Cytomegalovirus reactivation in ICU patients

Intensive Care Medicine

Volumn 42, Issue 1, 2016, Pages 28-37

  Papazian, Laurent ^a,b   Hraiech, Sami ^a,b   Lehingue, Samuel ^a,b   Roch, Antoine ^a,c   Chiche, Laurent ^d   Wiramus, Sandrine ^e   Forel, Jean Marie ^a,b  

^a AIX MARSEILLE UNIVERSITY   (France)

^b HÔPITAL NORD   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE   (France)

^d Unité de médecine interne Hôpital européen   (France)

^e HÔPITAL DE LA CONCEPTION   (France)

Author keywords

Cytomegalovirus; ICU; Incidence; Mechanical ventilation; Mortality; Reactivation

Indexed keywords

GAMMA INTERFERON; ANTIVIRUS AGENT;

ADULT RESPIRATORY DISTRESS SYNDROME; ANTIVIRAL THERAPY; ARTICLE; CYTOMEGALOVIRUS INFECTION; HOST RESISTANCE; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; PATHOGENICITY; PATHOPHYSIOLOGY; RISK FACTOR; SEROLOGY; VENTILATED PATIENT; VIRUS REACTIVATION; ADVERSE EFFECTS; ARTIFICIAL VENTILATION; CHEMOPROPHYLAXIS; CRITICAL ILLNESS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; IMMUNOCOMPETENCE; IMMUNOLOGY; ISOLATION AND PURIFICATION; MICROBIOLOGICAL EXAMINATION; PNEUMONIA, VIRAL; PROCEDURES; RISK ASSESSMENT; STANDARDS; STATISTICS AND NUMERICAL DATA;

ANTIVIRAL AGENTS; CHEMOPREVENTION; CRITICAL ILLNESS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; HUMANS; IMMUNOCOMPETENCE; INCIDENCE; INTENSIVE CARE UNITS; MICROBIOLOGICAL TECHNIQUES; PNEUMONIA, VIRAL; RESPIRATION, ARTIFICIAL; RISK ASSESSMENT; SEROEPIDEMIOLOGIC STUDIES;

EID: 84948585553     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-015-4066-9     Document Type: Article

References (51)

1. Chiche L, Forel JM, Papazian L (2011) The role of viruses in nosocomial pneumonia. Curr Opin Infect Dis 24:152–156
2. Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw KT, Wareham NJ (2012) Higher immunoglobulin G antibody levels against cytomegalovirus are associated with incident ischemic heart disease in the population-based EPIC-Norfolk cohort. J Infect Dis 206:1897–1903
3. Barry SM, Johnson MA, Janossy G (2000) Cytopathology or immunopathology? The puzzle of cytomegalovirus pneumonitis revisited. Bone Marrow Transplant 26:591–597
4. Papazian L, Fraisse A, Garbe L, Zandotti C, Thomas P, Saux P, Pierrin G, Gouin F (1996) Cytomegalovirus. An unexpected cause of ventilator-associated pneumonia. Anesthesiology 84:280–287
5. Papazian L, Thomas P, Bregeon F, Garbe L, Zandotti C, Saux P, Gaillat F, Drancourt M, Auffray JP, Gouin F (1998) Open-lung biopsy in patients with acute respiratory distress syndrome. Anesthesiology 88:935–944
6. Grundy JE, Shanley JD, Griffiths PD (1987) Is cytomegalovirus interstitial pneumonitis in transplant recipients an immunopathological condition? Lancet 2:996–999
7. Chiche L, Forel JM, Roch A, Guervilly C, Pauly V, Allardet-Servent J, Gainnier M, Zandotti C, Papazian L (2009) Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients. Crit Care Med 37:1850–1857
8. Cook CH, Martin LC, Yenchar JK, Lahm MC, McGuinness B, Davies EA, Ferguson RM (2003) Occult herpes family viral infections are endemic in critically ill surgical patients. Crit Care Med 31:1923–1929
9. Jaber S, Chanques G, Borry J, Souche B, Verdier R, Perrigault PF, Eledjam JJ (2005) Cytomegalovirus infection in critically ill patients: associated factors and consequences. Chest 127:233–241
10. Walton AH, Muenzer JT, Rasche D, Boomer JS, Sato B, Brownstein BH, Pachot A, Brooks TL, Deych E, Shannon WD, Green JM, Storch GA, Hotchkiss RS (2014) Reactivation of multiple viruses in patients with sepsis. PLoS One 9:e98819
11. Papazian L, Thomas P, Garbe L, Guignon I, Thirion X, Charrel J, Bollet C, Fuentes P, Gouin F (1995) Bronchoscopic or blind sampling techniques for the diagnosis of ventilator-associated pneumonia. Am J Respir Crit Care Med 152:1982–1991
12. Brenner T, Rosenhagen C, Hornig I, Schmidt K, Lichtenstern C, Mieth M, Bruckner T, Martin E, Schnitzler P, Hofer S, Weigand MA (2012) Viral infections in septic shock (VISS-trial)-crosslinks between inflammation and immunosuppression. J Surg Res 176:571–582
13. Cook CH, Trgovcich J, Zimmerman PD, Zhang Y, Sedmak DD (2006) Lipopolysaccharide, tumor necrosis factor alpha, or interleukin-1beta triggers reactivation of latent cytomegalovirus in immunocompetent mice. J Virol 80:9151–9158
14. Florescu DF, Kalil AC (2011) Cytomegalovirus infections in non-immunocompromised and immunocompromised patients in the intensive care unit. Infect Disord Drug Targets 11:354–364
15. Heininger A, Haeberle H, Fischer I, Beck R, Riessen R, Rohde F, Meisner C, Jahn G, Koenigsrainer A, Unertl K, Hamprecht K (2011) Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis. Crit Care 15:R77
16. Docke WD, Prosch S, Fietze E, Kimel V, Zuckermann H, Klug C, Syrbe U, Kruger DH, von Baehr R, Volk HD (1994) Cytomegalovirus reactivation and tumour necrosis factor. Lancet 343:268–269
17. Hummel M, Abecassis MM (2002) A model for reactivation of CMV from latency. J Clin Virol 25(Suppl 2):S123–S136
18. Hotchkiss RS, Coopersmith CM, McDunn JE, Ferguson TA (2009) The sepsis seesaw: tilting toward immunosuppression. Nat Med 15:496–497
19. Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862–874
20. Boeckh M, Murphy WJ, Peggs KS (2015) Recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies. Biol Blood Marrow Transplant 21:24–29
21. Clari MA, Aguilar G, Benet I, Belda J, Gimenez E, Bravo D, Carbonell JA, Henao L, Navarro D (2013) Evaluation of cytomegalovirus (CMV)-specific T-cell immunity for the assessment of the risk of active CMV infection in non-immunosuppressed surgical and trauma intensive care unit patients. J Med Virol 85:1802–1810
22. Chilet M, Aguilar G, Benet I, Belda J, Tormo N, Carbonell JA, Clari MA, Costa E, Navarro D (2010) Virological and immunological features of active cytomegalovirus infection in nonimmunosuppressed patients in a surgical and trauma intensive care unit. J Med Virol 82:1384–1391
23. von Muller L, Klemm A, Durmus N, Weiss M, Suger-Wiedeck H, Schneider M, Hampl W, Mertens T (2007) Cellular immunity and active human cytomegalovirus infection in patients with septic shock. J Infect Dis 196:1288–1295
24. Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL (2002) Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296:1323–1326
25. Biron CA, Byron KS, Sullivan JL (1989) Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med 320:1731–1735
26. Chiche L, Forel JM, Thomas G, Farnarier C, Cognet C, Guervilly C, Zandotti C, Vely F, Roch A, Vivier E, Papazian L (2012) Interferon-gamma production by natural killer cells and cytomegalovirus in critically ill patients. Crit Care Med 40:3162–3169
27. Min-Oo G, Lanier LL (2014) Cytomegalovirus generates long-lived antigen-specific NK cells with diminished bystander activation to heterologous infection. J Exp Med 211:2669–2680
28. Avdic S, McSharry BP, Slobedman B (2014) Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus. Front Microbiol 5:337
29. Coisel Y, Bousbia S, Forel JM, Hraiech S, Lascola B, Roch A, Zandotti C, Million M, Jaber S, Raoult D, Papazian L (2012) Cytomegalovirus and herpes simplex virus effect on the prognosis of mechanically ventilated patients suspected to have ventilator-associated pneumonia. PLoS One 7:e51340
30. Kalil AC, Florescu DF (2009) Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit. Crit Care Med 37:2350–2358
31. Kalil AC, Florescu DF (2011) Is cytomegalovirus reactivation increasing the mortality of patients with severe sepsis? Crit Care 15:138
32. Limaye AP, Kirby KA, Rubenfeld GD, Leisenring WM, Bulger EM, Neff MJ, Gibran NS, Huang ML, Santo Hayes TK, Corey L, Boeckh M (2008) Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA 300:413–422
33. Lopez Roa P, Hill JA, Kirby KA, Leisenring WM, Huang ML, Santo TK, Jerome KR, Boeckh M, Limaye AP (2015) Coreactivation of human herpesvirus 6 and cytomegalovirus is associated with worse clinical outcome in critically ill adults. Crit Care Med 43:1415–1422
34. Papazian L, Doddoli C, Chetaille B, Gernez Y, Thirion X, Roch A, Donati Y, Bonnety M, Zandotti C, Thomas P (2007) A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients. Crit Care Med 35:755–762
35. Siciliano RF, Castelli JB, Randi BA, Vieira RD, Strabelli TM (2014) Cytomegalovirus colitis in immunocompetent critically ill patients. Int J Infect Dis 20:71–73
36. Fisman DN (2000) Hemophagocytic syndromes and infection. Emerg Infect Dis 6:601–608
37. Osawa R, Singh N (2009) Cytomegalovirus infection in critically ill patients: a systematic review. Crit Care 13:R68
38. De Vlieger G, Meersseman W, Lagrou K, Wouters P, Wilmer A, Peetermans WE, Van den Berghe G, Van Wijngaerden E (2012) Cytomegalovirus serostatus and outcome in nonimmunocompromised critically ill patients. Crit Care Med 40:36–42
39. Ong DS, Klein Klouwenberg PM, Verduyn Lunel FM, Spitoni C, Frencken JF, Dekker HA, Schultz MJ, Bonten MJ, Cremer OL (2015) Cytomegalovirus seroprevalence as a risk factor for poor outcome in acute respiratory distress syndrome. Crit Care Med 43:394–400
40. Forel JM, Martin-Loeches I, Luyt CE (2014) Treating HSV and CMV reactivations in critically ill patients who are not immunocompromised: pro. Intensive Care Med 40:1945–1949
41. Domart Y, Trouillet JL, Fagon JY, Chastre J, Brun-Vezinet F, Gibert C (1990) Incidence and morbidity of cytomegaloviral infection in patients with mediastinitis following cardiac surgery. Chest 97:18–22
42. Stephan F, Meharzi D, Ricci S, Fajac A, Clergue F, Bernaudin JF (1996) Evaluation by polymerase chain reaction of cytomegalovirus reactivation in intensive care patients under mechanical ventilation. Intensive Care Med 22:1244–1249
43. Kutza AS, Muhl E, Hackstein H, Kirchner H, Bein G (1998) High incidence of active cytomegalovirus infection among septic patients. Clin Infect Dis 26:1076–1082
44. Cook CH, Yenchar JK, Kraner TO, Davies EA, Ferguson RM (1998) Occult herpes family viruses may increase mortality in critically ill surgical patients. Am J Surg 176:357–360
45. Heininger A, Jahn G, Engel C, Notheisen T, Unertl K, Hamprecht K (2001) Human cytomegalovirus infections in nonimmunosuppressed critically ill patients. Crit Care Med 29:541–547
46. Desachy A, Ranger-Rogez S, Francois B, Venot C, Traccard I, Gastinne H, Denis F, Vignon P (2001) Reactivation of human herpesvirus type 6 in multiple organ failure syndrome. Clin Infect Dis 32:197–203
47. Razonable RR, Fanning C, Brown RA, Espy MJ, Rivero A, Wilson J, Kremers W, Smith TF, Paya CV (2002) Selective reactivation of human herpesvirus 6 variant a occurs in critically ill immunocompetent hosts. J Infect Dis 185:110–113
48. von Muller L, Klemm A, Weiss M, Schneider M, Suger-Wiedeck H, Durmus N, Hampl W, Mertens T (2006) Active cytomegalovirus infection in patients with septic shock. Emerg Infect Dis 12:1517–1522
49. Ziemann M, Sedemund-Adib B, Reiland P, Schmucker P, Hennig H (2008) Increased mortality in long-term intensive care patients with active cytomegalovirus infection. Crit Care Med 36:3145–3150
50. Bordes J, Gaillard T, Maslin J, Esnault P, Goutorbe P, Brisou P (2011) Cytomegalovirus infection monitored by quantitative real-time PCR in critically ill patients. Crit Care 15:412
51. Frantzeskaki FG, Karampi ES, Kottaridi C, Alepaki M, Routsi C, Tzanela M, Vassiliadi DA, Douka E, Tsaousi S, Gennimata V, Ilias I, Nikitas N, Armaganidis A, Karakitsos P, Papaevangelou V, Dimopoulou I (2015) Cytomegalovirus reactivation in a general, nonimmunosuppressed intensive care unit population: incidence, risk factors, associations with organ dysfunction, and inflammatory biomarkers. J Crit Care 30:276–281