Hypofractionated radiotherapy in early breast cancer: Clinical, dosimetric and radio-genomic issues

Breast

Volumn 24, Issue , 2015, Pages S108-S113

  Yarnold, John ^a   Somaiah, Navita ^a   Bliss, Judith M ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Breast cancer; Clinical trials; Hypofractionation; Radiotherapy

Indexed keywords

ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; DOSIMETRY; FOLLOW UP; HEART INJURY; HUMAN; HYPOFRACTIONATION RADIOTHERAPY; INTRAOPERATIVE RADIOTHERAPY; MASTECTOMY; MOLECULAR DYNAMICS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RADIATION INJURY; RISK REDUCTION; TREATMENT RESPONSE; ADJUVANT RADIOTHERAPY; ADULT; AGED; ANATOMY AND HISTOLOGY; BREAST; BREAST NEOPLASMS; CANADA; DNA DAMAGE; DNA END JOINING REPAIR; FEMALE; GENETICS; GREAT BRITAIN; HYPOFRACTIONATED RADIOTHERAPY; INTENSITY MODULATED RADIATION THERAPY; MIDDLE AGED; ORGAN SIZE; PATHOLOGY; PEROPERATIVE CARE; RADIATION RESPONSE; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ADULT; AGED; BREAST; BREAST NEOPLASMS; CANADA; DNA DAMAGE; DNA END-JOINING REPAIR; DOSE HYPOFRACTIONATION; FEMALE; GREAT BRITAIN; HUMANS; INTRAOPERATIVE CARE; MIDDLE AGED; ORGAN SIZE; RADIOTHERAPY, ADJUVANT; RADIOTHERAPY, INTENSITY-MODULATED; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84948719508     PISSN: 09609776     EISSN: 15323080     Source Type: Journal    
DOI: 10.1016/j.breast.2015.07.025     Document Type: Article

References (39)

1. Thames H.D., Bentzen S.M., Turesson I., Overgaard M., van den Bogaert W. Fractionation parameters for human tissues and tumors. Int J Radiat Biol 1989, 56:701-710.
2. Stuschke M., Thames H.D. Fractionation sensitivities and dose-control relations of head and neck carcinomas: analysis of the randomized hyperfractionation trials. Radiother Oncol 1999, 51:113-121.
3. Yarnold J., Ashton A., Bliss J., et al. Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial. Radiother Oncol 2005, 75:9-17.
4. Owen J.R., Ashton A., Bliss J.M., et al. Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial. Lancet Oncol 2006, 7:467-471.
5. Whelan T.J., Pignol J.P., Levine M.N., et al. Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 2010, 362:513-520.
6. Agrawal R.K., Alhasso A., Barrett-Lee P.J., et al. First results of the randomised UK FAST trial of radiotherapy hypofractionation for treatment of early breast cancer (CRUKE/04/015). Radiother Oncol 2011, 100:93-100.
7. Haviland J.S., Owen J.R., Dewar J.A., et al. The UK standardisation of breast radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol 2013, 14:1086-1094.
8. Hopwood P., Haviland J.S., Sumo G., Mills J., Bliss J.M., Yarnold J.R. Comparison of patient-reported breast, arm, and shoulder symptoms and body image after radiotherapy for early breast cancer: 5-year follow-up in the randomised standardisation of breast radiotherapy (START) trials. Lancet Oncol 2010, 11:231-240.
9. Harnett A., Smallwood J., Titshall V., Champion A. Diagnosis and treatment of early breast cancer, including locally advanced disease-summary of NICE guidance. BMJ 2009, 338. b438.
10. Darby S.C., Ewertz M., McGale P., et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 2013, 368:987-998.
11. Appelt A.L., Vogelius I.R., Bentzen S.M. Modern hypofractionation schedules for tangential whole breast irradiation decrease the fraction size-corrected dose to the heart. Clin Oncol R Coll Radiol 2013, 25:147-152.
12. Jones B., Dale R.G., Deehan C., Hopkins K.I., Morgan D.A. The role of biologically effective dose (BED) in clinical oncology. Clin Oncol R Coll Radiol 2001, 13:71-81.
13. Bentzen S.M., Agrawal R.K., Aird E.G., et al. The UK standardisation of breast radiotherapy (START) trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet Oncol 2008, 9:331-341.
14. Bentzen S.M., Agrawal R.K., Aird E.G., et al. The UK standardisation of breast radiotherapy (START) trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet 2008, 371:1098-1107.
15. Cohen L. Radiotherapy in breast cancer I. The dose-time relationship theoretical considerations. Br J Radiol 1952, 25:636-642.
16. Douglas B.G., Castro J.R. Novel fractionation schemes and high linear energy transfer. Prog Exp Tumor Res 1984, 28:152-165.
17. Coles C., Yarnold J. The IMPORT trials are launched (September 2006). Clin Oncol R Coll Radiol 2006, 18:587-590.
18. Olivotto I.A., Whelan T.J., Parpia S., et al. Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy. J Clin Oncol 2013, 31:4038-4045.
19. IMPORT LOW. ISRCTN12852634. Randomised trial testing intensity modulated radiotherapy and partial organ radiotherapy following breast conservation surgery for early breast cancer. Protocol Information Can be Found at: . http://www.controlled-trials.com/ISRCTN12852634/import+low.
20. Veronesi U., Orecchia R., Maisonneuve P., et al. Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol 2013, 14:1269-1277.
21. Vaidya J.S., Wenz F., Bulsara M., et al. Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. Lancet 2014, 383:603-613.
22. Haviland J.S., A'Hern R., Bentzen S.M., Whelan T., Bliss J.M. Radiotherapy for breast cancer, the TARGIT-A trial. Lancet 2014, 383:1716-1717.
23. Mackenzie P., Fyles A., Chung C. Radiotherapy for breast cancer, the TARGIT-A trial. Lancet 2014, 383:1717.
24. Yarnold J., Offersen B.V., Olivotto I., Poortmans P., Sarin R. Radiotherapy for breast cancer, the TARGIT-A trial. Lancet 2014, 383:1717-1718.
25. Harness J.K., Silverstein M.J., Wazer D.E., Riker A.I. Radiotherapy for breast cancer, the TARGIT-A trial. Lancet 2014, 383:1718-1719.
26. Hepel J., Wazer D. A flawed study should not define a new standard of care. Int J Radiat Oncol Biol Phys 2015, 91:2.
27. Cuzick J. Radiotherapy for breast cancer, the TARGIT-A trial. Lancet 2014, 383:1716.
28. Nyman J., Turesson I. Basal cell density in human skin for various fractionation schedules in radiotherapy. Radiother Oncol 1994, 33:117-124.
29. Yarnold J., Brotons M.C. Pathogenetic mechanisms in radiation fibrosis. Radiother Oncol 2010, 97:149-161.
30. Steel G.G. The ESTRO breur lecture. Cellular sensitivity to low dose-rate irradiation focuses the problem of tumour radioresistance. Radiother Oncol 1991, 20:71-83.
31. Kolesnick R.N., Haimovitz-Friedman A., Fuks Z. The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, FAS, and ionizing radiation. Biochem Cell Biol Biochim Biol Cell 1994, 72:471-474.
32. Loucas B.D., Eberle R., Bailey S.M., Cornforth M.N. Influence of dose rate on the induction of simple and complex chromosome exchanges by gamma rays. Radiat Res 2004, 162:339-349.
33. Jeggo P.A., Geuting V., Lobrich M. The role of homologous recombination in radiation-induced double-strand break repair. Radiother Oncol 2011, 101:7-12.
34. Somaiah N., Yarnold J., Daley F., et al. The relationship between homologous recombination repair and the sensitivity of human epidermis to the size of daily doses over a 5-week course of breast radiotherapy. Clin Cancer Res 2012, 18:5479-5488.
35. Somaiah N., Yarnold J., Lagerqvist A., Rothkamm K., Helleday T. Homologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy. Radiother Oncol 2013, 108:155-161.
36. ClinicalTrials.gov (Breast and cancer and radiation and fractionation).
37. Yarnold J., Bentzen S.M., Coles C., Haviland J. Hypofractionated whole-breast radiotherapy for women with early breast cancer: myths and realities. Int J Radiat Oncol Biol Phys 2011, 79:1-9.
38. Owen J.R., Yarnold J.R., Ashton A., et al. Fractionation sensitivity of breast cancer: results of a randomised trial. Eur J Oncol Suppl 2003, 1:S9.
39. Whelan T., MacKenzie R., Julian J., et al. Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst 2002, 94:1143-1150.