-
1
-
-
0017118272
-
DTIC (NSC-45388) in malignant melanoma: A perspective
-
Comis RL (1976) DTIC (NSC-45388) in malignant melanoma: a perspective. Cancer Treat Rep 60(2):165–176
-
(1976)
Cancer Treat Rep
, vol.60
, Issue.2
, pp. 165-176
-
-
Comis, R.L.1
-
2
-
-
4344656396
-
Management of cutaneous melanoma
-
Tsao H, Atkins MB, Sober AJ (2004) Management of cutaneous melanoma. N Engl J Med 351(10):998–1012
-
(2004)
N Engl J Med
, vol.351
, Issue.10
, pp. 998-1012
-
-
Tsao, H.1
Atkins, M.B.2
Sober, A.J.3
-
3
-
-
0033024863
-
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
-
Atkins MB et al (1999) High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol Off J Am Soc Clin Oncol 17(7):2105–2116
-
(1999)
J Clin Oncol off J am Soc Clin Oncol
, vol.17
, Issue.7
, pp. 2105-2116
-
-
Atkins, M.B.1
-
4
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363(8):711–723
-
(2010)
N Engl J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
-
5
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert C et al (2011) Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364(26):2517–2526
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2517-2526
-
-
Robert, C.1
-
6
-
-
84908354848
-
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
-
Robert C et al (2014) Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 384(9948):1109–1117
-
(2014)
Lancet
, vol.384
, Issue.9948
, pp. 1109-1117
-
-
Robert, C.1
-
7
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364(26):2507–2516
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
-
8
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT et al (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363(9):809–819
-
(2010)
N Engl J Med
, vol.363
, Issue.9
, pp. 809-819
-
-
Flaherty, K.T.1
-
9
-
-
79959776574
-
BRIM-2: An open-label, multicenter Phase II study of RG7204 (PLX4032) in previously treated patients with BRAF V600E mutation-positive metastatic melanoma
-
Ribas A., Kim K, Schuchter L, Gonzalez R, Pavlick AC, Weber J, McArthur G, Hutson TE, Flaherty K, Moschos S, Lawrence DP, Hersey P, Kefford R, Chmielowski B, Puzanov I, Li J, Nolop K, Lee R, Joe A, Sosman J (2011) BRIM-2: An open-label, multicenter Phase II study of RG7204 (PLX4032) in previously treated patients with BRAF V600E mutation-positive metastatic melanoma. J Clin Oncol Off J Am Soc Clin Oncol 29
-
(2011)
J Clin Oncol off J am Soc Clin Oncol
, pp. 29
-
-
Ribas, A.1
Kim, K.2
Schuchter, L.3
Gonzalez, R.4
Pavlick, A.C.5
Weber, J.6
McArthur, G.7
Hutson, T.E.8
Flaherty, K.9
Moschos, S.10
Lawrence, D.P.11
Hersey, P.12
Kefford, R.13
Chmielowski, B.14
Puzanov, I.15
Li, J.16
Nolop, K.17
Lee, R.18
Joe, A.19
Sosman, J.20
more..
-
10
-
-
84863116743
-
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
-
Sosman JA et al (2012) Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med 366(8):707–714
-
(2012)
N Engl J Med
, vol.366
, Issue.8
, pp. 707-714
-
-
Sosman, J.A.1
-
11
-
-
77957350123
-
Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors
-
Kefford R, Arkenau H, Brown MP, Millward M, Infante JR, Long GV, Ouellet D, Curtis M, Lebowitz PF, Falchokk GS (2010) Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors. Proc Am Soc Clin Oncol 28:611s
-
(2010)
Proc am Soc Clin Oncol
, vol.28
, pp. 611
-
-
Kefford, R.1
Arkenau, H.2
Brown, M.P.3
Millward, M.4
Infante, J.R.5
Long, G.V.6
Ouellet, D.7
Curtis, M.8
Lebowitz, P.F.9
Falchokk, G.S.10
-
12
-
-
84908245075
-
Combined vemurafenib and cobimetinib in BRAF-mutated melanoma
-
Larkin J et al (2014) Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N Engl J Med 371(20):1867–1876
-
(2014)
N Engl J Med
, vol.371
, Issue.20
, pp. 1867-1876
-
-
Larkin, J.1
-
13
-
-
84921491301
-
Improved overall survival in melanoma with combined dabrafenib and trametinib
-
Robert C et al (2014) Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med
-
(2014)
N Engl J Med
-
-
Robert, C.1
-
14
-
-
84908257665
-
Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma
-
Long GV et al (2014) Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma. N Engl J Med 371(20):1877–1888
-
(2014)
N Engl J Med
, vol.371
, Issue.20
, pp. 1877-1888
-
-
Long, G.V.1
-
15
-
-
0021228230
-
A novel transforming gene in a human malignant melanoma cell line
-
Padua RA, Barrass N, Currie GA (1984) A novel transforming gene in a human malignant melanoma cell line. Nature 311(5987):671–673
-
(1984)
Nature
, vol.311
, Issue.5987
, pp. 671-673
-
-
Padua, R.A.1
Barrass, N.2
Currie, G.A.3
-
16
-
-
46749143660
-
Malignant melanoma in the 21st century: The emerging molecular landscape
-
Mayo Clinic
-
Sekulic A et al (2008) Malignant melanoma in the 21st century: the emerging molecular landscape. In: Mayo Clinic proceedings. Mayo Clinic vol 83(7), pp 825–846
-
(2008)
Mayo Clinic Proceedings
, vol.83
, Issue.7
, pp. 825-846
-
-
Sekulic, A.1
-
17
-
-
0036894746
-
BRAF and RAS mutations in human lung cancer and melanoma
-
Brose MS et al (2002) BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res 62(23):6997–7000
-
(2002)
Cancer Res
, vol.62
, Issue.23
, pp. 6997-7000
-
-
Brose, M.S.1
-
18
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
Curtin JA et al (2005) Distinct sets of genetic alterations in melanoma. N Engl J Med 353 (20):2135–2147
-
(2005)
N Engl J Med
, vol.353
, Issue.20
, pp. 2135-2147
-
-
Curtin, J.A.1
-
19
-
-
33646266991
-
Genetic alterations in signaling pathways in melanoma
-
Haluska FG et al (2006) Genetic alterations in signaling pathways in melanoma. Clin Cancer Res Off J Am Assoc Cancer Res 12(7 Pt 2):2301s–2307s
-
(2006)
Clin Cancer Res off J am Assoc Cancer Res
, vol.12
, Issue.7
, pp. 2301s-2307s
-
-
Haluska, F.G.1
-
20
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian R et al (2010) Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468(7326):973–977
-
(2010)
Nature
, vol.468
, Issue.7326
, pp. 973-977
-
-
Nazarian, R.1
-
21
-
-
33748325763
-
Sorafenib in advanced melanoma: A Phase II randomised discontinuation trial analysis
-
Eisen T et al (2006) Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer 95(5):581–586
-
(2006)
Br J Cancer
, vol.95
, Issue.5
, pp. 581-586
-
-
Eisen, T.1
-
22
-
-
78650824497
-
A phase II trial of sorafenib in metastatic melanoma with tissue correlates
-
Ott PA et al (2010) A phase II trial of sorafenib in metastatic melanoma with tissue correlates. PLoS ONE 5(12):e15588
-
(2010)
Plos ONE
, vol.5
, Issue.12
, pp. e15588
-
-
Ott, P.A.1
-
23
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag G et al (2010) Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 467(7315):596–599
-
(2010)
Nature
, vol.467
, Issue.7315
, pp. 596-599
-
-
Bollag, G.1
-
24
-
-
84896714827
-
Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF (V600K) mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, open-label study
-
McArthur GA et al (2014) Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF (V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol 15(3):323–332
-
(2014)
Lancet Oncol
, vol.15
, Issue.3
, pp. 323-332
-
-
McArthur, G.A.1
-
25
-
-
84891648456
-
Phase II trial (BREAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma
-
Ascierto PA et al (2013) Phase II trial (BREAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma. J Clin Oncol Off J Am Soc Clin Oncol 31(26):3205–3211
-
(2013)
J Clin Oncol off J am Soc Clin Oncol
, vol.31
, Issue.26
, pp. 3205-3211
-
-
Ascierto, P.A.1
-
26
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A et al (2012) Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380(9839):358–365
-
(2012)
Lancet
, vol.380
, Issue.9839
, pp. 358-365
-
-
Hauschild, A.1
-
27
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
-
Poulikakos PI et al (2010) RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 464(7287):427–430
-
(2010)
Nature
, vol.464
, Issue.7287
, pp. 427-430
-
-
Poulikakos, P.I.1
-
28
-
-
74849109743
-
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
-
Heidorn SJ et al (2010) Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 140(2):209–221
-
(2010)
Cell
, vol.140
, Issue.2
, pp. 209-221
-
-
Heidorn, S.J.1
-
29
-
-
84862908097
-
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
-
Su F et al (2012) RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med 366(3):207–215
-
(2012)
N Engl J Med
, vol.366
, Issue.3
, pp. 207-215
-
-
Su, F.1
-
30
-
-
80051625929
-
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
-
Wagle N et al (2011) Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol Off J Am Soc Clin Oncol 29(22):3085–3096
-
(2011)
J Clin Oncol off J am Soc Clin Oncol
, vol.29
, Issue.22
, pp. 3085-3096
-
-
Wagle, N.1
-
31
-
-
84859183431
-
Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance
-
Shi H et al (2012) Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance. Nat Commun 3:724
-
(2012)
Nat Commun
, vol.3
, pp. 724
-
-
Shi, H.1
-
32
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
-
Poulikakos PI et al (2011) RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480(7377):387–390
-
(2011)
Nature
, vol.480
, Issue.7377
, pp. 387-390
-
-
Poulikakos, P.I.1
-
33
-
-
84862732834
-
Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations
-
Greger JG et al (2012) Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther 11(4):909–920
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.4
, pp. 909-920
-
-
Greger, J.G.1
-
34
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Johannessen CM et al (2010) COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468(7326):968–972
-
(2010)
Nature
, vol.468
, Issue.7326
, pp. 968-972
-
-
Johannessen, C.M.1
-
35
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
Villanueva J et al (2010) Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18 (6):683–695
-
(2010)
Cancer Cell
, vol.18
, Issue.6
, pp. 683-695
-
-
Villanueva, J.1
-
36
-
-
84891898344
-
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
-
Shi H et al (2014) Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy. Cancer Discov 4(1):80–93
-
(2014)
Cancer Discov
, vol.4
, Issue.1
, pp. 80-93
-
-
Shi, H.1
-
37
-
-
83355170673
-
Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway
-
Atefi M, von Euw E, Attar N, Chu C, Guo D, Nazarian R, Chmielowski B, Glaspy JA, Mischel P, Lo R, Ribas A (2011) Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway. PloS one 6(12):e28973
-
(2011)
Plos One
, vol.6
, Issue.12
, pp. e28973
-
-
Atefi, M.1
Von Euw, E.2
Attar, N.3
Chu, C.4
Guo, D.5
Nazarian, R.6
Chmielowski, B.7
Glaspy, J.A.8
Mischel, P.9
Lo, R.10
Ribas, A.11
-
38
-
-
79960946383
-
Combinatorial treatments that overcome PDGFRbeta-driven resistance of melanoma cells to V600 EB-RAF inhibition
-
Shi H et al (2011) Combinatorial treatments that overcome PDGFRbeta-driven resistance of melanoma cells to V600 EB-RAF inhibition. Cancer Res 71(15):5067–5074
-
(2011)
Cancer Res
, vol.71
, Issue.15
, pp. 5067-5074
-
-
Shi, H.1
-
39
-
-
84864340896
-
Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: A phase 1 dose-escalation trial
-
Infante JR et al (2012) Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial. Lancet Oncol 13(8):773–781
-
(2012)
Lancet Oncol
, vol.13
, Issue.8
, pp. 773-781
-
-
Infante, J.R.1
-
40
-
-
84874777853
-
Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor
-
Kim KB et al (2013) Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor. J Clin Oncol Off J Am Soc Clin Oncol 31(4):482–489
-
(2013)
J Clin Oncol off J am Soc Clin Oncol
, vol.31
, Issue.4
, pp. 482-489
-
-
Kim, K.B.1
-
41
-
-
84904916223
-
Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: A phase 1b study
-
Ribas A et al (2014) Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: a phase 1b study. Lancet Oncol 15(9):954–965
-
(2014)
Lancet Oncol
, vol.15
, Issue.9
, pp. 954-965
-
-
Ribas, A.1
-
42
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
Flaherty KT et al (2012) Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. The New England journal of medicine 367(18):1694–1703
-
(2012)
The New England Journal of Medicine
, vol.367
, Issue.18
, pp. 1694-1703
-
-
Flaherty, K.T.1
-
43
-
-
80053154225
-
Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436)
-
p(suppl; abstr CRA8503)
-
Infante JR et al (2011) Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436). J Clin Oncol 29:p(suppl; abstr CRA8503)
-
(2011)
J Clin Oncol
, pp. 29
-
-
Infante, J.R.1
-
44
-
-
84859810061
-
Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines
-
von Euw E et al (2012) Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines. Mol Cancer 11(1):22
-
(2012)
Mol Cancer
, vol.11
, Issue.1
, pp. 22
-
-
Von Euw, E.1
-
45
-
-
84864371119
-
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: A phase 1 dose-escalation trial
-
Falchook GS et al (2012) Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol 13(8):782–789
-
(2012)
Lancet Oncol
, vol.13
, Issue.8
, pp. 782-789
-
-
Falchook, G.S.1
-
46
-
-
84875235432
-
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A non-randomised, open-label phase 2 study
-
Ascierto PA et al (2013) MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol 14 (3):249–256
-
(2013)
Lancet Oncol
, vol.14
, Issue.3
, pp. 249-256
-
-
Ascierto, P.A.1
-
47
-
-
84862726767
-
ERK inhibition overcomes acquired resistance to MEK inhibitors
-
Hatzivassiliou G et al (2012) ERK inhibition overcomes acquired resistance to MEK inhibitors. Mol Cancer Ther
-
(2012)
Mol Cancer Ther
-
-
Hatzivassiliou, G.1
-
48
-
-
84910023724
-
Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma
-
Wong DJ et al (2014) Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma. Mol Cancer 13:194
-
(2014)
Mol Cancer
, vol.13
, pp. 194
-
-
Wong, D.J.1
-
49
-
-
84880254869
-
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors
-
Morris EJ et al (2013) Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov 3(7):742–750
-
(2013)
Cancer Discov
, vol.3
, Issue.7
, pp. 742-750
-
-
Morris, E.J.1
-
50
-
-
84899657912
-
Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma
-
Lassen A et al (2014) Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma. Mol Cancer 13:83
-
(2014)
Mol Cancer
, vol.13
, pp. 83
-
-
Lassen, A.1
-
51
-
-
84905825810
-
Combining targeted therapy with immunotherapy in BRAF-mutant melanoma: Promise and challenges
-
Hu-Lieskovan S et al (2014) Combining targeted therapy with immunotherapy in BRAF-mutant melanoma: promise and challenges. J Clin Oncol Off J Am Soc Clin Oncol 32(21):2248–2254
-
(2014)
J Clin Oncol off J am Soc Clin Oncol
, vol.32
, Issue.21
, pp. 2248-2254
-
-
Hu-Lieskovan, S.1
-
52
-
-
78650391890
-
The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations
-
Comin-Anduix B et al (2010) The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations. Clin Cancer Res Off J Am Assoc Cancer Res 16(24):6040–6048
-
(2010)
Clin Cancer Res off J am Assoc Cancer Res
, vol.16
, Issue.24
, pp. 6040-6048
-
-
Comin-Anduix, B.1
|