CD11c hi Dendritic Cells Regulate Ly-6Chi Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Kim, Jin Hyoung ^a   Choi, Jin Young ^a   Kim, Seong Bum ^a   Uyangaa, Erdenebelig ^a   Patil, Ajit Mahadev ^a   Han, Young Woo ^a   Park, Sang Youel ^a   Lee, John Hwa ^a   Kim, Koanhoi ^b   Eo, Seong Kug ^a  

^a Chonbuk National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P 15095; LY ANTIGEN; LY-6C ANTIGEN, MOUSE;

ANIMAL; CELL DIFFERENTIATION; CELL MOTION; CENTRAL NERVOUS SYSTEM; DENDRITIC CELL; EPIDEMIC ENCEPHALITIS; FLAVIVIRUS INFECTION; GENETICS; IMMUNOLOGY; JAPANESE ENCEPHALITIS VIRUS; MONOCYTE; MOUSE; PATHOLOGY; TRANSGENIC MOUSE; VIROLOGY;

ANIMALS; ANTIGENS, CD11C; ANTIGENS, LY; CELL DIFFERENTIATION; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM; DENDRITIC CELLS; ENCEPHALITIS VIRUSES, JAPANESE; ENCEPHALITIS, ARBOVIRUS; FLAVIVIRUS INFECTIONS; MICE; MICE, TRANSGENIC; MONOCYTES;

EID: 84948808387     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep17548     Document Type: Article

References (46)

1. Ransohoff, R. M., Brown, M. A. Innate immunity in the central nervous system. J. Clin. Invest. 122, 1164-1171, doi: 10.1172/JCI58644 (2012).
2. Rezai-Zadeh, K., Gate, D., Town, T. CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease J. Neuroimmune Pharmacol. 4, 462-475, doi: 10.1007/s11481-009-9166-2 (2009).
3. Louveau, A. et al. Structural and functional features of central nervous system lymphatic vessels. Nature 523, 337-341, doi: 10.1038/nature14432 (2015).
4. Terry, R. L. et al. Inflammatory monocytes and the pathogenesis of viral encephalitis. J. Neuroinflammation 9, 270, doi: 10.1186/1742-2094-9-270 (2012).
5. Getts, D. R. et al. Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. J. Exp. Med. 205, 2319-2337, doi: 10.1084/jem.20080421 (2008).
6. Ginhoux, F. et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841-845, doi: 10.1126/science.1194637 (2010).
7. Izikson, L., Klein, R. S., Charo, I. F., Weiner, H. L., Luster, A. D. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor CCR2. J. Exp. Med. 192, 1075-1080 (2000).
8. Fife, B. T., Huffnagle, G. B., Kuziel, W. A., Karpus, W. J. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 192, 899-905 (2000).
9. Lim, J. K. et al. Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis. J. Immunol. 186, 471-478, doi: 10.4049/jimmunol.1003003 (2011).
10. Ben-Nathan, D., Huitinga, I., Lustig, S., Rooijen, N. V., Kobiler D. West Nile virus neuroinvasion and encephalitis induced by macrophage depletion in mice. Arch. Virol. 141, 459-469 (1996).
11. Iijima, N., Mattei, L. M., Iwasaki, A. Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue. Proc. Natl. Acad. Sci. USA 108, 284-289, doi: 10.1073/pnas.1005201108 (2011).
12. Chen, B. P., Kuziel. W. A., Lane, T. E. Lack of CCR2 results in increased mortality and impaired leukocyte activation and trafficking following infection of the central nervous system with a neurotropic coronavirus. J. Immunol. 167, 4585-4592 (2001).
13. Hettinger, J. et al. Origin of monocytes and macrophages in a committed progenitor. Nat. Immunol. 8, 821-830, doi: 10.1038/ni.2638 (2013).
14. Ginhoux, F., Jung, S. Monocytes and macrophages: development pathways and tissue homeostasis. Nat. Rev. Immunol. 14, 392-404, doi: 10.1038/nri3671 (2014).
15. Satpathy, A. T., Wu, X., Albring, J. C., Murphy, K. M. Re(de)fining the dendritic cell lineage. Nat. Immunol. 13, 1145-1154, doi: 10.1038/ni.2467 (2012).
16. Italiani, P., Boraschi, D. From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation. Front. Immunol. 5, 514, doi: 10.3389/fimmu.2014.00514 (2014).
17. Italiani, P., Boraschi, D. New Insights into tissue macrophages: From their origin to the development of memory. Immune Netw. 15, 167-176, doi: 10.4110/in.2015.15.4.167 (2015).
18. Center for Disease Control. Japanese encephalitis surveillance and immunization-Asia and the Western pacific, 2012. MMWR Morb Mortal Wkly Rep 62, 658-662 (2013).
19. Center for Disease Control. West Nile activity-Human disease cases reported. 2005-2009 (2009) Available at: http://www.cdc. gov/ncidod/dvbid/westnile/sur&control.htm. (Accessed: 4th September 2014).
20. Bar-On, L., Jung, S. Defining in vivo dendritic cell functions using CD11c-DTR transgenic mice. Methods Mol. Biol. 595, 429-442, doi: 10.1007/978-1-60761-421-0-28 (2010).
21. Jung, S. et al. In Vivo Depletion of CD11c Dendritic Cells Abrogates Priming of CD8 T Cells by Exogenous Cell-Associated Antigens. Immunity 17, 211-220 (2002).
22. Tittel, A. P. et al. Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat. Methods 9, 385-390, doi: 10.1038/nmeth.1905 (2012).
23. Autenrieth, S. E. et al. Depletion of Dendritic Cells Enhances Innate Anti-Bacterial Host Defense through Modulation of Phagocyte Homeostasis. PLoS Pathog. 8, e1002552, doi: 10.1371/journal.ppat.1002552 (2012).
24. Blijswijk, J. V., Schrami, B. U., Reis e Sousa, C. Advantages and limitations of mouse models to deplete dendritic cells. Eur. J. Immunol. 43, 22-26, doi: 10.1002/eji.201243022 (2013).
25. Anzai, A. et al. Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling. Circulation 125, 1234-1245, doi: 10.1161/CIRCULATIONAHA.111.052126 (2012).
26. Ford, A. L., Foulcher, E., Lemckert, F. A., Sedgwick, J. D. Microglia induce CD4 T lymphocyte final effector function and death. J. Exp. Med. 184, 1737-1745 (1996).
27. Ghosh, D., Basu, A. Japanese encephalitis-a pathologival and cinical perspective. PLoS Negl. Trop. Dis. 3(9), e437, doi: 10.1371/journal.pntd.0000437 (2009).
28. Chen, C. J. et al. Glial activation involvement in neuronal death by Japanese encephalitis virus infection. J. Gen. Virol. 91, 1028-1037, doi: 10.1099/vir.0.013565-0 (2010).
29. Han, Y. W., Sunit, S. K., Eo, S. K. The Roles and Perspectives of Toll-Like Receptors and CD4(+ ) Helper T Cell Subsets in Acute Viral Encephalitis. Immune Netw. 12, 48-57, doi: 10.4110/in.2012.12.2.48 (2012).
30. Goasguen, J. E. et al. International Working Group on Morphology of Myelodysplastic Syndrome. Morphological evaluation of monocytes and their precursors. Haematologica 94, 994-997, doi: 10.3324/haematol.2008.005421 (2009).
31. Birnberg, T. et al. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 29, 986-997, doi: 10.1016/j.immuni.2008.10.012 (2008).
32. Lanteri, M. C. et al. Tregs control the development of symptomatic West Nile virus infection in humans and mice. J. Clin. Invest. 119, 3266-3277, doi: 10.1172/JCI39387 (2009).
33. Askenase, M. H. et al. Bone-marrow-resident NK cells prime monocytes for regulatory function during infection. Immunity 42, 1130-1142, doi: 10.1016/j.immuni.2015.05.011 (2015).
34. Trujillo, J. A., Fleming, E. L., Perlman, S. Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection. J. Virol. 87, 2376-2389, doi: 10.1128/JVI.03089-12 (2013).
35. Barichello, T. et al. Brain-blood barrier breakdown and pro-inflammatory mediators in neonate rats submitted meningitis by Streptococcus pneumoniae. Brain Res. 1471, 162-168, doi: 10.1016/j.brainres.2012.06.054 (2012).
36. Hesske, L. et al. Induction of inhibitory central nervous system-derived and stimulatory blood-derived dendritic cells suggests a dual role for granulocyte-macrophage colony-stimulating factor in central nervous system inflammation. Brain 133, 1637-1654, doi: 10.1093/brain/awq081 (2010).
37. Ito, S., Tanaka, Y., Nishio, N., Thanasegaran, S., Isobe, K. I. Establishment of self-renewable GM-CSF-dependent immature macrophages in vitro from murine bone marrow. PLoS One 8, e76943, doi: 10.1371/journal.pone.0076943 (2013).
38. Collins, C. B. et al. Flt3 ligand expands CD103+ dendritic cells and Foxp3+ T regulatory cells, and attenuates Crohn's-like murine ileitis. Gut 61, 1154-1162, doi: 10.1136/gutjnl-2011-300820 (2012).
39. Sekar, D., Brune, B., Weigert, A. Generation of human pDC equivalents from primary monocytes using Flt3-L and their functional validation under hypoxia. J. Leukoc. Biol. 88, 413-424, doi: 10.1189/jlb.0809543 (2010).
40. Esahi, E. et al. The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity 28, 509-520, doi: 10.1016/j.immuni. 2008.02.013 (2008).
41. Gilliet, M. et al. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 195, 953-958 (2002).
42. Bao, Y. E., Kim, E., Bhosle, S., Mehta, H., Cho, S. A role for spleen monocytes in post-ischemic brain inflammation and injury. J. Neuroinflammation 7, 92, doi: 10.1186/1742-2094-7-92 (2010).
43. Probst, H. C. et al. Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin. Exp. Immunol. 141, 398-404 (2005).
44. Wuest, T. R., Carr, D. The role of chemokines during herpes simplex virus-1 infection. Front. Biosci. 13, 4862-4872 (2008).
45. Persidsky, Y. et al. Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis. Am. J. Pathol. 155, 1599-1611 (1999).
46. Grimaldi, D. et al. Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock. Intensive Care Medicine 37, 1438-1446, doi: 10.1007/s00134-011-2306-1 (2011).