Cytomegalovirus serostatus and outcome in nonimmunocompromised critically ill Patients

Critical Care Medicine

Volumn 40, Issue 1, 2012, Pages 36-42

  De Vlieger, Greet ^a   Meersseman, Wouter ^a   Lagrou, Katrien ^a   Wouters, Pieter ^a   Wilmer, Alexander ^a   Peetermans, Willy E ^a   Van Den Berghe, Greet ^a   Van Wijngaerden, Eric ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Critically ill; Cytomegalovirus; Herpes virus; Intensive care unit; Nonimmunocompromised; Reactivation

Indexed keywords

CYTOMEGALOVIRUS ANTIBODY; IMMUNOGLOBULIN G; INSULIN; NORADRENALIN; STEROID;

ADULT; AGED; APACHE; ARTICLE; ARTIFICIAL VENTILATION; BLOOD ANALYSIS; BLOOD GLUCOSE MONITORING; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CYTOMEGALOVIRUS INFECTION; ERYTHROCYTE TRANSFUSION; FEMALE; HOSPITAL DISCHARGE; HUMAN; INSULIN TREATMENT; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; OBESITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RENAL REPLACEMENT THERAPY; RETROSPECTIVE STUDY; RISK ASSESSMENT; SEPSIS; SEROLOGY; VIRUS REACTIVATION;

AGED; CHI-SQUARE DISTRIBUTION; CRITICAL ILLNESS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HOSPITAL BED CAPACITY, 500 AND OVER; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; MIDDLE AGED; RENAL REPLACEMENT THERAPY; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; TIME FACTORS; TREATMENT OUTCOME; VENTILATOR WEANING;

EID: 84055161234     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31822b50ae     Document Type: Article

References (32)

1. Zhang LJ, Hanff P, Rutherford C, et al: Detection of human cytomegalovirus DNA, RNA, and antibody in normal donor blood. J Infect Dis 1995; 171:1002-1006
2. Stanberry LR, Rosenthal SL, Mills L, et al: Longitudinal risk of herpes simplex virus (HSV) type 1, HSV type 2, and cytomegalovirus infections among young adolescent girls. Clin Infect Dis 2004; 39:1433-1438
3. Gandhi MK, Khanna R: Human cytomegalovirus: Clinical aspects, immune regulation, and emerging treatments. Lancet Infect Dis 2004; 4:725-738
4. Bale JF Jr, Kealey GP, Massanari RM, et al: The epidemiology of cytomegalovirus infection among patients with burns. Infect Control Hosp Epidemiol 1990; 11:17-22
5. von Müller L, Klemm A, Weiss M, et al: Active cytomegalovirus infection in patients with septic shock. Emerg Infect Dis 2006; 12: 1517-1522
6. Domart Y, Trouillet JL, Fagon JY, et al: Incidence and morbidity of cytomegaloviral infection in patients with mediastinitis following cardiac surgery. Chest 1990; 97:18-22
7. Heininger A, Jahn G, Engel C, et al: Human cytomegalovirus infections in nonimmunosuppressed critically ill patients. Crit Care Med 2001; 29:541-547
8. Cook CH, Martin LC, Yenchar JK, et al: Occult herpes family viral infections are endemic in critically ill surgical patients. Crit Care Med 2003; 31:1923-1929
9. Jaber S, Chanques G, Borry J, et al: Cytomegalovirus infection in critically ill patients: Associated factors and consequences. Chest 2005; 127:233-241
10. Limaye AP, Kirby KA, Rubenfeld GD, et al: Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA 2008; 300:413-422
11. Ziemann M, Sedemund-Adib B, Reiland P, et al: Increased mortality in long-term intensive care patients with active cytomegalovirus infection. Crit Care Med 2008; 36: 3145-3150
12. Chiche L, Forel JM, Roch A, et al: Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients. Crit Care Med 2009; 37:1850-1857
13. Heininger A, Haeberlee H, Fischer I, et al: Cytomegalovirus reactivation and associated outcome in critically ill patients with severe sepsis. Crit Care 2011; 15:R77
14. Papazian L, Fraisse A, Garbe L, et al: Cytomegalovirus. An unexpected cause of ventilator-associated pneumonia. Anesthesiology 1996; 84:280-287
15. Kalil AC, Florescu DF: Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit. Crit Care Med 2009; 37: 2350-2358
16. Cook CH, Yenchar JK, Kraner TO, et al: Occult herpes family viruses may increase mortality in critically ill surgical patients. Am J Surg 1998; 176:357-360
17. Osawa R, Singh N: Cytomegalovirus infection in critically ill patients: A systematic review. Crit Care 2009; 13:R68
18. Cook CH: Cytomegalovirus reactivation and mortality during critical illness: A $64,000 question. Crit Care Med 2009; 37:2475-2476
19. Griffiths PD: Cytomegalovirus in intensive care. Rev Med Virol 2010; 20:1-3
20. van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-1367
21. Van den Berghe G, Wilmer A, Hermans G, et al: Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354:449-461
22. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992. Chest 2009; 136(Suppl 5):e28
23. Lagrou K, Bodeus M, Van Ranst M, et al: Evaluation of the new architect cytomegalovirus immunoglobulin M (IgM), IgG, and IgG avidity assays. J Clin Microbiol 2009; 47:1695-1699
24. Andersen PK, Abildstrom SZ, Rosthøj S: Competing risks as a multi-state model. Stat Methods Med Res 2002; 11:203-215
25. Kutza AS, Muhl E, Hackstein H, et al: High incidence of active cytomegalovirus infection among septic patients. Clin Infect Dis 1998; 26:1076-1082
26. Stéphan F, Méharzi D, Ricci S, et al: Evaluation by polymerase chain reaction of cytomegalovirus reactivation in intensive care patients under mechanical ventilation. Intensive Care Med 1996; 22:1244-1249
27. Prösch S, Wendt CE, Reinke P, et al: A novel link between stress and human cytomegalovirus (HCMV) infection: Sympathetic hyperactivity stimulates HCMV activation. Virology 2000; 272:357-365
28. Forster MR, Trgovcich J, Zimmerman P, et al: Antiviral prevention of sepsis induced cytomegalovirus reactivation in immunocompetent mice. Antiviral Res 2009; 85: 496-503
29. Cook CH, Zhang Y, Sedmak DD, et al: Pulmonary cytomegalovirus reactivation causes pathology in immunocompetent mice. Crit Care Med 2006; 34:842-849
30. Heininger A, Hamprecht K: How cytomegalorvirus reactivation could cause pulmonary pathology in septic hosts. Crit Care Med 2006; 34:929-930
31. Kalil AC: A silent killer: cytomegalovirus infection in the nonimmunocompromised critically ill patient. Crit Care Med 2008; 36: 3261-3264
32. Bordes J, Maslin J, Prunet B, et al: Cytomegalovirus infection in severe burn patients monitoring by real-time polymerase chain reaction: A prospective study. Burns 2011; 37:434-439