Inhibition of autophagy by sera from pregnant women

Reproductive Sciences

Volumn 20, Issue 11, 2013, Pages 1327-1331

  Kanninen, Tomi T ^a,b   De Andrade Ramos, Bruna Ribeiro ^a   Jaffe, Shirlee ^a   Bongiovanni, Ann Marie ^a   Linhares, Iara Moreno ^a,c   Renzo, Gian Carlo Di ^b   Witkin, Steven S ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

autophagy; insulin resistance; p62; pregnancy; rapamycin

Indexed keywords

INTERLEUKIN 13; PROTEIN P62; RAPAMYCIN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1; AUTACOID; IGF1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN;

ADULT; ARTICLE; AUTOPHAGY; CELL ORGANELLE; CONTROLLED STUDY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INSULIN RESISTANCE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PREGNANT WOMAN; PRIORITY JOURNAL; SENESCENCE; BLOOD; CELL CULTURE; DRUG EFFECTS; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; PREGNANCY; SERUM; TIME;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AUTOPHAGY; CELLS, CULTURED; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-13; LEUKOCYTES, MONONUCLEAR; PREGNANCY; SERUM; SIROLIMUS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84885641245     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719113485301     Document Type: Article

References (23)

1. Mizushima N. Physiological functions of autophagy. Curr Top Microbiol Immunol. 2009 ; 335: 71-84
2. Jing K, Lim K. Why is autophagy important in human diseases?. Exper Molec Med. 2012 ; 44 (2). 69-72
3. Shi CS, Shenderov K, Huang NN, et al. Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquinated inflammasomes for destruction. Nat Immunol. 2012 ; 13 (3). 255-263
4. Mintern JD, Villadangos JA. Autophagy and mechanisms of effective immunity. Frontiers Immunol. 2012 ; 3: 60
5. Deretic V. Autophagy: an emerging immunological paradigm. J Immunol. 2012 ; 189 (1). 15-20
6. Tsukamoto S, Kuma A, Murakami M, Kishi C, Yamamoto A, Mizushima N. Autophagy is essential for preimplantation development of mouse embryos. Science. 2008 ; 321 (5885). 117-120
7. Shen ZY, Xu LY, Li EM, et al. Autophagy and endocytosis in the amnion. J Structural Biol. 2008 ; 162 (2). 197-204
8. Hirota Y, Cha J, Yoshie M, Daikoku T, Dey SK. Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice. Proc Natl Acad Sci. USA. 2011 ; 108 (44). 18073-18078
9. Screening and diagnosis of gestational diabetes mellitus. Obstet Gynecol. 2011 ; 118 (3). 751-753
10. Massey DC, Bredin F, Parkes M. Use of sirolimus (rapamycin) to treat refractory Crohn's disease. Gut. 2008 ; 57 (9). 1294-1296
11. Ichimura Y, Komatsu M. Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models. Exp Anim. 2011 ; 60 (4). 329-345
12. Xu X, Ren J. Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac dysfunction. Clin Exp Pharmacol Physiol. 2012 ; 39 (2). 200-208
13. Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature. 2011 ; 469 (7330). 323-335
14. Sobolewska A, Gajewska M, Zarzynska J, Gajkowska B, Motyl J.. IGF-1, EGF, and sex steroids regulate autophagy in bovine mammary epithelial cells via the mTOR pathways. Eur J Cell Biol. 2009 ; 88 (2). 117-130
15. Ghadimi D, de Vrese M, Heller KJ, Schrezenmeir J. Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1-autophagy-promoting cytokine (IFN-γ) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen. Int Immunopharmacol. 2010 ; 10 (6). 694-706
16. Xu Y, Yang S, Huang J, Ruan S, Zheng Z, Lin J. TGF-β1 induces autophagy and promotes apoptosis in renal tubular epithelial cells. Int J Mol Med. 2012 ; 29 (5). 781-790
17. Patel AS, Lin L, Geyer A, et al. Autophagy in idiopathic pulmonary fibrosis. PLoS One. 2012 ; 7 (7). e41394
18. Oh SY, Choi SJ, Kim KH, Cho EY, Kim JH, Roh CR. Autophagy-related proteins, LC3 and Beclin-1, in placentas from pregnancies complicated by preeclampsia. Reprod Sci. 2008 ; 15 (9). 912-920
19. Hung TH, Chen SF, Lo LM, Li MJ, Yeh YL, Hsieh TT. Increased autophagy in placentas of intrauterine growth restricted pregnancies. PLoS One. 2012 ; 7 (7). e40957
20. Abumaree MH, Chamley LW, Badri M, El-Muzaini MF. Trophoblast debris modulates the expression of immune proteins in macrophages: a key to maternal tolerance of the fetal allograft?. J Reprod Immunol. 2012 ; 94 (2). 131-141
21. Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care. 2007 ; (30 suppl 2). S112 - S119
22. Lain KY, Catalano PM. Metabolic changes in pregnancy. Clin Obstet Gynecol. 2007 ; 50 (4). 938-948
23. Chen ZF, Li YB, Han JY, et al. The double-edged effect of autophagy in pancreatic beta cells and diabetes. Autophagy. 2011 ; 7 (1). 12-16