Induction of the 70 kDa heat shock protein stress response inhibits autophagy: Possible consequences for pregnancy outcome

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 29, Issue 1, 2016, Pages 159-162

  Kanninen, Tomi T ^a   Sisti, Giovanni ^a   Witkin, Steven S ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Autophagy; Hsp70; Mononuclear lymphoid cells; P62; Pregnancy

Indexed keywords

HEAT SHOCK PROTEIN 70; PROTEIN P62;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PREGNANCY OUTCOME; PREGNANT WOMAN; PRIORITY JOURNAL; INTRACELLULAR FLUID; METABOLISM; MONONUCLEAR CELL; PREGNANCY;

AUTOPHAGY; FEMALE; HEALTHY VOLUNTEERS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INTRACELLULAR FLUID; LEUKOCYTES, MONONUCLEAR; PREGNANCY; PREGNANCY OUTCOME;

EID: 84948706753     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2014.991916     Document Type: Article

References (21)

1. Craig EA. The stress response: changes in eukaryotic gene expression in response to environmental stress. Science 1985; 230: 800-1.
2. Mizushima N. Physiological functions of autophagy. Curr Top Microbiol Immunol 2009; 335: 71-84.
3. Gabai VL, Meriin AB, Mosser DD, et al. Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. J Biol Chem 1997; 272: 18033-7.
4. Dokladny K, Zuhl MN, Mandell M, et al. Regulatory coordination between two major intracellular homeostasis systems: heat shock response and autophagy. J Biol Chem 2013; 288: 14959-72.
5. Chou S-D, Prince T, Gong J, Calderwood SK. mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis. PLoS One 2012; 7: e39679.
6. Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Rev Molec Cell Biol 2011; 12: 21-35.
7. Kanninen TT, de Andrade Ramos BR, Jaffe S, et al. Inhibition of autophagy by sera from pregnant women. Reprod Sci 2013; 20: 1327-31.
8. Massey DCO, Bredin F, Parkes M. Use of sirolimus (rapamycin) to treat refractory Crohns disease. Gut 2008; 57: 1294-6.
9. Ichimura Y, Komatsu M. Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models. Exp Anim 2011; 60: 329-45.
10. Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011; 469: 323-35.
11. Xu X, Ren J. Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac dysfunction. Clin Exp Pharmacol Physiol 2012; 39: 200-8.
12. Kanninen TT, de Andrade Ramos B, Witkin SS. The role of autophagy in reproduction from gametogenesis to parturition. Eur J Obstet Gynecol Reprod Biol 2013; 171: 3-8.
13. Tsukamoto S, Kuma A, Murakami M, et al. Autophagy is essential for preimplantation development of mouse embryos. Science 2008; 321: 117-20.
14. Shen Z-Y, Xu L-Y, Li E-M, et al. Autophagy and endocytosis in the amnion. J Struct Biol 2008; 162: 197-204.
15. Hirota Y, Cha J, Yoshie M, et al. Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice. Proc Natl Acad Sci USA 2011; 108: 18073-8.
16. Jean-Pierre C, Perni SC, Bongiovanni AM, et al. Extracellular 70-kd heat shock protein in mid-trimester amniotic fluid and its effect on cytokine production by ex vivo-cultured amniotic fluid cells. Am J Obstet Gynecol 2006; 194: 694-8.
17. Asea A, Jean-Pierre C, Kaur P, et al. Heat shock protein-containing exosomes in mid-trimester amniotic fluids. J Reprod Immunol 2008; 79: 12-17.
18. Oh S-Y, Choi S-J, Kim KH, et al. Autophagy-related proteins, LC3 and Beclin-1, in placentas from pregnancies complicated by preeclampsia. Reprod Sci 2008; 15: 912-20.
19. Hung T-H, Chen S-F, Lo L-M, et al. Increased autophagy in placentas of intrauterine growth restricted pregnancies. PLoS One 2012; 7: e40957.
20. Chaiworapongsa T, Erez O, Kusanovic JP, et al. Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition. J matern Fetal neonatal Med 2008; 21: 449-61.
21. Tan H, Xu Y, Xu J, et al. Association of increased heat shock protein 70 levels in the lymphocyte with high risk of adverse pregnancy outcomes in early pregnancy: a nested case-control study. Cell Stress Chaperones 2007; 12: 230-6.