Erythropoietin does not reduce plasma lactate, H+, and K+ during intense exercise

Scandinavian Journal of Medicine and Science in Sports

Volumn 25, Issue 6, 2015, Pages e566-e575

  Nordsborg, N B ^a   Robach, P ^b   Boushel, R ^c   Calbet, J A L ^d   Lundby, C ^e  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Ecole Nationale des Sports de Montagne   (France)

^c SWEDISH SCHOOL OF SPORT AND HEALTH SCIENCES   (Sweden)

^d UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^e UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

K+; Lactate; Oxygen uptake; pH

Indexed keywords

ANTIANEMIC AGENT; ERYTHROPOIETIN; LACTIC ACID; POTASSIUM; RECOMBINANT PROTEIN;

ADULT; BLOOD; BLOOD FLOW; DRUG EFFECTS; EXERCISE; EXERCISE TEST; HOMEOSTASIS; HUMAN; LEG; MALE; METABOLISM; OXYGEN CONSUMPTION; PH; PHYSIOLOGY; SKELETAL MUSCLE; VASCULARIZATION; YOUNG ADULT;

ADULT; ERYTHROPOIETIN; EXERCISE; EXERCISE TEST; HEMATINICS; HOMEOSTASIS; HUMANS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; LEG; MALE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHYSICAL EXERTION; POTASSIUM; RECOMBINANT PROTEINS; REGIONAL BLOOD FLOW; YOUNG ADULT;

EID: 84948714995     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/sms.12374     Document Type: Article

References (32)

1. Amann M. Significance of Group III and IV muscle afferents for the endurance exercising human. Clin Exp Pharmacol Physiol 2012: 39: 831-835.
2. Andersen P, Adams RP, Sjogaard G, Thorboe A, Saltin B. Dynamic knee extension as model for study of isolated exercising muscle in humans. J Appl Physiol 1985: 59: 1647-1653.
3. Andersen P, Saltin B. Maximal perfusion of skeletal muscle in man. J Physiol 1985: 366: 233-249.
4. Bangsbo J, Madsen K, Kiens B, Richter EA. Effect of muscle acidity on muscle metabolism and fatigue during intense exercise in man. J Physiol (Lond) 1996: 495 (Pt 2): 587-596.
5. Birkeland KI, Stray-Gundersen J, Hemmersbach P, Hallen J, Haug E, Bahr R. Effect of rhEPO administration on serum levels of sTfR and cycling performance. Med Sci Sports Exerc 2000: 32: 1238-1243.
6. Bonne TC, Doucende G, Flück D, Jacobs RA, Nordsborg NB, Robach P, Walther G, Lundby C. Phlebotomy eliminates the maximal cardiac output response to six weeks of exercise training. Am J Physiol Regul Integr Comp Physiol 2014: 306: R752-R760.
7. Cnaan A, Laird NM, Slasor P. Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data. Stat Med 1997: 16: 2349-2380.
8. - conductance. J Physiol 2010: 588: 4785-4794.
9. Fitts RH. Cellular mechanisms of muscle fatigue. Physiol Rev 1994: 74: 49-94.
10. Fitts RH. The cross-bridge cycle and skeletal muscle fatigue. J Appl Physiol 2008: 104: 551-558.
11. Gjedsted J, Buhl M, Nielsen S, Schmitz O, Vestergaard ET, Tonnesen E, Moller N. Effects of adrenaline on lactate, glucose, lipid and protein metabolism in the placebo controlled bilaterally perfused human leg. Acta Physiol (Oxf) 2011: 202: 641-648.
12. Grunze M, Kohlmann M, Mulligan M, Gruner I, Koeppel M, Bommer J. Mechanisms of improved physical performance of chronic hemodialysis patients after erythropoietin treatment. Am J Nephrol 1990: 10 (Suppl. 2): 15-18.
13. + balance of the quadriceps muscle during dynamic exercise with and without beta-adrenoceptor blockade. J Appl Physiol 1995: 78: 513-523.
14. Jones AM, Carter H. The effect of endurance training on parameters of aerobic fitness. Sports Med 2000: 29: 373-386.
15. Juel C, Thomsen JJ, Rentsch RL, Lundby C. Effects of prolonged recombinant human erythropoietin administration on muscle membrane transport systems and metabolic marker enzymes. Eur J Appl Physiol 2007: 102: 41-44.
16. Khan MH, Sinoway LI. Muscle reflex control of sympathetic nerve activity in heart failure: the role of exercise conditioning. Heart Fail Rev 2000: 5: 87-100.
17. Kurokawa K, Massry SG. Evidence for stimulation of renal gluconeogenesis by catecholamines. J Clin Invest 1973: 52: 961-964.
18. Lundby C, Hellsten Y, Jensen MB, Munch AS, Pilegaard H. Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle. J Appl Physiol 2008a: 104: 1154-1160.
19. Lundby C, Robach P, Boushel R, Thomsen JJ, Rasmussen P, Koskolou M, Calbet JA. Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport? J Appl Physiol 2008b: 105: 581-587.
20. Lundby C, Thomsen JJ, Boushel R, Koskolou M, Warberg J, Calbet JA, Robach P. Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume. J Physiol 2007: 578: 309-314.
21. McKenna MJ, Harmer AR, Fraser SF, Li JL. Effects of training on potassium, calcium and hydrogen ion regulation in skeletal muscle and blood during exercise. Acta Physiol Scand 1996: 156: 335-346.
22. McMahon LP, Johns JA, McKenzie A, Austin M, Fowler R, Dawborn JK. Haemodynamic changes and physical performance at comparative levels of haemoglobin after long-term treatment with recombinant erythropoietin. Nephrol Dial Transplant 1992: 7: 1199-1206.
23. Nordsborg N, Mohr M, Pedersen LD, Nielsen JJ, Langberg H, Bangsbo J. Muscle interstitial potassium kinetics during intense exhaustive exercise: effect of previous arm exercise. Am J Physiol Regul Integr Comp Physiol 2003: 285: R143-R148.
24. + release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4, 100m. Am J Physiol Regul Integr Comp Physiol 2010: 299: R306-R313.
25. Pedersen TH, Nielsen OB, Lamb GD, Stephenson DG. Intracellular acidosis enhances the excitability of working muscle. Science 2004: 305: 1144-1147.
26. Rentsch RL, Damsgaard R, Lundby C, Juel C. Effects of darbepoetin injections on erythrocyte membrane transport protein expressions in humans. J Appl Physiol 2006: 101: 164-168.
27. Sawka MN, Convertino VA, Eichner ER, Schnieder SM, Young AJ. Blood volume: importance and adaptations to exercise training, environmental stresses, and trauma/sickness. Med Sci Sports Exerc 2000: 32: 332-348.
28. Sejersted OM, Sjogaard G. Dynamics and consequences of potassium shifts in skeletal muscle and heart during exercise. Physiol Rev 2000: 80: 1411-1481.
29. Siggaard-Andersen O. The van Slyke equation. Scand J Clin Lab Invest Suppl 1977: 37: 15-20.
30. Thomsen JJ, Rentsch RL, Robach P, Calbet JA, Boushel R, Rasmussen P, Juel C, Lundby C. Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity. Eur J Appl Physiol 2007: 101: 481-486.
31. Wasserman DH, Connolly CC, Pagliassotti MJ. Regulation of hepatic lactate balance during exercise. Med Sci Sports Exerc 1991: 23: 912-919.
32. Westerblad H, Allen DG. Cellular mechanisms of skeletal muscle fatigue. Adv Exp Med Biol 2003: 538: 563-570.