30418550)
    • (1998) American Journal of Human Genetics , vol.63 , Issue.5 , pp. 1531-1540
    • Nielsen, D.M.1    Ehm, M.G.2    Weir, B.S.3
  • 25
    • 84890417804 scopus 로고
    • The genetical structure of populations
    • Wright, S. The genetical structure of populations. Ann. Eugen. 15, 323-354 (1951).
    • (1951) Ann. Eugen. , vol.15 , pp. 323-354
    • Wright, S.1
  • 26
    • 78049349396 scopus 로고    scopus 로고
    • Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
    • Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V. et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat. Genet. 42, 949-960 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 949-960
    • Heid, I.M.1    Jackson, A.U.2    Randall, J.C.3    Winkler, T.W.4    Qi, L.5    Steinthorsdottir, V.6
  • 27
    • 69449085258 scopus 로고    scopus 로고
    • Diabetes medications and body weight
    • Mitri, J. & Hamdy, O. Diabetes medications and body weight. Expert Opin. Drug Saf. 8, 573-584 (2009).
    • (2009) Expert Opin. Drug Saf. , vol.8 , pp. 573-584
    • Mitri, J.1    Hamdy, O.2
  • 28
    • 77953230966 scopus 로고    scopus 로고
    • Blood pressure and hypertension are associated with 7 loci in the Japanese population
    • Takeuchi, F., Isono, M., Katsuya, T., Yamamoto, K., Yokota, M., Sugiyama, T. et al. Blood pressure and hypertension are associated with 7 loci in the Japanese population. Circulation 121, 2302-2309 (2010).
    • (2010) Circulation , vol.121 , pp. 2302-2309
    • Takeuchi, F.1    Isono, M.2    Katsuya, T.3    Yamamoto, K.4    Yokota, M.5    Sugiyama, T.6
  • 30
    • 78649450343 scopus 로고    scopus 로고
    • At the crossroads of steroid hormone biosynthesis: The role, substrate specificity and evolutionary development of CYP17
    • Gilep, A. A., Sushko, T. A. & Usanov, S. A. At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17. Biochim. Biophys. Acta 1814, 200-209 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1814 , pp. 200-209
    • Gilep, A.A.1    Sushko, T.A.2    Usanov, S.A.3
  • 31
    • 0027274023 scopus 로고
    • Imp-Gmp 5¢-nucleotidase
    • Itoh, R. IMP-GMP 5¢-nucleotidase. Comp. Biochem. Physiol. B 105, 13-19 (1993).
    • (1993) Comp. Biochem. Physiol. B , vol.105 , pp. 13-19
    • Itoh, R.1
  • 32
    • 25144506445 scopus 로고    scopus 로고
    • Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter
    • DOI 10.1152/physiolgenomics.00058.2005
    • Goytain, A. & Quamme, G. A. Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter. Physiol. Genomics 22, 382-389 (2005). (Pubitemid 41356369)
    • (2005) Physiological Genomics , vol.22 , pp. 382-389
    • Goytain, A.1    Quamme, G.A.2
  • 33
    • 67349166946 scopus 로고    scopus 로고
    • Detecting gene-gene interactions that underlie human diseases
    • Cordell, H. Detecting gene-gene interactions that underlie human diseases. Nat. Rev. Genet. 10, 392-404 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 392-404
    • Cordell, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.