Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Shon, Woo Jeong ^a   Lee, Young Kwan ^a   Shin, Ji Hee ^a   Choi, Eun Young ^a   Shin, Dong Mi ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DODECYL SULFATE SODIUM; ENZYME INHIBITOR; IDO1 PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLEAMINE 2,3 DIOXYGENASE; MYD88 PROTEIN, MOUSE; MYELOID DIFFERENTIATION FACTOR 88; NONSTEROID ANTIINFLAMMATORY AGENT; TLR2 PROTEIN, MOUSE; TLR6 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 6; TRANSCRIPTOME; TRYPTOPHAN; TRYPTOPHAN METHYL ESTER;

ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; COLITIS; COLON; DEFICIENCY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOUSE; PATHOLOGY; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COLITIS; COLON; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; SODIUM DODECYL SULFATE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 6; TRANSCRIPTION, GENETIC; TRANSCRIPTOME; TRYPTOPHAN;

EID: 84948456220     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep17305     Document Type: Article

References (45)

1. Takikawa, O., Yoshida, R., Kido, R. & Hayaishi, O. Tryptophan degradation in mice initiated by indoleamine. 2, 3-dioxygenase. J Biol Chem. 261, 3648-3653 (1986
2. Rios-Avila, L., Nijhout, H. F., Reed, M. C., Sitren, H. S. & Gregory, J. F A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiencky, tryptophan loading, and induction of tryptophan. 2, 3-dioxygenase on tryptophan metabolites. J Nutr. 143, 1509-1519 (2013
3. Stavrum, A.-K., Heiland, I., Schuster, S., Puntervoll, P. & Ziegler, M. Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data. J Biol Chem. 288, 34555-34566 (2013
4. Matteoli, G, et al. Gut CD103+ dendritic cells express indoleamine. 2, 3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction. Gut. 59, 595-604 (2010
5. Yoshida, R, et al. Regulation of indoleamine. 2, 3-dioxygenase activity in the small intestine and the epididymis of mice. Arch Biochem Biophys. 203, 343-351 (1980
6. Kwidzinski, E, et al. Indolamine. 2, 3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation. FASEB J. 19, 1347-1349 (2005
7. Boasso, A, et al. Regulatory T-cell markers, indoleamine. 2, 3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection. J Virol. 81, 11593-11603 (2007
8. Romani, L, et al. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature. 451, 211-215 (2008
9. Jrad-Lamine, A, et al. Indoleamine. 2, 3-dioxygenase 1 (IDO1) is involved in the control of mouse caput epididymis immune environment. PLoS One. 8, e66494 (2013
10. Mellor, A. L. & Munn, D. H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol. 4, 762-774 (2004
11. Munn, D. H, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 281, 1191-1193 (1998
12. Jasperson, L. K, et al. Indoleamine. 2, 3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality. Blood. 111, 3257-3265 (2008
13. Lu, Y, et al. IFN-? and indoleamine. 2, 3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity. Blood. 119, 1075-1085 (2012
14. Favre, D, et al. Tryptophan catabolism by indoleamine. 2, 3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med. 2, 32ra36 (2010
15. Liu, X, et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood. 115, 3520-3530 (2010
16. Terness, P, et al. Inhibition of Allogeneic T Cell Proliferation by Indoleamine. 2, 3-Dioxygenase-expressing Dendritic Cells Mediation of Suppression by Tryptophan Metabolites. J Exp Med. 196, 447-457 (2002
17. Takamatsu, M, et al. IDO1 Plays an Immunosuppressive Role in. 2, 4, 6-Trinitrobenzene Sulfate-Induced Colitis in Mice. J Immunol. 191, 3057-3064 (2013
18. Gurtner, G. J., Newberry, R. D., Schloemann, S. R., McDonald, K. G. & Stenson, W. F. Inhibition of indoleamine. 2, 3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice. Gastroenterology. 125, 1762-1773 (2003
19. Thaker, A. I, et al. IDO1 metabolites activate β -catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice. Gastroenterology. 145, 416-425 (2013
20. Strober, W., Fuss, I. J. & Blumberg, R. S. The immunology of mucosal models of inflammation. Annu Rev Immunol. 20, 495-549 (2002
21. Henao-Mejia, J., Elinav, E., Strowig, T. & Flavell, R. A. Inflammasomes: far beyond inflammation. Nat Immunol. 13, 321-324 (2012
22. Teijaro, J. R, et al. Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science. 340, 207-211 (2013
23. Deretic, V., Saitoh, T. & Akira, S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol. 13, 722-737 (2013
24. Jim?ez, V. C, et al. Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons. Sci Rep. 2, doi: 10.1038/srep00763 (2012
25. Jagannathan-Bogdan, M, et al. Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes. J Immunol. 186, 1162-1172 (2011
26. Gabrilovich, D. I., Ostrand-Rosenberg, S. & Bronte, V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol. 12, 253-268 (2012
27. Kr?er, A., Green, J., Pollard, J. & Tugendreich, S. Causal Analysis Approaches in Ingenuity Pathway Analysis (IPA). Bioinformatics. 30, 523-530 (2014
28. Jostins, L, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 491, 119-124 (2012
29. Maloy, K. J. & Powrie, F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature. 474, 298-306 (2011
30. Strober, W. & Fuss, I. J. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 140, 1756-1767 (2011
31. Ciorba, M. A, et al. Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis. J Immunol. 184, 3907-3916 (2010
32. Alex, P, et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis. 15, 341-352 (2009
33. McAuley, J. L, et al. MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. J Clin Invest. 117, 2313-2324 (2007
34. Linden, S., Sutton, P., Karlsson, N., Korolik, V. & McGuckin, M. Mucins in the mucosal barrier to infection. Mucosal immunol. 1, 183-197 (2008
35. Ueno, K, et al. MUC1 mucin is a negative regulator of toll-like receptor signaling. Am J Respir Cell Mol Biol. 38, 263-268 (2008
36. Williams, M. A, et al. Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligands. J Innate Immun. 2, 123-143 (2010
37. Mellor, A. L. & Munn, D. H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol. 4, 762-774 (2004
38. Platten, M., Wick, W. & Van den Eynde, B. J. Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res. 72, 5435-5440 (2012
39. Klonowski, K, et al. Inhibition of Indoleamine. 2, 3-dioxygenase (IDO) enhances the memory CD8 T cell response and modulates the immunodominance hierarchy following influenza infection. J Immunol. 188, 48.17 (2012
40. Blumenthal, A, et al. M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. PLoS One. 7, e37314 (2012
41. Scott, G. N, et al. The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity. J Immunol. 182, 7509-7517 (2009
42. Laroui, H, et al. Dextran sodium sulfate (DSS) induces colitis in mice by forming nano-lipocomplexes with medium-chain-length fatty acids in the colon. PLoS One. 7, e32084 (2012
43. Weigmann, B, et al. Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue. Nat Protoc. 2, 2307-2311 (2007
44. Subramanian, A, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102, 15545-15550 (2005
45. Sturn, A., Quackenbush, J. & Trajanoski, Z. Genesis: cluster analysis of microarray data. Bioinformatics. 18, 207-208 (2002