Whole‑transcriptome analysis of mouse adipose tissue in response to short‑term caloric restriction

Molecular Genetics and Genomics

Volumn 291, Issue 2, 2016, Pages 831-847

  Kim, Seung Soo ^a   Choi, Kyung Mi ^a   Kim, Soyoung ^b   Park, Taesun ^b   Cho, In Cheol ^c   Lee, Jae Won ^a   Lee, Cheol Koo ^a  

^a Korea University   (South Korea)

^b Yonsei University   (South Korea)

^c National Institute of Animal Science   (South Korea)

Author keywords

Adipose tissue; Caloric restriction strength; Mice; Transcription factor; Transcriptome

Indexed keywords

ALPHA INTEGRIN; ALPHA1 INTEGRIN; ALPHA6 INTEGRIN; BETA5 INTEGRIN; CALPAIN 2; CASPASE 8; COLLAGEN TYPE 15; COLLAGEN TYPE 4; COLLAGEN TYPE 5; ELASTIN; ELASTIN MICROFIBRIL INTERFACER 2 PROTEIN; ENTACTIN; EPIDERMAL GROWTH FACTOR; FAMILY WITH SEQUENCE SIMILARITY 114 MEMBER A1 PROTEIN; FIBRONECTIN; FIBULIN 5; GRAM DOMAIN CONTAINING 4 PROTEIN; INTEGRIN ALPHA M; LIPOCORTIN 1; PERIOSTIN OSTEOBLAST SPECIFIC FACTOR; PROTEIN; RECEPTOR ACCESSORY PROTEIN 6; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PITX2; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT PROTEIN; EYE PROTEIN; HOMEODOMAIN PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CELL ADHESION; CELL CYCLE; CITRIC ACID CYCLE; COMPUTER MODEL; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; EPIDIDYMIS FAT; EXTRACELLULAR MATRIX; GENE; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; MALE; MOUSE; MOUSE MAMMARY TUMOR VIRUS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REDUCTION; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; UPREGULATION; WHOLE TRANSCRIPTOME ANALYSIS; WNT SIGNALING PATHWAY; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; LIVER; LONGEVITY; METABOLISM; OXIDATION REDUCTION REACTION; PROCEDURES;

ADIPOSE TISSUE; ANIMALS; CALORIC RESTRICTION; EPIDERMAL GROWTH FACTOR; EYE PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; LIVER; LONGEVITY; MICE; OXIDATION-REDUCTION; PAIRED BOX TRANSCRIPTION FACTORS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; WNT SIGNALING PATHWAY;

EID: 84948181488     PISSN: 16174615     EISSN: 16174623     Source Type: Journal    
DOI: 10.1007/s00438-015-1150-3     Document Type: Article

References (110)

1. Abdollahi A (2007) LOT1 (ZAC1/PLAGL1) and its family members: mechanisms and functions. J Cell Physiol 210(1):16–25
2. Abe T, Nakajima A, Satoh N, Ohkoshi M, Sakuragi S, Koizumi A (2001) Suppression of experimental autoimmune uveoretinitis by dietary calorie restriction. Jpn J Ophthalmol 45(1):46–52
3. Aga-Mizrachi S, Brutman-Barazani T, Jacob AI, Bak A, Elson A, Sampson SR (2008) Cytosolic protein tyrosine phosphataseepsilon is a negative regulator of insulin signaling in skeletal muscle. Endocrinology 149(2):605–614
4. Barzilai N, Gabriely I (2001) The role of fat depletion in the biological benefits of caloric restriction. J Nutr 131(3):903S–906S
5. Barzilai N, Gupta G (1999) Revisiting the role of fat mass in the life extension induced by caloric restriction. J Gerontol A Biol Sci Med Sci 54(3):B89–B96 (discussion B97-88)
6. Barzilai N, She L, Liu BQ, Vuguin P, Cohen P, Wang J, Rossetti L (1999) Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 48(1):94–98
7. Bertrand HA, Lynd FT, Masoro EJ, Yu BP (1980) Changes in adipose mass and cellularity through the adult life of rats fed ad libitum or a life-prolonging restricted diet. J Gerontol 35(6):827–835
8. Bluher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, Kahn CR (2002) Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 3(1):25–38
9. Bluher M, Kahn BB, Kahn CR (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299(5606):572–574
10. Borisov N, Aksamitiene E, Kiyatkin A, Legewie S, Berkhout J, Maiwald T, Kaimachnikov NP, Timmer J, Hoek JB, Kholodenko BN (2009) Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. Mol Syst Biol 5:256
11. Briata P, Ilengo C, Corte G, Moroni C, Rosenfeld MG, Chen CY, Gherzi R (2003) The Wnt/beta-catenin–> Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs. Mol Cell 12(5):1201–1211
12. Carey JR, Liedo P, Harshman L, Zhang Y, Muller HG, Partridge L, Wang JL (2002) Life history response of Mediterranean fruit flies to dietary restriction. Aging Cell 1(2):140–148
13. Chen XW, Leto D, Xiong T, Yu G, Cheng A, Decker S, Saltiel AR (2011) A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell 22(1):141–152
14. Chen JY, Lin JR, Cimprich KA, Meyer T (2012) A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. Mol Cell 45(2):196–209
15. Chiba T, Ezaki O (2010) Dietary restriction suppresses inflammation and delays the onset of stroke in stroke-prone spontaneously hypertensive rats. Biochem Biophys Res Commun 399(1):98–103
16. Choi JS, Lee CK (2013) Maintenance of cellular ATP level by caloric restriction correlates chronological survival of budding yeast. Biochem Biophys Res Commun 439(1):126–131
17. Choi JS, Choi KM, Lee CK (2011) Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae. Biochem Biophys Res Commun 409(2):308–314
18. Choi KM, Kwon YY, Lee CK (2015) Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast. FEBS Lett 589(3):349–357
19. Christodoulides C, Lagathu C, Sethi JK, Vidal-Puig A (2009) Adipogenesis and WNT signalling. Trends Endocrinol Metab 20(1):16–24
20. Chujo Y, Fujii N, Okita N, Konishi T, Narita T, Yamada A, Haruyama Y, Tashiro K, Chiba T, Shimokawa I, Higami Y (2013) Caloric restriction-associated remodeling of rat white adipose tissue: effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration. Age (Dordr) 35(4):1143–1156
21. Cooper TM, Mockett RJ, Sohal BH, Sohal RS, Orr WC (2004) Effect of caloric restriction on life span of the housefly, Musca domestica. FASEB J 18(13):1591–1593
22. Coppack SW, Fisher RM, Gibbons GF, Humphreys SM, McDonough MJ, Potts JL, Frayn KN (1990) Postprandial substrate deposition in human forearm and adipose tissues in vivo. Clin Sci (Lond) 79(4):339–348
23. Das M, Gabriely I, Barzilai N (2004) Caloric restriction, body fat and ageing in experimental models. Obes Rev 5(1):13–19
24. Davis LM, Pauly JR, Readnower RD, Rho JM, Sullivan PG (2008) Fasting is neuroprotective following traumatic brain injury. J Neurosci Res 86(8):1812–1822
25. DeClercq V, Taylor C, Zahradka P (2008) Adipose tissue: the link between obesity and cardiovascular disease. Cardiovasc Hematol Disord: Drug Targets 8(3):228–237
26. Demas GE (2004) The energetics of immunity: a neuroendocrine link between energy balance and immune function. Horm Behav 45(3):173–180
27. Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S Jr, Elmquist JK, Lowell BB (2006) Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49(2):191–203
28. Douville E, Downward J (1997) EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2. Oncogene 15(4):373–383
29. Fernandes G, Yunis EJ, Good RA (1976) Influence of diet on survival of mice. Proc Natl Acad Sci USA 73(4):1279–1283
30. Forster MJ, Morris P, Sohal RS (2003) Genotype and age influence the effect of caloric intake on mortality in mice. FASEB J 17(6):690–692
31. Frayn KN (2002) Adipose tissue as a buffer for daily lipid flux. Diabetologia 45(9):1201–1210
32. Fu C, Hickey M, Morrison M, McCarter R, Han ES (2006) Tissue specific and non-specific changes in gene expression by aging and by early stage CR. Mech Ageing Dev 127(12):905–916
33. Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N (2002) Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 51(10):2951–2958
34. Gardner EM (2005) Caloric restriction decreases survival of aged mice in response to primary influenza infection. J Gerontol A Biol Sci Med Sci 60(6):688–694
35. Gehring WJ, Ikeo K (1999) Pax 6: mastering eye morphogenesis and eye evolution. Trends Genet 15(9):371–377
36. Genander M, Halford MM, Xu NJ, Eriksson M, Yu Z, Qiu Z, Martling A, Greicius G, Thakar S, Catchpole T, Chumley MJ, Zdunek S, Wang C, Holm T, Goff SP, Pettersson S, Pestell RG, Henkemeyer M, Frisen J (2009) Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 139(4):679–692
37. Ghosh S, Wanders D, Stone KP, Van NT, Cortez CC, Gettys TW (2014) A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats. FASEB J 28(6):2577–2590
38. Gosmain Y, Katz LS, Masson MH, Cheyssac C, Poisson C, Philippe J (2012) Pax6 is crucial for beta-cell function, insulin biosynthesis, and glucose-induced insulin secretion. Mol Endocrinol 26(4):696–709
39. Harper JM, Leathers CW, Austad SN (2006) Does caloric restriction extend life in wild mice? Aging Cell 5(6):441–449
40. Harrison DE, Archer JR (1987) Genetic differences in effects of food restriction on aging in mice. J Nutr 117(2):376–382
41. Higami Y, Pugh TD, Page GP, Allison DB, Prolla TA, Weindruch R (2004) Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction. FASEB J 18(2):415–417
42. Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R (2006) Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. J Nutr 136(2):343–352
43. Hochberg Y, Benjamini Y (1990) More powerful procedures for multiple significance testing. Stat Med 9(7):811–818
44. Huffman DM, Barzilai N (2009) Role of visceral adipose tissue in aging. Biochim Biophys Acta 1790(10):1117–1123
45. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP (2003) Summaries of Affymetrix GeneChip probe level data. Nucl Acids Res 31(4):e15
46. Jin Q, Esteva FJ (2008) Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer. J Mammary Gland Biol Neoplasia 13(4):485–498
47. Jung H, Lee SK, Jho EH (2011) Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation. Biochem J 436(2):263–269
48. Kasumovic MM, Brooks RC, Andrade MC (2009) Body condition but not dietary restriction prolongs lifespan in a semelparous capital breeder. Biol Lett 5(5):636–638
49. Katoh Y, Katoh M (2006) FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. Int J Mol Med 17(3):529–532
50. Kawanishi N, Yano H, Yokogawa Y, Suzuki K (2010) Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice. Exerc Immunol Rev 16:105–118
51. Klein S, Fontana L, Young VL, Coggan AR, Kilo C, Patterson BW, Mohammed BS (2004) Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med 350(25):2549–2557
52. Kohonen T, Hynninen J, Kangas J, Laaksonen J (1996) Som pak: the self-organizing map program package. Report A31, Helsinki University of Technology, Laboratory of Computer and Information Science
53. Koza RA, Nikonova L, Hogan J, Rim JS, Mendoza T, Faulk C, Skaf J, Kozak LP (2006) Changes in gene expression foreshadow dietinduced obesity in genetically identical mice. PLoS Genet 2(5):e81
54. Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, Nora ED, Campbell M, Medina-Gomez G, Cheyette BN, Vidal-Puig AJ, Sethi JK (2009) Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. Diabetes 58(3):609–619
55. Laxminarayan KM, Chan BK, Tetaz T, Bird PI, Mitchell CA (1994) Characterization of a cDNA encoding the 43-kDa membraneassociated inositol-polyphosphate 5-phosphatase. J Biol Chem 269(25):17305–17310
56. Lee YL, Lee CK (2008) Transcriptional response according to strength of calorie restriction in Saccharomyces cerevisiae. Mol Cells 26(3):299–307
57. Lee KP, Simpson SJ, Clissold FJ, Brooks R, Ballard JW, Taylor PW, Soran N, Raubenheimer D (2008) Lifespan and reproduction in Drosophila: new insights from nutritional geometry. Proc Natl Acad Sci USA 105(7):2498–2503
58. Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD (2010) Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res 70(4):1564–1572
59. Lemmon MA, Schlessinger J (2010) Cell signaling by receptor tyrosine kinases. Cell 141(7):1117–1134
60. Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF (2010) Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell 9(1):92–95
61. Liao CY, Rikke BA, Johnson TE, Gelfond JA, Diaz V, Nelson JF (2011) Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell 10(4):629–639
62. Lipman RD, Smith DE, Bronson RT, Blumberg J (1995) Is late-life caloric restriction beneficial? Aging (Milano) 7(2):136–139
63. Lipman RD, Smith DE, Blumberg JB, Bronson RT (1998) Effects of caloric restriction or augmentation in adult rats: longevity and lesion biomarkers of aging. Aging (Milano) 10(6):463–470
64. Liu HS, Hsu PY, Lai MD, Chang HY, Ho CL, Cheng HL, Chen HT, Lin YJ, Wu TJ, Tzai TS, Chow NH (2010) An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells. Carcinogenesis 31(8):1456–1464
65. Liu R, Zhou Z, Huang J, Chen C (2011) PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21 Cip1 signaling pathway. J Pathol 223(5):683–694
66. MacDonald L, Radler M, Paolini AG, Kent S (2011) Calorie restriction attenuates LPS-induced sickness behavior and shifts hypothalamic signaling pathways to an anti-inflammatory bias. Am J Physiol Regul Integr Comp Physiol 301(1):R172–R184
67. Malliri A, Rygiel TP, van der Kammen RA, Song JY, Engers R, Hurlstone AF, Clevers H, Collard JG (2006) The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem 281(1):543–548
68. Margoni A, Fotis L, Papavassiliou AG (2012) The transforming growth factor-beta/bone morphogenetic protein signalling pathway in adipogenesis. Int J Biochem Cell Biol 44(3):475–479
69. Masoro EJ (2005) Overview of caloric restriction and ageing. Mech Ageing Dev 126(9):913–922
70. Matsubara T, Mita A, Minami K, Hosooka T, Kitazawa S, Takahashi K, Tamori Y, Yokoi N, Watanabe M, Matsuo E, Nishimura O, Seino S (2012) PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue. Cell Metab 15(1):38–50
71. Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R (2012) Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489(7415):318–321
72. Millership S, Ninkina N, Rochford JJ, Buchman VL (2013) gammasynuclein is a novel player in the control of body lipid metabolism. Adipocyte 2(4):276–280
73. Mitchell JR, Verweij M, Brand K, van de Ven M, Goemaere N, van den Engel S, Chu T, Forrer F, Muller C, de Jong M, van IW, JN IJ, Hoeijmakers JH, de Bruin RW (2010) Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice. Aging Cell 9(1):40–53
74. Molleman F, Ding J, Boggs CL, Carey JR, Arlet ME (2009) Does dietary restriction reduce life span in male fruit-feeding butterflies? Exp Gerontol 44(9):601–606
75. Moraes RC, Blondet A, Birkenkamp-Demtroeder K, Tirard J, Orntoft TF, Gertler A, Durand P, Naville D, Begeot M (2003) Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. Endocrinology 144(11):4773–4782
76. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW (2006) Central nervous system control of food intake and body weight. Nature 443(7109):289–295
77. Muzumdar R, Allison DB, Huffman DM, Ma X, Atzmon G, Einstein FH, Fishman S, Poduval AD, McVei T, Keith SW, Barzilai N (2008) Visceral adipose tissue modulates mammalian longevity. Aging Cell 7(3):438–440
78. Nacher J, Varea E, Blasco-Ibanez JM, Castillo-Gomez E, Crespo C, Martinez-Guijarro FJ, McEwen BS (2005) Expression of the transcription factor Pax 6 in the adult rat dentate gyrus. J Neurosci Res 81(6):753–761
79. Nikolich-Zugich J, Messaoudi I (2005) Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune system of non-human primates. Exp Gerontol 40(11):884–893
80. Niu C, Liang C, Guo J, Cheng L, Zhang H, Qin X, Zhang Q, Ding L, Yuan B, Xu X, Li J, Lin J, Ye Q (2012) Downregulation and growth inhibitory role of FHL1 in lung cancer. Int J Cancer 130(11):2549–2556
81. Okada Y, Sakaue H, Nagare T, Kasuga M (2009) Diet-induced upregulation of gene expression in adipocytes without changes in DNA methylation. Kobe J Med Sci 54(5):E241–E249
82. Okita N, Hayashida Y, Kojima Y, Fukushima M, Yuguchi K, Mikami K, Yamauchi A, Watanabe K, Noguchi M, Nakamura M, Toda T, Higami Y (2012) Differential responses of white adipose tissue and brown adipose tissue to caloric restriction in rats. Mech Ageing Dev 133(5):255–266
83. Oort PJ, Knotts TA, Grino M, Naour N, Bastard JP, Clement K, Ninkina N, Buchman VL, Permana PA, Luo X, Pan G, Dunn TN, Adams SH (2008) Gamma-synuclein is an adipocyte-neuron gene coordinately expressed with leptin and increased in human obesity. J Nutr 138(5):841–848
84. Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou Z, Wang L (2009) FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 16(3):259–266
85. Plunet WT, Streijger F, Lam CK, Lee JH, Liu J, Tetzlaff W (2008) Dietary restriction started after spinal cord injury improves functional recovery. Exp Neurol 213(1):28–35
86. Robertson LT, Mitchell JR (2013) Benefits of short-term dietary restriction in mammals. Exp Gerontol 48(10):1043–1048
87. Schayek H, Bentov I, Jacob-Hirsch J, Yeung C, Khanna C, Helman LJ, Plymate SR, Werner H (2012) Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer. Horm Metab Res 44(7):511–519
88. Sethi JK, Vidal-Puig AJ (2007) Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res 48(6):1253–1262
89. Sethi JK, Vidal-Puig A (2010) Wnt signalling and the control of cellular metabolism. Biochem J 427(1):1–17
90. Sima A, Manolescu DC, Bhat P (2011) Retinoids and retinoid-metabolic gene expression in mouse adipose tissues. Biochem Cell Biol 89(6):578–584
91. Skurk T, Alberti-Huber C, Herder C, Hauner H (2007) Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 92(3):1023–1033
92. Speakman JR, Mitchell SE (2011) Caloric restriction. Mol Asp Med 32(3):159–221
93. Sutphin GL, Kaeberlein M (2008) Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Exp Gerontol 43(3):130–135
94. Swindell WR (2009) Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse. BMC Genom 10:585
95. Takahashi M, Kamei Y, Ezaki O (2005) Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size. Am J Physiol Endocrinol Metab 288(1):E117–E124
96. Tremblay F, Revett T, Huard C, Zhang Y, Tobin JF, Martinez RV, Gimeno RE (2009) Bidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB. J Biol Chem 284(12):8136–8147
97. Tripathi R, Mishra R (2012) Aging-associated modulation in the expression of Pax6 in mouse brain. Cell Mol Neurobiol 32(2):209–218
98. Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW (1999) Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. J Gerontol A Biol Sci Med Sci 54(11):B492–B501
99. Venda LL, Cragg SJ, Buchman VL, Wade-Martins R (2010) alpha- Synuclein and dopamine at the crossroads of Parkinson’s disease. Trends Neurosci 33(12):559–568
100. Voigt A, Agnew K, van Schothorst EM, Keijer J, Klaus S (2013) Short-term, high fat feeding-induced changes in white adipose tissue gene expression are highly predictive for long-term changes. Mol Nutr Food Res 57(8):1423–1434
101. Walden TB, Hansen IR, Timmons JA, Cannon B, Nedergaard J (2012) Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues. Am J Physiol Endocrinol Metab 302(1):E19–E31
102. Wang JY, Yeh CL, Chou HC, Yang CH, Fu YN, Chen YT, Cheng HW, Huang CY, Liu HP, Huang SF, Chen YR (2011) Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer. J Biol Chem 286(12):10177–10184
103. Weithoff G (2007) Dietary restriction in two rotifer species: the effect of the length of food deprivation on life span and reproduction. Oecologia 153(2):303–308
104. Wellmann A, Fogt F, Hollerbach S, Hahne J, Koenig-Hoffmann K, Smeets D, Brinkmann U (2010) Polymorphisms of the apoptosis- associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease. J Cancer Res Clin Oncol 136(6):795–802
105. Yabana N, Shibuya M (2002) Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. Oncogene 21(50):7720–7729
106. Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG (2011) Protection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling. Cell Metab 14(1):67–79
107. Yamagishi T, Bessho M, Yanagida S, Nishizawa K, Kusuhara M, Ohsuzu F, Tamai S (2010) Severe, short-term food restriction improves cardiac function following ischemia/reperfusion in perfused rat hearts. Heart Vessels 25(5):417–425
108. Yu BP, Masoro EJ, McMahan CA (1985) Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics. J Gerontol 40(6):657–670
109. Zeeberg BR, Feng W, Wang G, Wang MD, Fojo AT, Sunshine M, Narasimhan S, Kane DW, Reinhold WC, Lababidi S, Bussey KJ, Riss J, Barrett JC, Weinstein JN (2003) GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol 4(4):R28
110. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372(6505):425–432