Inhibitory activities of the marine streptomycete-derived compound SF2446A2 against Chlamydia trachomatis and Schistosoma mansoni

Journal of Antibiotics

Volumn 68, Issue 11, 2015, Pages 674-679

  Reimer, Anastasija ^a   Blohm, Ariane ^b   Quack, Thomas ^b   Grevelding, Christoph G ^b   Kozjak Pavlovic, Vera ^a   Rudel, Thomas ^a   Hentschel, Ute ^c   Abdelmohsen, Usama Ramadan ^c,d  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d Minia University   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTISCHISTOSOMAL AGENT; CALCIUM ALGINATE; DIMETHYL SULFOXIDE; SF 2446A 2; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; SF 2446A2;

ARTICLE; BACTERIUM CULTURE; BIOASSAY; CELL LYSATE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS SPECTROMETRY; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCHISTOSOMA; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; STREPTOMYCES; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DRUG EFFECTS; HELA CELL LINE; MICROBIOLOGY; SPONGE (PORIFERA);

AMINOGLYCOSIDES; ANIMALS; CHLAMYDIA TRACHOMATIS; HELA CELLS; HUMANS; PORIFERA; SCHISTOSOMA MANSONI; STREPTOMYCES; WATER MICROBIOLOGY;

EID: 84948687464     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2015.54     Document Type: Article

References (25)

1. Somani, J., Bhullar, V. B., Workowski, K. A., Farshy, C. E. & Black, C. M. Multiple drugresistant Chlamydia trachomatis associated with clinical treatment failure. J. Infect. Dis. 181, 1421-1427 (2000
2. Stephens, R. S. The cellular paradigm of chlamydial pathogenesis. Trends Microbiol. 11, 44-51 (2003
3. Sharma, M. & Rudel, T. Apoptosis resistance in Chlamydia-infected cells: a fate worse than death?. FEMS Immunol. Med. Microbiol. 55, 154-161 (2009
4. Beatty, W. L., Morrison, R. P. & Byrne, G. I. Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol. Rev. 58, 686-699 (1994
5. Hogan, R. J., Mathews, S. A., Mukhopadhyay, S., Summersgill, J. T. & Timms, P. Chlamydial persistence: beyond the biphasic paradigm. Infect. Immun. 72, 1843-1855 (2004
6. World Health Organization Schistosomiasis. Fact sheet N 115, (2013). Available from http://www.who.int/mediacentre/factsheets/fs115/en/.(accessed February 2014
7. Fallon, P. G. Immunopathology of schistosomiasis: a cautionary tale of mice and men. Immunol. Today. 21, 29-35 (2000
8. Doenhoff, M. J., Cioli, D. & Utzinger, J. Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr. Opin. Infect. Dis. 21, 659-667 (2008
9. Fenical, W. & Jensen, P. R. Developing a new resource for drug discovery: marine actinomycete bacteria. Nat. Chem. Biol. 2, 666-673 (2006
10. Abdelmohsen, U. R., Bayer, K. & Hentschel, U. Diversity, abundance and natural products of marine sponge-Associated actinomycetes. Nat. Prod. Rep. 31, 381-399 (2014
11. Eltamany, E. E, et al. New antibacterial xanthone from the marine sponge-derived Micrococcus sp. EG45. Bioorg. Med. Chem. Lett. 24, 4939-4942 (2014
12. Pimentel-Elardo, S. M, et al. Anti-parasitic compounds from Streptomyces sp. strains isolated from Mediterranean sponges. Mar. Drugs. 8, 373-380 (2010
13. Mayer, A. M. & Hamann, M. T. Marine pharmacology in 2001-2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action. Comp. Biochem. Physiol. Toxicol. Pharmacol. 140, 265-286 (2005
14. Blunt, J. W., Copp, B. R., Keyzers, R. A., Munro, M. H. & Prinsep, M. R. Marine natural products. Nat. Prod. Rep. 30, 237-323 (2013
15. Abdelmohsen, U. R, et al. Antioxidant and anti-protease activities of diazepinomicin from the sponge-Associated Micromonospora strain RV115. Mar. Drugs. 10, 2208-2221 (2012
16. Bull, A. T. & Stach, J. E. Marine actinobacteria: new opportunities for natural product search and discovery. Trends Microbiol. 15, 491-499 (2007
17. Solanki, R., Khanna, M. & Lal, R. Bioactive compounds from marine actinomycetes. Indian J. Microbiol. 48, 410-431 (2008
18. Subramani, R. & Aalbersberg, W. Marine actinomycetes: an ongoing source of novel bioactive metabolites. Microbiol. Res. 167, 571-580 (2012
19. Tiwari, K. & Gupta, R. K. Rare actinomycetes: a potential storehouse for novel antibiotics. Crit. Rev. Biotechnol. 32, 108-132 (2012
20. Takeda, U, et al. SF2446, new benzo[a]naphthacene quinone antibiotics. I. Taxonomy and fermentation of the producing strain, isolation and characterization of antibiotics. J. Antibiot. (Tokyo) 41, 417-424 (1988
21. Abdelmohsen, U. R, et al. Isolation, phylogenetic analysis and anti-infective activity screening of marine sponge-Associated actinomycetes. Mar. Drugs. 8, 399-412 (2010
22. Wang, Y, et al. Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector. PLoS Pathog. 7, e1002258 (2011) Appendix A to the European Convention for the Protection of Vertebrate Animals used for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes ETS No.123) Guidelines for accommodation and care of animals (Article 5 of the Convention) http://conventions.coe.int/Treaty/EN/Treaties/Html/123-A. htm (accessed 24 April 2015
23. Grevelding, C. G. The female-specific W1 sequence of the Puerto Rican strain of Schistosoma mansoni occurs in both genders of a Liberian strain. Mol. Biochem. Parasitol. 71, 269-272 (1995
24. Beckmann, S., Leutner, S., Gouignard, N., Dissous, C. & Grevelding, C. G. Protein kinases as potential targets for novel anti-schistosomal strategies. Curr. Pharm. Des. 18, 3579-3594 (2012
25. Gomi, S., Sasaki, T., Itoh, J. & Sezaki, M. SF2446, new benzo[a]naphthacene quinone antibiotics. II. The structural elucidation. J. Antibiot. (Tokyo) 41, 425-432 (1988